Q9H2C5 (O52A5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 52A5

Alternative name(s):
Odorant receptor HOR3'beta5
Olfactory receptor OR11-33

Gene names

Name:

OR52A5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	Olfactory receptor 52A5		PRO_0000150766
Regions
	Topological domain	1 – 27	27	Extracellular Potential
	Transmembrane	28 – 48	21	Helical; Name=1; Potential
	Topological domain	49 – 56	8	Cytoplasmic Potential
	Transmembrane	57 – 77	21	Helical; Name=2; Potential
	Topological domain	78 – 101	24	Extracellular Potential
	Transmembrane	102 – 122	21	Helical; Name=3; Potential
	Topological domain	123 – 141	19	Cytoplasmic Potential
	Transmembrane	142 – 162	21	Helical; Name=4; Potential
	Topological domain	163 – 199	37	Extracellular Potential
	Transmembrane	200 – 220	21	Helical; Name=5; Potential
	Topological domain	221 – 240	20	Cytoplasmic Potential
	Transmembrane	241 – 261	21	Helical; Name=6; Potential
	Topological domain	262 – 276	15	Extracellular Potential
	Transmembrane	277 – 297	21	Helical; Name=7; Potential
	Topological domain	298 – 316	19	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9H2C5 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 0B0820B4BE747623	FASTA	316	35,955
	10 20 30 40 50 60 MPTFNGSVFM PSAFILIGIP GLESVQCWIG IPFSAMYLIG VIGNSLILVI IKYENSLHIP 70 80 90 100 110 120 MYIFLAMLAA TDIALNTCIL PKMLGIFWFH LPEISFDACL FQMWLIHSFQ AIESGILLAM 130 140 150 160 170 180 ALDRYVAICI PLRHATIFSQ QFLTHIGLGV TLRAAILIIP SLGLIKCCLK HYRTTVISHS 190 200 210 220 230 240 YCEHMAIVKL ATEDIRVNKI YGLFVAFAIL GFDIIFITLS YVQIFITVFQ LPQKEARFKA 250 260 270 280 290 300 FNTCIAHICV FLQFYLLAFF SFFTHRFGSH IPPYIHILLS NLYLLVPPFL NPIVYGVKTK 310 QIRDHIVKVF FFKKVT

References

[1]	"Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters." Bulger M., Bender M.A., van Doorninck J.H., Wertman B., Farrell C.M., Felsenfeld G., Groudine M., Hardison R. Proc. Natl. Acad. Sci. U.S.A. 97:14560-14565(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[3]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF289204 Genomic DNA. Translation: AAG42368.1. BK004433 Genomic DNA. Translation: DAA04831.1.
IPI	IPI00399290.
RefSeq	NP_001005160.1. NM_001005160.2.
UniGene	Hs.546593.
3D structure databases
ProteinModelPortal	Q9H2C5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000303469.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	74762730.
Proteomic databases
PaxDb	Q9H2C5.
PRIDE	Q9H2C5.
Protocols and materials databases
DNASU	390054.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000307388; ENSP00000303469; ENSG00000171944.
GeneID	390054.
KEGG	hsa:390054.
UCSC	uc010qyx.2. human.
Organism-specific databases
CTD	390054.
GeneCards	GC11M005152.
HGNC	HGNC:19580. OR52A5.
neXtProt	NX_Q9H2C5.
PharmGKB	PA134991603.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG86443.
HOGENOM	HOG000041363.
HOVERGEN	HBG017625.
InParanoid	Q9H2C5.
KO	K04257.
OMA	LIKCCLK.
OrthoDB	EOG4JQ3Z5.
PhylomeDB	Q9H2C5.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR52A5.
Genevestigator	Q9H2C5.
Family and domain databases
InterPro	IPR019424. 7TM_GPCR_olfarory/Srsx. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
Pfam	PF10320. 7TM_GPCR_Srsx. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	390054.
NextBio	103317.

Entry information

Entry name

O52A5_HUMAN

Accession

Primary (citable) accession number: Q9H2C5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.