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Q9H2C8 (O51V1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 51V1
Alternative name(s):
Odorant receptor HOR3'beta1
Olfactory receptor 51A12
Olfactory receptor OR11-36
Gene names
Name:OR51V1
Synonyms:OR51A12
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Olfactory receptor 51V1
PRO_0000150764

Regions

Topological domain1 – 3434Extracellular Potential
Transmembrane35 – 5521Helical; Name=1; Potential
Topological domain56 – 638Cytoplasmic Potential
Transmembrane64 – 8421Helical; Name=2; Potential
Topological domain85 – 10824Extracellular Potential
Transmembrane109 – 12921Helical; Name=3; Potential
Topological domain130 – 14819Cytoplasmic Potential
Transmembrane149 – 16921Helical; Name=4; Potential
Topological domain170 – 20536Extracellular Potential
Transmembrane206 – 22621Helical; Name=5; Potential
Topological domain227 – 24620Cytoplasmic Potential
Transmembrane247 – 26721Helical; Name=6; Potential
Topological domain268 – 28215Extracellular Potential
Transmembrane283 – 30321Helical; Name=7; Potential
Topological domain304 – 32118Cytoplasmic Potential

Amino acid modifications

Glycosylation181N-linked (GlcNAc...) Potential
Disulfide bond106 ↔ 188 By similarity

Natural variations

Natural variant2331S → L.
Corresponds to variant rs7933549 [ dbSNP | Ensembl ].
VAR_057580

Experimental info

Sequence conflict361L → F in AAG42364. Ref.1
Sequence conflict961G → R in AAG42364. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9H2C8 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 3CF758D12EB5B1A0

FASTA32136,749
        10         20         30         40         50         60 
MFLSSRMITS VSPSTSTNSS FLLTGFSGME QQYPWLSIPF SSIYAMVLLG NCMVLHVIWT 

        70         80         90        100        110        120 
EPSLHQPMFY FLSMLALTDL CMGLSTVYTV LGILWGIIRE ISLDSCIAQS YFIHGLSFME 

       130        140        150        160        170        180 
SSVLLTMAFD RYIAICNPLR YSSILTNSRI IKIGLTIIGR SFFFITPPII CLKFFNYCHF 

       190        200        210        220        230        240 
HILSHSFCLH QDLLRLACSD IRFNSYYALM LVICILLLDA ILILFSYILI LKSVLAVASQ 

       250        260        270        280        290        300 
EERHKLFQTC ISHICAVLVF YIPIISLTMV HRFGKHLSPV AHVLIGNIYI LFPPLMNPII 

       310        320 
YSVKTQQIHT RMLRLFSLKR Y 

« Hide

References

« Hide 'large scale' references
[1]"Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF289203 Genomic DNA. Translation: AAG42364.1.
AC104389 Genomic DNA. No translation available.
BK004432 Genomic DNA. Translation: DAA04830.1.
RefSeqNP_001004760.2. NM_001004760.2.
UniGeneHs.553670.

3D structure databases

ProteinModelPortalQ9H2C8.
SMRQ9H2C8. Positions 36-301.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000321729.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9H2C8.

Polymorphism databases

DMDM296439246.

Proteomic databases

PaxDbQ9H2C8.
PRIDEQ9H2C8.

Protocols and materials databases

DNASU283111.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000321255; ENSP00000321729; ENSG00000176742.
GeneID283111.
KEGGhsa:283111.
UCSCuc010qyz.2. human.

Organism-specific databases

CTD283111.
GeneCardsGC11M005220.
HGNCHGNC:19597. OR51V1.
neXtProtNX_Q9H2C8.
PharmGKBPA134873075.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG148145.
HOGENOMHOG000041363.
HOVERGENHBG017625.
InParanoidQ9H2C8.
KOK04257.
OMAQQYPWIS.
OrthoDBEOG7PVWQ1.
PhylomeDBQ9H2C8.
TreeFamTF342735.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR51V1.
GenevestigatorQ9H2C8.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR51V1.
GenomeRNAi283111.
NextBio93625.
PROQ9H2C8.

Entry information

Entry nameO51V1_HUMAN
AccessionPrimary (citable) accession number: Q9H2C8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries