Q9H2A7 (CXL16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-X-C motif chemokine 16

Alternative name(s):
Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
Short name=SR-PSOX
Small-inducible cytokine B16
Transmembrane chemokine CXCL16

Gene names

Name:	CXCL16
Synonyms:	SCYB16, SRPSOX
ORF Names:	UNQ2759/PRO6714

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis By similarity. Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
Subcellular location	Cell membrane; Single-pass type I membrane protein Potential. Secreted. Note: Also exists as a soluble form.
Tissue specificity	Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.
Post-translational modification	Glycosylated.
Sequence similarities	Belongs to the intercrine alpha (chemokine CxC) family.
Sequence caution	The sequence AAG34365.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH17588.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH44930.1 differs from that shown. Reason: Erroneous initiation. The sequence ABK41925.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB55078.1 differs from that shown. Reason: Erroneous initiation. The sequence BAF84803.1 differs from that shown. Reason: Erroneous initiation. The sequence BAG37507.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lymphocyte chemotaxis Non-traceable author statement Ref.1. Source: UniProtKB positive regulation of cell growth Inferred from mutant phenotype PubMed 18373975. Source: BHF-UCL positive regulation of cell migration Inferred from mutant phenotype PubMed 18373975. Source: BHF-UCL response to interferon-gamma Inferred from direct assay PubMed 18373975. Source: BHF-UCL response to tumor necrosis factor Inferred from direct assay PubMed 18373975. Source: BHF-UCL
Cellular_component	extracellular space Inferred from direct assay PubMed 18373975. Source: BHF-UCL integral to membrane Non-traceable author statement Ref.1Ref.2. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	chemokine activity Inferred from sequence or structural similarity. Source: UniProtKB low-density lipoprotein receptor activity Inferred from sequence or structural similarity. Source: UniProtKB scavenger receptor activity Traceable author statement Ref.3. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 254	225	C-X-C motif chemokine 16		PRO_0000005118
Regions
	Topological domain	30 – 205	176	Extracellular Potential
	Transmembrane	206 – 226	21	Helical; Potential
	Topological domain	227 – 254	28	Cytoplasmic Potential
	Region	32 – 107	76	Chemokine
Amino acid modifications
	Glycosylation	168	1	N-linked (GlcNAc...) Potential
	Disulfide bond	38 ↔ 68		By similarity
	Disulfide bond	40 ↔ 82		By similarity
Natural variations
	Natural variant	123	1	I → T. Ref.1 Ref.6 Ref.7		VAR_015424
	Natural variant	181	1	A → V. Ref.1 Ref.2 Ref.6 Ref.7 Corresponds to variant rs2277680 [ dbSNP | Ensembl ].		VAR_015425
Experimental info
	Sequence conflict	67	1	R → W in BAG37507. Ref.6
	Sequence conflict	135	1	H → L in BAB55078. Ref.6
	Sequence conflict	143	1	S → P in BAG37507. Ref.6
	Sequence conflict	222	1	L → P in AAK38275. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9H2A7 [UniParc]. Last modified October 14, 2008. Version 4. Checksum: EA627A87958B83B6	FASTA	254	27,579
	10 20 30 40 50 60 MGRDLRPGSR VLLLLLLLLL VYLTQPGNGN EGSVTGSCYC GKRISSDSPP SVQFMNRLRK 70 80 90 100 110 120 HLRAYHRCLY YTRFQLLSWS VCGGNKDPWV QELMSCLDLK ECGHAYSGIV AHQKHLLPTS 130 140 150 160 170 180 PPISQASEGA SSDIHTPAQM LLSTLQSTQR PTLPVGSLSS DKELTRPNET TIHTAGHSLA 190 200 210 220 230 240 AGPEAGENQK QPEKNAGPTA RTSATVPVLC LLAIIFILTA ALSYVLCKRR RGQSPQSSPD 250 LPVHYIPVAP DSNT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo." Matloubian M., David A., Engel S., Ryan J.E., Cyster J.G. Nat. Immunol. 1:298-304(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS THR-123 AND VAL-181.
[2]	"Expression cloning of the strl33/bonzo/tymstr ligand reveals elements of cc, cxc, and cx3c chemokines." Wilbanks A., Zondlo S.C., Murphy K., Mak S., Soler D., Langdon P., Andrew D.P., Wu L., Briskin M. J. Immunol. 166:5145-5154(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-181.
[3]	"Molecular cloning of a novel scavenger receptor for oxidized low density lipoprotein, SR-PSOX, on macrophages." Shimaoka T., Kume N., Minami M., Hayashida K., Kataoka H., Kita T., Yonehara S. J. Biol. Chem. 275:40663-40666(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-123 AND VAL-181. Tissue: Mammary gland, Synovium and Tongue.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-123 AND VAL-181. Tissue: Lung, Spleen and Testis.
+	Additional computationally mapped references.

Web resources

Wikipedia

CXCL16 entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF301016 mRNA. Translation: AAG34365.1. Different initiation. AF337812 mRNA. Translation: AAK38275.1. AF275260 mRNA. Translation: AAG31750.1. EF064742 Genomic DNA. Translation: ABK41925.1. Different initiation. AY358909 mRNA. Translation: AAQ89268.1. AK027389 mRNA. Translation: BAB55078.1. Different initiation. AK292114 mRNA. Translation: BAF84803.1. Different initiation. AK315017 mRNA. Translation: BAG37507.1. Different initiation. BC017588 mRNA. Translation: AAH17588.1. Different initiation. BC044930 mRNA. Translation: AAH44930.1. Different initiation.
IPI	IPI00004946.
RefSeq	NP_001094282.1. NM_001100812.1. NP_071342.2. NM_022059.2.
UniGene	Hs.730800.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000293778.
PTM databases
PhosphoSite	Q9H2A7.
Polymorphism databases
DMDM	209572770.
Proteomic databases
PaxDb	Q9H2A7.
PRIDE	Q9H2A7.
Protocols and materials databases
DNASU	58191.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000293778; ENSP00000293778; ENSG00000161921. ENST00000574412; ENSP00000459592; ENSG00000161921.
GeneID	58191.
KEGG	hsa:58191.
UCSC	uc002fyr.4. human.
Organism-specific databases
CTD	58191.
GeneCards	GC17M004637.
H-InvDB	HIX0013447.
HGNC	HGNC:16642. CXCL16.
MIM	605398. gene.
neXtProt	NX_Q9H2A7.
PharmGKB	PA27057.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45036.
HOVERGEN	HBG107790.
InParanoid	Q9H2A7.
KO	K10035.
OrthoDB	EOG4VT5XW.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q9H2A7.
Bgee	Q9H2A7.
CleanEx	HS_CXCL16.
Genevestigator	Q9H2A7.
GermOnline	ENSG00000161921. Homo sapiens.
Family and domain databases
InterPro	IPR026296. CXCL16. [Graphical view]
PANTHER	PTHR14385. PTHR14385. 1 hit.
PROSITE	PS00471. SMALL_CYTOKINES_CXC. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CXCL16. human.
GenomeRNAi	58191.
NextBio	64890.
SOURCE	Search...

Entry information

Entry name

CXL16_HUMAN

Accession

Primary (citable) accession number: Q9H2A7
Secondary accession number(s): A0N0N4 , A8K7U9, B2RCB0, Q8TC80, Q96K63, Q9BXD6, Q9H2F6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
Last sequence update:	October 14, 2008
Last modified:	April 3, 2013
This is version 110 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.