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Protein

Aldehyde dehydrogenase family 8 member A1

Gene

ALDH8A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro).1 Publication

Kineticsi

  1. KM=17.5 µM for benzaldehyde1 Publication
  2. KM=3.15 µM for 9-cis-retinal1 Publication

    pH dependencei

    Optimum pH is 9.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei155 – 1551Transition state stabilizerBy similarity
    Active sitei253 – 2531Proton acceptorPROSITE-ProRule annotation
    Active sitei287 – 2871NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi209 – 2157NADSequence Analysis

    GO - Molecular functioni

    • aldehyde dehydrogenase (NAD) activity Source: GO_Central
    • retinal dehydrogenase activity Source: UniProtKB

    GO - Biological processi

    • 9-cis-retinoic acid biosynthetic process Source: Ensembl
    • retinal metabolic process Source: UniProtKB
    • retinoic acid metabolic process Source: UniProtKB
    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BRENDAi1.2.1.3. 2681.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase family 8 member A1 (EC:1.2.1.-)
    Alternative name(s):
    Aldehyde dehydrogenase 12
    Gene namesi
    Name:ALDH8A1
    Synonyms:ALDH12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640 Componenti: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:15471. ALDH8A1.

    Subcellular locationi

    GO - Cellular componenti

    • cytoplasm Source: UniProtKB-SubCell
    • extracellular exosome Source: UniProtKB
    • intracellular Source: UniProtKB
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24705.

    Polymorphism and mutation databases

    BioMutaiALDH8A1.
    DMDMi74752601.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 487487Aldehyde dehydrogenase family 8 member A1PRO_0000312954Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei362 – 3621Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9H2A2.
    PaxDbiQ9H2A2.
    PRIDEiQ9H2A2.

    PTM databases

    PhosphoSiteiQ9H2A2.

    Expressioni

    Tissue specificityi

    Highly expressed in adult kidney and liver. Detected at lower levels in fetal liver and kidney.1 Publication

    Gene expression databases

    BgeeiQ9H2A2.
    CleanExiHS_ALDH8A1.
    ExpressionAtlasiQ9H2A2. baseline and differential.
    GenevisibleiQ9H2A2. HS.

    Organism-specific databases

    HPAiHPA026292.
    HPA055414.

    Interactioni

    Protein-protein interaction databases

    BioGridi122204. 4 interactions.
    IntActiQ9H2A2. 1 interaction.
    STRINGi9606.ENSP00000265605.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H2A2.
    SMRiQ9H2A2. Positions 10-486.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    GeneTreeiENSGT00800000124121.
    HOGENOMiHOG000271505.
    HOVERGENiHBG000097.
    InParanoidiQ9H2A2.
    OMAiGEALVCH.
    OrthoDBiEOG7FV3Q2.
    PhylomeDBiQ9H2A2.
    TreeFamiTF314129.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: Q9H2A2-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MAGTNALLML ENFIDGKFLP CSSYIDSYDP STGEVYCRVP NSGKDEIEAA
    60 70 80 90 100
    VKAAREAFPS WSSRSPQERS RVLNQVADLL EQSLEEFAQA ESKDQGKTLA
    110 120 130 140 150
    LARTMDIPRS VQNFRFFASS SLHHTSECTQ MDHLGCMHYT VRAPVGVAGL
    160 170 180 190 200
    ISPWNLPLYL LTWKIAPAMA AGNTVIAKPS ELTSVTAWML CKLLDKAGVP
    210 220 230 240 250
    PGVVNIVFGT GPRVGEALVS HPEVPLISFT GSQPTAERIT QLSAPHCKKL
    260 270 280 290 300
    SLELGGKNPA IIFEDANLDE CIPATVRSSF ANQGEICLCT SRIFVQKSIY
    310 320 330 340 350
    SEFLKRFVEA TRKWKVGIPS DPLVSIGALI SKAHLEKVRS YVKRALAEGA
    360 370 380 390 400
    QIWCGEGVDK LSLPARNQAG YFMLPTVITD IKDESCCMTE EIFGPVTCVV
    410 420 430 440 450
    PFDSEEEVIE RANNVKYGLA ATVWSSNVGR VHRVAKKLQS GLVWTNCWLI
    460 470 480
    RELNLPFGGM KSSGIGREGA KDSYDFFTEI KTITVKH
    Length:487
    Mass (Da):53,401
    Last modified:March 1, 2001 - v1
    Checksum:i3CC09F6A7CCC269F
    GO
    Isoform 2 (identifier: Q9H2A2-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         284-337: Missing.

    Note: Lacks enzymatic activity.
    Show »
    Length:433
    Mass (Da):47,325
    Checksum:i9777AFD28CE20C14
    GO
    Isoform 3 (identifier: Q9H2A2-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         148-160: AGLISPWNLPLYL → VPGYTCRTCRFVT
         161-487: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
    Show »
    Length:160
    Mass (Da):17,809
    Checksum:iC94538B542A8ECAD
    GO
    Isoform 4 (identifier: Q9H2A2-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         148-197: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:437
    Mass (Da):48,036
    Checksum:i9544E73B210BABD6
    GO

    Sequence cautioni

    The sequence AAI14474.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti252 – 2521L → P in BAD96568 (Ref. 3) Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti402 – 4021F → S.
    Corresponds to variant rs2294315 [ dbSNP | Ensembl ].
    VAR_037618

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei148 – 19750Missing in isoform 4. 1 PublicationVSP_043279Add
    BLAST
    Alternative sequencei148 – 16013AGLIS…LPLYL → VPGYTCRTCRFVT in isoform 3. 1 PublicationVSP_039759Add
    BLAST
    Alternative sequencei161 – 487327Missing in isoform 3. 1 PublicationVSP_039760Add
    BLAST
    Alternative sequencei284 – 33754Missing in isoform 2. 3 PublicationsVSP_029972Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF303134 mRNA. Translation: AAG42417.1.
    AK290784 mRNA. Translation: BAF83473.1.
    AK298325 mRNA. Translation: BAH12757.1.
    AK222848 mRNA. Translation: BAD96568.1.
    AL021939, AL445190 Genomic DNA. Translation: CAI20305.1.
    AL021939, AL445190 Genomic DNA. Translation: CAI20306.1.
    AL445190, AL021939 Genomic DNA. Translation: CAI95158.1.
    AL445190, AL021939 Genomic DNA. Translation: CAI95159.1.
    CH471051 Genomic DNA. Translation: EAW47985.1.
    CH471051 Genomic DNA. Translation: EAW47986.1.
    BC113862 mRNA. Translation: AAI13863.1.
    BC114473 mRNA. Translation: AAI14474.1. Sequence problems.
    CCDSiCCDS5171.1. [Q9H2A2-1]
    CCDS5172.1. [Q9H2A2-2]
    CCDS55057.1. [Q9H2A2-4]
    RefSeqiNP_001180409.1. NM_001193480.1. [Q9H2A2-4]
    NP_072090.1. NM_022568.3. [Q9H2A2-1]
    NP_739577.1. NM_170771.2. [Q9H2A2-2]
    UniGeneiHs.486520.

    Genome annotation databases

    EnsembliENST00000265605; ENSP00000265605; ENSG00000118514.
    ENST00000349305; ENSP00000325473; ENSG00000118514. [Q9H2A2-3]
    ENST00000367845; ENSP00000356819; ENSG00000118514. [Q9H2A2-2]
    ENST00000367847; ENSP00000356821; ENSG00000118514. [Q9H2A2-4]
    GeneIDi64577.
    KEGGihsa:64577.
    UCSCiuc003qew.3. human. [Q9H2A2-1]
    uc003qex.3. human. [Q9H2A2-2]
    uc011ecx.2. human. [Q9H2A2-4]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF303134 mRNA. Translation: AAG42417.1.
    AK290784 mRNA. Translation: BAF83473.1.
    AK298325 mRNA. Translation: BAH12757.1.
    AK222848 mRNA. Translation: BAD96568.1.
    AL021939, AL445190 Genomic DNA. Translation: CAI20305.1.
    AL021939, AL445190 Genomic DNA. Translation: CAI20306.1.
    AL445190, AL021939 Genomic DNA. Translation: CAI95158.1.
    AL445190, AL021939 Genomic DNA. Translation: CAI95159.1.
    CH471051 Genomic DNA. Translation: EAW47985.1.
    CH471051 Genomic DNA. Translation: EAW47986.1.
    BC113862 mRNA. Translation: AAI13863.1.
    BC114473 mRNA. Translation: AAI14474.1. Sequence problems.
    CCDSiCCDS5171.1. [Q9H2A2-1]
    CCDS5172.1. [Q9H2A2-2]
    CCDS55057.1. [Q9H2A2-4]
    RefSeqiNP_001180409.1. NM_001193480.1. [Q9H2A2-4]
    NP_072090.1. NM_022568.3. [Q9H2A2-1]
    NP_739577.1. NM_170771.2. [Q9H2A2-2]
    UniGeneiHs.486520.

    3D structure databases

    ProteinModelPortaliQ9H2A2.
    SMRiQ9H2A2. Positions 10-486.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi122204. 4 interactions.
    IntActiQ9H2A2. 1 interaction.
    STRINGi9606.ENSP00000265605.

    PTM databases

    PhosphoSiteiQ9H2A2.

    Polymorphism and mutation databases

    BioMutaiALDH8A1.
    DMDMi74752601.

    Proteomic databases

    MaxQBiQ9H2A2.
    PaxDbiQ9H2A2.
    PRIDEiQ9H2A2.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000265605; ENSP00000265605; ENSG00000118514.
    ENST00000349305; ENSP00000325473; ENSG00000118514. [Q9H2A2-3]
    ENST00000367845; ENSP00000356819; ENSG00000118514. [Q9H2A2-2]
    ENST00000367847; ENSP00000356821; ENSG00000118514. [Q9H2A2-4]
    GeneIDi64577.
    KEGGihsa:64577.
    UCSCiuc003qew.3. human. [Q9H2A2-1]
    uc003qex.3. human. [Q9H2A2-2]
    uc011ecx.2. human. [Q9H2A2-4]

    Organism-specific databases

    CTDi64577.
    GeneCardsiGC06M135238.
    HGNCiHGNC:15471. ALDH8A1.
    HPAiHPA026292.
    HPA055414.
    MIMi606467. gene.
    neXtProtiNX_Q9H2A2.
    PharmGKBiPA24705.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiCOG1012.
    GeneTreeiENSGT00800000124121.
    HOGENOMiHOG000271505.
    HOVERGENiHBG000097.
    InParanoidiQ9H2A2.
    OMAiGEALVCH.
    OrthoDBiEOG7FV3Q2.
    PhylomeDBiQ9H2A2.
    TreeFamiTF314129.

    Enzyme and pathway databases

    BRENDAi1.2.1.3. 2681.

    Miscellaneous databases

    GenomeRNAii64577.
    NextBioi66507.
    PROiQ9H2A2.
    SOURCEiSearch...

    Gene expression databases

    BgeeiQ9H2A2.
    CleanExiHS_ALDH8A1.
    ExpressionAtlasiQ9H2A2. baseline and differential.
    GenevisibleiQ9H2A2. HS.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Publicationsi

    « Hide 'large scale' publications
    1. "cDNA cloning and expression of a human aldehyde dehydrogenase (ALDH) active with 9-cis-retinal and identification of a rat ortholog, ALDH12."
      Lin M., Napoli J.L.
      J. Biol. Chem. 275:40106-40112(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
      Tissue: Kidney.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
      Tissue: Kidney and Liver.
    3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Liver.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
      Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
      J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiAL8A1_HUMAN
    AccessioniPrimary (citable) accession number: Q9H2A2
    Secondary accession number(s): B7Z521
    , O60793, Q24JS9, Q53GT3, Q5TI80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 1, 2001
    Last modified: July 22, 2015
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.