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Q9H2A3

- NGN2_HUMAN

UniProt

Q9H2A3 - NGN2_HUMAN

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Protein

Neurogenin-2

Gene
NEUROG2, ATOH4, BHLHA8, NGN2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').

GO - Molecular functioni

  1. E-box binding Source: UniProtKB
  2. sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. axon guidance Source: Ensembl
  2. cell fate commitment Source: Ensembl
  3. central nervous system neuron development Source: Ensembl
  4. forebrain development Source: Ensembl
  5. neuron migration Source: Ensembl
  6. positive regulation of neuron differentiation Source: Ensembl
  7. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  8. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenin-2
Short name:
NGN-2
Alternative name(s):
Class A basic helix-loop-helix protein 8
Short name:
bHLHa8
Protein atonal homolog 4
Gene namesi
Name:NEUROG2
Synonyms:ATOH4, BHLHA8, NGN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:13805. NEUROG2.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31570.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Neurogenin-2PRO_0000127400Add
BLAST

Proteomic databases

PaxDbiQ9H2A3.
PRIDEiQ9H2A3.

PTM databases

PhosphoSiteiQ9H2A3.

Expressioni

Gene expression databases

BgeeiQ9H2A3.
CleanExiHS_NEUROG2.
GenevestigatoriQ9H2A3.

Organism-specific databases

HPAiCAB012342.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein By similarity.

Protein-protein interaction databases

BioGridi122020. 2 interactions.
IntActiQ9H2A3. 1 interaction.
MINTiMINT-3066627.
STRINGi9606.ENSP00000317333.

Structurei

3D structure databases

ProteinModelPortaliQ9H2A3.
SMRiQ9H2A3. Positions 113-169.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 16453bHLHAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi198 – 24649Ser-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG238746.
HOGENOMiHOG000063655.
HOVERGENiHBG101129.
InParanoidiQ9H2A3.
KOiK09082.
OMAiHECKRRP.
OrthoDBiEOG7TTQB1.
PhylomeDBiQ9H2A3.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H2A3-1 [UniParc]FASTAAdd to Basket

« Hide

MFVKSETLEL KEEEDVLVLL GSASPALAAL TPLSSSADEE EEEEPGASGG    50
ARRQRGAEAG QGARGGVAAG AEGCRPARLL GLVHDCKRRP SRARAVSRGA 100
KTAETVQRIK KTRRLKANNR ERNRMHNLNA ALDALREVLP TFPEDAKLTK 150
IETLRFAHNY IWALTETLRL ADHCGGGGGG LPGALFSEAV LLSPGGASAA 200
LSSSGDSPSP ASTWSCTNSP APSSSVSSNS TSPYSCTLSP ASPAGSDMDY 250
WQPPPPDKHR YAPHLPIARD CI 272
Length:272
Mass (Da):28,621
Last modified:February 1, 2005 - v2
Checksum:i57AB37CC4A9E15FC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC036847 mRNA. Translation: AAH36847.1.
AF303002 Genomic DNA. Translation: AAG40770.1.
CCDSiCCDS3698.1.
RefSeqiNP_076924.1. NM_024019.3.
UniGeneiHs.744415.

Genome annotation databases

EnsembliENST00000313341; ENSP00000317333; ENSG00000178403.
GeneIDi63973.
KEGGihsa:63973.
UCSCiuc003ias.3. human.

Polymorphism databases

DMDMi60392832.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC036847 mRNA. Translation: AAH36847.1 .
AF303002 Genomic DNA. Translation: AAG40770.1 .
CCDSi CCDS3698.1.
RefSeqi NP_076924.1. NM_024019.3.
UniGenei Hs.744415.

3D structure databases

ProteinModelPortali Q9H2A3.
SMRi Q9H2A3. Positions 113-169.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122020. 2 interactions.
IntActi Q9H2A3. 1 interaction.
MINTi MINT-3066627.
STRINGi 9606.ENSP00000317333.

PTM databases

PhosphoSitei Q9H2A3.

Polymorphism databases

DMDMi 60392832.

Proteomic databases

PaxDbi Q9H2A3.
PRIDEi Q9H2A3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000313341 ; ENSP00000317333 ; ENSG00000178403 .
GeneIDi 63973.
KEGGi hsa:63973.
UCSCi uc003ias.3. human.

Organism-specific databases

CTDi 63973.
GeneCardsi GC04M113434.
HGNCi HGNC:13805. NEUROG2.
HPAi CAB012342.
MIMi 606624. gene.
neXtProti NX_Q9H2A3.
PharmGKBi PA31570.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG238746.
HOGENOMi HOG000063655.
HOVERGENi HBG101129.
InParanoidi Q9H2A3.
KOi K09082.
OMAi HECKRRP.
OrthoDBi EOG7TTQB1.
PhylomeDBi Q9H2A3.
TreeFami TF315153.

Miscellaneous databases

GeneWikii NEUROG2.
GenomeRNAii 63973.
NextBioi 65766.
PROi Q9H2A3.
SOURCEi Search...

Gene expression databases

Bgeei Q9H2A3.
CleanExi HS_NEUROG2.
Genevestigatori Q9H2A3.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Neurogenin 2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers."
    Simmons A.D., Horton S., Abney A.L., Johnson J.E.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-272.

Entry informationi

Entry nameiNGN2_HUMAN
AccessioniPrimary (citable) accession number: Q9H2A3
Secondary accession number(s): Q8N416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: February 1, 2005
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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