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Protein

Olfactory receptor 51V1

Gene

OR51V1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
  2. sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51V1
Alternative name(s):
Odorant receptor HOR3'beta1
Olfactory receptor 51A12
Olfactory receptor OR11-36
Gene namesi
Name:OR51V1
Synonyms:OR51A12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:19597. OR51V1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434ExtracellularSequence AnalysisAdd
BLAST
Transmembranei35 – 5521Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini56 – 638CytoplasmicSequence Analysis
Transmembranei64 – 8421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini85 – 10824ExtracellularSequence AnalysisAdd
BLAST
Transmembranei109 – 12921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini130 – 14819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei149 – 16921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini170 – 20536ExtracellularSequence AnalysisAdd
BLAST
Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini227 – 24620CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei247 – 26721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini268 – 28215ExtracellularSequence AnalysisAdd
BLAST
Transmembranei283 – 30321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini304 – 32118CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134873075.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Olfactory receptor 51V1PRO_0000150764Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi106 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H2C8.
PRIDEiQ9H2C8.

PTM databases

PhosphoSiteiQ9H2C8.

Expressioni

Gene expression databases

CleanExiHS_OR51V1.
GenevestigatoriQ9H2C8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321729.

Structurei

3D structure databases

ProteinModelPortaliQ9H2C8.
SMRiQ9H2C8. Positions 36-301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148145.
GeneTreeiENSGT00780000121866.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H2C8.
KOiK04257.
OMAiQQYPWIS.
OrthoDBiEOG7PVWQ1.
PhylomeDBiQ9H2C8.
TreeFamiTF342735.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H2C8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFLSSRMITS VSPSTSTNSS FLLTGFSGME QQYPWLSIPF SSIYAMVLLG
60 70 80 90 100
NCMVLHVIWT EPSLHQPMFY FLSMLALTDL CMGLSTVYTV LGILWGIIRE
110 120 130 140 150
ISLDSCIAQS YFIHGLSFME SSVLLTMAFD RYIAICNPLR YSSILTNSRI
160 170 180 190 200
IKIGLTIIGR SFFFITPPII CLKFFNYCHF HILSHSFCLH QDLLRLACSD
210 220 230 240 250
IRFNSYYALM LVICILLLDA ILILFSYILI LKSVLAVASQ EERHKLFQTC
260 270 280 290 300
ISHICAVLVF YIPIISLTMV HRFGKHLSPV AHVLIGNIYI LFPPLMNPII
310 320
YSVKTQQIHT RMLRLFSLKR Y
Length:321
Mass (Da):36,749
Last modified:May 18, 2010 - v2
Checksum:i3CF758D12EB5B1A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 361L → F in AAG42364. (PubMed:11121057)Curated
Sequence conflicti96 – 961G → R in AAG42364. (PubMed:11121057)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti233 – 2331S → L.
Corresponds to variant rs7933549 [ dbSNP | Ensembl ].
VAR_057580

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289203 Genomic DNA. Translation: AAG42364.1.
AC104389 Genomic DNA. No translation available.
BK004432 Genomic DNA. Translation: DAA04830.1.
CCDSiCCDS31375.1.
RefSeqiNP_001004760.2. NM_001004760.2.
UniGeneiHs.553670.

Genome annotation databases

EnsembliENST00000321255; ENSP00000321729; ENSG00000176742.
GeneIDi283111.
KEGGihsa:283111.
UCSCiuc010qyz.2. human.

Polymorphism databases

DMDMi296439246.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289203 Genomic DNA. Translation: AAG42364.1.
AC104389 Genomic DNA. No translation available.
BK004432 Genomic DNA. Translation: DAA04830.1.
CCDSiCCDS31375.1.
RefSeqiNP_001004760.2. NM_001004760.2.
UniGeneiHs.553670.

3D structure databases

ProteinModelPortaliQ9H2C8.
SMRiQ9H2C8. Positions 36-301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000321729.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9H2C8.

Polymorphism databases

DMDMi296439246.

Proteomic databases

PaxDbiQ9H2C8.
PRIDEiQ9H2C8.

Protocols and materials databases

DNASUi283111.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321255; ENSP00000321729; ENSG00000176742.
GeneIDi283111.
KEGGihsa:283111.
UCSCiuc010qyz.2. human.

Organism-specific databases

CTDi283111.
GeneCardsiGC11M005220.
HGNCiHGNC:19597. OR51V1.
neXtProtiNX_Q9H2C8.
PharmGKBiPA134873075.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG148145.
GeneTreeiENSGT00780000121866.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H2C8.
KOiK04257.
OMAiQQYPWIS.
OrthoDBiEOG7PVWQ1.
PhylomeDBiQ9H2C8.
TreeFamiTF342735.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR51V1.
GenomeRNAii283111.
NextBioi93625.
PROiQ9H2C8.

Gene expression databases

CleanExiHS_OR51V1.
GenevestigatoriQ9H2C8.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
    Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
    Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO51V1_HUMAN
AccessioniPrimary (citable) accession number: Q9H2C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 18, 2010
Last modified: February 4, 2015
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.