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Protein

Olfactory receptor 51V1

Gene

OR51V1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

  • sensory perception of smell Source: UniProtKB
  • signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176742-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51V1
Alternative name(s):
Odorant receptor HOR3'beta1
Olfactory receptor 51A12
Olfactory receptor OR11-36
Gene namesi
Name:OR51V1
Synonyms:OR51A12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19597. OR51V1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 55Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini56 – 63CytoplasmicSequence analysis8
Transmembranei64 – 84Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini85 – 108ExtracellularSequence analysisAdd BLAST24
Transmembranei109 – 129Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini130 – 148CytoplasmicSequence analysisAdd BLAST19
Transmembranei149 – 169Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini170 – 205ExtracellularSequence analysisAdd BLAST36
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 246CytoplasmicSequence analysisAdd BLAST20
Transmembranei247 – 267Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini268 – 282ExtracellularSequence analysisAdd BLAST15
Transmembranei283 – 303Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini304 – 321CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi283111.
OpenTargetsiENSG00000176742.
PharmGKBiPA134873075.

Polymorphism and mutation databases

BioMutaiOR51V1.
DMDMi296439246.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507641 – 321Olfactory receptor 51V1Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi18N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi106 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H2C8.
PeptideAtlasiQ9H2C8.
PRIDEiQ9H2C8.

PTM databases

iPTMnetiQ9H2C8.
PhosphoSitePlusiQ9H2C8.

Expressioni

Gene expression databases

CleanExiHS_OR51V1.

Interactioni

Protein-protein interaction databases

BioGridi129462. 1 interactor.
STRINGi9606.ENSP00000321729.

Structurei

3D structure databases

ProteinModelPortaliQ9H2C8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIYI. Eukaryota.
ENOG4111DWS. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H2C8.
KOiK04257.
OMAiHKLFQTC.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9H2C8.
TreeFamiTF342735.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H2C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLSSRMITS VSPSTSTNSS FLLTGFSGME QQYPWLSIPF SSIYAMVLLG
60 70 80 90 100
NCMVLHVIWT EPSLHQPMFY FLSMLALTDL CMGLSTVYTV LGILWGIIRE
110 120 130 140 150
ISLDSCIAQS YFIHGLSFME SSVLLTMAFD RYIAICNPLR YSSILTNSRI
160 170 180 190 200
IKIGLTIIGR SFFFITPPII CLKFFNYCHF HILSHSFCLH QDLLRLACSD
210 220 230 240 250
IRFNSYYALM LVICILLLDA ILILFSYILI LKSVLAVASQ EERHKLFQTC
260 270 280 290 300
ISHICAVLVF YIPIISLTMV HRFGKHLSPV AHVLIGNIYI LFPPLMNPII
310 320
YSVKTQQIHT RMLRLFSLKR Y
Length:321
Mass (Da):36,749
Last modified:May 18, 2010 - v2
Checksum:i3CF758D12EB5B1A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36L → F in AAG42364 (PubMed:11121057).Curated1
Sequence conflicti96G → R in AAG42364 (PubMed:11121057).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057580233S → L.Corresponds to variant rs7933549dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289203 Genomic DNA. Translation: AAG42364.1.
AC104389 Genomic DNA. No translation available.
BK004432 Genomic DNA. Translation: DAA04830.1.
CCDSiCCDS31375.1.
RefSeqiNP_001004760.2. NM_001004760.2.
UniGeneiHs.553670.

Genome annotation databases

EnsembliENST00000321255; ENSP00000321729; ENSG00000176742.
GeneIDi283111.
KEGGihsa:283111.
UCSCiuc010qyz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289203 Genomic DNA. Translation: AAG42364.1.
AC104389 Genomic DNA. No translation available.
BK004432 Genomic DNA. Translation: DAA04830.1.
CCDSiCCDS31375.1.
RefSeqiNP_001004760.2. NM_001004760.2.
UniGeneiHs.553670.

3D structure databases

ProteinModelPortaliQ9H2C8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129462. 1 interactor.
STRINGi9606.ENSP00000321729.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9H2C8.
PhosphoSitePlusiQ9H2C8.

Polymorphism and mutation databases

BioMutaiOR51V1.
DMDMi296439246.

Proteomic databases

PaxDbiQ9H2C8.
PeptideAtlasiQ9H2C8.
PRIDEiQ9H2C8.

Protocols and materials databases

DNASUi283111.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321255; ENSP00000321729; ENSG00000176742.
GeneIDi283111.
KEGGihsa:283111.
UCSCiuc010qyz.2. human.

Organism-specific databases

CTDi283111.
DisGeNETi283111.
GeneCardsiOR51V1.
HGNCiHGNC:19597. OR51V1.
neXtProtiNX_Q9H2C8.
OpenTargetsiENSG00000176742.
PharmGKBiPA134873075.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIYI. Eukaryota.
ENOG4111DWS. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H2C8.
KOiK04257.
OMAiHKLFQTC.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9H2C8.
TreeFamiTF342735.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176742-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR51V1.
GenomeRNAii283111.
PROiQ9H2C8.

Gene expression databases

CleanExiHS_OR51V1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO51V1_HUMAN
AccessioniPrimary (citable) accession number: Q9H2C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.