Q9H293 (IL25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-25
Short name=IL-25

Alternative name(s):
Interleukin-17E
Short name=IL-17E

Gene names

Name:	IL25
Synonyms:	IL17E
ORF Names:	UNQ3120/PRO10272

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.
Subcellular location	Secreted.
Tissue specificity	Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea.
Sequence similarities	Belongs to the IL-17 family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	eosinophil differentiation Inferred from electronic annotation. Source: Compara inflammatory response to antigenic stimulus Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara response to fungus Inferred from electronic annotation. Source: Compara response to nematode Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW membrane Non-traceable author statement. Source: UniProtKB
Molecular_function	interleukin-17E receptor binding Traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H293-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H293-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MRERPRLGEDSSLISLFL → MY

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 32	32	Ref.7
	Chain	33 – 177	145	Interleukin-25		PRO_0000015431
Amino acid modifications
	Glycosylation	136	1	N-linked (GlcNAc...) Potential
	Disulfide bond	110 ↔ 168		By similarity
	Disulfide bond	115 ↔ 170		By similarity
Natural variations
	Alternative sequence	1 – 18	18	MRERP…ISLFL → MY in isoform 2.		VSP_010159
Experimental info
	Sequence conflict	177	1	G → A in AAL57622. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 52D895710CD59871	FASTA	177	20,330
	10 20 30 40 50 60 MRERPRLGED SSLISLFLQV VAFLAMVMGT HTYSHWPSCC PSKGQDTSEE LLRWSTVPVP 70 80 90 100 110 120 PLEPARPNRH PESCRASEDG PLNSRAISPW RYELDRDLNR LPQDLYHARC LCPHCVSLQT 130 140 150 160 170 GSHMDPRGNS ELLYHNQTVF YRRPCHGEKG THKGYCLERR LYRVSLACVC VRPRVMG
	Isoform 2 [UniParc]. Checksum: 37685913FCFE151D	FASTA	161	18,523
	10 20 30 40 50 60 MYQVVAFLAM VMGTHTYSHW PSCCPSKGQD TSEELLRWST VPVPPLEPAR PNRHPESCRA 70 80 90 100 110 120 SEDGPLNSRA ISPWRYELDR DLNRLPQDLY HARCLCPHCV SLQTGSHMDP RGNSELLYHN 130 140 150 160 QTVFYRRPCH GEKGTHKGYC LERRLYRVSL ACVCVRPRVM G

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1." Lee J., Ho W.-H., Maruoka M., Corpuz R.T., Baldwin D.T., Foster J.S., Goddard A.D., Yansura D.G., Vandlen R.L., Wood W.I., Gurney A.L. J. Biol. Chem. 276:1660-1664(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo." Fort M.M., Cheung J., Yen D., Li J., Zurawski S.M., Lo S., Menon S., Clifford T., Hunte B., Lesley R., Muchamuel T., Hurst S.D., Zurawski G., Leach M.W., Gorman D.M., Rennick D.M. Immunity 15:985-995(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	"Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production." Kim M.R., Manoukian R., Yeh R., Silbiger S.M., Danilenko D.M., Scully S., Sun J., DeRose M.L., Stolina M., Chang D., Van G.Y., Clarkin K., Nguyen H.Q., Yu Y.B., Jing S., Senaldi G., Elliott G., Medlock E.S. Blood 100:2330-2340(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Testis.
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[7]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 33-47.
+	Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-17 entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF305200 mRNA. Translation: AAG40848.1. AF458059 mRNA. Translation: AAL57622.1. AF461739 mRNA. Translation: AAN39038.1. AY359127 mRNA. Translation: AAQ89484.1. CH471078 Genomic DNA. Translation: EAW66162.1. BC069565 mRNA. Translation: AAH69565.1. BC104929 mRNA. Translation: AAI04930.1. BC104931 mRNA. Translation: AAI04932.1.
IPI	IPI00009731. IPI00332192.
RefSeq	NP_073626.1. NM_022789.3. NP_758525.1. NM_172314.1.
UniGene	Hs.302036.
3D structure databases
ProteinModelPortal	Q9H293.
SMR	Q9H293. Positions 81-173.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H293. 1 interaction.
STRING	9606.ENSP00000328111.
PTM databases
PhosphoSite	Q9H293.
Polymorphism databases
DMDM	20138730.
Proteomic databases
PaxDb	Q9H293.
PRIDE	Q9H293.
Protocols and materials databases
DNASU	64806.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000329715; ENSP00000328111; ENSG00000166090. ENST00000397242; ENSP00000380417; ENSG00000166090.
GeneID	64806.
KEGG	hsa:64806.
UCSC	uc001wjq.3. human. uc001wjr.3. human.
Organism-specific databases
CTD	64806.
GeneCards	GC14P023843.
HGNC	HGNC:13765. IL25.
HPA	CAB024864.
MIM	605658. gene.
neXtProt	NX_Q9H293.
PharmGKB	PA29799.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45274.
HOGENOM	HOG000113041.
HOVERGEN	HBG052097.
KO	K05493.
OMA	KGYCLER.
OrthoDB	EOG4GMTZ3.
PhylomeDB	Q9H293.
Gene expression databases
Bgee	Q9H293.
CleanEx	HS_IL25.
Genevestigator	Q9H293.
GermOnline	ENSG00000166090. Homo sapiens.
Family and domain databases
InterPro	IPR010345. Interleukin-17. [Graphical view]
PANTHER	PTHR21295. PTHR21295. 1 hit.
Pfam	PF06083. IL17. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	64806.
NextBio	66902.
SOURCE	Search...

Entry information

Entry name

IL25_HUMAN

Accession

Primary (citable) accession number: Q9H293
Secondary accession number(s): Q2M3F0, Q8IZV3, Q8WXB0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.