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Protein

Neurogenin-2

Gene

NEUROG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ9H2A3

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenin-2
Short name:
NGN-2
Alternative name(s):
Class A basic helix-loop-helix protein 8
Short name:
bHLHa8
Protein atonal homolog 4
Gene namesi
Name:NEUROG2
Synonyms:ATOH4, BHLHA8, NGN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000178403.3
HGNCiHGNC:13805 NEUROG2
MIMi606624 gene
neXtProtiNX_Q9H2A3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi63973
OpenTargetsiENSG00000178403
PharmGKBiPA31570

Polymorphism and mutation databases

BioMutaiNEUROG2
DMDMi60392832

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274001 – 272Neurogenin-2Add BLAST272

Proteomic databases

PaxDbiQ9H2A3
PRIDEiQ9H2A3

PTM databases

iPTMnetiQ9H2A3
PhosphoSitePlusiQ9H2A3

Expressioni

Gene expression databases

BgeeiENSG00000178403
CleanExiHS_NEUROG2
GenevisibleiQ9H2A3 HS

Organism-specific databases

HPAiCAB012342

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122020, 2 interactors
IntActiQ9H2A3, 1 interactor
MINTiQ9H2A3
STRINGi9606.ENSP00000317333

Structurei

3D structure databases

ProteinModelPortaliQ9H2A3
SMRiQ9H2A3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 164bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi198 – 246Ser-richAdd BLAST49

Phylogenomic databases

eggNOGiENOG410IQ4B Eukaryota
ENOG410XZ4C LUCA
GeneTreeiENSGT00680000099860
HOGENOMiHOG000063655
HOVERGENiHBG101129
InParanoidiQ9H2A3
KOiK09082
OMAiSDMDYWQ
OrthoDBiEOG091G0PNH
PhylomeDBiQ9H2A3
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR032655 Ngn2
PANTHERiPTHR19290:SF105 PTHR19290:SF105, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H2A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVKSETLEL KEEEDVLVLL GSASPALAAL TPLSSSADEE EEEEPGASGG
60 70 80 90 100
ARRQRGAEAG QGARGGVAAG AEGCRPARLL GLVHDCKRRP SRARAVSRGA
110 120 130 140 150
KTAETVQRIK KTRRLKANNR ERNRMHNLNA ALDALREVLP TFPEDAKLTK
160 170 180 190 200
IETLRFAHNY IWALTETLRL ADHCGGGGGG LPGALFSEAV LLSPGGASAA
210 220 230 240 250
LSSSGDSPSP ASTWSCTNSP APSSSVSSNS TSPYSCTLSP ASPAGSDMDY
260 270
WQPPPPDKHR YAPHLPIARD CI
Length:272
Mass (Da):28,621
Last modified:February 1, 2005 - v2
Checksum:i57AB37CC4A9E15FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC036847 mRNA Translation: AAH36847.1
AF303002 Genomic DNA Translation: AAG40770.1
CCDSiCCDS3698.1
RefSeqiNP_076924.1, NM_024019.3
UniGeneiHs.744415

Genome annotation databases

EnsembliENST00000313341; ENSP00000317333; ENSG00000178403
GeneIDi63973
KEGGihsa:63973
UCSCiuc003ias.3 human

Similar proteinsi

Entry informationi

Entry nameiNGN2_HUMAN
AccessioniPrimary (citable) accession number: Q9H2A3
Secondary accession number(s): Q8N416
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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