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Protein

Neurogenin-2

Gene

NEUROG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogenin-2
Short name:
NGN-2
Alternative name(s):
Class A basic helix-loop-helix protein 8
Short name:
bHLHa8
Protein atonal homolog 4
Gene namesi
Name:NEUROG2
Synonyms:ATOH4, BHLHA8, NGN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:13805. NEUROG2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31570.

Polymorphism and mutation databases

BioMutaiNEUROG2.
DMDMi60392832.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Neurogenin-2PRO_0000127400Add
BLAST

Proteomic databases

PaxDbiQ9H2A3.
PRIDEiQ9H2A3.

PTM databases

PhosphoSiteiQ9H2A3.

Expressioni

Gene expression databases

BgeeiQ9H2A3.
CleanExiHS_NEUROG2.
GenevisibleiQ9H2A3. HS.

Organism-specific databases

HPAiCAB012342.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.By similarity

Protein-protein interaction databases

BioGridi122020. 2 interactions.
IntActiQ9H2A3. 1 interaction.
MINTiMINT-3066627.
STRINGi9606.ENSP00000317333.

Structurei

3D structure databases

ProteinModelPortaliQ9H2A3.
SMRiQ9H2A3. Positions 113-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 16453bHLHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi198 – 24649Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG238746.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000063655.
HOVERGENiHBG101129.
InParanoidiQ9H2A3.
KOiK09082.
OMAiGCRPARL.
OrthoDBiEOG7TTQB1.
PhylomeDBiQ9H2A3.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H2A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVKSETLEL KEEEDVLVLL GSASPALAAL TPLSSSADEE EEEEPGASGG
60 70 80 90 100
ARRQRGAEAG QGARGGVAAG AEGCRPARLL GLVHDCKRRP SRARAVSRGA
110 120 130 140 150
KTAETVQRIK KTRRLKANNR ERNRMHNLNA ALDALREVLP TFPEDAKLTK
160 170 180 190 200
IETLRFAHNY IWALTETLRL ADHCGGGGGG LPGALFSEAV LLSPGGASAA
210 220 230 240 250
LSSSGDSPSP ASTWSCTNSP APSSSVSSNS TSPYSCTLSP ASPAGSDMDY
260 270
WQPPPPDKHR YAPHLPIARD CI
Length:272
Mass (Da):28,621
Last modified:February 1, 2005 - v2
Checksum:i57AB37CC4A9E15FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC036847 mRNA. Translation: AAH36847.1.
AF303002 Genomic DNA. Translation: AAG40770.1.
CCDSiCCDS3698.1.
RefSeqiNP_076924.1. NM_024019.3.
UniGeneiHs.744415.

Genome annotation databases

EnsembliENST00000313341; ENSP00000317333; ENSG00000178403.
GeneIDi63973.
KEGGihsa:63973.
UCSCiuc003ias.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC036847 mRNA. Translation: AAH36847.1.
AF303002 Genomic DNA. Translation: AAG40770.1.
CCDSiCCDS3698.1.
RefSeqiNP_076924.1. NM_024019.3.
UniGeneiHs.744415.

3D structure databases

ProteinModelPortaliQ9H2A3.
SMRiQ9H2A3. Positions 113-169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122020. 2 interactions.
IntActiQ9H2A3. 1 interaction.
MINTiMINT-3066627.
STRINGi9606.ENSP00000317333.

PTM databases

PhosphoSiteiQ9H2A3.

Polymorphism and mutation databases

BioMutaiNEUROG2.
DMDMi60392832.

Proteomic databases

PaxDbiQ9H2A3.
PRIDEiQ9H2A3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313341; ENSP00000317333; ENSG00000178403.
GeneIDi63973.
KEGGihsa:63973.
UCSCiuc003ias.3. human.

Organism-specific databases

CTDi63973.
GeneCardsiGC04M113434.
HGNCiHGNC:13805. NEUROG2.
HPAiCAB012342.
MIMi606624. gene.
neXtProtiNX_Q9H2A3.
PharmGKBiPA31570.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG238746.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000063655.
HOVERGENiHBG101129.
InParanoidiQ9H2A3.
KOiK09082.
OMAiGCRPARL.
OrthoDBiEOG7TTQB1.
PhylomeDBiQ9H2A3.
TreeFamiTF315153.

Miscellaneous databases

GeneWikiiNEUROG2.
GenomeRNAii63973.
NextBioi65766.
PROiQ9H2A3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H2A3.
CleanExiHS_NEUROG2.
GenevisibleiQ9H2A3. HS.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Neurogenin 2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers."
    Simmons A.D., Horton S., Abney A.L., Johnson J.E.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-272.

Entry informationi

Entry nameiNGN2_HUMAN
AccessioniPrimary (citable) accession number: Q9H2A3
Secondary accession number(s): Q8N416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: February 1, 2005
Last modified: July 22, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.