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Q9H2A3 (NGN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurogenin-2

Short name=NGN-2
Alternative name(s):
Class A basic helix-loop-helix protein 8
Short name=bHLHa8
Protein atonal homolog 4
Gene names
Name:NEUROG2
Synonyms:ATOH4, BHLHA8, NGN2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein By similarity.

Subcellular location

Nucleus Potential.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272Neurogenin-2
PRO_0000127400

Regions

Domain112 – 16453bHLH
Compositional bias198 – 24649Ser-rich

Sequences

Sequence LengthMass (Da)Tools
Q9H2A3 [UniParc].

Last modified February 1, 2005. Version 2.
Checksum: 57AB37CC4A9E15FC

FASTA27228,621
        10         20         30         40         50         60 
MFVKSETLEL KEEEDVLVLL GSASPALAAL TPLSSSADEE EEEEPGASGG ARRQRGAEAG 

        70         80         90        100        110        120 
QGARGGVAAG AEGCRPARLL GLVHDCKRRP SRARAVSRGA KTAETVQRIK KTRRLKANNR 

       130        140        150        160        170        180 
ERNRMHNLNA ALDALREVLP TFPEDAKLTK IETLRFAHNY IWALTETLRL ADHCGGGGGG 

       190        200        210        220        230        240 
LPGALFSEAV LLSPGGASAA LSSSGDSPSP ASTWSCTNSP APSSSVSSNS TSPYSCTLSP 

       250        260        270 
ASPAGSDMDY WQPPPPDKHR YAPHLPIARD CI 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"Neurogenin 2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers."
Simmons A.D., Horton S., Abney A.L., Johnson J.E.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-272.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC036847 mRNA. Translation: AAH36847.1.
AF303002 Genomic DNA. Translation: AAG40770.1.
CCDSCCDS3698.1.
RefSeqNP_076924.1. NM_024019.3.
UniGeneHs.744415.

3D structure databases

ProteinModelPortalQ9H2A3.
SMRQ9H2A3. Positions 113-169.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122020. 2 interactions.
IntActQ9H2A3. 1 interaction.
MINTMINT-3066627.
STRING9606.ENSP00000317333.

PTM databases

PhosphoSiteQ9H2A3.

Polymorphism databases

DMDM60392832.

Proteomic databases

PaxDbQ9H2A3.
PRIDEQ9H2A3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000313341; ENSP00000317333; ENSG00000178403.
GeneID63973.
KEGGhsa:63973.
UCSCuc003ias.3. human.

Organism-specific databases

CTD63973.
GeneCardsGC04M113434.
HGNCHGNC:13805. NEUROG2.
HPACAB012342.
MIM606624. gene.
neXtProtNX_Q9H2A3.
PharmGKBPA31570.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG238746.
HOGENOMHOG000063655.
HOVERGENHBG101129.
InParanoidQ9H2A3.
KOK09082.
OMAHECKRRP.
OrthoDBEOG7TTQB1.
PhylomeDBQ9H2A3.
TreeFamTF315153.

Gene expression databases

BgeeQ9H2A3.
CleanExHS_NEUROG2.
GenevestigatorQ9H2A3.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNEUROG2.
GenomeRNAi63973.
NextBio65766.
PROQ9H2A3.
SOURCESearch...

Entry information

Entry nameNGN2_HUMAN
AccessionPrimary (citable) accession number: Q9H2A3
Secondary accession number(s): Q8N416
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: February 1, 2005
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM