Q9H2D1 (MFTC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial folate transporter/carrier

Alternative name(s):
Solute carrier family 25 member 32

Gene names

Name:	SLC25A32
Synonyms:	MFT, MFTC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transports folate across the inner membranes of mitochondria.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification] Contains 3 Solcar repeats.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	folic acid metabolic process Traceable author statement. Source: Reactome mitochondrial transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Non-traceable author statement Ref.1. Source: UniProtKB
Molecular_function	folic acid transporter activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Mitochondrial folate transporter/carrier		PRO_0000090641
Regions
	Transmembrane	26 – 43	18	Helical; Name=1; Potential
	Transmembrane	89 – 106	18	Helical; Name=2; Potential
	Transmembrane	123 – 143	21	Helical; Name=3; Potential
	Transmembrane	186 – 203	18	Helical; Name=4; Potential
	Transmembrane	227 – 243	17	Helical; Name=5; Potential
	Transmembrane	281 – 300	20	Helical; Name=6; Potential
	Repeat	20 – 109	90	Solcar 1
	Repeat	118 – 209	92	Solcar 2
	Repeat	222 – 306	85	Solcar 3
Natural variations
	Natural variant	117	1	R → H. Ref.1 Corresponds to variant rs17803441 [ dbSNP | Ensembl ].		VAR_050130
Experimental info
	Sequence conflict	306	1	F → L in BAB55368. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9H2D1 [UniParc]. Last modified August 22, 2003. Version 2. Checksum: EED376828B4D1069	FASTA	315	35,407
	10 20 30 40 50 60 MTGQGQSASG SSAWSTVFRH VRYENLIAGV SGGVLSNLAL HPLDLVKIRF AVSDGLELRP 70 80 90 100 110 120 KYNGILHCLT TIWKLDGLRG LYQGVTPNIW GAGLSWGLYF FFYNAIKSYK TEGRAERLEA 130 140 150 160 170 180 TEYLVSAAEA GAMTLCITNP LWVTKTRLML QYDAVVNSPH RQYKGMFDTL VKIYKYEGVR 190 200 210 220 230 240 GLYKGFVPGL FGTSHGALQF MAYELLKLKY NQHINRLPEA QLSTVEYISV AALSKIFAVA 250 260 270 280 290 300 ATYPYQVVRA RLQDQHMFYS GVIDVITKTW RKEGVGGFYK GIAPNLIRVT PACCITFVVY 310 ENVSHFLLDL REKRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Retrovirally mediated complementation of the glyB phenotype. Cloning of a human gene encoding the carrier for entry of folates into mitochondria." Titus S.A., Moran R.G. J. Biol. Chem. 275:36811-36817(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-117.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF283645 mRNA. Translation: AAG37834.1. AK027531 mRNA. Translation: BAB55180.1. AK027787 mRNA. Translation: BAB55368.1. BC021893 mRNA. Translation: AAH21893.1.
IPI	IPI00300886.
RefSeq	NP_110407.2. NM_030780.3.
UniGene	Hs.607819.
3D structure databases
ProteinModelPortal	Q9H2D1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000297578.
Protein family/group databases
TCDB	2.A.29.10.2. mitochondrial carrier (MC) family.
PTM databases
PhosphoSite	Q9H2D1.
Polymorphism databases
DMDM	34223740.
Proteomic databases
PaxDb	Q9H2D1.
PeptideAtlas	Q9H2D1.
PRIDE	Q9H2D1.
Protocols and materials databases
DNASU	81034.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000297578; ENSP00000297578; ENSG00000164933.
GeneID	81034.
KEGG	hsa:81034.
UCSC	uc003yll.3. human.
Organism-specific databases
CTD	81034.
GeneCards	GC08M104410.
HGNC	HGNC:29683. SLC25A32.
HPA	HPA047402.
MIM	610815. gene.
neXtProt	NX_Q9H2D1.
PharmGKB	PA142670905.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG314559.
HOGENOM	HOG000188210.
HOVERGEN	HBG101979.
InParanoid	Q9H2D1.
KO	K15115.
OMA	KLKYNQH.
OrthoDB	EOG45TCNK.
PhylomeDB	Q9H2D1.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	Q9H2D1.
Bgee	Q9H2D1.
CleanEx	HS_SLC25A32.
Genevestigator	Q9H2D1.
GermOnline	ENSG00000164933. Homo sapiens.
Family and domain databases
Gene3D	1.50.40.10. 1 hit.
InterPro	IPR002030. Mit_uncoupling. IPR018108. Mitochondrial_sb/sol_carrier. IPR023395. Mt_carrier_dom. [Graphical view]
Pfam	PF00153. Mito_carr. 3 hits. [Graphical view]
PRINTS	PR00784. MTUNCOUPLING.
SUPFAM	SSF103506. Mitoch_carrier. 1 hit.
PROSITE	PS50920. SOLCAR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC25A32. human.
DrugBank	DB00158. Folic Acid.
GenomeRNAi	81034.
NextBio	71372.
SOURCE	Search...

Entry information

Entry name

MFTC_HUMAN

Accession

Primary (citable) accession number: Q9H2D1
Secondary accession number(s): Q96JZ6, Q96SU7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	August 22, 2003
Last modified:	May 1, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.