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Q9H2A3

- NGN2_HUMAN

UniProt

Q9H2A3 - NGN2_HUMAN

Protein

Neurogenin-2

Gene

NEUROG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').

    GO - Molecular functioni

    1. E-box binding Source: UniProtKB
    2. sequence-specific DNA binding Source: Ensembl

    GO - Biological processi

    1. axon guidance Source: Ensembl
    2. cell fate commitment Source: Ensembl
    3. central nervous system neuron development Source: Ensembl
    4. forebrain development Source: Ensembl
    5. neuron migration Source: Ensembl
    6. positive regulation of neuron differentiation Source: Ensembl
    7. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
    8. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    9. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurogenin-2
    Short name:
    NGN-2
    Alternative name(s):
    Class A basic helix-loop-helix protein 8
    Short name:
    bHLHa8
    Protein atonal homolog 4
    Gene namesi
    Name:NEUROG2
    Synonyms:ATOH4, BHLHA8, NGN2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:13805. NEUROG2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31570.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 272272Neurogenin-2PRO_0000127400Add
    BLAST

    Proteomic databases

    PaxDbiQ9H2A3.
    PRIDEiQ9H2A3.

    PTM databases

    PhosphoSiteiQ9H2A3.

    Expressioni

    Gene expression databases

    BgeeiQ9H2A3.
    CleanExiHS_NEUROG2.
    GenevestigatoriQ9H2A3.

    Organism-specific databases

    HPAiCAB012342.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein.By similarity

    Protein-protein interaction databases

    BioGridi122020. 2 interactions.
    IntActiQ9H2A3. 1 interaction.
    MINTiMINT-3066627.
    STRINGi9606.ENSP00000317333.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H2A3.
    SMRiQ9H2A3. Positions 113-169.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini112 – 16453bHLHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi198 – 24649Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG238746.
    HOGENOMiHOG000063655.
    HOVERGENiHBG101129.
    InParanoidiQ9H2A3.
    KOiK09082.
    OMAiHECKRRP.
    OrthoDBiEOG7TTQB1.
    PhylomeDBiQ9H2A3.
    TreeFamiTF315153.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H2A3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFVKSETLEL KEEEDVLVLL GSASPALAAL TPLSSSADEE EEEEPGASGG    50
    ARRQRGAEAG QGARGGVAAG AEGCRPARLL GLVHDCKRRP SRARAVSRGA 100
    KTAETVQRIK KTRRLKANNR ERNRMHNLNA ALDALREVLP TFPEDAKLTK 150
    IETLRFAHNY IWALTETLRL ADHCGGGGGG LPGALFSEAV LLSPGGASAA 200
    LSSSGDSPSP ASTWSCTNSP APSSSVSSNS TSPYSCTLSP ASPAGSDMDY 250
    WQPPPPDKHR YAPHLPIARD CI 272
    Length:272
    Mass (Da):28,621
    Last modified:February 1, 2005 - v2
    Checksum:i57AB37CC4A9E15FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC036847 mRNA. Translation: AAH36847.1.
    AF303002 Genomic DNA. Translation: AAG40770.1.
    CCDSiCCDS3698.1.
    RefSeqiNP_076924.1. NM_024019.3.
    UniGeneiHs.744415.

    Genome annotation databases

    EnsembliENST00000313341; ENSP00000317333; ENSG00000178403.
    GeneIDi63973.
    KEGGihsa:63973.
    UCSCiuc003ias.3. human.

    Polymorphism databases

    DMDMi60392832.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC036847 mRNA. Translation: AAH36847.1 .
    AF303002 Genomic DNA. Translation: AAG40770.1 .
    CCDSi CCDS3698.1.
    RefSeqi NP_076924.1. NM_024019.3.
    UniGenei Hs.744415.

    3D structure databases

    ProteinModelPortali Q9H2A3.
    SMRi Q9H2A3. Positions 113-169.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122020. 2 interactions.
    IntActi Q9H2A3. 1 interaction.
    MINTi MINT-3066627.
    STRINGi 9606.ENSP00000317333.

    PTM databases

    PhosphoSitei Q9H2A3.

    Polymorphism databases

    DMDMi 60392832.

    Proteomic databases

    PaxDbi Q9H2A3.
    PRIDEi Q9H2A3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313341 ; ENSP00000317333 ; ENSG00000178403 .
    GeneIDi 63973.
    KEGGi hsa:63973.
    UCSCi uc003ias.3. human.

    Organism-specific databases

    CTDi 63973.
    GeneCardsi GC04M113434.
    HGNCi HGNC:13805. NEUROG2.
    HPAi CAB012342.
    MIMi 606624. gene.
    neXtProti NX_Q9H2A3.
    PharmGKBi PA31570.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG238746.
    HOGENOMi HOG000063655.
    HOVERGENi HBG101129.
    InParanoidi Q9H2A3.
    KOi K09082.
    OMAi HECKRRP.
    OrthoDBi EOG7TTQB1.
    PhylomeDBi Q9H2A3.
    TreeFami TF315153.

    Miscellaneous databases

    GeneWikii NEUROG2.
    GenomeRNAii 63973.
    NextBioi 65766.
    PROi Q9H2A3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H2A3.
    CleanExi HS_NEUROG2.
    Genevestigatori Q9H2A3.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    2. "Neurogenin 2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers."
      Simmons A.D., Horton S., Abney A.L., Johnson J.E.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-272.

    Entry informationi

    Entry nameiNGN2_HUMAN
    AccessioniPrimary (citable) accession number: Q9H2A3
    Secondary accession number(s): Q8N416
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3