Synaptotagmin-4 - Homo sapiens (Human)

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Q9H2B2 (SYT4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 113. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Synaptotagmin-4

Alternative name(s):
Synaptotagmin IV
Short name=SytIV

Gene names

Name:	SYT4
Synonyms:	KIAA1342

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	425 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in Ca²⁺-dependent exocytosis of secretory vesicles through Ca²⁺ and phospholipid binding to the C2 domain or may serve as Ca²⁺ sensors in the process of vesicular trafficking and exocytosis.
Cofactor	Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.
Subcellular location	Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Single-pass membrane protein.
Tissue specificity	Expressed in brain. Within brain, expression is highest in hippocampus, with substantial levels also detected in amygdala and thalamus.
Sequence similarities	Belongs to the synaptotagmin family. Contains 2 C2 domains.
Sequence caution	The sequence BAA92580.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell junction Cytoplasmic vesicle Membrane Synapse
Coding sequence diversity	Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neurotransmitter secretion Inferred from electronic annotation. Source: Compara
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW neuron projection Inferred from electronic annotation. Source: Compara perinuclear region of cytoplasm Inferred from electronic annotation. Source: Compara synaptic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: Compara transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 425

425

Synaptotagmin-4

PRO_0000183948

Regions

Topological domain

1 – 16

Vesicular Potential

Transmembrane

17 – 37

Helical; Potential

Topological domain

38 – 425

388

Cytoplasmic Potential

Domain

155 – 258

104

C2 1

Domain

289 – 392

104

C2 2

Region

147 – 297

151

Phospholipid binding Probable

Sites

Metal binding

184

Calcium 1 By similarity

Metal binding

184

Calcium 2 By similarity

Metal binding

191

Calcium 1 By similarity

Metal binding

245

Calcium 1; via carbonyl oxygen By similarity

Metal binding

246

Calcium 1 By similarity

Metal binding

246

Calcium 2 By similarity

Metal binding

246

Calcium 3 By similarity

Metal binding

249

Calcium 3 By similarity

Metal binding

252

Calcium 2 By similarity

Metal binding

252

Calcium 3 By similarity

Natural variations

Natural variant

142

S → N.
Corresponds to variant rs16977447 [ dbSNP | Ensembl ].

VAR_052239

Secondary structure

425

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q9H2B2 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: DA3D4CB175CB528D
Show »

FASTA

425

47,958

        10         20         30         40         50         60 
MAPITTSREE FDEIPTVVGI FSAFGLVFTV SLFAWICCQR KSSKSNKTPP YKFVHVLKGV 

        70         80         90        100        110        120 
DIYPENLNSK KKFGADDKNE VKNKPAVPKN SLHLDLEKRD LNGNFPKTNL KPGSPSDLEN 

       130        140        150        160        170        180 
ATPKLFLEGE KESVSPESLK SSTSLTSEEK QEKLGTLFFS LEYNFERKAF VVNIKEARGL 

       190        200        210        220        230        240 
PAMDEQSMTS DPYIKMTILP EKKHKVKTRV LRKTLDPAFD ETFTFYGIPY TQIQELALHF 

       250        260        270        280        290        300 
TILSFDRFSR DDIIGEVLIP LSGIELSEGK MLMNREIIKR NVRKSSGRGE LLISLCYQST 

       310        320        330        340        350        360 
TNTLTVVVLK ARHLPKSDVS GLSDPYVKVN LYHAKKRISK KKTHVKKCTP NAVFNELFVF 

       370        380        390        400        410        420 
DIPCEGLEDI SVEFLVLDSE RGSRNEVIGQ LVLGAAAEGT GGEHWKEICD YPRRQIAKWH 


VLCDG

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity." Ferguson G.D., Chen X.-N., Korenberg J.R., Herschman H.R. J. Biol. Chem. 275:36920-36926(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Solution structure of the first C2 domain of synaptotagmin IV from human fetal brain (KIAA1342)." RIKEN structural genomics initiative (RSGI) Submitted (DEC-2003) to the PDB data bank Cited for: STRUCTURE BY NMR OF 154-278.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF299075 mRNA. Translation: AAG37229.1.
AB037763 mRNA. Translation: BAA92580.1. Different initiation.
BC036538 mRNA. Translation: AAH36538.1.

IPI

IPI00022735.

RefSeq

NP_065834.1. NM_020783.3.

UniGene

Hs.8059.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1UGK	NMR	-	A	154-278	[»]

ProteinModelPortal

Q9H2B2.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9H2B2. 1 interaction.

MINT

MINT-1451266.

STRING

9606.ENSP00000255224.

PTM databases

PhosphoSite

Q9H2B2.

Polymorphism databases

DMDM

18202937.

Proteomic databases

PaxDb

Q9H2B2.

PRIDE

Q9H2B2.

Protocols and materials databases

DNASU

6860.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000255224; ENSP00000255224; ENSG00000132872.

GeneID

6860.

KEGG

hsa:6860.

UCSC

uc002law.3. human.

Organism-specific databases

CTD

6860.

GeneCards

GC18M040847.

HGNC

HGNC:11512. SYT4.

HPA

HPA010574.

MIM

600103. gene.

neXtProt

NX_Q9H2B2.

PharmGKB

PA36293.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG292488.

HOGENOM

HOG000232126.

HOVERGEN

HBG005010.

InParanoid

Q9H2B2.

OMA

QIAKWHM.

OrthoDB

EOG4GMTX0.

PhylomeDB

Q9H2B2.

Gene expression databases

ArrayExpress

Q9H2B2.

Bgee

Q9H2B2.

CleanEx

HS_SYT4.

Genevestigator

Q9H2B2.

GermOnline

ENSG00000132872. Homo sapiens.

Family and domain databases

InterPro

IPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR018029. C2_membr_targeting.
IPR001565. Synaptotagmin.
[Graphical view]

Pfam

PF00168. C2. 2 hits.
[Graphical view]

PRINTS

PR00399. SYNAPTOTAGMN.

SMART

SM00239. C2. 2 hits.
[Graphical view]

SUPFAM

SSF49562. C2_CaLB. 2 hits.

PROSITE

PS50004. C2. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9H2B2.

GenomeRNAi

6860.

NextBio

26771.

SOURCE

Search...

Entry information

Entry name

SYT4_HUMAN

Accession

Primary (citable) accession number: Q9H2B2
Secondary accession number(s): Q9P2K4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 113 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Natural variations

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents