Q9H2C8 (O51V1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 51V1

Alternative name(s):
Odorant receptor HOR3'beta1
Olfactory receptor 51A12
Olfactory receptor OR11-36

Gene names

Name:	OR51V1
Synonyms:	OR51A12

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Olfactory receptor 51V1		PRO_0000150764
Regions
	Topological domain	1 – 34	34	Extracellular Potential
	Transmembrane	35 – 55	21	Helical; Name=1; Potential
	Topological domain	56 – 63	8	Cytoplasmic Potential
	Transmembrane	64 – 84	21	Helical; Name=2; Potential
	Topological domain	85 – 108	24	Extracellular Potential
	Transmembrane	109 – 129	21	Helical; Name=3; Potential
	Topological domain	130 – 148	19	Cytoplasmic Potential
	Transmembrane	149 – 169	21	Helical; Name=4; Potential
	Topological domain	170 – 205	36	Extracellular Potential
	Transmembrane	206 – 226	21	Helical; Name=5; Potential
	Topological domain	227 – 246	20	Cytoplasmic Potential
	Transmembrane	247 – 267	21	Helical; Name=6; Potential
	Topological domain	268 – 282	15	Extracellular Potential
	Transmembrane	283 – 303	21	Helical; Name=7; Potential
	Topological domain	304 – 321	18	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	18	1	N-linked (GlcNAc...) Potential
	Disulfide bond	106 ↔ 188		By similarity
Natural variations
	Natural variant	233	1	S → L. Corresponds to variant rs7933549 [ dbSNP | Ensembl ].		VAR_057580
Experimental info
	Sequence conflict	36	1	L → F in AAG42364. Ref.1
	Sequence conflict	96	1	G → R in AAG42364. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9H2C8 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 3CF758D12EB5B1A0	FASTA	321	36,749
	10 20 30 40 50 60 MFLSSRMITS VSPSTSTNSS FLLTGFSGME QQYPWLSIPF SSIYAMVLLG NCMVLHVIWT 70 80 90 100 110 120 EPSLHQPMFY FLSMLALTDL CMGLSTVYTV LGILWGIIRE ISLDSCIAQS YFIHGLSFME 130 140 150 160 170 180 SSVLLTMAFD RYIAICNPLR YSSILTNSRI IKIGLTIIGR SFFFITPPII CLKFFNYCHF 190 200 210 220 230 240 HILSHSFCLH QDLLRLACSD IRFNSYYALM LVICILLLDA ILILFSYILI LKSVLAVASQ 250 260 270 280 290 300 EERHKLFQTC ISHICAVLVF YIPIISLTMV HRFGKHLSPV AHVLIGNIYI LFPPLMNPII 310 320 YSVKTQQIHT RMLRLFSLKR Y

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters." Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R. Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[4]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF289203 Genomic DNA. Translation: AAG42364.1. AC104389 Genomic DNA. No translation available. BK004432 Genomic DNA. Translation: DAA04830.1.
IPI	IPI00300877.
RefSeq	NP_001004760.2. NM_001004760.2.
UniGene	Hs.553670.
3D structure databases
ProteinModelPortal	Q9H2C8.
SMR	Q9H2C8. Positions 42-149.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000321729.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9H2C8.
Polymorphism databases
DMDM	296439246.
Proteomic databases
PaxDb	Q9H2C8.
PRIDE	Q9H2C8.
Protocols and materials databases
DNASU	283111.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000321255; ENSP00000321729; ENSG00000176742.
GeneID	283111.
KEGG	hsa:283111.
UCSC	uc010qyz.2. human.
Organism-specific databases
CTD	283111.
GeneCards	GC11M005220.
HGNC	HGNC:19597. OR51V1.
neXtProt	NX_Q9H2C8.
PharmGKB	PA134873075.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG148145.
HOGENOM	HOG000041363.
HOVERGEN	HBG017625.
InParanoid	Q9H2C8.
KO	K04257.
OMA	TIIGRSF.
OrthoDB	EOG48SGTP.
PhylomeDB	Q9H2C8.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR51V1.
Genevestigator	Q9H2C8.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	283111.
NextBio	93625.

Entry information

Entry name

O51V1_HUMAN

Accession

Primary (citable) accession number: Q9H2C8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.