Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9H2B2 (SYT4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synaptotagmin-4
Alternative name(s):
Synaptotagmin IV
Short name=SytIV
Gene names
Name:SYT4
Synonyms:KIAA1342
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.

Cofactor

Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.

Subcellular location

Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane; Single-pass membrane protein.

Tissue specificity

Expressed in brain. Within brain, expression is highest in hippocampus, with substantial levels also detected in amygdala and thalamus.

Sequence similarities

Belongs to the synaptotagmin family.

Contains 2 C2 domains.

Sequence caution

The sequence BAA92580.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425Synaptotagmin-4
PRO_0000183948

Regions

Topological domain1 – 1616Vesicular Potential
Transmembrane17 – 3721Helical; Potential
Topological domain38 – 425388Cytoplasmic Potential
Domain155 – 258104C2 1
Domain289 – 392104C2 2
Region147 – 297151Phospholipid binding Probable

Sites

Metal binding1841Calcium 1 By similarity
Metal binding1841Calcium 2 By similarity
Metal binding1911Calcium 1 By similarity
Metal binding2451Calcium 1; via carbonyl oxygen By similarity
Metal binding2461Calcium 1 By similarity
Metal binding2461Calcium 2 By similarity
Metal binding2461Calcium 3 By similarity
Metal binding2491Calcium 3 By similarity
Metal binding2521Calcium 2 By similarity
Metal binding2521Calcium 3 By similarity

Natural variations

Natural variant1421S → N.
Corresponds to variant rs16977447 [ dbSNP | Ensembl ].
VAR_052239

Secondary structure

....................... 425
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9H2B2 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: DA3D4CB175CB528D

FASTA42547,958
        10         20         30         40         50         60 
MAPITTSREE FDEIPTVVGI FSAFGLVFTV SLFAWICCQR KSSKSNKTPP YKFVHVLKGV 

        70         80         90        100        110        120 
DIYPENLNSK KKFGADDKNE VKNKPAVPKN SLHLDLEKRD LNGNFPKTNL KPGSPSDLEN 

       130        140        150        160        170        180 
ATPKLFLEGE KESVSPESLK SSTSLTSEEK QEKLGTLFFS LEYNFERKAF VVNIKEARGL 

       190        200        210        220        230        240 
PAMDEQSMTS DPYIKMTILP EKKHKVKTRV LRKTLDPAFD ETFTFYGIPY TQIQELALHF 

       250        260        270        280        290        300 
TILSFDRFSR DDIIGEVLIP LSGIELSEGK MLMNREIIKR NVRKSSGRGE LLISLCYQST 

       310        320        330        340        350        360 
TNTLTVVVLK ARHLPKSDVS GLSDPYVKVN LYHAKKRISK KKTHVKKCTP NAVFNELFVF 

       370        380        390        400        410        420 
DIPCEGLEDI SVEFLVLDSE RGSRNEVIGQ LVLGAAAEGT GGEHWKEICD YPRRQIAKWH 


VLCDG 

« Hide

References

« Hide 'large scale' references
[1]"The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity."
Ferguson G.D., Chen X.-N., Korenberg J.R., Herschman H.R.
J. Biol. Chem. 275:36920-36926(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Solution structure of the first C2 domain of synaptotagmin IV from human fetal brain (KIAA1342)."
RIKEN structural genomics initiative (RSGI)
Submitted (DEC-2003) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 154-278.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF299075 mRNA. Translation: AAG37229.1.
AB037763 mRNA. Translation: BAA92580.1. Different initiation.
BC036538 mRNA. Translation: AAH36538.1.
RefSeqNP_065834.1. NM_020783.3.
UniGeneHs.8059.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1UGKNMR-A154-278[»]
ProteinModelPortalQ9H2B2.
SMRQ9H2B2. Positions 152-425.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112724. 2 interactions.
IntActQ9H2B2. 1 interaction.
MINTMINT-1451266.
STRING9606.ENSP00000255224.

PTM databases

PhosphoSiteQ9H2B2.

Polymorphism databases

DMDM18202937.

Proteomic databases

PaxDbQ9H2B2.
PRIDEQ9H2B2.

Protocols and materials databases

DNASU6860.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000255224; ENSP00000255224; ENSG00000132872.
GeneID6860.
KEGGhsa:6860.
UCSCuc002law.3. human.

Organism-specific databases

CTD6860.
GeneCardsGC18M040847.
HGNCHGNC:11512. SYT4.
HPAHPA010574.
MIM600103. gene.
neXtProtNX_Q9H2B2.
PharmGKBPA36293.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG292488.
HOGENOMHOG000232126.
HOVERGENHBG005010.
InParanoidQ9H2B2.
OMAQIAKWHM.
OrthoDBEOG75J0N2.
PhylomeDBQ9H2B2.
TreeFamTF315600.

Gene expression databases

ArrayExpressQ9H2B2.
BgeeQ9H2B2.
CleanExHS_SYT4.
GenevestigatorQ9H2B2.

Family and domain databases

Gene3D2.60.40.150. 2 hits.
InterProIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028683. SYT4.
[Graphical view]
PANTHERPTHR10024:SF114. PTHR10024:SF114. 1 hit.
PfamPF00168. C2. 2 hits.
[Graphical view]
PRINTSPR00399. SYNAPTOTAGMN.
SMARTSM00239. C2. 2 hits.
[Graphical view]
SUPFAMSSF49562. SSF49562. 2 hits.
PROSITEPS50004. C2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9H2B2.
GeneWikiSYT4.
GenomeRNAi6860.
NextBio26771.
PROQ9H2B2.
SOURCESearch...

Entry information

Entry nameSYT4_HUMAN
AccessionPrimary (citable) accession number: Q9H2B2
Secondary accession number(s): Q9P2K4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM