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Q9H2A7 (CXL16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C motif chemokine 16
Alternative name(s):
Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
Short name=SR-PSOX
Small-inducible cytokine B16
Transmembrane chemokine CXCL16
Gene names
Name:CXCL16
Synonyms:SCYB16, SRPSOX
ORF Names:UNQ2759/PRO6714
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis By similarity. Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.

Subcellular location

Cell membrane; Single-pass type I membrane protein Potential. Secreted. Note: Also exists as a soluble form.

Tissue specificity

Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.

Post-translational modification

Glycosylated.

Sequence similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Sequence caution

The sequence AAG34365.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH17588.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH44930.1 differs from that shown. Reason: Erroneous initiation.

The sequence ABK41925.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB55078.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAF84803.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAG37507.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processChemotaxis
   Cellular componentCell membrane
Membrane
Secreted
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processchemotaxis

Non-traceable author statement Ref.2. Source: UniProtKB

lymphocyte chemotaxis

Non-traceable author statement Ref.1. Source: UniProtKB

positive regulation of cell growth

Inferred from mutant phenotype PubMed 18373975. Source: BHF-UCL

positive regulation of cell migration

Inferred from mutant phenotype PubMed 18373975. Source: BHF-UCL

receptor-mediated endocytosis

Non-traceable author statement Ref.3. Source: UniProtKB

response to cytokine

Inferred from direct assay PubMed 18373975. Source: BHF-UCL

response to interferon-gamma

Inferred from direct assay PubMed 18373975. Source: BHF-UCL

response to tumor necrosis factor

Inferred from direct assay PubMed 18373975. Source: BHF-UCL

   Cellular_componentextracellular region

Non-traceable author statement Ref.1. Source: UniProtKB

extracellular space

Inferred from direct assay PubMed 18373975. Source: BHF-UCL

integral component of membrane

Non-traceable author statement Ref.1Ref.2. Source: UniProtKB

membrane

Traceable author statement Ref.3. Source: UniProtKB

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionchemokine activity

Inferred from sequence or structural similarity. Source: UniProtKB

low-density lipoprotein receptor activity

Inferred from sequence or structural similarity. Source: UniProtKB

receptor binding

Non-traceable author statement Ref.1. Source: UniProtKB

scavenger receptor activity

Traceable author statement Ref.3. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 254225C-X-C motif chemokine 16
PRO_0000005118

Regions

Topological domain30 – 205176Extracellular Potential
Transmembrane206 – 22621Helical; Potential
Topological domain227 – 25428Cytoplasmic Potential
Region32 – 10776Chemokine

Amino acid modifications

Glycosylation1681N-linked (GlcNAc...) Potential
Disulfide bond38 ↔ 68 By similarity
Disulfide bond40 ↔ 82 By similarity

Natural variations

Natural variant1231I → T. Ref.1 Ref.6 Ref.7
VAR_015424
Natural variant1811A → V. Ref.1 Ref.2 Ref.6 Ref.7
Corresponds to variant rs2277680 [ dbSNP | Ensembl ].
VAR_015425

Experimental info

Sequence conflict671R → W in BAG37507. Ref.6
Sequence conflict1351H → L in BAB55078. Ref.6
Sequence conflict1431S → P in BAG37507. Ref.6
Sequence conflict2221L → P in AAK38275. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9H2A7 [UniParc].

Last modified October 14, 2008. Version 4.
Checksum: EA627A87958B83B6

FASTA25427,579
        10         20         30         40         50         60 
MGRDLRPGSR VLLLLLLLLL VYLTQPGNGN EGSVTGSCYC GKRISSDSPP SVQFMNRLRK 

        70         80         90        100        110        120 
HLRAYHRCLY YTRFQLLSWS VCGGNKDPWV QELMSCLDLK ECGHAYSGIV AHQKHLLPTS 

       130        140        150        160        170        180 
PPISQASEGA SSDIHTPAQM LLSTLQSTQR PTLPVGSLSS DKELTRPNET TIHTAGHSLA 

       190        200        210        220        230        240 
AGPEAGENQK QPEKNAGPTA RTSATVPVLC LLAIIFILTA ALSYVLCKRR RGQSPQSSPD 

       250 
LPVHYIPVAP DSNT 

« Hide

References

« Hide 'large scale' references
[1]"A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo."
Matloubian M., David A., Engel S., Ryan J.E., Cyster J.G.
Nat. Immunol. 1:298-304(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS THR-123 AND VAL-181.
[2]"Expression cloning of the strl33/bonzo/tymstr ligand reveals elements of cc, cxc, and cx3c chemokines."
Wilbanks A., Zondlo S.C., Murphy K., Mak S., Soler D., Langdon P., Andrew D.P., Wu L., Briskin M.
J. Immunol. 166:5145-5154(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-181.
[3]"Molecular cloning of a novel scavenger receptor for oxidized low density lipoprotein, SR-PSOX, on macrophages."
Shimaoka T., Kume N., Minami M., Hayashida K., Kataoka H., Kita T., Yonehara S.
J. Biol. Chem. 275:40663-40666(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-123 AND VAL-181.
Tissue: Mammary gland, Synovium and Tongue.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-123 AND VAL-181.
Tissue: Lung, Spleen and Testis.
+Additional computationally mapped references.

Web resources

Wikipedia

CXCL16 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF301016 mRNA. Translation: AAG34365.1. Different initiation.
AF337812 mRNA. Translation: AAK38275.1.
AF275260 mRNA. Translation: AAG31750.1.
EF064742 Genomic DNA. Translation: ABK41925.1. Different initiation.
AY358909 mRNA. Translation: AAQ89268.1.
AK027389 mRNA. Translation: BAB55078.1. Different initiation.
AK292114 mRNA. Translation: BAF84803.1. Different initiation.
AK315017 mRNA. Translation: BAG37507.1. Different initiation.
BC017588 mRNA. Translation: AAH17588.1. Different initiation.
BC044930 mRNA. Translation: AAH44930.1. Different initiation.
RefSeqNP_001094282.1. NM_001100812.1.
NP_071342.2. NM_022059.3.
UniGeneHs.745037.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121805. 2 interactions.
STRING9606.ENSP00000293778.

PTM databases

PhosphoSiteQ9H2A7.

Polymorphism databases

DMDM209572770.

Proteomic databases

MaxQBQ9H2A7.
PaxDbQ9H2A7.
PRIDEQ9H2A7.

Protocols and materials databases

DNASU58191.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000293778; ENSP00000293778; ENSG00000161921.
ENST00000574412; ENSP00000459592; ENSG00000161921.
GeneID58191.
KEGGhsa:58191.
UCSCuc002fyr.4. human.

Organism-specific databases

CTD58191.
GeneCardsGC17M004637.
H-InvDBHIX0013447.
HGNCHGNC:16642. CXCL16.
HPAHPA056559.
MIM605398. gene.
neXtProtNX_Q9H2A7.
PharmGKBPA27057.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45036.
HOVERGENHBG107790.
InParanoidQ9H2A7.
KOK10035.
OrthoDBEOG7XWPQ1.
PhylomeDBQ9H2A7.
TreeFamTF337941.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ9H2A7.
BgeeQ9H2A7.
CleanExHS_CXCL16.
GenevestigatorQ9H2A7.

Family and domain databases

InterProIPR026296. CXCL16.
[Graphical view]
PANTHERPTHR14385. PTHR14385. 1 hit.
ProtoNetSearch...

Other

ChiTaRSCXCL16. human.
GenomeRNAi58191.
NextBio64890.
PROQ9H2A7.
SOURCESearch...

Entry information

Entry nameCXL16_HUMAN
AccessionPrimary (citable) accession number: Q9H2A7
Secondary accession number(s): A0N0N4 expand/collapse secondary AC list , A8K7U9, B2RCB0, Q8TC80, Q96K63, Q9BXD6, Q9H2F6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 14, 2008
Last modified: July 9, 2014
This is version 120 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM