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Protein

Dendritic cell-specific transmembrane protein

Gene

DCSTAMP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation, Immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164935-MONOMER.

Protein family/group databases

TCDBi1.N.1.1.1. the osteoclast fusion complex (ofc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Dendritic cell-specific transmembrane protein
Short name:
DC-STAMP
Short name:
hDC-STAMP
Alternative name(s):
Dendrocyte-expressed seven transmembrane protein
IL-four-induced protein
Short name:
FIND
Transmembrane 7 superfamily member 4
Gene namesi
Name:DCSTAMP
Synonyms:TM7SF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:18549. DCSTAMP.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34CytoplasmicSequence analysisAdd BLAST34
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 57ExtracellularSequence analysis2
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 97CytoplasmicSequence analysisAdd BLAST19
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 209ExtracellularSequence analysisAdd BLAST91
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Topological domaini231 – 292CytoplasmicSequence analysisAdd BLAST62
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Topological domaini314 – 376ExtracellularSequence analysisAdd BLAST63
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 470Cytoplasmic1 PublicationAdd BLAST73

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
  • endoplasmic reticulum membrane Source: UniProtKB
  • endosome membrane Source: UniProtKB
  • integral component of endoplasmic reticulum membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81501.
OpenTargetsiENSG00000164935.
PharmGKBiPA134938623.

Polymorphism and mutation databases

BioMutaiDCSTAMP.
DMDMi71153342.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725841 – 470Dendritic cell-specific transmembrane proteinAdd BLAST470

Post-translational modificationi

Glycosylated.By similarity

Proteomic databases

PaxDbiQ9H295.
PeptideAtlasiQ9H295.
PRIDEiQ9H295.

PTM databases

iPTMnetiQ9H295.
PhosphoSitePlusiQ9H295.

Expressioni

Tissue specificityi

Preferentially expressed by dendritic cells (DCs). Detected in both immature and mature DCs. Highly expressed in lymph nodes, lung, kidney and liver. Expressed at lower levels in pancreas, bone marrow, spleen, leukocytes, in freshly isolated peripheral blood mononuclear cells (PBMC) and B-cells. Not expressed in freshly isolated monocytes.2 Publications

Developmental stagei

Constitutively expressed in dendritic cells from day 3-8 in culture.1 Publication

Inductioni

Expression is down-regulated by dexamethasone and up-regulated by IL4/interleukin-4 in macrophages. Down-regulated in CD40L-activated dendritic cells.2 Publications

Gene expression databases

BgeeiENSG00000164935.
CleanExiHS_TM7SF4.
GenevisibleiQ9H295. HS.

Interactioni

Subunit structurei

Monomer. Homodimer. Isoform 1 interacts (via the C-terminus cytoplasmic tail) with OS9 isoform 1 (via the C-terminus tail); the interaction induces DCSTAMP redistribution to the endoplasmic reticulum-Golgi intermediate compartment. Isoform 1 interacts (via the C-terminus cytoplasmic tail) with OS9 isoform 2 (via the C-terminus tail) (By similarity). Interacts with CREB3.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CREB3O43889-26EBI-6095316,EBI-625022

Protein-protein interaction databases

BioGridi123504. 1 interactor.
IntActiQ9H295. 1 interactor.
STRINGi9606.ENSP00000297581.

Structurei

3D structure databases

ProteinModelPortaliQ9H295.
SMRiQ9H295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi60 – 63Poly-AlaSequence analysis4

Domaini

Several domains are necessary for interacting with OS9. The region in the cytoplasmic tail that is necessary for interaction with OS9, is also required for its transport (By similarity).By similarity

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUUT. Eukaryota.
ENOG4111T6M. LUCA.
GeneTreeiENSGT00730000111246.
HOGENOMiHOG000060200.
HOVERGENiHBG085084.
InParanoidiQ9H295.
OMAiPVLKMIR.
OrthoDBiEOG091G0GX3.
PhylomeDBiQ9H295.
TreeFamiTF318254.

Family and domain databases

InterProiIPR012858. DC_STAMP-like.
[Graphical view]
PfamiPF07782. DC_STAMP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H295-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGIWTSGTDI FLSLWEIYVS PRSPGWMDFI QHLGVCCLVA LISVGLLSVA
60 70 80 90 100
ACWFLPSIIA AAASWIITCV LLCCSKHARC FILLVFLSCG LREGRNALIA
110 120 130 140 150
AGTGIVILGH VENIFHNFKG LLDGMTCNLR AKSFSIHFPL LKKYIEAIQW
160 170 180 190 200
IYGLATPLSV FDDLVSWNQT LAVSLFSPSH VLEAQLNDSK GEVLSVLYQM
210 220 230 240 250
ATTTEVLSSL GQKLLAFAGL SLVLLGTGLF MKRFLGPCGW KYENIYITRQ
260 270 280 290 300
FVQFDERERH QQRPCVLPLN KEERRKYVII PTFWPTPKER KNLGLFFLPI
310 320 330 340 350
LIHLCIWVLF AAVDYLLYRL IFSVSKQFQS LPGFEVHLKL HGEKQGTQDI
360 370 380 390 400
IHDSSFNISV FEPNCIPKPK FLLSETWVPL SVILLILVML GLLSSILMQL
410 420 430 440 450
KILVSASFYP SVERKRIQYL HAKLLKKRSK QPLGEVKRRL SLYLTKIHFW
460 470
LPVLKMIRKK QMDMASADKS
Length:470
Mass (Da):53,393
Last modified:March 1, 2001 - v1
Checksum:iEA2B858FD2C7560C
GO
Isoform 2 (identifier: Q9H295-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     277-283: YVIIPTF → FISGFQS
     284-470: Missing.

Note: No experimental confirmation available.
Show »
Length:283
Mass (Da):31,586
Checksum:i4BB890F27FBC9319
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200M → R in AAI71732 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051438349D → G.Corresponds to variant rs3802204dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044787277 – 283YVIIPTF → FISGFQS in isoform 2. 1 Publication7
Alternative sequenceiVSP_044788284 – 470Missing in isoform 2. 1 PublicationAdd BLAST187

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305068 mRNA. Translation: AAG39167.1.
AF277290 mRNA. Translation: AAL02152.1.
AP003471 Genomic DNA. No translation available.
BC069349 mRNA. Translation: AAH69349.1.
BC112018 mRNA. Translation: AAI12019.1.
BC112020 mRNA. Translation: AAI12021.1.
BC171732 mRNA. Translation: AAI71732.1.
CCDSiCCDS59111.1. [Q9H295-2]
CCDS6301.1. [Q9H295-1]
RefSeqiNP_001244246.1. NM_001257317.1. [Q9H295-2]
NP_110415.1. NM_030788.3. [Q9H295-1]
XP_011515623.1. XM_011517321.1. [Q9H295-1]
XP_011515626.1. XM_011517324.1. [Q9H295-2]
XP_016869367.1. XM_017013878.1. [Q9H295-1]
XP_016869369.1. XM_017013880.1. [Q9H295-2]
UniGeneiHs.652230.
Hs.741954.

Genome annotation databases

EnsembliENST00000297581; ENSP00000297581; ENSG00000164935. [Q9H295-1]
ENST00000517991; ENSP00000428869; ENSG00000164935. [Q9H295-2]
ENST00000622554; ENSP00000480546; ENSG00000164935. [Q9H295-2]
GeneIDi81501.
KEGGihsa:81501.
UCSCiuc003ylx.3. human. [Q9H295-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305068 mRNA. Translation: AAG39167.1.
AF277290 mRNA. Translation: AAL02152.1.
AP003471 Genomic DNA. No translation available.
BC069349 mRNA. Translation: AAH69349.1.
BC112018 mRNA. Translation: AAI12019.1.
BC112020 mRNA. Translation: AAI12021.1.
BC171732 mRNA. Translation: AAI71732.1.
CCDSiCCDS59111.1. [Q9H295-2]
CCDS6301.1. [Q9H295-1]
RefSeqiNP_001244246.1. NM_001257317.1. [Q9H295-2]
NP_110415.1. NM_030788.3. [Q9H295-1]
XP_011515623.1. XM_011517321.1. [Q9H295-1]
XP_011515626.1. XM_011517324.1. [Q9H295-2]
XP_016869367.1. XM_017013878.1. [Q9H295-1]
XP_016869369.1. XM_017013880.1. [Q9H295-2]
UniGeneiHs.652230.
Hs.741954.

3D structure databases

ProteinModelPortaliQ9H295.
SMRiQ9H295.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123504. 1 interactor.
IntActiQ9H295. 1 interactor.
STRINGi9606.ENSP00000297581.

Protein family/group databases

TCDBi1.N.1.1.1. the osteoclast fusion complex (ofc) family.

PTM databases

iPTMnetiQ9H295.
PhosphoSitePlusiQ9H295.

Polymorphism and mutation databases

BioMutaiDCSTAMP.
DMDMi71153342.

Proteomic databases

PaxDbiQ9H295.
PeptideAtlasiQ9H295.
PRIDEiQ9H295.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297581; ENSP00000297581; ENSG00000164935. [Q9H295-1]
ENST00000517991; ENSP00000428869; ENSG00000164935. [Q9H295-2]
ENST00000622554; ENSP00000480546; ENSG00000164935. [Q9H295-2]
GeneIDi81501.
KEGGihsa:81501.
UCSCiuc003ylx.3. human. [Q9H295-1]

Organism-specific databases

CTDi81501.
DisGeNETi81501.
GeneCardsiDCSTAMP.
HGNCiHGNC:18549. DCSTAMP.
MIMi605933. gene.
neXtProtiNX_Q9H295.
OpenTargetsiENSG00000164935.
PharmGKBiPA134938623.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUUT. Eukaryota.
ENOG4111T6M. LUCA.
GeneTreeiENSGT00730000111246.
HOGENOMiHOG000060200.
HOVERGENiHBG085084.
InParanoidiQ9H295.
OMAiPVLKMIR.
OrthoDBiEOG091G0GX3.
PhylomeDBiQ9H295.
TreeFamiTF318254.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164935-MONOMER.

Miscellaneous databases

GenomeRNAii81501.
PROiQ9H295.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164935.
CleanExiHS_TM7SF4.
GenevisibleiQ9H295. HS.

Family and domain databases

InterProiIPR012858. DC_STAMP-like.
[Graphical view]
PfamiPF07782. DC_STAMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCSTP_HUMAN
AccessioniPrimary (citable) accession number: Q9H295
Secondary accession number(s): B7ZVW2, E7ESG0, Q2M2D5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.