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Protein

SH3 domain-binding glutamic acid-rich-like protein 3

Gene

SH3BGRL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Could act as a modulator of glutaredoxin biological activity.

GO - Molecular functioni

  • electron carrier activity Source: InterPro
  • GTPase activator activity Source: UniProtKB
  • protein disulfide oxidoreductase activity Source: InterPro
  • semaphorin receptor binding Source: UniProtKB

GO - Biological processi

  • cell redox homeostasis Source: InterPro
  • positive regulation of GTPase activity Source: UniProtKB
  • regulation of actin cytoskeleton organization Source: UniProtKB
  • regulation of actin filament depolymerization Source: UniProtKB
  • regulation of blood vessel endothelial cell migration Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000142669-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-binding glutamic acid-rich-like protein 3
Alternative name(s):
SH3 domain-binding protein 1
Short name:
SH3BP-1
Gene namesi
ORF Names:P1725
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15568. SH3BGRL3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • lamellipodium Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000142669.
PharmGKBiPA37979.

Polymorphism and mutation databases

BioMutaiSH3BGRL3.
DMDMi24638222.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002207492 – 93SH3 domain-binding glutamic acid-rich-like protein 3Add BLAST92

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9H299.
MaxQBiQ9H299.
PaxDbiQ9H299.
PeptideAtlasiQ9H299.
PRIDEiQ9H299.
TopDownProteomicsiQ9H299.

PTM databases

iPTMnetiQ9H299.
PhosphoSitePlusiQ9H299.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000142669.
CleanExiHS_SH3BGRL3.
ExpressionAtlasiQ9H299. baseline and differential.
GenevisibleiQ9H299. HS.

Organism-specific databases

HPAiHPA030848.

Interactioni

GO - Molecular functioni

  • semaphorin receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123644. 5 interactors.
IntActiQ9H299. 1 interactor.
MINTiMINT-1547823.
STRINGi9606.ENSP00000270792.

Structurei

Secondary structure

193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 8Combined sources4
Beta strandi14 – 16Combined sources3
Helixi17 – 30Combined sources14
Beta strandi36 – 39Combined sources4
Helixi44 – 53Combined sources10
Beta strandi63 – 73Combined sources11
Helixi74 – 81Combined sources8
Turni82 – 84Combined sources3
Helixi86 – 90Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SJ6NMR-A1-93[»]
ProteinModelPortaliQ9H299.
SMRiQ9H299.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H299.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 93GlutaredoxinPROSITE-ProRule annotationAdd BLAST92

Sequence similaritiesi

Belongs to the SH3BGR family.Curated
Contains 1 glutaredoxin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4023. Eukaryota.
ENOG4111N7M. LUCA.
GeneTreeiENSGT00440000039098.
HOGENOMiHOG000095212.
HOVERGENiHBG054781.
InParanoidiQ9H299.
PhylomeDBiQ9H299.
TreeFamiTF105574.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006993. Glut_rich_SH3-bd.
IPR002109. Glutaredoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF04908. SH3BGR. 1 hit.
[Graphical view]
PIRSFiPIRSF008142. SH3-bind_E-rich_L. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H299-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLRVYSTS VTGSREIKSQ QSEVTRILDG KRIQYQLVDI SQDNALRDEM
60 70 80 90
RALAGNPKAT PPQIVNGDQY CGDYELFVEA VEQNTLQEFL KLA
Length:93
Mass (Da):10,438
Last modified:March 1, 2001 - v1
Checksum:iC30BE3251D5B82CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297915 mRNA. Translation: CAC35770.1.
AF247790 mRNA. Translation: AAL95695.1.
AF304163 mRNA. Translation: AAG41412.1.
AL451139 Genomic DNA. Translation: CAI15827.1.
BC030135 mRNA. Translation: AAH30135.1.
CCDSiCCDS278.1.
PIRiJC7711.
RefSeqiNP_112576.1. NM_031286.3.
UniGeneiHs.109051.

Genome annotation databases

EnsembliENST00000270792; ENSP00000270792; ENSG00000142669.
GeneIDi83442.
KEGGihsa:83442.
UCSCiuc001blu.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297915 mRNA. Translation: CAC35770.1.
AF247790 mRNA. Translation: AAL95695.1.
AF304163 mRNA. Translation: AAG41412.1.
AL451139 Genomic DNA. Translation: CAI15827.1.
BC030135 mRNA. Translation: AAH30135.1.
CCDSiCCDS278.1.
PIRiJC7711.
RefSeqiNP_112576.1. NM_031286.3.
UniGeneiHs.109051.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SJ6NMR-A1-93[»]
ProteinModelPortaliQ9H299.
SMRiQ9H299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123644. 5 interactors.
IntActiQ9H299. 1 interactor.
MINTiMINT-1547823.
STRINGi9606.ENSP00000270792.

PTM databases

iPTMnetiQ9H299.
PhosphoSitePlusiQ9H299.

Polymorphism and mutation databases

BioMutaiSH3BGRL3.
DMDMi24638222.

Proteomic databases

EPDiQ9H299.
MaxQBiQ9H299.
PaxDbiQ9H299.
PeptideAtlasiQ9H299.
PRIDEiQ9H299.
TopDownProteomicsiQ9H299.

Protocols and materials databases

DNASUi83442.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270792; ENSP00000270792; ENSG00000142669.
GeneIDi83442.
KEGGihsa:83442.
UCSCiuc001blu.4. human.

Organism-specific databases

CTDi83442.
GeneCardsiSH3BGRL3.
HGNCiHGNC:15568. SH3BGRL3.
HPAiHPA030848.
MIMi615679. gene.
neXtProtiNX_Q9H299.
OpenTargetsiENSG00000142669.
PharmGKBiPA37979.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4023. Eukaryota.
ENOG4111N7M. LUCA.
GeneTreeiENSGT00440000039098.
HOGENOMiHOG000095212.
HOVERGENiHBG054781.
InParanoidiQ9H299.
PhylomeDBiQ9H299.
TreeFamiTF105574.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000142669-MONOMER.

Miscellaneous databases

ChiTaRSiSH3BGRL3. human.
EvolutionaryTraceiQ9H299.
GeneWikiiSH3BGRL3.
GenomeRNAii83442.
PROiQ9H299.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142669.
CleanExiHS_SH3BGRL3.
ExpressionAtlasiQ9H299. baseline and differential.
GenevisibleiQ9H299. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006993. Glut_rich_SH3-bd.
IPR002109. Glutaredoxin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF04908. SH3BGR. 1 hit.
[Graphical view]
PIRSFiPIRSF008142. SH3-bind_E-rich_L. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSH3L3_HUMAN
AccessioniPrimary (citable) accession number: Q9H299
Secondary accession number(s): Q5T122
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.