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Q9H2C5

- O52A5_HUMAN

UniProt

Q9H2C5 - O52A5_HUMAN

Protein

Olfactory receptor 52A5

Gene

OR52A5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
    2. sensory perception of smell Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 52A5
    Alternative name(s):
    Odorant receptor HOR3'beta5
    Olfactory receptor OR11-33
    Gene namesi
    Name:OR52A5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:19580. OR52A5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134991603.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Olfactory receptor 52A5PRO_0000150766Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9H2C5.
    PRIDEiQ9H2C5.

    Expressioni

    Gene expression databases

    CleanExiHS_OR52A5.
    GenevestigatoriQ9H2C5.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000303469.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H2C5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 568CytoplasmicSequence Analysis
    Topological domaini78 – 10124ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini123 – 14119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 19937ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini221 – 24020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini262 – 27615ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini298 – 31619CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG86443.
    HOGENOMiHOG000041363.
    HOVERGENiHBG017625.
    InParanoidiQ9H2C5.
    KOiK04257.
    OMAiALNTCIL.
    OrthoDBiEOG754HPV.
    PhylomeDBiQ9H2C5.
    TreeFamiTF352744.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR019424. 7TM_GPCR_olfarory/Srsx.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PfamiPF10320. 7TM_GPCR_Srsx. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H2C5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTFNGSVFM PSAFILIGIP GLESVQCWIG IPFSAMYLIG VIGNSLILVI    50
    IKYENSLHIP MYIFLAMLAA TDIALNTCIL PKMLGIFWFH LPEISFDACL 100
    FQMWLIHSFQ AIESGILLAM ALDRYVAICI PLRHATIFSQ QFLTHIGLGV 150
    TLRAAILIIP SLGLIKCCLK HYRTTVISHS YCEHMAIVKL ATEDIRVNKI 200
    YGLFVAFAIL GFDIIFITLS YVQIFITVFQ LPQKEARFKA FNTCIAHICV 250
    FLQFYLLAFF SFFTHRFGSH IPPYIHILLS NLYLLVPPFL NPIVYGVKTK 300
    QIRDHIVKVF FFKKVT 316
    Length:316
    Mass (Da):35,955
    Last modified:March 1, 2001 - v1
    Checksum:i0B0820B4BE747623
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF289204 Genomic DNA. Translation: AAG42368.1.
    BK004433 Genomic DNA. Translation: DAA04831.1.
    CCDSiCCDS31373.1.
    RefSeqiNP_001005160.1. NM_001005160.2.
    UniGeneiHs.546593.

    Genome annotation databases

    EnsembliENST00000307388; ENSP00000303469; ENSG00000171944.
    GeneIDi390054.
    KEGGihsa:390054.
    UCSCiuc010qyx.2. human.

    Polymorphism databases

    DMDMi74762730.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF289204 Genomic DNA. Translation: AAG42368.1 .
    BK004433 Genomic DNA. Translation: DAA04831.1 .
    CCDSi CCDS31373.1.
    RefSeqi NP_001005160.1. NM_001005160.2.
    UniGenei Hs.546593.

    3D structure databases

    ProteinModelPortali Q9H2C5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000303469.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 74762730.

    Proteomic databases

    PaxDbi Q9H2C5.
    PRIDEi Q9H2C5.

    Protocols and materials databases

    DNASUi 390054.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307388 ; ENSP00000303469 ; ENSG00000171944 .
    GeneIDi 390054.
    KEGGi hsa:390054.
    UCSCi uc010qyx.2. human.

    Organism-specific databases

    CTDi 390054.
    GeneCardsi GC11M005152.
    HGNCi HGNC:19580. OR52A5.
    neXtProti NX_Q9H2C5.
    PharmGKBi PA134991603.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG86443.
    HOGENOMi HOG000041363.
    HOVERGENi HBG017625.
    InParanoidi Q9H2C5.
    KOi K04257.
    OMAi ALNTCIL.
    OrthoDBi EOG754HPV.
    PhylomeDBi Q9H2C5.
    TreeFami TF352744.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR52A5.
    GenomeRNAii 390054.
    NextBioi 103317.
    PROi Q9H2C5.

    Gene expression databases

    CleanExi HS_OR52A5.
    Genevestigatori Q9H2C5.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR019424. 7TM_GPCR_olfarory/Srsx.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    Pfami PF10320. 7TM_GPCR_Srsx. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
      Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
      Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: IDENTIFICATION.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO52A5_HUMAN
    AccessioniPrimary (citable) accession number: Q9H2C5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3