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Protein

LIM/homeobox protein Lhx5

Gene

LHX5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi180 – 23960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx5
Short name:
LIM homeobox protein 5
Gene namesi
Name:LHX5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:14216. LHX5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30367.

Polymorphism and mutation databases

BioMutaiLHX5.
DMDMi18202938.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402LIM/homeobox protein Lhx5PRO_0000075789Add
BLAST

Proteomic databases

EPDiQ9H2C1.
PaxDbiQ9H2C1.
PeptideAtlasiQ9H2C1.
PRIDEiQ9H2C1.

PTM databases

iPTMnetiQ9H2C1.
PhosphoSiteiQ9H2C1.

Expressioni

Tissue specificityi

Expressed in fetal brain and in various regions of the adult central nervous system including the spinal cord, the thalamus, and the cerebellum.

Gene expression databases

BgeeiQ9H2C1.
CleanExiHS_LHX5.
GenevisibleiQ9H2C1. HS.

Organism-specific databases

HPAiHPA053908.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000261731.

Structurei

3D structure databases

ProteinModelPortaliQ9H2C1.
SMRiQ9H2C1. Positions 5-158, 186-236.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 6159LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini62 – 12564LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118921.
HOGENOMiHOG000231630.
HOVERGENiHBG006263.
InParanoidiQ9H2C1.
KOiK18493.
OMAiQDPMQDD.
OrthoDBiEOG7PP56T.
PhylomeDBiQ9H2C1.
TreeFamiTF315442.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H2C1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVHCAGCER PILDRFLLNV LDRAWHIKCV QCCECKTNLS EKCFSREGKL
60 70 80 90 100
YCKNDFFRRF GTKCAGCAQG ISPSDLVRKA RSKVFHLNCF TCMVCNKQLS
110 120 130 140 150
TGEELYVIDE NKFVCKDDYL SSSSLKEGSL NSVSSCTDRS LSPDLQDALQ
160 170 180 190 200
DDPKETDNST SSDKETANNE NEEQNSGTKR RGPRTTIKAK QLETLKAAFA
210 220 230 240 250
ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ LSALGARRHA
260 270 280 290 300
FFRSPRRMRP LGGRLDESEM LGSTPYTYYG DYQGDYYAPG SNYDFFAHGP
310 320 330 340 350
PSQAQSPADS SFLAASGPGS TPLGALEPPL AGPHAADNPR FTDMISHPDT
360 370 380 390 400
PSPEPGLPGT LHPMPGEVFS GGPSPPFPMS GTSGYSGPLS HPNPELNEAA

VW
Length:402
Mass (Da):44,406
Last modified:March 1, 2001 - v1
Checksum:iE880138A1A3FCA2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291181 mRNA. Translation: AAG36963.1.
BC109230 mRNA. Translation: AAI09231.1.
CCDSiCCDS9171.1.
RefSeqiNP_071758.1. NM_022363.2.
UniGeneiHs.302029.

Genome annotation databases

EnsembliENST00000261731; ENSP00000261731; ENSG00000089116.
GeneIDi64211.
KEGGihsa:64211.
UCSCiuc001tvj.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF291181 mRNA. Translation: AAG36963.1.
BC109230 mRNA. Translation: AAI09231.1.
CCDSiCCDS9171.1.
RefSeqiNP_071758.1. NM_022363.2.
UniGeneiHs.302029.

3D structure databases

ProteinModelPortaliQ9H2C1.
SMRiQ9H2C1. Positions 5-158, 186-236.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000261731.

PTM databases

iPTMnetiQ9H2C1.
PhosphoSiteiQ9H2C1.

Polymorphism and mutation databases

BioMutaiLHX5.
DMDMi18202938.

Proteomic databases

EPDiQ9H2C1.
PaxDbiQ9H2C1.
PeptideAtlasiQ9H2C1.
PRIDEiQ9H2C1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261731; ENSP00000261731; ENSG00000089116.
GeneIDi64211.
KEGGihsa:64211.
UCSCiuc001tvj.2. human.

Organism-specific databases

CTDi64211.
GeneCardsiLHX5.
HGNCiHGNC:14216. LHX5.
HPAiHPA053908.
MIMi605992. gene.
neXtProtiNX_Q9H2C1.
PharmGKBiPA30367.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118921.
HOGENOMiHOG000231630.
HOVERGENiHBG006263.
InParanoidiQ9H2C1.
KOiK18493.
OMAiQDPMQDD.
OrthoDBiEOG7PP56T.
PhylomeDBiQ9H2C1.
TreeFamiTF315442.

Miscellaneous databases

GenomeRNAii64211.
PROiQ9H2C1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H2C1.
CleanExiHS_LHX5.
GenevisibleiQ9H2C1. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic structure, chromosomal localization and expression of the human LIM-homeobox gene LHX5."
    Zhao Y., Hermesz E., Yarolin M.C., Westphal H.
    Gene 260:95-101(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiLHX5_HUMAN
AccessioniPrimary (citable) accession number: Q9H2C1
Secondary accession number(s): Q32MA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.