Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SH3 domain-binding glutamic acid-rich-like protein 3

Gene

SH3BGRL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could act as a modulator of glutaredoxin biological activity.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-binding glutamic acid-rich-like protein 3
Alternative name(s):
SH3 domain-binding protein 1
Short name:
SH3BP-1
Gene namesi
ORF Names:P1725
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000142669.13
HGNCiHGNC:15568 SH3BGRL3
MIMi615679 gene
neXtProtiNX_Q9H299

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi83442
OpenTargetsiENSG00000142669
PharmGKBiPA37979

Polymorphism and mutation databases

BioMutaiSH3BGRL3
DMDMi24638222

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002207492 – 93SH3 domain-binding glutamic acid-rich-like protein 3Add BLAST92

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9H299
MaxQBiQ9H299
PaxDbiQ9H299
PeptideAtlasiQ9H299
PRIDEiQ9H299
TopDownProteomicsiQ9H299

PTM databases

iPTMnetiQ9H299
PhosphoSitePlusiQ9H299

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000142669
CleanExiHS_SH3BGRL3
ExpressionAtlasiQ9H299 baseline and differential
GenevisibleiQ9H299 HS

Organism-specific databases

HPAiHPA030848
HPA076219

Interactioni

Protein-protein interaction databases

BioGridi123644, 8 interactors
IntActiQ9H299, 3 interactors
MINTiQ9H299
STRINGi9606.ENSP00000270792

Structurei

Secondary structure

193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 8Combined sources4
Beta strandi14 – 16Combined sources3
Helixi17 – 30Combined sources14
Beta strandi36 – 39Combined sources4
Helixi44 – 53Combined sources10
Beta strandi63 – 73Combined sources11
Helixi74 – 81Combined sources8
Turni82 – 84Combined sources3
Helixi86 – 90Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SJ6NMR-A1-93[»]
ProteinModelPortaliQ9H299
SMRiQ9H299
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H299

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 93GlutaredoxinPROSITE-ProRule annotationAdd BLAST92

Sequence similaritiesi

Belongs to the SH3BGR family.Curated

Phylogenomic databases

eggNOGiKOG4023 Eukaryota
ENOG4111N7M LUCA
GeneTreeiENSGT00440000039098
HOGENOMiHOG000095212
HOVERGENiHBG054781
InParanoidiQ9H299
OMAiYCGNYEM
PhylomeDBiQ9H299
TreeFamiTF105574

Family and domain databases

CDDicd03030 GRX_SH3BGR, 1 hit
InterProiView protein in InterPro
IPR006993 Glut_rich_SH3-bd
IPR002109 Glutaredoxin
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF04908 SH3BGR, 1 hit
PIRSFiPIRSF008142 SH3-bind_E-rich_L, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51354 GLUTAREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H299-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLRVYSTS VTGSREIKSQ QSEVTRILDG KRIQYQLVDI SQDNALRDEM
60 70 80 90
RALAGNPKAT PPQIVNGDQY CGDYELFVEA VEQNTLQEFL KLA
Length:93
Mass (Da):10,438
Last modified:March 1, 2001 - v1
Checksum:iC30BE3251D5B82CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297915 mRNA Translation: CAC35770.1
AF247790 mRNA Translation: AAL95695.1
AF304163 mRNA Translation: AAG41412.1
AL451139 Genomic DNA No translation available.
BC030135 mRNA Translation: AAH30135.1
CCDSiCCDS278.1
PIRiJC7711
RefSeqiNP_112576.1, NM_031286.3
UniGeneiHs.109051

Genome annotation databases

EnsembliENST00000270792; ENSP00000270792; ENSG00000142669
GeneIDi83442
KEGGihsa:83442
UCSCiuc001blu.4 human

Similar proteinsi

Entry informationi

Entry nameiSH3L3_HUMAN
AccessioniPrimary (citable) accession number: Q9H299
Secondary accession number(s): Q5T122
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health