SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9H2D6

- TARA_HUMAN

UniProt

Q9H2D6 - TARA_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

TRIO and F-actin-binding protein

Gene
TRIOBP, KIAA1662, TARA, HRIHFB2122
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.1 Publication

GO - Molecular functioni

  1. actin filament binding Source: MGI
  2. GTP-Rho binding Source: UniProtKB
  3. myosin II binding Source: UniProtKB
  4. ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

  1. actin modification Source: UniProtKB
  2. barbed-end actin filament capping Source: UniProtKB
  3. mitotic nuclear division Source: UniProtKB-KW
  4. positive regulation of substrate adhesion-dependent cell spreading Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TRIO and F-actin-binding protein
Alternative name(s):
Protein Tara
Trio-associated repeat on actin
Gene namesi
Name:TRIOBP
Synonyms:KIAA1662, TARA
ORF Names:HRIHFB2122
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:17009. TRIOBP.

Subcellular locationi

Nucleus. Cytoplasmcytoskeleton
Note: Localized to F-actin in a periodic pattern.2 Publications
Isoform 1 : Nucleus. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Midbody
Note: Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-457 and lasts from prophase to anaphase. At telophase, relocalizes to midbody.2 Publications

GO - Cellular componenti

  1. actin cytoskeleton Source: UniProtKB
  2. cytoplasm Source: HPA
  3. microtubule organizing center Source: UniProtKB-SubCell
  4. midbody Source: UniProtKB-SubCell
  5. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal recessive, 28 (DFNB28) [MIM:609823]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1019 – 10191G → R in DFNB28. 1 Publication
VAR_025719

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

MIMi609823. phenotype.
Orphaneti90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.
PharmGKBiPA142670699.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23652365TRIO and F-actin-binding proteinPRO_0000072433Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1949 – 19491Phosphoserine2 Publications
Modified residuei1955 – 19551Phosphoserine3 Publications
Modified residuei2229 – 22291Phosphothreonine; by PLK11 Publication

Post-translational modificationi

Ubiquitinated by HECTD3, leading to its degradation by the proteasome.1 Publication
Isoform 1: Phosphorylation at Thr-457 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9H2D6.
PaxDbiQ9H2D6.
PRIDEiQ9H2D6.

PTM databases

PhosphoSiteiQ9H2D6.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in heart and placenta. Isoform 3 is expressed in fetal brain, retina and cochlea but is not detectable in the other tissues.1 Publication

Gene expression databases

ArrayExpressiQ9H2D6.
BgeeiQ9H2D6.
GenevestigatoriQ9H2D6.

Organism-specific databases

HPAiHPA003747.
HPA019769.

Interactioni

Subunit structurei

Binds to TRIO and F-actin. May also interact with myosin II. Interacts with HECTD3.1 Publication

Protein-protein interaction databases

BioGridi116261. 9 interactions.
IntActiQ9H2D6. 9 interactions.
MINTiMINT-1397991.

Structurei

3D structure databases

ProteinModelPortaliQ9H2D6.
SMRiQ9H2D6. Positions 1781-1886.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1778 – 1887110PHAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili2062 – 2247186 Reviewed predictionAdd
BLAST
Coiled coili2281 – 236181 Reviewed predictionAdd
BLAST

Domaini

Sequence similaritiesi

Contains 1 PH domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG12793.
HOVERGENiHBG094025.
InParanoidiQ9H2D6.
OMAiPYCDLPR.
OrthoDBiEOG773XKP.
PhylomeDBiQ9H2D6.
TreeFamiTF343361.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 2 (identifier: Q9H2D6-1) [UniParc]FASTAAdd to Basket

Also known as: TRIOBP-6

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEEVPGDALC EHFEANILTQ NRCQNCFHPE EAHGARYQEL RSPSGAEVPY     50
CDLPRCPPAP EDPLSASTSG CQSVVDPGLR PGPKRGPSPS AGLPEEGPTA 100
APRSRSRELE AVPYLEGLTT SLCGSCNEDP GSDPTSSPDS ATPDDTSNSS 150
SVDWDTVERQ EEEAPSWDEL AVMIPRRPRE GPRADSSQRA PSLLTRSPVG 200
GDAAGQKKED TGGGGRSAGQ HWARLRGESG LSLERHRSTL TQASSMTPHS 250
GPRSTTSQAS PAQRDTAQAA STREIPRASS PHRITQRDTS RASSTQQEIS 300
RASSTQQETS RASSTQEDTP RASSTQEDTP RASSTQWNTP RASSPSRSTQ 350
LDNPRTSSTQ QDNPQTSFPT CTPQRENPRT PCVQQDDPRA SSPNRTTQRE 400
NSRTSCAQRD NPKASRTSSP NRATRDNPRT SCAQRDNPRA SSPSRATRDN 450
PTTSCAQRDN PRASRTSSPN RATRDNPRTS CAQRDNPRAS SPSRATRDNP 500
TTSCAQRDNP RASRTSSPNR ATRDNPRTSC AQRDNPRASS PNRAARDNPT 550
TSCAQRDNPR ASRTSSPNRA TRDNPRTSCA QRDNPRASSP NRATRDNPTT 600
SCAQRDNPRA SRTSSPNRAT RDNPRTSCAQ RDNPRASSPN RTTQQDSPRT 650
SCARRDDPRA SSPNRTIQQE NPRTSCALRD NPRASSPSRT IQQENPRTSC 700
AQRDDPRASS PNRTTQQENP RTSCARRDNP RASSRNRTIQ RDNPRTSCAQ 750
RDNPRASSPN RTIQQENLRT SCTRQDNPRT SSPNRATRDN PRTSCAQRDN 800
LRASSPIRAT QQDNPRTCIQ QNIPRSSSTQ QDNPKTSCTK RDNLRPTCTQ 850
RDRTQSFSFQ RDNPGTSSSQ CCTQKENLRP SSPHRSTQWN NPRNSSPHRT 900
NKDIPWASFP LRPTQSDGPR TSSPSRSKQS EVPWASIALR PTQGDRPQTS 950
SPSRPAQHDP PQSSFGPTQY NLPSRATSSS HNPGHQSTSR TSSPVYPAAY 1000
GAPLTSPEPS QPPCAVCIGH RDAPRASSPP RYLQHDPFPF FPEPRAPESE 1050
PPHHEPPYIP PAVCIGHRDA PRASSPPRHT QFDPFPFLPD TSDAEHQCQS 1100
PQHEPLQLPA PVCIGYRDAP RASSPPRQAP EPSLLFQDLP RASTESLVPS 1150
MDSLHECPHI PTPVCIGHRD APSFSSPPRQ APEPSLFFQD PPGTSMESLA 1200
PSTDSLHGSP VLIPQVCIGH RDAPRASSPP RHPPSDLAFL APSPSPGSSG 1250
GSRGSAPPGE TRHNLEREEY TVLADLPPPR RLAQRQPGPQ AQCSSGGRTH 1300
SPGRAEVERL FGQERRKSEA AGAFQAQDEG RSQQPSQGQS QLLRRQSSPA 1350
PSRQVTMLPA KQAELTRRSQ AEPPHPWSPE KRPEGDRQLQ GSPLPPRTSA 1400
RTPERELRTQ RPLESGQAGP RQPLGVWQSQ EEPPGSQGPH RHLERSWSSQ 1450
EGGLGPGGWW GCGEPSLGAA KAPEGAWGGT SREYKESWGQ PEAWEEKPTH 1500
ELPRELGKRS PLTSPPENWG GPAESSQSWH SGTPTAVGWG AEGACPYPRG 1550
SERRPELDWR DLLGLLRAPG EGVWARVPSL DWEGLLELLQ ARLPRKDPAG 1600
HRDDLARALG PELGPPGTND VPEQESHSQP EGWAEATPVN GHSPALQSQS 1650
PVQLPSPACT STQWPKIKVT RGPATATLAG LEQTGPLGSR STAKGPSLPE 1700
LQFQPEEPEE SEPSRGQDPL TDQKQADSAD KRPAEGKAGS PLKGRLVTSW 1750
RMPGDRPTLF NPFLLSLGVL RWRRPDLLNF KKGWMSILDE PGEPPSPSLT 1800
TTSTSQWKKH WFVLTDSSLK YYRDSTAEEA DELDGEIDLR SCTDVTEYAV 1850
QRNYGFQIHT KDAVYTLSAM TSGIRRNWIE ALRKTVRPTS APDVTKLSDS 1900
NKENALHSYS TQKGPLKAGE QRAGSEVISR GGPRKADGQR QALDYVELSP 1950
LTQASPQRAR TPARTPDRLA KQEELERDLA QRSEERRKWF EATDSRTPEV 2000
PAGEGPRRGL GAPLTEDQQN RLSEEIEKKW QELEKLPLRE NKRVPLTALL 2050
NQSRGERRGP PSDGHEALEK EVQALRAQLE AWRLQGEAPQ SALRSQEDGH 2100
IPPGYISQEA CERSLAEMES SHQQVMEELQ RHHERELQRL QQEKEWLLAE 2150
ETAATASAIE AMKKAYQEEL SRELSKTRSL QQGPDGLRKQ HQSDVEALKR 2200
ELQVLSEQYS QKCLEIGALM RQAEEREHTL RRCQQEGQEL LRHNQELHGR 2250
LSEEIDQLRG FIASQGMGNG CGRSNERSSC ELEVLLRVKE NELQYLKKEV 2300
QCLRDELQMM QKDKRFTSGK YQDVYVELSH IKTRSEREIE QLKEHLRLAM 2350
AALQEKESMR NSLAE 2365
Length:2,365
Mass (Da):261,376
Last modified:March 21, 2006 - v3
Checksum:iB2CF9AD57E930283
GO
Isoform 3 (identifier: Q9H2D6-2) [UniParc]FASTAAdd to Basket

Also known as: Long isoform

The sequence of this isoform differs from the canonical sequence as follows:
     1317-1355: Missing.
     1729-1774: Missing.
     1794-1806: Missing.

Show »
Length:2,267
Mass (Da):250,724
Checksum:iA0055359F5C3D655
GO
Isoform 4 (identifier: Q9H2D6-3) [UniParc]FASTAAdd to Basket

Also known as: TRIOBP-3

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: Missing.

Show »
Length:2,193
Mass (Da):243,071
Checksum:i2056F789C0E11E01
GO
Isoform 5 (identifier: Q9H2D6-4) [UniParc]FASTAAdd to Basket

Also known as: TRIOBP-4

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: Missing.
     1317-2365: Missing.

Show »
Length:1,144
Mass (Da):125,524
Checksum:i90E403C1C0B946FD
GO
Isoform 1 (identifier: Q9H2D6-5) [UniParc]FASTAAdd to Basket

Also known as: TRIOBP-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-1772: Missing.
     1773-1774: RR → MT

Show »
Length:593
Mass (Da):68,041
Checksum:i109AA7D9CC10B21A
GO
Isoform 6 (identifier: Q9H2D6-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MEEVPGDALC...DLPRCPPAPE → MGGWKGPGQR...LPPPWGAAMT
     62-1774: Missing.
     2109-2144: EACERSLAEMESSHQQVMEELQRHHERELQRLQQEK → LVGVITVPVLQTRPLSSERLCDLPKVTPPAGLKGGI
     2145-2365: Missing.

Note: No experimental confirmation available.

Show »
Length:431
Mass (Da):47,624
Checksum:i499617230FA5DAC3
GO
Isoform 7 (identifier: Q9H2D6-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MEEVPGDALC...DLPRCPPAPE → MGGWKGPGQR...LPPPWGAAMT
     62-1774: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »
Length:652
Mass (Da):74,048
Checksum:i2B3B90A23A047212
GO

Sequence cautioni

The sequence BAA34800.1 differs from that shown. Reason: Frameshift at position 478.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti217 – 2171S → N.
Corresponds to variant rs12628603 [ dbSNP | Ensembl ].
VAR_059725
Natural varianti493 – 4931S → N.
Corresponds to variant rs4821700 [ dbSNP | Ensembl ].
VAR_059726
Natural varianti817 – 8171T → S.
Corresponds to variant rs41302575 [ dbSNP | Ensembl ].
VAR_061708
Natural varianti863 – 8631N → K.
Corresponds to variant rs9610841 [ dbSNP | Ensembl ].
VAR_051412
Natural varianti1019 – 10191G → R in DFNB28. 1 Publication
VAR_025719
Natural varianti1187 – 11871F → L.
Corresponds to variant rs5756795 [ dbSNP | Ensembl ].
VAR_059727
Natural varianti1300 – 13001H → R.
Corresponds to variant rs739138 [ dbSNP | Ensembl ].
VAR_059728
Natural varianti1372 – 13721E → D.
Corresponds to variant rs8140207 [ dbSNP | Ensembl ].
VAR_051413
Natural varianti1377 – 13771W → R.2 Publications
Corresponds to variant rs8140958 [ dbSNP | Ensembl ].
VAR_051414

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 17721772Missing in isoform 1. VSP_017711Add
BLAST
Alternative sequencei1 – 172172Missing in isoform 4 and isoform 5. VSP_017712Add
BLAST
Alternative sequencei1 – 6161MEEVP…PPAPE → MGGWKGPGQRRGKEGPEARR RAAERGGGGGGGGVPAPRSP AREPRPRSCLLLPPPWGAAM T in isoform 6 and isoform 7. VSP_047498Add
BLAST
Alternative sequencei62 – 17741713Missing in isoform 6 and isoform 7. VSP_047499Add
BLAST
Alternative sequencei1317 – 23651049Missing in isoform 5. VSP_017713Add
BLAST
Alternative sequencei1317 – 135539Missing in isoform 3. VSP_017714Add
BLAST
Alternative sequencei1729 – 177446Missing in isoform 3. VSP_017715Add
BLAST
Alternative sequencei1773 – 17742RR → MT in isoform 1. VSP_017716
Alternative sequencei1794 – 180613Missing in isoform 3. VSP_017717Add
BLAST
Alternative sequencei2109 – 214436EACER…LQQEK → LVGVITVPVLQTRPLSSERL CDLPKVTPPAGLKGGI in isoform 6. VSP_047500Add
BLAST
Alternative sequencei2145 – 2365221Missing in isoform 6. VSP_047501Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti713 – 7197RTTQQEN → KSTFGCL in BAB33332. 1 Publication
Sequence conflicti1421 – 14211R → S in ABB77204. 1 Publication
Sequence conflicti1689 – 16891S → G in ABB77204. 1 Publication
Sequence conflicti1896 – 18961Missing in ABB77204. 1 Publication
Sequence conflicti1904 – 19041N → D in ABB77204. 1 Publication
Sequence conflicti2114 – 21141S → T in AAG44841. 1 Publication
Sequence conflicti2141 – 21411Q → L in AAH04303. 1 Publication
Sequence conflicti2274 – 22741S → T in AAG44841. 1 Publication
Sequence conflicti2283 – 22831E → EHLYPQ in AAH04303. 1 Publication
Sequence conflicti2359 – 23591M → I in AAG44841. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF281030 mRNA. Translation: AAG44841.1.
DQ228003 mRNA. Translation: ABB59559.1.
DQ228004 mRNA. Translation: ABB59560.1.
DQ228005 mRNA. Translation: ABB59561.1.
DQ278603 mRNA. Translation: ABB77204.1.
Z83844 Genomic DNA. No translation available.
BC003618 mRNA. Translation: AAH03618.1.
BC004303 mRNA. Translation: AAH04303.1.
BC013278 mRNA. Translation: AAH13278.2.
BC022200 mRNA. No translation available.
AB015343 mRNA. Translation: BAA34800.1. Frameshift.
AB051449 mRNA. Translation: BAB33332.2.
CCDSiCCDS33644.1. [Q9H2D6-6]
CCDS43015.1. [Q9H2D6-1]
CCDS43016.1. [Q9H2D6-7]
RefSeqiNP_001034230.1. NM_001039141.2. [Q9H2D6-1]
NP_008963.3. NM_007032.5. [Q9H2D6-7]
NP_619538.2. NM_138632.2. [Q9H2D6-6]
UniGeneiHs.533030.

Genome annotation databases

EnsembliENST00000403663; ENSP00000386026; ENSG00000100106.
ENST00000406386; ENSP00000384312; ENSG00000100106. [Q9H2D6-1]
ENST00000407319; ENSP00000383913; ENSG00000100106. [Q9H2D6-6]
GeneIDi11078.
KEGGihsa:11078.
UCSCiuc003atq.1. human. [Q9H2D6-1]
uc003ats.1. human. [Q9H2D6-4]

Polymorphism databases

DMDMi90110075.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF281030 mRNA. Translation: AAG44841.1 .
DQ228003 mRNA. Translation: ABB59559.1 .
DQ228004 mRNA. Translation: ABB59560.1 .
DQ228005 mRNA. Translation: ABB59561.1 .
DQ278603 mRNA. Translation: ABB77204.1 .
Z83844 Genomic DNA. No translation available.
BC003618 mRNA. Translation: AAH03618.1 .
BC004303 mRNA. Translation: AAH04303.1 .
BC013278 mRNA. Translation: AAH13278.2 .
BC022200 mRNA. No translation available.
AB015343 mRNA. Translation: BAA34800.1 . Frameshift.
AB051449 mRNA. Translation: BAB33332.2 .
CCDSi CCDS33644.1. [Q9H2D6-6 ]
CCDS43015.1. [Q9H2D6-1 ]
CCDS43016.1. [Q9H2D6-7 ]
RefSeqi NP_001034230.1. NM_001039141.2. [Q9H2D6-1 ]
NP_008963.3. NM_007032.5. [Q9H2D6-7 ]
NP_619538.2. NM_138632.2. [Q9H2D6-6 ]
UniGenei Hs.533030.

3D structure databases

ProteinModelPortali Q9H2D6.
SMRi Q9H2D6. Positions 1781-1886.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116261. 9 interactions.
IntActi Q9H2D6. 9 interactions.
MINTi MINT-1397991.

PTM databases

PhosphoSitei Q9H2D6.

Polymorphism databases

DMDMi 90110075.

Proteomic databases

MaxQBi Q9H2D6.
PaxDbi Q9H2D6.
PRIDEi Q9H2D6.

Protocols and materials databases

DNASUi 11078.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000403663 ; ENSP00000386026 ; ENSG00000100106 .
ENST00000406386 ; ENSP00000384312 ; ENSG00000100106 . [Q9H2D6-1 ]
ENST00000407319 ; ENSP00000383913 ; ENSG00000100106 . [Q9H2D6-6 ]
GeneIDi 11078.
KEGGi hsa:11078.
UCSCi uc003atq.1. human. [Q9H2D6-1 ]
uc003ats.1. human. [Q9H2D6-4 ]

Organism-specific databases

CTDi 11078.
GeneCardsi GC22P038092.
GeneReviewsi TRIOBP.
HGNCi HGNC:17009. TRIOBP.
HPAi HPA003747.
HPA019769.
MIMi 609761. gene.
609823. phenotype.
neXtProti NX_Q9H2D6.
Orphaneti 90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.
PharmGKBi PA142670699.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOVERGENi HBG094025.
InParanoidi Q9H2D6.
OMAi PYCDLPR.
OrthoDBi EOG773XKP.
PhylomeDBi Q9H2D6.
TreeFami TF343361.

Miscellaneous databases

ChiTaRSi TRIOBP. human.
GeneWikii TRIOBP.
GenomeRNAii 11078.
NextBioi 42114.
PROi Q9H2D6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9H2D6.
Bgeei Q9H2D6.
Genevestigatori Q9H2D6.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF00169. PH. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
[Graphical view ]
PROSITEi PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization."
    Seipel K., O'Brien S.P., Iannotti E., Medley Q.G., Streuli M.
    J. Cell Sci. 114:389-399(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness."
    Riazuddin S., Khan S.N., Ahmed Z.M., Ghosh M., Caution K., Nazli S., Kabra M., Zafar A.U., Chen K., Naz S., Antonellis A., Pavan W.J., Green E.D., Wilcox E.R., Friedman P.L., Morell R.J., Riazuddin S., Friedman T.B.
    Am. J. Hum. Genet. 78:137-143(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 4 AND 5), INVOLVEMENT IN DFNB28.
    Tissue: Inner ear.
  3. "Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss."
    Shahin H., Walsh T., Sobe T., Abu Sa'ed J., Abu Rayan A., Lynch E.D., Lee M.K., Avraham K.B., King M.-C., Kanaan M.
    Am. J. Hum. Genet. 78:144-152(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, VARIANTS DFNB28 ARG-1019 AND ARG-1377.
    Tissue: Brain.
  4. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-431 (ISOFORM 6).
    Tissue: Colon and Pancreas.
  6. "Selection system for genes encoding nuclear-targeted proteins."
    Ueki N., Oda T., Kondo M., Yano K., Noguchi T., Muramatsu M.-A.
    Nat. Biotechnol. 16:1338-1342(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 340-563, SUBCELLULAR LOCATION.
    Tissue: Fetal brain.
  7. "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping."
    Hirosawa M., Nagase T., Murahashi Y., Kikuno R., Ohara O.
    DNA Res. 8:1-9(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 713-2365, VARIANT ARG-1377.
    Tissue: Brain.
  8. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  9. "The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara."
    Yu J., Lan J., Zhu Y., Li X., Lai X., Xue Y., Jin C., Huang H.
    Biochem. Biophys. Res. Commun. 367:805-812(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH HECTD3, UBIQUITINATION.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1949 AND SER-1955, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1955, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1949 AND SER-1955, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Phosphorylation of Tara by Plk1 is essential for faithful chromosome segregation in mitosis."
    Zhu Y., Wang C., Lan J., Yu J., Jin C., Huang H.
    Exp. Cell Res. 318:2344-2352(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-2229, SUBCELLULAR LOCATION (ISOFORM 1).

Entry informationi

Entry nameiTARA_HUMAN
AccessioniPrimary (citable) accession number: Q9H2D6
Secondary accession number(s): B1AHD4
, B1AHD7, F2Z2W0, F8W6V6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 21, 2006
Last modified: September 3, 2014
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Has been identified in 1 Publication by a selection system for genes encoding nuclear-targeted protein.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi