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Q9H2A7

- CXL16_HUMAN

UniProt

Q9H2A7 - CXL16_HUMAN

Protein

C-X-C motif chemokine 16

Gene

CXCL16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 4 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis By similarity. Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.By similarity

    GO - Molecular functioni

    1. chemokine activity Source: UniProtKB
    2. low-density lipoprotein receptor activity Source: UniProtKB
    3. receptor binding Source: UniProtKB
    4. scavenger receptor activity Source: UniProtKB

    GO - Biological processi

    1. chemotaxis Source: UniProtKB
    2. lymphocyte chemotaxis Source: UniProtKB
    3. positive regulation of cell growth Source: BHF-UCL
    4. positive regulation of cell migration Source: BHF-UCL
    5. receptor-mediated endocytosis Source: UniProtKB
    6. response to cytokine Source: BHF-UCL
    7. response to interferon-gamma Source: BHF-UCL
    8. response to tumor necrosis factor Source: BHF-UCL

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C motif chemokine 16
    Alternative name(s):
    Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
    Short name:
    SR-PSOX
    Small-inducible cytokine B16
    Transmembrane chemokine CXCL16
    Gene namesi
    Name:CXCL16
    Synonyms:SCYB16, SRPSOX
    ORF Names:UNQ2759/PRO6714
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:16642. CXCL16.

    Subcellular locationi

    Cell membrane Curated; Single-pass type I membrane protein Curated. Secreted
    Note: Also exists as a soluble form.

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: BHF-UCL
    3. integral component of membrane Source: UniProtKB
    4. membrane Source: UniProtKB
    5. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27057.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 254225C-X-C motif chemokine 16PRO_0000005118Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi38 ↔ 68By similarity
    Disulfide bondi40 ↔ 82By similarity
    Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9H2A7.
    PaxDbiQ9H2A7.
    PRIDEiQ9H2A7.

    PTM databases

    PhosphoSiteiQ9H2A7.

    Expressioni

    Tissue specificityi

    Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.

    Gene expression databases

    ArrayExpressiQ9H2A7.
    BgeeiQ9H2A7.
    CleanExiHS_CXCL16.
    GenevestigatoriQ9H2A7.

    Organism-specific databases

    HPAiHPA056559.

    Interactioni

    Protein-protein interaction databases

    BioGridi121805. 2 interactions.
    STRINGi9606.ENSP00000293778.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 205176ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 25428CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei206 – 22621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni32 – 10776ChemokineAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45036.
    HOVERGENiHBG107790.
    InParanoidiQ9H2A7.
    KOiK10035.
    OrthoDBiEOG7XWPQ1.
    PhylomeDBiQ9H2A7.
    TreeFamiTF337941.

    Family and domain databases

    InterProiIPR026296. CXCL16.
    [Graphical view]
    PANTHERiPTHR14385. PTHR14385. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9H2A7-1 [UniParc]FASTAAdd to Basket

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    MGRDLRPGSR VLLLLLLLLL VYLTQPGNGN EGSVTGSCYC GKRISSDSPP    50
    SVQFMNRLRK HLRAYHRCLY YTRFQLLSWS VCGGNKDPWV QELMSCLDLK 100
    ECGHAYSGIV AHQKHLLPTS PPISQASEGA SSDIHTPAQM LLSTLQSTQR 150
    PTLPVGSLSS DKELTRPNET TIHTAGHSLA AGPEAGENQK QPEKNAGPTA 200
    RTSATVPVLC LLAIIFILTA ALSYVLCKRR RGQSPQSSPD LPVHYIPVAP 250
    DSNT 254
    Length:254
    Mass (Da):27,579
    Last modified:October 14, 2008 - v4
    Checksum:iEA627A87958B83B6
    GO

    Sequence cautioni

    The sequence AAG34365.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH17588.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH44930.1 differs from that shown. Reason: Erroneous initiation.
    The sequence ABK41925.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB55078.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAF84803.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAG37507.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 671R → W in BAG37507. (PubMed:14702039)Curated
    Sequence conflicti135 – 1351H → L in BAB55078. (PubMed:14702039)Curated
    Sequence conflicti143 – 1431S → P in BAG37507. (PubMed:14702039)Curated
    Sequence conflicti222 – 2221L → P in AAK38275. (PubMed:11290797)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti123 – 1231I → T.3 Publications
    VAR_015424
    Natural varianti181 – 1811A → V.4 Publications
    Corresponds to variant rs2277680 [ dbSNP | Ensembl ].
    VAR_015425

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF301016 mRNA. Translation: AAG34365.1. Different initiation.
    AF337812 mRNA. Translation: AAK38275.1.
    AF275260 mRNA. Translation: AAG31750.1.
    EF064742 Genomic DNA. Translation: ABK41925.1. Different initiation.
    AY358909 mRNA. Translation: AAQ89268.1.
    AK027389 mRNA. Translation: BAB55078.1. Different initiation.
    AK292114 mRNA. Translation: BAF84803.1. Different initiation.
    AK315017 mRNA. Translation: BAG37507.1. Different initiation.
    BC017588 mRNA. Translation: AAH17588.1. Different initiation.
    BC044930 mRNA. Translation: AAH44930.1. Different initiation.
    RefSeqiNP_001094282.1. NM_001100812.1.
    NP_071342.2. NM_022059.3.
    UniGeneiHs.745037.

    Genome annotation databases

    EnsembliENST00000293778; ENSP00000293778; ENSG00000161921.
    ENST00000574412; ENSP00000459592; ENSG00000161921.
    GeneIDi58191.
    KEGGihsa:58191.
    UCSCiuc002fyr.4. human.

    Polymorphism databases

    DMDMi209572770.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CXCL16 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF301016 mRNA. Translation: AAG34365.1 . Different initiation.
    AF337812 mRNA. Translation: AAK38275.1 .
    AF275260 mRNA. Translation: AAG31750.1 .
    EF064742 Genomic DNA. Translation: ABK41925.1 . Different initiation.
    AY358909 mRNA. Translation: AAQ89268.1 .
    AK027389 mRNA. Translation: BAB55078.1 . Different initiation.
    AK292114 mRNA. Translation: BAF84803.1 . Different initiation.
    AK315017 mRNA. Translation: BAG37507.1 . Different initiation.
    BC017588 mRNA. Translation: AAH17588.1 . Different initiation.
    BC044930 mRNA. Translation: AAH44930.1 . Different initiation.
    RefSeqi NP_001094282.1. NM_001100812.1.
    NP_071342.2. NM_022059.3.
    UniGenei Hs.745037.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121805. 2 interactions.
    STRINGi 9606.ENSP00000293778.

    PTM databases

    PhosphoSitei Q9H2A7.

    Polymorphism databases

    DMDMi 209572770.

    Proteomic databases

    MaxQBi Q9H2A7.
    PaxDbi Q9H2A7.
    PRIDEi Q9H2A7.

    Protocols and materials databases

    DNASUi 58191.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000293778 ; ENSP00000293778 ; ENSG00000161921 .
    ENST00000574412 ; ENSP00000459592 ; ENSG00000161921 .
    GeneIDi 58191.
    KEGGi hsa:58191.
    UCSCi uc002fyr.4. human.

    Organism-specific databases

    CTDi 58191.
    GeneCardsi GC17M004637.
    H-InvDB HIX0013447.
    HGNCi HGNC:16642. CXCL16.
    HPAi HPA056559.
    MIMi 605398. gene.
    neXtProti NX_Q9H2A7.
    PharmGKBi PA27057.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45036.
    HOVERGENi HBG107790.
    InParanoidi Q9H2A7.
    KOi K10035.
    OrthoDBi EOG7XWPQ1.
    PhylomeDBi Q9H2A7.
    TreeFami TF337941.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    ChiTaRSi CXCL16. human.
    GenomeRNAii 58191.
    NextBioi 64890.
    PROi Q9H2A7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H2A7.
    Bgeei Q9H2A7.
    CleanExi HS_CXCL16.
    Genevestigatori Q9H2A7.

    Family and domain databases

    InterProi IPR026296. CXCL16.
    [Graphical view ]
    PANTHERi PTHR14385. PTHR14385. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo."
      Matloubian M., David A., Engel S., Ryan J.E., Cyster J.G.
      Nat. Immunol. 1:298-304(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS THR-123 AND VAL-181.
    2. "Expression cloning of the strl33/bonzo/tymstr ligand reveals elements of cc, cxc, and cx3c chemokines."
      Wilbanks A., Zondlo S.C., Murphy K., Mak S., Soler D., Langdon P., Andrew D.P., Wu L., Briskin M.
      J. Immunol. 166:5145-5154(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-181.
    3. "Molecular cloning of a novel scavenger receptor for oxidized low density lipoprotein, SR-PSOX, on macrophages."
      Shimaoka T., Kume N., Minami M., Hayashida K., Kataoka H., Kita T., Yonehara S.
      J. Biol. Chem. 275:40663-40666(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-123 AND VAL-181.
      Tissue: Mammary gland, Synovium and Tongue.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-123 AND VAL-181.
      Tissue: Lung, Spleen and Testis.

    Entry informationi

    Entry nameiCXL16_HUMAN
    AccessioniPrimary (citable) accession number: Q9H2A7
    Secondary accession number(s): A0N0N4
    , A8K7U9, B2RCB0, Q8TC80, Q96K63, Q9BXD6, Q9H2F6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 122 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3