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Q9H293 (IL25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-25

Short name=IL-25
Alternative name(s):
Interleukin-17E
Short name=IL-17E
Gene names
Name:IL25
Synonyms:IL17E
ORF Names:UNQ3120/PRO10272
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length177 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.

Subcellular location

Secreted.

Tissue specificity

Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea.

Sequence similarities

Belongs to the IL-17 family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H293-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H293-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MRERPRLGEDSSLISLFL → MY

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Ref.7
Chain33 – 177145Interleukin-25
PRO_0000015431

Amino acid modifications

Glycosylation1361N-linked (GlcNAc...) Potential
Disulfide bond110 ↔ 168 By similarity
Disulfide bond115 ↔ 170 By similarity

Natural variations

Alternative sequence1 – 1818MRERP…ISLFL → MY in isoform 2.
VSP_010159

Experimental info

Sequence conflict1771G → A in AAL57622. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 52D895710CD59871

FASTA17720,330
        10         20         30         40         50         60 
MRERPRLGED SSLISLFLQV VAFLAMVMGT HTYSHWPSCC PSKGQDTSEE LLRWSTVPVP 

        70         80         90        100        110        120 
PLEPARPNRH PESCRASEDG PLNSRAISPW RYELDRDLNR LPQDLYHARC LCPHCVSLQT 

       130        140        150        160        170 
GSHMDPRGNS ELLYHNQTVF YRRPCHGEKG THKGYCLERR LYRVSLACVC VRPRVMG 

« Hide

Isoform 2 [UniParc].

Checksum: 37685913FCFE151D
Show »

FASTA16118,523

References

« Hide 'large scale' references
[1]"IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1."
Lee J., Ho W.-H., Maruoka M., Corpuz R.T., Baldwin D.T., Foster J.S., Goddard A.D., Yansura D.G., Vandlen R.L., Wood W.I., Gurney A.L.
J. Biol. Chem. 276:1660-1664(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo."
Fort M.M., Cheung J., Yen D., Li J., Zurawski S.M., Lo S., Menon S., Clifford T., Hunte B., Lesley R., Muchamuel T., Hurst S.D., Zurawski G., Leach M.W., Gorman D.M., Rennick D.M.
Immunity 15:985-995(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]"Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production."
Kim M.R., Manoukian R., Yeh R., Silbiger S.M., Danilenko D.M., Scully S., Sun J., DeRose M.L., Stolina M., Chang D., Van G.Y., Clarkin K., Nguyen H.Q., Yu Y.B., Jing S., Senaldi G., Elliott G., Medlock E.S.
Blood 100:2330-2340(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Testis.
[4]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[7]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 33-47.
+Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-17 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF305200 mRNA. Translation: AAG40848.1.
AF458059 mRNA. Translation: AAL57622.1.
AF461739 mRNA. Translation: AAN39038.1.
AY359127 mRNA. Translation: AAQ89484.1.
CH471078 Genomic DNA. Translation: EAW66162.1.
BC069565 mRNA. Translation: AAH69565.1.
BC104929 mRNA. Translation: AAI04930.1.
BC104931 mRNA. Translation: AAI04932.1.
CCDSCCDS45086.1. [Q9H293-2]
CCDS9597.1. [Q9H293-1]
RefSeqNP_073626.1. NM_022789.3. [Q9H293-1]
NP_758525.1. NM_172314.1. [Q9H293-2]
UniGeneHs.302036.

3D structure databases

ProteinModelPortalQ9H293.
SMRQ9H293. Positions 31-175.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122310. 2 interactions.
IntActQ9H293. 1 interaction.
STRING9606.ENSP00000328111.

PTM databases

PhosphoSiteQ9H293.

Polymorphism databases

DMDM20138730.

Proteomic databases

PaxDbQ9H293.
PRIDEQ9H293.

Protocols and materials databases

DNASU64806.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000329715; ENSP00000328111; ENSG00000166090. [Q9H293-1]
ENST00000397242; ENSP00000380417; ENSG00000166090. [Q9H293-2]
GeneID64806.
KEGGhsa:64806.
UCSCuc001wjq.3. human. [Q9H293-2]
uc001wjr.3. human. [Q9H293-1]

Organism-specific databases

CTD64806.
GeneCardsGC14P023843.
HGNCHGNC:13765. IL25.
HPACAB024864.
MIM605658. gene.
neXtProtNX_Q9H293.
PharmGKBPA29799.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45274.
HOGENOMHOG000113041.
HOVERGENHBG052097.
KOK05493.
OMAKGYCLER.
OrthoDBEOG7KSX9Z.
PhylomeDBQ9H293.
TreeFamTF314701.

Gene expression databases

BgeeQ9H293.
CleanExHS_IL25.
GenevestigatorQ9H293.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERPTHR21295. PTHR21295. 1 hit.
PfamPF06083. IL17. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
ProtoNetSearch...

Other

GeneWikiInterleukin_25.
GenomeRNAi64806.
NextBio66902.
PROQ9H293.
SOURCESearch...

Entry information

Entry nameIL25_HUMAN
AccessionPrimary (citable) accession number: Q9H293
Secondary accession number(s): Q2M3F0, Q8IZV3, Q8WXB0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM