Q9H2A3 (NGN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurogenin-2
Short name=NGN-2

Alternative name(s):
Class A basic helix-loop-helix protein 8
Short name=bHLHa8
Protein atonal homolog 4

Gene names

Name:	NEUROG2
Synonyms:	ATOH4, BHLHA8, NGN2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').
Subunit structure	Efficient DNA binding requires dimerization with another bHLH protein By similarity.
Subcellular location	Nucleus Potential.
Sequence similarities	Contains 1 bHLH (basic helix-loop-helix) domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Inferred from electronic annotation. Source: Compara cell fate commitment Inferred from electronic annotation. Source: Compara central nervous system neuron development Inferred from electronic annotation. Source: Compara forebrain development Inferred from electronic annotation. Source: Compara neuron migration Inferred from electronic annotation. Source: Compara positive regulation of neuron differentiation Inferred from electronic annotation. Source: Compara positive regulation of sequence-specific DNA binding transcription factor activity Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	E-box binding Inferred from sequence or structural similarity. Source: UniProtKB sequence-specific DNA binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Neurogenin-2		PRO_0000127400
Regions
	Domain	112 – 164	53	bHLH
	Compositional bias	198 – 246	49	Ser-rich

Sequences

	Sequence		Length	Mass (Da)
	Q9H2A3 [UniParc]. Last modified February 1, 2005. Version 2. Checksum: 57AB37CC4A9E15FC	FASTA	272	28,621
	10 20 30 40 50 60 MFVKSETLEL KEEEDVLVLL GSASPALAAL TPLSSSADEE EEEEPGASGG ARRQRGAEAG 70 80 90 100 110 120 QGARGGVAAG AEGCRPARLL GLVHDCKRRP SRARAVSRGA KTAETVQRIK KTRRLKANNR 130 140 150 160 170 180 ERNRMHNLNA ALDALREVLP TFPEDAKLTK IETLRFAHNY IWALTETLRL ADHCGGGGGG 190 200 210 220 230 240 LPGALFSEAV LLSPGGASAA LSSSGDSPSP ASTWSCTNSP APSSSVSSNS TSPYSCTLSP 250 260 270 ASPAGSDMDY WQPPPPDKHR YAPHLPIARD CI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"Neurogenin 2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers." Simmons A.D., Horton S., Abney A.L., Johnson J.E. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-272.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC036847 mRNA. Translation: AAH36847.1. AF303002 Genomic DNA. Translation: AAG40770.1.
IPI	IPI00218802.
RefSeq	NP_076924.1. NM_024019.3.
UniGene	Hs.741709.
3D structure databases
ProteinModelPortal	Q9H2A3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000317333.
PTM databases
PhosphoSite	Q9H2A3.
Polymorphism databases
DMDM	60392832.
Proteomic databases
PaxDb	Q9H2A3.
PRIDE	Q9H2A3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000313341; ENSP00000317333; ENSG00000178403.
GeneID	63973.
KEGG	hsa:63973.
UCSC	uc003ias.3. human.
Organism-specific databases
CTD	63973.
GeneCards	GC04M113434.
HGNC	HGNC:13805. NEUROG2.
HPA	CAB012342.
MIM	606624. gene.
neXtProt	NX_Q9H2A3.
PharmGKB	PA31570.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG238746.
HOGENOM	HOG000063655.
HOVERGEN	HBG101129.
InParanoid	Q9H2A3.
KO	K09082.
OMA	HECKRRP.
OrthoDB	EOG4JM7R1.
PhylomeDB	Q9H2A3.
Gene expression databases
Bgee	Q9H2A3.
CleanEx	HS_NEUROG2.
Genevestigator	Q9H2A3.
GermOnline	ENSG00000178403. Homo sapiens.
Family and domain databases
Gene3D	4.10.280.10. 1 hit.
InterPro	IPR011598. bHLH_dom. [Graphical view]
Pfam	PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. BHLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	63973.
NextBio	65766.
SOURCE	Search...

Entry information

Entry name

NGN2_HUMAN

Accession

Primary (citable) accession number: Q9H2A3
Secondary accession number(s): Q8N416

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	February 1, 2005
Last modified:	May 1, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.