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Q9H2C5 (O52A5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 52A5
Alternative name(s):
Odorant receptor HOR3'beta5
Olfactory receptor OR11-33
Gene names
Name:OR52A5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Olfactory receptor 52A5
PRO_0000150766

Regions

Topological domain1 – 2727Extracellular Potential
Transmembrane28 – 4821Helical; Name=1; Potential
Topological domain49 – 568Cytoplasmic Potential
Transmembrane57 – 7721Helical; Name=2; Potential
Topological domain78 – 10124Extracellular Potential
Transmembrane102 – 12221Helical; Name=3; Potential
Topological domain123 – 14119Cytoplasmic Potential
Transmembrane142 – 16221Helical; Name=4; Potential
Topological domain163 – 19937Extracellular Potential
Transmembrane200 – 22021Helical; Name=5; Potential
Topological domain221 – 24020Cytoplasmic Potential
Transmembrane241 – 26121Helical; Name=6; Potential
Topological domain262 – 27615Extracellular Potential
Transmembrane277 – 29721Helical; Name=7; Potential
Topological domain298 – 31619Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9H2C5 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 0B0820B4BE747623

FASTA31635,955
        10         20         30         40         50         60 
MPTFNGSVFM PSAFILIGIP GLESVQCWIG IPFSAMYLIG VIGNSLILVI IKYENSLHIP 

        70         80         90        100        110        120 
MYIFLAMLAA TDIALNTCIL PKMLGIFWFH LPEISFDACL FQMWLIHSFQ AIESGILLAM 

       130        140        150        160        170        180 
ALDRYVAICI PLRHATIFSQ QFLTHIGLGV TLRAAILIIP SLGLIKCCLK HYRTTVISHS 

       190        200        210        220        230        240 
YCEHMAIVKL ATEDIRVNKI YGLFVAFAIL GFDIIFITLS YVQIFITVFQ LPQKEARFKA 

       250        260        270        280        290        300 
FNTCIAHICV FLQFYLLAFF SFFTHRFGSH IPPYIHILLS NLYLLVPPFL NPIVYGVKTK 

       310 
QIRDHIVKVF FFKKVT 

« Hide

References

[1]"Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters."
Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R.
Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF289204 Genomic DNA. Translation: AAG42368.1.
BK004433 Genomic DNA. Translation: DAA04831.1.
RefSeqNP_001005160.1. NM_001005160.2.
UniGeneHs.546593.

3D structure databases

ProteinModelPortalQ9H2C5.
SMRQ9H2C5. Positions 20-59, 111-142, 283-312.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000303469.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM74762730.

Proteomic databases

PaxDbQ9H2C5.
PRIDEQ9H2C5.

Protocols and materials databases

DNASU390054.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000307388; ENSP00000303469; ENSG00000171944.
GeneID390054.
KEGGhsa:390054.
UCSCuc010qyx.2. human.

Organism-specific databases

CTD390054.
GeneCardsGC11M005152.
HGNCHGNC:19580. OR52A5.
neXtProtNX_Q9H2C5.
PharmGKBPA134991603.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG86443.
HOGENOMHOG000041363.
HOVERGENHBG017625.
InParanoidQ9H2C5.
KOK04257.
OMAALNTCIL.
OrthoDBEOG754HPV.
PhylomeDBQ9H2C5.
TreeFamTF352744.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR52A5.
GenevestigatorQ9H2C5.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR019424. 7TM_GPCR_olfarory/Srsx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamPF10320. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR52A5.
GenomeRNAi390054.
NextBio103317.
PROQ9H2C5.

Entry information

Entry nameO52A5_HUMAN
AccessionPrimary (citable) accession number: Q9H2C5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries