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Protein

C-X-C motif chemokine 16

Gene

CXCL16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.By similarity

GO - Molecular functioni

  • chemokine activity Source: UniProtKB
  • low-density lipoprotein receptor activity Source: UniProtKB
  • scavenger receptor activity Source: UniProtKB

GO - Biological processi

  • cellular response to lipopolysaccharide Source: Ensembl
  • chemotaxis Source: UniProtKB
  • positive regulation of cell growth Source: BHF-UCL
  • positive regulation of cell migration Source: BHF-UCL
  • receptor-mediated endocytosis Source: UniProtKB
  • response to cytokine Source: BHF-UCL
  • response to interferon-gamma Source: BHF-UCL
  • response to tumor necrosis factor Source: BHF-UCL
  • T cell chemotaxis Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161921-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Protein family/group databases

TCDBi9.B.173.1.1. the chemokine, cxcl16 (cxcl16) family.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 16
Alternative name(s):
Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
Short name:
SR-PSOX
Small-inducible cytokine B16
Transmembrane chemokine CXCL16
Gene namesi
Name:CXCL16
Synonyms:SCYB16, SRPSOX
ORF Names:UNQ2759/PRO6714
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:16642. CXCL16.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 205ExtracellularSequence analysisAdd BLAST176
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 254CytoplasmicSequence analysisAdd BLAST28

GO - Cellular componenti

  • extracellular region Source: Reactome
  • extracellular space Source: BHF-UCL
  • integral component of membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi58191.
PharmGKBiPA27057.

Polymorphism and mutation databases

BioMutaiCXCL16.
DMDMi209572770.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000511830 – 254C-X-C motif chemokine 16Add BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 68By similarity
Disulfide bondi40 ↔ 82By similarity
Glycosylationi168N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9H2A7.
PaxDbiQ9H2A7.
PeptideAtlasiQ9H2A7.
PRIDEiQ9H2A7.

PTM databases

iPTMnetiQ9H2A7.
PhosphoSitePlusiQ9H2A7.

Expressioni

Tissue specificityi

Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.

Gene expression databases

BgeeiENSG00000161921.
CleanExiHS_CXCL16.
ExpressionAtlasiQ9H2A7. baseline and differential.
GenevisibleiQ9H2A7. HS.

Organism-specific databases

HPAiHPA053253.
HPA066315.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121805. 14 interactors.
STRINGi9606.ENSP00000293778.

Structurei

3D structure databases

ProteinModelPortaliQ9H2A7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni32 – 107ChemokineAdd BLAST76

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8A5. Eukaryota.
ENOG4111D6H. LUCA.
HOVERGENiHBG107790.
InParanoidiQ9H2A7.
KOiK10035.
OrthoDBiEOG091G0P40.
PhylomeDBiQ9H2A7.
TreeFamiTF337941.

Family and domain databases

InterProiIPR026296. CXCL16.
[Graphical view]
PANTHERiPTHR14385. PTHR14385. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H2A7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRDLRPGSR VLLLLLLLLL VYLTQPGNGN EGSVTGSCYC GKRISSDSPP
60 70 80 90 100
SVQFMNRLRK HLRAYHRCLY YTRFQLLSWS VCGGNKDPWV QELMSCLDLK
110 120 130 140 150
ECGHAYSGIV AHQKHLLPTS PPISQASEGA SSDIHTPAQM LLSTLQSTQR
160 170 180 190 200
PTLPVGSLSS DKELTRPNET TIHTAGHSLA AGPEAGENQK QPEKNAGPTA
210 220 230 240 250
RTSATVPVLC LLAIIFILTA ALSYVLCKRR RGQSPQSSPD LPVHYIPVAP

DSNT
Length:254
Mass (Da):27,579
Last modified:October 14, 2008 - v4
Checksum:iEA627A87958B83B6
GO

Sequence cautioni

The sequence AAG34365 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH17588 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH44930 differs from that shown. Reason: Erroneous initiation.Curated
The sequence ABK41925 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55078 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAF84803 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG37507 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67R → W in BAG37507 (PubMed:14702039).Curated1
Sequence conflicti135H → L in BAB55078 (PubMed:14702039).Curated1
Sequence conflicti143S → P in BAG37507 (PubMed:14702039).Curated1
Sequence conflicti222L → P in AAK38275 (PubMed:11290797).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015424123I → T.3 Publications1
Natural variantiVAR_015425181A → V.4 PublicationsCorresponds to variant rs2277680dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301016 mRNA. Translation: AAG34365.1. Different initiation.
AF337812 mRNA. Translation: AAK38275.1.
AF275260 mRNA. Translation: AAG31750.1.
EF064742 Genomic DNA. Translation: ABK41925.1. Different initiation.
AY358909 mRNA. Translation: AAQ89268.1.
AK027389 mRNA. Translation: BAB55078.1. Different initiation.
AK292114 mRNA. Translation: BAF84803.1. Different initiation.
AK315017 mRNA. Translation: BAG37507.1. Different initiation.
BC017588 mRNA. Translation: AAH17588.1. Different initiation.
BC044930 mRNA. Translation: AAH44930.1. Different initiation.
RefSeqiNP_001094282.1. NM_001100812.1.
NP_071342.2. NM_022059.3.
UniGeneiHs.745037.

Genome annotation databases

EnsembliENST00000293778; ENSP00000293778; ENSG00000161921.
ENST00000574412; ENSP00000459592; ENSG00000161921.
GeneIDi58191.
KEGGihsa:58191.
UCSCiuc002fyr.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CXCL16 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301016 mRNA. Translation: AAG34365.1. Different initiation.
AF337812 mRNA. Translation: AAK38275.1.
AF275260 mRNA. Translation: AAG31750.1.
EF064742 Genomic DNA. Translation: ABK41925.1. Different initiation.
AY358909 mRNA. Translation: AAQ89268.1.
AK027389 mRNA. Translation: BAB55078.1. Different initiation.
AK292114 mRNA. Translation: BAF84803.1. Different initiation.
AK315017 mRNA. Translation: BAG37507.1. Different initiation.
BC017588 mRNA. Translation: AAH17588.1. Different initiation.
BC044930 mRNA. Translation: AAH44930.1. Different initiation.
RefSeqiNP_001094282.1. NM_001100812.1.
NP_071342.2. NM_022059.3.
UniGeneiHs.745037.

3D structure databases

ProteinModelPortaliQ9H2A7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121805. 14 interactors.
STRINGi9606.ENSP00000293778.

Protein family/group databases

TCDBi9.B.173.1.1. the chemokine, cxcl16 (cxcl16) family.

PTM databases

iPTMnetiQ9H2A7.
PhosphoSitePlusiQ9H2A7.

Polymorphism and mutation databases

BioMutaiCXCL16.
DMDMi209572770.

Proteomic databases

MaxQBiQ9H2A7.
PaxDbiQ9H2A7.
PeptideAtlasiQ9H2A7.
PRIDEiQ9H2A7.

Protocols and materials databases

DNASUi58191.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293778; ENSP00000293778; ENSG00000161921.
ENST00000574412; ENSP00000459592; ENSG00000161921.
GeneIDi58191.
KEGGihsa:58191.
UCSCiuc002fyr.6. human.

Organism-specific databases

CTDi58191.
DisGeNETi58191.
GeneCardsiCXCL16.
H-InvDBHIX0013447.
HGNCiHGNC:16642. CXCL16.
HPAiHPA053253.
HPA066315.
MIMi605398. gene.
neXtProtiNX_Q9H2A7.
PharmGKBiPA27057.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J8A5. Eukaryota.
ENOG4111D6H. LUCA.
HOVERGENiHBG107790.
InParanoidiQ9H2A7.
KOiK10035.
OrthoDBiEOG091G0P40.
PhylomeDBiQ9H2A7.
TreeFamiTF337941.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161921-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSiCXCL16. human.
GenomeRNAii58191.
PROiQ9H2A7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000161921.
CleanExiHS_CXCL16.
ExpressionAtlasiQ9H2A7. baseline and differential.
GenevisibleiQ9H2A7. HS.

Family and domain databases

InterProiIPR026296. CXCL16.
[Graphical view]
PANTHERiPTHR14385. PTHR14385. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCXL16_HUMAN
AccessioniPrimary (citable) accession number: Q9H2A7
Secondary accession number(s): A0N0N4
, A8K7U9, B2RCB0, Q8TC80, Q96K63, Q9BXD6, Q9H2F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 14, 2008
Last modified: November 2, 2016
This is version 138 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.