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Protein

Olfactory receptor 52A5

Gene

OR52A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

  • sensory perception of smell Source: UniProtKB
  • signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171944-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52A5
Alternative name(s):
Odorant receptor HOR3'beta5
Olfactory receptor OR11-33
Gene namesi
Name:OR52A5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19580. OR52A5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 199ExtracellularSequence analysisAdd BLAST37
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 240CytoplasmicSequence analysisAdd BLAST20
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 276ExtracellularSequence analysisAdd BLAST15
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 316CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171944.
PharmGKBiPA134991603.

Polymorphism and mutation databases

BioMutaiOR52A5.
DMDMi74762730.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507661 – 316Olfactory receptor 52A5Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9H2C5.
PeptideAtlasiQ9H2C5.
PRIDEiQ9H2C5.

Expressioni

Gene expression databases

CleanExiHS_OR52A5.
ExpressionAtlasiQ9H2C5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303469.

Structurei

3D structure databases

ProteinModelPortaliQ9H2C5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVT7. Eukaryota.
ENOG4111EGC. LUCA.
GeneTreeiENSGT00840000129788.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H2C5.
KOiK04257.
OMAiFSAMYLI.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9H2C5.
TreeFamiTF352744.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H2C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTFNGSVFM PSAFILIGIP GLESVQCWIG IPFSAMYLIG VIGNSLILVI
60 70 80 90 100
IKYENSLHIP MYIFLAMLAA TDIALNTCIL PKMLGIFWFH LPEISFDACL
110 120 130 140 150
FQMWLIHSFQ AIESGILLAM ALDRYVAICI PLRHATIFSQ QFLTHIGLGV
160 170 180 190 200
TLRAAILIIP SLGLIKCCLK HYRTTVISHS YCEHMAIVKL ATEDIRVNKI
210 220 230 240 250
YGLFVAFAIL GFDIIFITLS YVQIFITVFQ LPQKEARFKA FNTCIAHICV
260 270 280 290 300
FLQFYLLAFF SFFTHRFGSH IPPYIHILLS NLYLLVPPFL NPIVYGVKTK
310
QIRDHIVKVF FFKKVT
Length:316
Mass (Da):35,955
Last modified:March 1, 2001 - v1
Checksum:i0B0820B4BE747623
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289204 Genomic DNA. Translation: AAG42368.1.
BK004433 Genomic DNA. Translation: DAA04831.1.
CCDSiCCDS31373.1.
RefSeqiNP_001005160.1. NM_001005160.2.
UniGeneiHs.546593.

Genome annotation databases

EnsembliENST00000307388; ENSP00000303469; ENSG00000171944.
GeneIDi390054.
KEGGihsa:390054.
UCSCiuc010qyx.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289204 Genomic DNA. Translation: AAG42368.1.
BK004433 Genomic DNA. Translation: DAA04831.1.
CCDSiCCDS31373.1.
RefSeqiNP_001005160.1. NM_001005160.2.
UniGeneiHs.546593.

3D structure databases

ProteinModelPortaliQ9H2C5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303469.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR52A5.
DMDMi74762730.

Proteomic databases

PaxDbiQ9H2C5.
PeptideAtlasiQ9H2C5.
PRIDEiQ9H2C5.

Protocols and materials databases

DNASUi390054.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307388; ENSP00000303469; ENSG00000171944.
GeneIDi390054.
KEGGihsa:390054.
UCSCiuc010qyx.2. human.

Organism-specific databases

CTDi390054.
GeneCardsiOR52A5.
HGNCiHGNC:19580. OR52A5.
neXtProtiNX_Q9H2C5.
OpenTargetsiENSG00000171944.
PharmGKBiPA134991603.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVT7. Eukaryota.
ENOG4111EGC. LUCA.
GeneTreeiENSGT00840000129788.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H2C5.
KOiK04257.
OMAiFSAMYLI.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9H2C5.
TreeFamiTF352744.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171944-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52A5.
GenomeRNAii390054.
PROiQ9H2C5.

Gene expression databases

CleanExiHS_OR52A5.
ExpressionAtlasiQ9H2C5. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO52A5_HUMAN
AccessioniPrimary (citable) accession number: Q9H2C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.