Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 51V1

Gene

OR51V1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • sensory perception of smell Source: UniProtKB
  • signal transduction Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51V1
Alternative name(s):
Odorant receptor HOR3'beta1
Olfactory receptor 51A12
Olfactory receptor OR11-36
Gene namesi
Name:OR51V1
Synonyms:OR51A12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000176742.1
HGNCiHGNC:19597 OR51V1
neXtProtiNX_Q9H2C8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 55Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini56 – 63CytoplasmicSequence analysis8
Transmembranei64 – 84Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini85 – 108ExtracellularSequence analysisAdd BLAST24
Transmembranei109 – 129Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini130 – 148CytoplasmicSequence analysisAdd BLAST19
Transmembranei149 – 169Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini170 – 205ExtracellularSequence analysisAdd BLAST36
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 246CytoplasmicSequence analysisAdd BLAST20
Transmembranei247 – 267Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini268 – 282ExtracellularSequence analysisAdd BLAST15
Transmembranei283 – 303Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini304 – 321CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176742
PharmGKBiPA134873075

Polymorphism and mutation databases

BioMutaiOR51V1
DMDMi296439246

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507641 – 321Olfactory receptor 51V1Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H2C8
PeptideAtlasiQ9H2C8
PRIDEiQ9H2C8

PTM databases

iPTMnetiQ9H2C8
PhosphoSitePlusiQ9H2C8

Expressioni

Gene expression databases

CleanExiHS_OR51V1

Interactioni

Protein-protein interaction databases

BioGridi1294621 interactor.
STRINGi9606.ENSP00000321729

Structurei

3D structure databases

ProteinModelPortaliQ9H2C8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIYI Eukaryota
ENOG4111DWS LUCA
GeneTreeiENSGT00910000144090
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ9H2C8
KOiK04257
OMAiHKLFQTC
OrthoDBiEOG091G0AZH
PhylomeDBiQ9H2C8
TreeFamiTF342735

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H2C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLSSRMITS VSPSTSTNSS FLLTGFSGME QQYPWLSIPF SSIYAMVLLG
60 70 80 90 100
NCMVLHVIWT EPSLHQPMFY FLSMLALTDL CMGLSTVYTV LGILWGIIRE
110 120 130 140 150
ISLDSCIAQS YFIHGLSFME SSVLLTMAFD RYIAICNPLR YSSILTNSRI
160 170 180 190 200
IKIGLTIIGR SFFFITPPII CLKFFNYCHF HILSHSFCLH QDLLRLACSD
210 220 230 240 250
IRFNSYYALM LVICILLLDA ILILFSYILI LKSVLAVASQ EERHKLFQTC
260 270 280 290 300
ISHICAVLVF YIPIISLTMV HRFGKHLSPV AHVLIGNIYI LFPPLMNPII
310 320
YSVKTQQIHT RMLRLFSLKR Y
Length:321
Mass (Da):36,749
Last modified:May 18, 2010 - v2
Checksum:i3CF758D12EB5B1A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36L → F in AAG42364 (PubMed:11121057).Curated1
Sequence conflicti96G → R in AAG42364 (PubMed:11121057).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079498211L → V1 Publication1
Natural variantiVAR_057580233S → L. Corresponds to variant dbSNP:rs7933549Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289203 Genomic DNA Translation: AAG42364.1
AC104389 Genomic DNA No translation available.
BK004432 Genomic DNA Translation: DAA04830.1
CCDSiCCDS31375.1
RefSeqiNP_001004760.2, NM_001004760.2
UniGeneiHs.553670

Genome annotation databases

EnsembliENST00000321255; ENSP00000321729; ENSG00000176742
GeneIDi283111
KEGGihsa:283111
UCSCiuc010qyz.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO51V1_HUMAN
AccessioniPrimary (citable) accession number: Q9H2C8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 18, 2010
Last modified: February 28, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome