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Q9H2A7

- CXL16_HUMAN

UniProt

Q9H2A7 - CXL16_HUMAN

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Protein

C-X-C motif chemokine 16

Gene

CXCL16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.By similarity

GO - Molecular functioni

  1. chemokine activity Source: UniProtKB
  2. low-density lipoprotein receptor activity Source: UniProtKB
  3. receptor binding Source: UniProtKB
  4. scavenger receptor activity Source: UniProtKB

GO - Biological processi

  1. chemotaxis Source: UniProtKB
  2. lymphocyte chemotaxis Source: UniProtKB
  3. positive regulation of cell growth Source: BHF-UCL
  4. positive regulation of cell migration Source: BHF-UCL
  5. receptor-mediated endocytosis Source: UniProtKB
  6. response to cytokine Source: BHF-UCL
  7. response to interferon-gamma Source: BHF-UCL
  8. response to tumor necrosis factor Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 16
Alternative name(s):
Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
Short name:
SR-PSOX
Small-inducible cytokine B16
Transmembrane chemokine CXCL16
Gene namesi
Name:CXCL16
Synonyms:SCYB16, SRPSOX
ORF Names:UNQ2759/PRO6714
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:16642. CXCL16.

Subcellular locationi

Cell membrane Curated; Single-pass type I membrane protein Curated. Secreted
Note: Also exists as a soluble form.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 205176ExtracellularSequence AnalysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence AnalysisAdd
BLAST
Topological domaini227 – 25428CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: BHF-UCL
  3. integral component of membrane Source: UniProtKB
  4. membrane Source: UniProtKB
  5. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27057.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 254225C-X-C motif chemokine 16PRO_0000005118Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi38 ↔ 68By similarity
Disulfide bondi40 ↔ 82By similarity
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9H2A7.
PaxDbiQ9H2A7.
PRIDEiQ9H2A7.

PTM databases

PhosphoSiteiQ9H2A7.

Expressioni

Tissue specificityi

Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.

Gene expression databases

BgeeiQ9H2A7.
CleanExiHS_CXCL16.
ExpressionAtlasiQ9H2A7. baseline and differential.
GenevestigatoriQ9H2A7.

Organism-specific databases

HPAiHPA056559.

Interactioni

Protein-protein interaction databases

BioGridi121805. 2 interactions.
STRINGi9606.ENSP00000293778.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni32 – 10776ChemokineAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45036.
GeneTreeiENSGT00390000002148.
HOVERGENiHBG107790.
InParanoidiQ9H2A7.
KOiK10035.
OrthoDBiEOG7XWPQ1.
PhylomeDBiQ9H2A7.
TreeFamiTF337941.

Family and domain databases

InterProiIPR026296. CXCL16.
[Graphical view]
PANTHERiPTHR14385. PTHR14385. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H2A7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRDLRPGSR VLLLLLLLLL VYLTQPGNGN EGSVTGSCYC GKRISSDSPP
60 70 80 90 100
SVQFMNRLRK HLRAYHRCLY YTRFQLLSWS VCGGNKDPWV QELMSCLDLK
110 120 130 140 150
ECGHAYSGIV AHQKHLLPTS PPISQASEGA SSDIHTPAQM LLSTLQSTQR
160 170 180 190 200
PTLPVGSLSS DKELTRPNET TIHTAGHSLA AGPEAGENQK QPEKNAGPTA
210 220 230 240 250
RTSATVPVLC LLAIIFILTA ALSYVLCKRR RGQSPQSSPD LPVHYIPVAP

DSNT
Length:254
Mass (Da):27,579
Last modified:October 14, 2008 - v4
Checksum:iEA627A87958B83B6
GO

Sequence cautioni

The sequence AAG34365.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH17588.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH44930.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence ABK41925.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB55078.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAF84803.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAG37507.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671R → W in BAG37507. (PubMed:14702039)Curated
Sequence conflicti135 – 1351H → L in BAB55078. (PubMed:14702039)Curated
Sequence conflicti143 – 1431S → P in BAG37507. (PubMed:14702039)Curated
Sequence conflicti222 – 2221L → P in AAK38275. (PubMed:11290797)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti123 – 1231I → T.3 Publications
VAR_015424
Natural varianti181 – 1811A → V.4 Publications
Corresponds to variant rs2277680 [ dbSNP | Ensembl ].
VAR_015425

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301016 mRNA. Translation: AAG34365.1. Different initiation.
AF337812 mRNA. Translation: AAK38275.1.
AF275260 mRNA. Translation: AAG31750.1.
EF064742 Genomic DNA. Translation: ABK41925.1. Different initiation.
AY358909 mRNA. Translation: AAQ89268.1.
AK027389 mRNA. Translation: BAB55078.1. Different initiation.
AK292114 mRNA. Translation: BAF84803.1. Different initiation.
AK315017 mRNA. Translation: BAG37507.1. Different initiation.
BC017588 mRNA. Translation: AAH17588.1. Different initiation.
BC044930 mRNA. Translation: AAH44930.1. Different initiation.
RefSeqiNP_001094282.1. NM_001100812.1.
NP_071342.2. NM_022059.3.
UniGeneiHs.745037.

Genome annotation databases

EnsembliENST00000293778; ENSP00000293778; ENSG00000161921.
ENST00000574412; ENSP00000459592; ENSG00000161921.
GeneIDi58191.
KEGGihsa:58191.
UCSCiuc002fyr.4. human.

Polymorphism databases

DMDMi209572770.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CXCL16 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301016 mRNA. Translation: AAG34365.1 . Different initiation.
AF337812 mRNA. Translation: AAK38275.1 .
AF275260 mRNA. Translation: AAG31750.1 .
EF064742 Genomic DNA. Translation: ABK41925.1 . Different initiation.
AY358909 mRNA. Translation: AAQ89268.1 .
AK027389 mRNA. Translation: BAB55078.1 . Different initiation.
AK292114 mRNA. Translation: BAF84803.1 . Different initiation.
AK315017 mRNA. Translation: BAG37507.1 . Different initiation.
BC017588 mRNA. Translation: AAH17588.1 . Different initiation.
BC044930 mRNA. Translation: AAH44930.1 . Different initiation.
RefSeqi NP_001094282.1. NM_001100812.1.
NP_071342.2. NM_022059.3.
UniGenei Hs.745037.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121805. 2 interactions.
STRINGi 9606.ENSP00000293778.

PTM databases

PhosphoSitei Q9H2A7.

Polymorphism databases

DMDMi 209572770.

Proteomic databases

MaxQBi Q9H2A7.
PaxDbi Q9H2A7.
PRIDEi Q9H2A7.

Protocols and materials databases

DNASUi 58191.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000293778 ; ENSP00000293778 ; ENSG00000161921 .
ENST00000574412 ; ENSP00000459592 ; ENSG00000161921 .
GeneIDi 58191.
KEGGi hsa:58191.
UCSCi uc002fyr.4. human.

Organism-specific databases

CTDi 58191.
GeneCardsi GC17M004637.
H-InvDB HIX0013447.
HGNCi HGNC:16642. CXCL16.
HPAi HPA056559.
MIMi 605398. gene.
neXtProti NX_Q9H2A7.
PharmGKBi PA27057.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45036.
GeneTreei ENSGT00390000002148.
HOVERGENi HBG107790.
InParanoidi Q9H2A7.
KOi K10035.
OrthoDBi EOG7XWPQ1.
PhylomeDBi Q9H2A7.
TreeFami TF337941.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSi CXCL16. human.
GenomeRNAii 58191.
NextBioi 64890.
PROi Q9H2A7.
SOURCEi Search...

Gene expression databases

Bgeei Q9H2A7.
CleanExi HS_CXCL16.
ExpressionAtlasi Q9H2A7. baseline and differential.
Genevestigatori Q9H2A7.

Family and domain databases

InterProi IPR026296. CXCL16.
[Graphical view ]
PANTHERi PTHR14385. PTHR14385. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo."
    Matloubian M., David A., Engel S., Ryan J.E., Cyster J.G.
    Nat. Immunol. 1:298-304(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS THR-123 AND VAL-181.
  2. "Expression cloning of the strl33/bonzo/tymstr ligand reveals elements of cc, cxc, and cx3c chemokines."
    Wilbanks A., Zondlo S.C., Murphy K., Mak S., Soler D., Langdon P., Andrew D.P., Wu L., Briskin M.
    J. Immunol. 166:5145-5154(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-181.
  3. "Molecular cloning of a novel scavenger receptor for oxidized low density lipoprotein, SR-PSOX, on macrophages."
    Shimaoka T., Kume N., Minami M., Hayashida K., Kataoka H., Kita T., Yonehara S.
    J. Biol. Chem. 275:40663-40666(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-123 AND VAL-181.
    Tissue: Mammary gland, Synovium and Tongue.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-123 AND VAL-181.
    Tissue: Lung, Spleen and Testis.

Entry informationi

Entry nameiCXL16_HUMAN
AccessioniPrimary (citable) accession number: Q9H2A7
Secondary accession number(s): A0N0N4
, A8K7U9, B2RCB0, Q8TC80, Q96K63, Q9BXD6, Q9H2F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 14, 2008
Last modified: October 29, 2014
This is version 123 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3