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Q9H2D6

- TARA_HUMAN

UniProt

Q9H2D6 - TARA_HUMAN

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Protein

TRIO and F-actin-binding protein

Gene

TRIOBP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.1 Publication

GO - Molecular functioni

  1. actin filament binding Source: MGI
  2. GTP-Rho binding Source: UniProtKB
  3. myosin II binding Source: UniProtKB
  4. ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

  1. actin modification Source: UniProtKB
  2. barbed-end actin filament capping Source: UniProtKB
  3. mitotic nuclear division Source: UniProtKB-KW
  4. positive regulation of substrate adhesion-dependent cell spreading Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TRIO and F-actin-binding protein
Alternative name(s):
Protein Tara
Trio-associated repeat on actin
Gene namesi
Name:TRIOBP
Synonyms:KIAA1662, TARA
ORF Names:HRIHFB2122
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:17009. TRIOBP.

Subcellular locationi

Nucleus 1 Publication. Cytoplasmcytoskeleton 1 Publication
Note: Localized to F-actin in a periodic pattern.
Isoform 1 : Nucleus 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication. Midbody 1 Publication
Note: Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-457 and lasts from prophase to anaphase. At telophase, relocalizes to midbody.

GO - Cellular componenti

  1. actin cytoskeleton Source: UniProtKB
  2. cytoplasm Source: HPA
  3. focal adhesion Source: UniProtKB
  4. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal recessive, 28 (DFNB28) [MIM:609823]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1019 – 10191G → R in DFNB28. 1 Publication
VAR_025719

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

MIMi609823. phenotype.
Orphaneti90636. Autosomal recessive non-syndromic sensorineural deafness type DFNB.
PharmGKBiPA142670699.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23652365TRIO and F-actin-binding proteinPRO_0000072433Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1949 – 19491Phosphoserine2 Publications
Modified residuei1955 – 19551Phosphoserine3 Publications
Modified residuei2229 – 22291Phosphothreonine; by PLK11 Publication

Post-translational modificationi

Ubiquitinated by HECTD3, leading to its degradation by the proteasome.1 Publication
Isoform 1: Phosphorylation at Thr-457 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation.4 Publications

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9H2D6.
PaxDbiQ9H2D6.
PRIDEiQ9H2D6.

PTM databases

PhosphoSiteiQ9H2D6.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in heart and placenta. Isoform 3 is expressed in fetal brain, retina and cochlea but is not detectable in the other tissues.1 Publication

Gene expression databases

BgeeiQ9H2D6.
ExpressionAtlasiQ9H2D6. baseline and differential.
GenevestigatoriQ9H2D6.

Organism-specific databases

HPAiHPA003747.
HPA019769.

Interactioni

Subunit structurei

Binds to TRIO and F-actin. May also interact with myosin II. Interacts with HECTD3.1 Publication

Protein-protein interaction databases

BioGridi116261. 11 interactions.
IntActiQ9H2D6. 9 interactions.
MINTiMINT-1397991.

Structurei

3D structure databases

ProteinModelPortaliQ9H2D6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1778 – 1887110PHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili2062 – 2247186Sequence AnalysisAdd
BLAST
Coiled coili2281 – 236181Sequence AnalysisAdd
BLAST

Domaini

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00530000063678.
HOVERGENiHBG094025.
InParanoidiQ9H2D6.
OMAiPYCDLPR.
OrthoDBiEOG773XKP.
PhylomeDBiQ9H2D6.
TreeFamiTF343361.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. Align

Isoform 2 (identifier: Q9H2D6-1) [UniParc]FASTAAdd to Basket

Also known as: TRIOBP-6

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEVPGDALC EHFEANILTQ NRCQNCFHPE EAHGARYQEL RSPSGAEVPY
60 70 80 90 100
CDLPRCPPAP EDPLSASTSG CQSVVDPGLR PGPKRGPSPS AGLPEEGPTA
110 120 130 140 150
APRSRSRELE AVPYLEGLTT SLCGSCNEDP GSDPTSSPDS ATPDDTSNSS
160 170 180 190 200
SVDWDTVERQ EEEAPSWDEL AVMIPRRPRE GPRADSSQRA PSLLTRSPVG
210 220 230 240 250
GDAAGQKKED TGGGGRSAGQ HWARLRGESG LSLERHRSTL TQASSMTPHS
260 270 280 290 300
GPRSTTSQAS PAQRDTAQAA STREIPRASS PHRITQRDTS RASSTQQEIS
310 320 330 340 350
RASSTQQETS RASSTQEDTP RASSTQEDTP RASSTQWNTP RASSPSRSTQ
360 370 380 390 400
LDNPRTSSTQ QDNPQTSFPT CTPQRENPRT PCVQQDDPRA SSPNRTTQRE
410 420 430 440 450
NSRTSCAQRD NPKASRTSSP NRATRDNPRT SCAQRDNPRA SSPSRATRDN
460 470 480 490 500
PTTSCAQRDN PRASRTSSPN RATRDNPRTS CAQRDNPRAS SPSRATRDNP
510 520 530 540 550
TTSCAQRDNP RASRTSSPNR ATRDNPRTSC AQRDNPRASS PNRAARDNPT
560 570 580 590 600
TSCAQRDNPR ASRTSSPNRA TRDNPRTSCA QRDNPRASSP NRATRDNPTT
610 620 630 640 650
SCAQRDNPRA SRTSSPNRAT RDNPRTSCAQ RDNPRASSPN RTTQQDSPRT
660 670 680 690 700
SCARRDDPRA SSPNRTIQQE NPRTSCALRD NPRASSPSRT IQQENPRTSC
710 720 730 740 750
AQRDDPRASS PNRTTQQENP RTSCARRDNP RASSRNRTIQ RDNPRTSCAQ
760 770 780 790 800
RDNPRASSPN RTIQQENLRT SCTRQDNPRT SSPNRATRDN PRTSCAQRDN
810 820 830 840 850
LRASSPIRAT QQDNPRTCIQ QNIPRSSSTQ QDNPKTSCTK RDNLRPTCTQ
860 870 880 890 900
RDRTQSFSFQ RDNPGTSSSQ CCTQKENLRP SSPHRSTQWN NPRNSSPHRT
910 920 930 940 950
NKDIPWASFP LRPTQSDGPR TSSPSRSKQS EVPWASIALR PTQGDRPQTS
960 970 980 990 1000
SPSRPAQHDP PQSSFGPTQY NLPSRATSSS HNPGHQSTSR TSSPVYPAAY
1010 1020 1030 1040 1050
GAPLTSPEPS QPPCAVCIGH RDAPRASSPP RYLQHDPFPF FPEPRAPESE
1060 1070 1080 1090 1100
PPHHEPPYIP PAVCIGHRDA PRASSPPRHT QFDPFPFLPD TSDAEHQCQS
1110 1120 1130 1140 1150
PQHEPLQLPA PVCIGYRDAP RASSPPRQAP EPSLLFQDLP RASTESLVPS
1160 1170 1180 1190 1200
MDSLHECPHI PTPVCIGHRD APSFSSPPRQ APEPSLFFQD PPGTSMESLA
1210 1220 1230 1240 1250
PSTDSLHGSP VLIPQVCIGH RDAPRASSPP RHPPSDLAFL APSPSPGSSG
1260 1270 1280 1290 1300
GSRGSAPPGE TRHNLEREEY TVLADLPPPR RLAQRQPGPQ AQCSSGGRTH
1310 1320 1330 1340 1350
SPGRAEVERL FGQERRKSEA AGAFQAQDEG RSQQPSQGQS QLLRRQSSPA
1360 1370 1380 1390 1400
PSRQVTMLPA KQAELTRRSQ AEPPHPWSPE KRPEGDRQLQ GSPLPPRTSA
1410 1420 1430 1440 1450
RTPERELRTQ RPLESGQAGP RQPLGVWQSQ EEPPGSQGPH RHLERSWSSQ
1460 1470 1480 1490 1500
EGGLGPGGWW GCGEPSLGAA KAPEGAWGGT SREYKESWGQ PEAWEEKPTH
1510 1520 1530 1540 1550
ELPRELGKRS PLTSPPENWG GPAESSQSWH SGTPTAVGWG AEGACPYPRG
1560 1570 1580 1590 1600
SERRPELDWR DLLGLLRAPG EGVWARVPSL DWEGLLELLQ ARLPRKDPAG
1610 1620 1630 1640 1650
HRDDLARALG PELGPPGTND VPEQESHSQP EGWAEATPVN GHSPALQSQS
1660 1670 1680 1690 1700
PVQLPSPACT STQWPKIKVT RGPATATLAG LEQTGPLGSR STAKGPSLPE
1710 1720 1730 1740 1750
LQFQPEEPEE SEPSRGQDPL TDQKQADSAD KRPAEGKAGS PLKGRLVTSW
1760 1770 1780 1790 1800
RMPGDRPTLF NPFLLSLGVL RWRRPDLLNF KKGWMSILDE PGEPPSPSLT
1810 1820 1830 1840 1850
TTSTSQWKKH WFVLTDSSLK YYRDSTAEEA DELDGEIDLR SCTDVTEYAV
1860 1870 1880 1890 1900
QRNYGFQIHT KDAVYTLSAM TSGIRRNWIE ALRKTVRPTS APDVTKLSDS
1910 1920 1930 1940 1950
NKENALHSYS TQKGPLKAGE QRAGSEVISR GGPRKADGQR QALDYVELSP
1960 1970 1980 1990 2000
LTQASPQRAR TPARTPDRLA KQEELERDLA QRSEERRKWF EATDSRTPEV
2010 2020 2030 2040 2050
PAGEGPRRGL GAPLTEDQQN RLSEEIEKKW QELEKLPLRE NKRVPLTALL
2060 2070 2080 2090 2100
NQSRGERRGP PSDGHEALEK EVQALRAQLE AWRLQGEAPQ SALRSQEDGH
2110 2120 2130 2140 2150
IPPGYISQEA CERSLAEMES SHQQVMEELQ RHHERELQRL QQEKEWLLAE
2160 2170 2180 2190 2200
ETAATASAIE AMKKAYQEEL SRELSKTRSL QQGPDGLRKQ HQSDVEALKR
2210 2220 2230 2240 2250
ELQVLSEQYS QKCLEIGALM RQAEEREHTL RRCQQEGQEL LRHNQELHGR
2260 2270 2280 2290 2300
LSEEIDQLRG FIASQGMGNG CGRSNERSSC ELEVLLRVKE NELQYLKKEV
2310 2320 2330 2340 2350
QCLRDELQMM QKDKRFTSGK YQDVYVELSH IKTRSEREIE QLKEHLRLAM
2360
AALQEKESMR NSLAE
Length:2,365
Mass (Da):261,376
Last modified:March 21, 2006 - v3
Checksum:iB2CF9AD57E930283
GO
Isoform 3 (identifier: Q9H2D6-2) [UniParc]FASTAAdd to Basket

Also known as: Long isoform

The sequence of this isoform differs from the canonical sequence as follows:
     1317-1355: Missing.
     1729-1774: Missing.
     1794-1806: Missing.

Show »
Length:2,267
Mass (Da):250,724
Checksum:iA0055359F5C3D655
GO
Isoform 4 (identifier: Q9H2D6-3) [UniParc]FASTAAdd to Basket

Also known as: TRIOBP-3

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: Missing.

Show »
Length:2,193
Mass (Da):243,071
Checksum:i2056F789C0E11E01
GO
Isoform 5 (identifier: Q9H2D6-4) [UniParc]FASTAAdd to Basket

Also known as: TRIOBP-4

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: Missing.
     1317-2365: Missing.

Show »
Length:1,144
Mass (Da):125,524
Checksum:i90E403C1C0B946FD
GO
Isoform 1 (identifier: Q9H2D6-5) [UniParc]FASTAAdd to Basket

Also known as: TRIOBP-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-1772: Missing.
     1773-1774: RR → MT

Show »
Length:593
Mass (Da):68,041
Checksum:i109AA7D9CC10B21A
GO
Isoform 6 (identifier: Q9H2D6-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MEEVPGDALC...DLPRCPPAPE → MGGWKGPGQR...LPPPWGAAMT
     62-1774: Missing.
     2109-2144: EACERSLAEMESSHQQVMEELQRHHERELQRLQQEK → LVGVITVPVLQTRPLSSERLCDLPKVTPPAGLKGGI
     2145-2365: Missing.

Note: No experimental confirmation available.

Show »
Length:431
Mass (Da):47,624
Checksum:i499617230FA5DAC3
GO
Isoform 7 (identifier: Q9H2D6-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MEEVPGDALC...DLPRCPPAPE → MGGWKGPGQR...LPPPWGAAMT
     62-1774: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.

Show »
Length:652
Mass (Da):74,048
Checksum:i2B3B90A23A047212
GO

Sequence cautioni

The sequence BAA34800.1 differs from that shown. Reason: Frameshift at position 478. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti713 – 7197RTTQQEN → KSTFGCL in BAB33332. (PubMed:11258795)Curated
Sequence conflicti1421 – 14211R → S in ABB77204. (PubMed:16385458)Curated
Sequence conflicti1689 – 16891S → G in ABB77204. (PubMed:16385458)Curated
Sequence conflicti1896 – 18961Missing in ABB77204. (PubMed:16385458)Curated
Sequence conflicti1904 – 19041N → D in ABB77204. (PubMed:16385458)Curated
Sequence conflicti2114 – 21141S → T in AAG44841. (PubMed:11148140)Curated
Sequence conflicti2141 – 21411Q → L in AAH04303. (PubMed:15489334)Curated
Sequence conflicti2274 – 22741S → T in AAG44841. (PubMed:11148140)Curated
Sequence conflicti2283 – 22831E → EHLYPQ in AAH04303. (PubMed:15489334)Curated
Sequence conflicti2359 – 23591M → I in AAG44841. (PubMed:11148140)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti217 – 2171S → N.
Corresponds to variant rs12628603 [ dbSNP | Ensembl ].
VAR_059725
Natural varianti493 – 4931S → N.
Corresponds to variant rs4821700 [ dbSNP | Ensembl ].
VAR_059726
Natural varianti817 – 8171T → S.
Corresponds to variant rs41302575 [ dbSNP | Ensembl ].
VAR_061708
Natural varianti863 – 8631N → K.
Corresponds to variant rs9610841 [ dbSNP | Ensembl ].
VAR_051412
Natural varianti1019 – 10191G → R in DFNB28. 1 Publication
VAR_025719
Natural varianti1187 – 11871F → L.
Corresponds to variant rs5756795 [ dbSNP | Ensembl ].
VAR_059727
Natural varianti1300 – 13001H → R.
Corresponds to variant rs739138 [ dbSNP | Ensembl ].
VAR_059728
Natural varianti1372 – 13721E → D.
Corresponds to variant rs8140207 [ dbSNP | Ensembl ].
VAR_051413
Natural varianti1377 – 13771W → R.2 Publications
Corresponds to variant rs8140958 [ dbSNP | Ensembl ].
VAR_051414

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 17721772Missing in isoform 1. 2 PublicationsVSP_017711Add
BLAST
Alternative sequencei1 – 172172Missing in isoform 4 and isoform 5. 1 PublicationVSP_017712Add
BLAST
Alternative sequencei1 – 6161MEEVP…PPAPE → MGGWKGPGQRRGKEGPEARR RAAERGGGGGGGGVPAPRSP AREPRPRSCLLLPPPWGAAM T in isoform 6 and isoform 7. 1 PublicationVSP_047498Add
BLAST
Alternative sequencei62 – 17741713Missing in isoform 6 and isoform 7. 1 PublicationVSP_047499Add
BLAST
Alternative sequencei1317 – 23651049Missing in isoform 5. 1 PublicationVSP_017713Add
BLAST
Alternative sequencei1317 – 135539Missing in isoform 3. 1 PublicationVSP_017714Add
BLAST
Alternative sequencei1729 – 177446Missing in isoform 3. 1 PublicationVSP_017715Add
BLAST
Alternative sequencei1773 – 17742RR → MT in isoform 1. 2 PublicationsVSP_017716
Alternative sequencei1794 – 180613Missing in isoform 3. 1 PublicationVSP_017717Add
BLAST
Alternative sequencei2109 – 214436EACER…LQQEK → LVGVITVPVLQTRPLSSERL CDLPKVTPPAGLKGGI in isoform 6. 1 PublicationVSP_047500Add
BLAST
Alternative sequencei2145 – 2365221Missing in isoform 6. 1 PublicationVSP_047501Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281030 mRNA. Translation: AAG44841.1.
DQ228003 mRNA. Translation: ABB59559.1.
DQ228004 mRNA. Translation: ABB59560.1.
DQ228005 mRNA. Translation: ABB59561.1.
DQ278603 mRNA. Translation: ABB77204.1.
Z83844 Genomic DNA. No translation available.
BC003618 mRNA. Translation: AAH03618.1.
BC004303 mRNA. Translation: AAH04303.1.
BC013278 mRNA. Translation: AAH13278.2.
BC022200 mRNA. No translation available.
AB015343 mRNA. Translation: BAA34800.1. Frameshift.
AB051449 mRNA. Translation: BAB33332.2.
CCDSiCCDS33644.1. [Q9H2D6-6]
CCDS43015.1. [Q9H2D6-1]
CCDS43016.1. [Q9H2D6-7]
RefSeqiNP_001034230.1. NM_001039141.2. [Q9H2D6-1]
NP_008963.3. NM_007032.5. [Q9H2D6-7]
NP_619538.2. NM_138632.2. [Q9H2D6-6]
UniGeneiHs.533030.

Genome annotation databases

EnsembliENST00000403663; ENSP00000386026; ENSG00000100106. [Q9H2D6-7]
ENST00000406386; ENSP00000384312; ENSG00000100106. [Q9H2D6-1]
ENST00000407319; ENSP00000383913; ENSG00000100106. [Q9H2D6-6]
GeneIDi11078.
KEGGihsa:11078.
UCSCiuc003atq.1. human. [Q9H2D6-1]
uc003ats.1. human. [Q9H2D6-4]

Polymorphism databases

DMDMi90110075.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF281030 mRNA. Translation: AAG44841.1 .
DQ228003 mRNA. Translation: ABB59559.1 .
DQ228004 mRNA. Translation: ABB59560.1 .
DQ228005 mRNA. Translation: ABB59561.1 .
DQ278603 mRNA. Translation: ABB77204.1 .
Z83844 Genomic DNA. No translation available.
BC003618 mRNA. Translation: AAH03618.1 .
BC004303 mRNA. Translation: AAH04303.1 .
BC013278 mRNA. Translation: AAH13278.2 .
BC022200 mRNA. No translation available.
AB015343 mRNA. Translation: BAA34800.1 . Frameshift.
AB051449 mRNA. Translation: BAB33332.2 .
CCDSi CCDS33644.1. [Q9H2D6-6 ]
CCDS43015.1. [Q9H2D6-1 ]
CCDS43016.1. [Q9H2D6-7 ]
RefSeqi NP_001034230.1. NM_001039141.2. [Q9H2D6-1 ]
NP_008963.3. NM_007032.5. [Q9H2D6-7 ]
NP_619538.2. NM_138632.2. [Q9H2D6-6 ]
UniGenei Hs.533030.

3D structure databases

ProteinModelPortali Q9H2D6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116261. 11 interactions.
IntActi Q9H2D6. 9 interactions.
MINTi MINT-1397991.

PTM databases

PhosphoSitei Q9H2D6.

Polymorphism databases

DMDMi 90110075.

Proteomic databases

MaxQBi Q9H2D6.
PaxDbi Q9H2D6.
PRIDEi Q9H2D6.

Protocols and materials databases

DNASUi 11078.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000403663 ; ENSP00000386026 ; ENSG00000100106 . [Q9H2D6-7 ]
ENST00000406386 ; ENSP00000384312 ; ENSG00000100106 . [Q9H2D6-1 ]
ENST00000407319 ; ENSP00000383913 ; ENSG00000100106 . [Q9H2D6-6 ]
GeneIDi 11078.
KEGGi hsa:11078.
UCSCi uc003atq.1. human. [Q9H2D6-1 ]
uc003ats.1. human. [Q9H2D6-4 ]

Organism-specific databases

CTDi 11078.
GeneCardsi GC22P038092.
GeneReviewsi TRIOBP.
HGNCi HGNC:17009. TRIOBP.
HPAi HPA003747.
HPA019769.
MIMi 609761. gene.
609823. phenotype.
neXtProti NX_Q9H2D6.
Orphaneti 90636. Autosomal recessive non-syndromic sensorineural deafness type DFNB.
PharmGKBi PA142670699.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00530000063678.
HOVERGENi HBG094025.
InParanoidi Q9H2D6.
OMAi PYCDLPR.
OrthoDBi EOG773XKP.
PhylomeDBi Q9H2D6.
TreeFami TF343361.

Miscellaneous databases

ChiTaRSi TRIOBP. human.
GeneWikii TRIOBP.
GenomeRNAii 11078.
NextBioi 42114.
PROi Q9H2D6.
SOURCEi Search...

Gene expression databases

Bgeei Q9H2D6.
ExpressionAtlasi Q9H2D6. baseline and differential.
Genevestigatori Q9H2D6.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF00169. PH. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
[Graphical view ]
PROSITEi PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization."
    Seipel K., O'Brien S.P., Iannotti E., Medley Q.G., Streuli M.
    J. Cell Sci. 114:389-399(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness."
    Riazuddin S., Khan S.N., Ahmed Z.M., Ghosh M., Caution K., Nazli S., Kabra M., Zafar A.U., Chen K., Naz S., Antonellis A., Pavan W.J., Green E.D., Wilcox E.R., Friedman P.L., Morell R.J., Riazuddin S., Friedman T.B.
    Am. J. Hum. Genet. 78:137-143(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 4 AND 5), INVOLVEMENT IN DFNB28.
    Tissue: Inner ear.
  3. "Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss."
    Shahin H., Walsh T., Sobe T., Abu Sa'ed J., Abu Rayan A., Lynch E.D., Lee M.K., Avraham K.B., King M.-C., Kanaan M.
    Am. J. Hum. Genet. 78:144-152(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, VARIANTS DFNB28 ARG-1019 AND ARG-1377.
    Tissue: Brain.
  4. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-431 (ISOFORM 6).
    Tissue: Colon and Pancreas.
  6. "Selection system for genes encoding nuclear-targeted proteins."
    Ueki N., Oda T., Kondo M., Yano K., Noguchi T., Muramatsu M.-A.
    Nat. Biotechnol. 16:1338-1342(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 340-563, SUBCELLULAR LOCATION.
    Tissue: Fetal brain.
  7. "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping."
    Hirosawa M., Nagase T., Murahashi Y., Kikuno R., Ohara O.
    DNA Res. 8:1-9(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 713-2365, VARIANT ARG-1377.
    Tissue: Brain.
  8. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  9. "The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara."
    Yu J., Lan J., Zhu Y., Li X., Lai X., Xue Y., Jin C., Huang H.
    Biochem. Biophys. Res. Commun. 367:805-812(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH HECTD3, UBIQUITINATION.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1949 AND SER-1955, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1955, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1949 AND SER-1955, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Phosphorylation of Tara by Plk1 is essential for faithful chromosome segregation in mitosis."
    Zhu Y., Wang C., Lan J., Yu J., Jin C., Huang H.
    Exp. Cell Res. 318:2344-2352(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-2229, SUBCELLULAR LOCATION (ISOFORM 1).

Entry informationi

Entry nameiTARA_HUMAN
AccessioniPrimary (citable) accession number: Q9H2D6
Secondary accession number(s): B1AHD4
, B1AHD7, F2Z2W0, F8W6V6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 21, 2006
Last modified: October 29, 2014
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Has been identified in PubMed:9853615 by a selection system for genes encoding nuclear-targeted protein.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3