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Q9H2D6 (TARA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
TRIO and F-actin-binding protein
Alternative name(s):
Protein Tara
Trio-associated repeat on actin
Gene names
Name:TRIOBP
Synonyms:KIAA1662, TARA
ORF Names:HRIHFB2122
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2365 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover. Ref.9

Subunit structure

Binds to TRIO and F-actin. May also interact with myosin II. Interacts with HECTD3. Ref.9

Subcellular location

Nucleus. Cytoplasmcytoskeleton. Note: Localized to F-actin in a periodic pattern. Ref.6 Ref.14

Isoform 1: Nucleus. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Midbody. Note: Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-457 and lasts from prophase to anaphase. At telophase, relocalizes to midbody. Ref.6 Ref.14

Tissue specificity

Widely expressed. Highly expressed in heart and placenta. Isoform 3 is expressed in fetal brain, retina and cochlea but is not detectable in the other tissues. Ref.3

Domain

Contains at least 2 actin-binding sites per coiled-coil dimer.

Post-translational modification

Ubiquitinated by HECTD3, leading to its degradation by the proteasome. Ref.9

Isoform 1:Phosphorylation at Thr-457 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation.

Involvement in disease

Deafness, autosomal recessive, 28 (DFNB28) [MIM:609823]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.2 Ref.3

Miscellaneous

Has been identified in Ref.6 by a selection system for genes encoding nuclear-targeted protein.

Sequence similarities

Contains 1 PH domain.

Sequence caution

The sequence BAA34800.1 differs from that shown. Reason: Frameshift at position 478.

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]
Isoform 2 (identifier: Q9H2D6-1)

Also known as: TRIOBP-6;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 3 (identifier: Q9H2D6-2)

Also known as: Long isoform;

The sequence of this isoform differs from the canonical sequence as follows:
     1317-1355: Missing.
     1729-1774: Missing.
     1794-1806: Missing.
Isoform 4 (identifier: Q9H2D6-3)

Also known as: TRIOBP-3;

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: Missing.
Isoform 5 (identifier: Q9H2D6-4)

Also known as: TRIOBP-4;

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: Missing.
     1317-2365: Missing.
Isoform 1 (identifier: Q9H2D6-5)

Also known as: TRIOBP-1;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1772: Missing.
     1773-1774: RR → MT
Isoform 6 (identifier: Q9H2D6-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MEEVPGDALC...DLPRCPPAPE → MGGWKGPGQR...LPPPWGAAMT
     62-1774: Missing.
     2109-2144: EACERSLAEMESSHQQVMEELQRHHERELQRLQQEK → LVGVITVPVLQTRPLSSERLCDLPKVTPPAGLKGGI
     2145-2365: Missing.
Note: No experimental confirmation available.
Isoform 7 (identifier: Q9H2D6-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MEEVPGDALC...DLPRCPPAPE → MGGWKGPGQR...LPPPWGAAMT
     62-1774: Missing.
Note: No experimental confirmation available. Gene prediction based on EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 23652365TRIO and F-actin-binding protein
PRO_0000072433

Regions

Domain1778 – 1887110PH
Coiled coil2062 – 2247186 Potential
Coiled coil2281 – 236181 Potential

Amino acid modifications

Modified residue19491Phosphoserine Ref.10 Ref.12
Modified residue19551Phosphoserine Ref.10 Ref.11 Ref.12
Modified residue22291Phosphothreonine; by PLK1 Ref.14

Natural variations

Alternative sequence1 – 17721772Missing in isoform 1.
VSP_017711
Alternative sequence1 – 172172Missing in isoform 4 and isoform 5.
VSP_017712
Alternative sequence1 – 6161MEEVP…PPAPE → MGGWKGPGQRRGKEGPEARR RAAERGGGGGGGGVPAPRSP AREPRPRSCLLLPPPWGAAM T in isoform 6 and isoform 7.
VSP_047498
Alternative sequence62 – 17741713Missing in isoform 6 and isoform 7.
VSP_047499
Alternative sequence1317 – 23651049Missing in isoform 5.
VSP_017713
Alternative sequence1317 – 135539Missing in isoform 3.
VSP_017714
Alternative sequence1729 – 177446Missing in isoform 3.
VSP_017715
Alternative sequence1773 – 17742RR → MT in isoform 1.
VSP_017716
Alternative sequence1794 – 180613Missing in isoform 3.
VSP_017717
Alternative sequence2109 – 214436EACER…LQQEK → LVGVITVPVLQTRPLSSERL CDLPKVTPPAGLKGGI in isoform 6.
VSP_047500
Alternative sequence2145 – 2365221Missing in isoform 6.
VSP_047501
Natural variant2171S → N.
Corresponds to variant rs12628603 [ dbSNP | Ensembl ].
VAR_059725
Natural variant4931S → N.
Corresponds to variant rs4821700 [ dbSNP | Ensembl ].
VAR_059726
Natural variant8171T → S.
Corresponds to variant rs41302575 [ dbSNP | Ensembl ].
VAR_061708
Natural variant8631N → K.
Corresponds to variant rs9610841 [ dbSNP | Ensembl ].
VAR_051412
Natural variant10191G → R in DFNB28. Ref.3
VAR_025719
Natural variant11871F → L.
Corresponds to variant rs5756795 [ dbSNP | Ensembl ].
VAR_059727
Natural variant13001H → R.
Corresponds to variant rs739138 [ dbSNP | Ensembl ].
VAR_059728
Natural variant13721E → D.
Corresponds to variant rs8140207 [ dbSNP | Ensembl ].
VAR_051413
Natural variant13771W → R. Ref.3 Ref.7
Corresponds to variant rs8140958 [ dbSNP | Ensembl ].
VAR_051414

Experimental info

Sequence conflict713 – 7197RTTQQEN → KSTFGCL in BAB33332. Ref.7
Sequence conflict14211R → S in ABB77204. Ref.3
Sequence conflict16891S → G in ABB77204. Ref.3
Sequence conflict18961Missing in ABB77204. Ref.3
Sequence conflict19041N → D in ABB77204. Ref.3
Sequence conflict21141S → T in AAG44841. Ref.1
Sequence conflict21411Q → L in AAH04303. Ref.5
Sequence conflict22741S → T in AAG44841. Ref.1
Sequence conflict22831E → EHLYPQ in AAH04303. Ref.5
Sequence conflict23591M → I in AAG44841. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 2 (TRIOBP-6) [UniParc].

Last modified March 21, 2006. Version 3.
Checksum: B2CF9AD57E930283

FASTA2,365261,376
        10         20         30         40         50         60 
MEEVPGDALC EHFEANILTQ NRCQNCFHPE EAHGARYQEL RSPSGAEVPY CDLPRCPPAP 

        70         80         90        100        110        120 
EDPLSASTSG CQSVVDPGLR PGPKRGPSPS AGLPEEGPTA APRSRSRELE AVPYLEGLTT 

       130        140        150        160        170        180 
SLCGSCNEDP GSDPTSSPDS ATPDDTSNSS SVDWDTVERQ EEEAPSWDEL AVMIPRRPRE 

       190        200        210        220        230        240 
GPRADSSQRA PSLLTRSPVG GDAAGQKKED TGGGGRSAGQ HWARLRGESG LSLERHRSTL 

       250        260        270        280        290        300 
TQASSMTPHS GPRSTTSQAS PAQRDTAQAA STREIPRASS PHRITQRDTS RASSTQQEIS 

       310        320        330        340        350        360 
RASSTQQETS RASSTQEDTP RASSTQEDTP RASSTQWNTP RASSPSRSTQ LDNPRTSSTQ 

       370        380        390        400        410        420 
QDNPQTSFPT CTPQRENPRT PCVQQDDPRA SSPNRTTQRE NSRTSCAQRD NPKASRTSSP 

       430        440        450        460        470        480 
NRATRDNPRT SCAQRDNPRA SSPSRATRDN PTTSCAQRDN PRASRTSSPN RATRDNPRTS 

       490        500        510        520        530        540 
CAQRDNPRAS SPSRATRDNP TTSCAQRDNP RASRTSSPNR ATRDNPRTSC AQRDNPRASS 

       550        560        570        580        590        600 
PNRAARDNPT TSCAQRDNPR ASRTSSPNRA TRDNPRTSCA QRDNPRASSP NRATRDNPTT 

       610        620        630        640        650        660 
SCAQRDNPRA SRTSSPNRAT RDNPRTSCAQ RDNPRASSPN RTTQQDSPRT SCARRDDPRA 

       670        680        690        700        710        720 
SSPNRTIQQE NPRTSCALRD NPRASSPSRT IQQENPRTSC AQRDDPRASS PNRTTQQENP 

       730        740        750        760        770        780 
RTSCARRDNP RASSRNRTIQ RDNPRTSCAQ RDNPRASSPN RTIQQENLRT SCTRQDNPRT 

       790        800        810        820        830        840 
SSPNRATRDN PRTSCAQRDN LRASSPIRAT QQDNPRTCIQ QNIPRSSSTQ QDNPKTSCTK 

       850        860        870        880        890        900 
RDNLRPTCTQ RDRTQSFSFQ RDNPGTSSSQ CCTQKENLRP SSPHRSTQWN NPRNSSPHRT 

       910        920        930        940        950        960 
NKDIPWASFP LRPTQSDGPR TSSPSRSKQS EVPWASIALR PTQGDRPQTS SPSRPAQHDP 

       970        980        990       1000       1010       1020 
PQSSFGPTQY NLPSRATSSS HNPGHQSTSR TSSPVYPAAY GAPLTSPEPS QPPCAVCIGH 

      1030       1040       1050       1060       1070       1080 
RDAPRASSPP RYLQHDPFPF FPEPRAPESE PPHHEPPYIP PAVCIGHRDA PRASSPPRHT 

      1090       1100       1110       1120       1130       1140 
QFDPFPFLPD TSDAEHQCQS PQHEPLQLPA PVCIGYRDAP RASSPPRQAP EPSLLFQDLP 

      1150       1160       1170       1180       1190       1200 
RASTESLVPS MDSLHECPHI PTPVCIGHRD APSFSSPPRQ APEPSLFFQD PPGTSMESLA 

      1210       1220       1230       1240       1250       1260 
PSTDSLHGSP VLIPQVCIGH RDAPRASSPP RHPPSDLAFL APSPSPGSSG GSRGSAPPGE 

      1270       1280       1290       1300       1310       1320 
TRHNLEREEY TVLADLPPPR RLAQRQPGPQ AQCSSGGRTH SPGRAEVERL FGQERRKSEA 

      1330       1340       1350       1360       1370       1380 
AGAFQAQDEG RSQQPSQGQS QLLRRQSSPA PSRQVTMLPA KQAELTRRSQ AEPPHPWSPE 

      1390       1400       1410       1420       1430       1440 
KRPEGDRQLQ GSPLPPRTSA RTPERELRTQ RPLESGQAGP RQPLGVWQSQ EEPPGSQGPH 

      1450       1460       1470       1480       1490       1500 
RHLERSWSSQ EGGLGPGGWW GCGEPSLGAA KAPEGAWGGT SREYKESWGQ PEAWEEKPTH 

      1510       1520       1530       1540       1550       1560 
ELPRELGKRS PLTSPPENWG GPAESSQSWH SGTPTAVGWG AEGACPYPRG SERRPELDWR 

      1570       1580       1590       1600       1610       1620 
DLLGLLRAPG EGVWARVPSL DWEGLLELLQ ARLPRKDPAG HRDDLARALG PELGPPGTND 

      1630       1640       1650       1660       1670       1680 
VPEQESHSQP EGWAEATPVN GHSPALQSQS PVQLPSPACT STQWPKIKVT RGPATATLAG 

      1690       1700       1710       1720       1730       1740 
LEQTGPLGSR STAKGPSLPE LQFQPEEPEE SEPSRGQDPL TDQKQADSAD KRPAEGKAGS 

      1750       1760       1770       1780       1790       1800 
PLKGRLVTSW RMPGDRPTLF NPFLLSLGVL RWRRPDLLNF KKGWMSILDE PGEPPSPSLT 

      1810       1820       1830       1840       1850       1860 
TTSTSQWKKH WFVLTDSSLK YYRDSTAEEA DELDGEIDLR SCTDVTEYAV QRNYGFQIHT 

      1870       1880       1890       1900       1910       1920 
KDAVYTLSAM TSGIRRNWIE ALRKTVRPTS APDVTKLSDS NKENALHSYS TQKGPLKAGE 

      1930       1940       1950       1960       1970       1980 
QRAGSEVISR GGPRKADGQR QALDYVELSP LTQASPQRAR TPARTPDRLA KQEELERDLA 

      1990       2000       2010       2020       2030       2040 
QRSEERRKWF EATDSRTPEV PAGEGPRRGL GAPLTEDQQN RLSEEIEKKW QELEKLPLRE 

      2050       2060       2070       2080       2090       2100 
NKRVPLTALL NQSRGERRGP PSDGHEALEK EVQALRAQLE AWRLQGEAPQ SALRSQEDGH 

      2110       2120       2130       2140       2150       2160 
IPPGYISQEA CERSLAEMES SHQQVMEELQ RHHERELQRL QQEKEWLLAE ETAATASAIE 

      2170       2180       2190       2200       2210       2220 
AMKKAYQEEL SRELSKTRSL QQGPDGLRKQ HQSDVEALKR ELQVLSEQYS QKCLEIGALM 

      2230       2240       2250       2260       2270       2280 
RQAEEREHTL RRCQQEGQEL LRHNQELHGR LSEEIDQLRG FIASQGMGNG CGRSNERSSC 

      2290       2300       2310       2320       2330       2340 
ELEVLLRVKE NELQYLKKEV QCLRDELQMM QKDKRFTSGK YQDVYVELSH IKTRSEREIE 

      2350       2360 
QLKEHLRLAM AALQEKESMR NSLAE 

« Hide

Isoform 3 (Long isoform) [UniParc].

Checksum: A0055359F5C3D655
Show »

FASTA2,267250,724
Isoform 4 (TRIOBP-3) [UniParc].

Checksum: 2056F789C0E11E01
Show »

FASTA2,193243,071
Isoform 5 (TRIOBP-4) [UniParc].

Checksum: 90E403C1C0B946FD
Show »

FASTA1,144125,524
Isoform 1 (TRIOBP-1) [UniParc].

Checksum: 109AA7D9CC10B21A
Show »

FASTA59368,041
Isoform 6 [UniParc].

Checksum: 499617230FA5DAC3
Show »

FASTA43147,624
Isoform 7 [UniParc].

Checksum: 2B3B90A23A047212
Show »

FASTA65274,048

References

« Hide 'large scale' references
[1]"Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization."
Seipel K., O'Brien S.P., Iannotti E., Medley Q.G., Streuli M.
J. Cell Sci. 114:389-399(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness."
Riazuddin S., Khan S.N., Ahmed Z.M., Ghosh M., Caution K., Nazli S., Kabra M., Zafar A.U., Chen K., Naz S., Antonellis A., Pavan W.J., Green E.D., Wilcox E.R., Friedman P.L., Morell R.J., Riazuddin S., Friedman T.B.
Am. J. Hum. Genet. 78:137-143(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 4 AND 5), INVOLVEMENT IN DFNB28.
Tissue: Inner ear.
[3]"Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss."
Shahin H., Walsh T., Sobe T., Abu Sa'ed J., Abu Rayan A., Lynch E.D., Lee M.K., Avraham K.B., King M.-C., Kanaan M.
Am. J. Hum. Genet. 78:144-152(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, VARIANTS DFNB28 ARG-1019 AND ARG-1377.
Tissue: Brain.
[4]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-431 (ISOFORM 6).
Tissue: Colon and Pancreas.
[6]"Selection system for genes encoding nuclear-targeted proteins."
Ueki N., Oda T., Kondo M., Yano K., Noguchi T., Muramatsu M.-A.
Nat. Biotechnol. 16:1338-1342(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 340-563, SUBCELLULAR LOCATION.
Tissue: Fetal brain.
[7]"Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping."
Hirosawa M., Nagase T., Murahashi Y., Kikuno R., Ohara O.
DNA Res. 8:1-9(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 713-2365, VARIANT ARG-1377.
Tissue: Brain.
[8]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[9]"The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara."
Yu J., Lan J., Zhu Y., Li X., Lai X., Xue Y., Jin C., Huang H.
Biochem. Biophys. Res. Commun. 367:805-812(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH HECTD3, UBIQUITINATION.
[10]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1949 AND SER-1955, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1955, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1949 AND SER-1955, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[13]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"Phosphorylation of Tara by Plk1 is essential for faithful chromosome segregation in mitosis."
Zhu Y., Wang C., Lan J., Yu J., Jin C., Huang H.
Exp. Cell Res. 318:2344-2352(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT THR-2229, SUBCELLULAR LOCATION (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF281030 mRNA. Translation: AAG44841.1.
DQ228003 mRNA. Translation: ABB59559.1.
DQ228004 mRNA. Translation: ABB59560.1.
DQ228005 mRNA. Translation: ABB59561.1.
DQ278603 mRNA. Translation: ABB77204.1.
Z83844 Genomic DNA. No translation available.
BC003618 mRNA. Translation: AAH03618.1.
BC004303 mRNA. Translation: AAH04303.1.
BC013278 mRNA. Translation: AAH13278.2.
BC022200 mRNA. No translation available.
AB015343 mRNA. Translation: BAA34800.1. Frameshift.
AB051449 mRNA. Translation: BAB33332.2.
RefSeqNP_001034230.1. NM_001039141.2.
NP_008963.3. NM_007032.5.
NP_619538.2. NM_138632.2.
UniGeneHs.533030.

3D structure databases

ProteinModelPortalQ9H2D6.
SMRQ9H2D6. Positions 1774-1892.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116261. 10 interactions.
IntActQ9H2D6. 9 interactions.
MINTMINT-1397991.

PTM databases

PhosphoSiteQ9H2D6.

Polymorphism databases

DMDM90110075.

Proteomic databases

PaxDbQ9H2D6.
PRIDEQ9H2D6.

Protocols and materials databases

DNASU11078.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000403663; ENSP00000386026; ENSG00000100106.
ENST00000406386; ENSP00000384312; ENSG00000100106. [Q9H2D6-1]
ENST00000407319; ENSP00000383913; ENSG00000100106. [Q9H2D6-6]
GeneID11078.
KEGGhsa:11078.
UCSCuc003atq.1. human. [Q9H2D6-1]
uc003ats.1. human. [Q9H2D6-4]

Organism-specific databases

CTD11078.
GeneCardsGC22P038092.
HGNCHGNC:17009. TRIOBP.
HPAHPA003747.
HPA019769.
MIM609761. gene.
609823. phenotype.
neXtProtNX_Q9H2D6.
Orphanet90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.
PharmGKBPA142670699.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOVERGENHBG094025.
InParanoidQ9H2D6.
OMAPYCDLPR.
OrthoDBEOG773XKP.
PhylomeDBQ9H2D6.
TreeFamTF343361.

Gene expression databases

ArrayExpressQ9H2D6.
BgeeQ9H2D6.
GenevestigatorQ9H2D6.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
[Graphical view]
PfamPF00169. PH. 1 hit.
[Graphical view]
SMARTSM00233. PH. 1 hit.
[Graphical view]
PROSITEPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTRIOBP. human.
GeneWikiTRIOBP.
GenomeRNAi11078.
NextBio42114.
PROQ9H2D6.
SOURCESearch...

Entry information

Entry nameTARA_HUMAN
AccessionPrimary (citable) accession number: Q9H2D6
Secondary accession number(s): B1AHD4 expand/collapse secondary AC list , B1AHD7, F2Z2W0, F8W6V6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 21, 2006
Last modified: April 16, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM