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Q9H2C5

- O52A5_HUMAN

UniProt

Q9H2C5 - O52A5_HUMAN

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Protein

Olfactory receptor 52A5

Gene

OR52A5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
  2. sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52A5
Alternative name(s):
Odorant receptor HOR3'beta5
Olfactory receptor OR11-33
Gene namesi
Name:OR52A5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:19580. OR52A5.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134991603.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Olfactory receptor 52A5PRO_0000150766Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9H2C5.
PRIDEiQ9H2C5.

Expressioni

Gene expression databases

CleanExiHS_OR52A5.
GenevestigatoriQ9H2C5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303469.

Structurei

3D structure databases

ProteinModelPortaliQ9H2C5.
SMRiQ9H2C5. Positions 111-142.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence Analysis
Topological domaini78 – 10124ExtracellularSequence AnalysisAdd
BLAST
Topological domaini123 – 14119CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini163 – 19937ExtracellularSequence AnalysisAdd
BLAST
Topological domaini221 – 24020CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini262 – 27615ExtracellularSequence AnalysisAdd
BLAST
Topological domaini298 – 31619CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei200 – 22021Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei241 – 26121Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG86443.
GeneTreeiENSGT00760000118843.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H2C5.
KOiK04257.
OMAiALNTCIL.
OrthoDBiEOG754HPV.
PhylomeDBiQ9H2C5.
TreeFamiTF352744.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR019424. 7TM_GPCR_olfarory/Srsx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF10320. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H2C5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTFNGSVFM PSAFILIGIP GLESVQCWIG IPFSAMYLIG VIGNSLILVI
60 70 80 90 100
IKYENSLHIP MYIFLAMLAA TDIALNTCIL PKMLGIFWFH LPEISFDACL
110 120 130 140 150
FQMWLIHSFQ AIESGILLAM ALDRYVAICI PLRHATIFSQ QFLTHIGLGV
160 170 180 190 200
TLRAAILIIP SLGLIKCCLK HYRTTVISHS YCEHMAIVKL ATEDIRVNKI
210 220 230 240 250
YGLFVAFAIL GFDIIFITLS YVQIFITVFQ LPQKEARFKA FNTCIAHICV
260 270 280 290 300
FLQFYLLAFF SFFTHRFGSH IPPYIHILLS NLYLLVPPFL NPIVYGVKTK
310
QIRDHIVKVF FFKKVT
Length:316
Mass (Da):35,955
Last modified:March 1, 2001 - v1
Checksum:i0B0820B4BE747623
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF289204 Genomic DNA. Translation: AAG42368.1.
BK004433 Genomic DNA. Translation: DAA04831.1.
CCDSiCCDS31373.1.
RefSeqiNP_001005160.1. NM_001005160.2.
UniGeneiHs.546593.

Genome annotation databases

EnsembliENST00000307388; ENSP00000303469; ENSG00000171944.
GeneIDi390054.
KEGGihsa:390054.
UCSCiuc010qyx.2. human.

Polymorphism databases

DMDMi74762730.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF289204 Genomic DNA. Translation: AAG42368.1 .
BK004433 Genomic DNA. Translation: DAA04831.1 .
CCDSi CCDS31373.1.
RefSeqi NP_001005160.1. NM_001005160.2.
UniGenei Hs.546593.

3D structure databases

ProteinModelPortali Q9H2C5.
SMRi Q9H2C5. Positions 111-142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000303469.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 74762730.

Proteomic databases

PaxDbi Q9H2C5.
PRIDEi Q9H2C5.

Protocols and materials databases

DNASUi 390054.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307388 ; ENSP00000303469 ; ENSG00000171944 .
GeneIDi 390054.
KEGGi hsa:390054.
UCSCi uc010qyx.2. human.

Organism-specific databases

CTDi 390054.
GeneCardsi GC11M005152.
HGNCi HGNC:19580. OR52A5.
neXtProti NX_Q9H2C5.
PharmGKBi PA134991603.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG86443.
GeneTreei ENSGT00760000118843.
HOGENOMi HOG000041363.
HOVERGENi HBG017625.
InParanoidi Q9H2C5.
KOi K04257.
OMAi ALNTCIL.
OrthoDBi EOG754HPV.
PhylomeDBi Q9H2C5.
TreeFami TF352744.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR52A5.
GenomeRNAii 390054.
NextBioi 103317.
PROi Q9H2C5.

Gene expression databases

CleanExi HS_OR52A5.
Genevestigatori Q9H2C5.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR019424. 7TM_GPCR_olfarory/Srsx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
Pfami PF10320. 7TM_GPCR_Srsx. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
    Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
    Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO52A5_HUMAN
AccessioniPrimary (citable) accession number: Q9H2C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3