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Q9H293

- IL25_HUMAN

UniProt

Q9H293 - IL25_HUMAN

Protein

Interleukin-25

Gene

IL25

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.

    GO - Molecular functioni

    1. interleukin-17E receptor binding Source: UniProtKB

    GO - Biological processi

    1. eosinophil differentiation Source: Ensembl
    2. inflammatory response to antigenic stimulus Source: Ensembl
    3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    4. response to fungus Source: Ensembl
    5. response to nematode Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-25
    Short name:
    IL-25
    Alternative name(s):
    Interleukin-17E
    Short name:
    IL-17E
    Gene namesi
    Name:IL25
    Synonyms:IL17E
    ORF Names:UNQ3120/PRO10272
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:13765. IL25.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29799.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 32321 PublicationAdd
    BLAST
    Chaini33 – 177145Interleukin-25PRO_0000015431Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi110 ↔ 168By similarity
    Disulfide bondi115 ↔ 170By similarity
    Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9H293.
    PRIDEiQ9H293.

    PTM databases

    PhosphoSiteiQ9H293.

    Expressioni

    Tissue specificityi

    Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea.

    Gene expression databases

    BgeeiQ9H293.
    CleanExiHS_IL25.
    GenevestigatoriQ9H293.

    Organism-specific databases

    HPAiCAB024864.

    Interactioni

    Protein-protein interaction databases

    BioGridi122310. 2 interactions.
    IntActiQ9H293. 1 interaction.
    STRINGi9606.ENSP00000328111.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H293.
    SMRiQ9H293. Positions 31-175.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-17 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45274.
    HOGENOMiHOG000113041.
    HOVERGENiHBG052097.
    KOiK05493.
    OMAiKGYCLER.
    OrthoDBiEOG7KSX9Z.
    PhylomeDBiQ9H293.
    TreeFamiTF314701.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR010345. IL-17_fam.
    [Graphical view]
    PANTHERiPTHR21295. PTHR21295. 1 hit.
    PfamiPF06083. IL17. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H293-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRERPRLGED SSLISLFLQV VAFLAMVMGT HTYSHWPSCC PSKGQDTSEE    50
    LLRWSTVPVP PLEPARPNRH PESCRASEDG PLNSRAISPW RYELDRDLNR 100
    LPQDLYHARC LCPHCVSLQT GSHMDPRGNS ELLYHNQTVF YRRPCHGEKG 150
    THKGYCLERR LYRVSLACVC VRPRVMG 177
    Length:177
    Mass (Da):20,330
    Last modified:March 1, 2001 - v1
    Checksum:i52D895710CD59871
    GO
    Isoform 2 (identifier: Q9H293-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-18: MRERPRLGEDSSLISLFL → MY

    Show »
    Length:161
    Mass (Da):18,523
    Checksum:i37685913FCFE151D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti177 – 1771G → A in AAL57622. (PubMed:11754819)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1818MRERP…ISLFL → MY in isoform 2. 3 PublicationsVSP_010159Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF305200 mRNA. Translation: AAG40848.1.
    AF458059 mRNA. Translation: AAL57622.1.
    AF461739 mRNA. Translation: AAN39038.1.
    AY359127 mRNA. Translation: AAQ89484.1.
    CH471078 Genomic DNA. Translation: EAW66162.1.
    BC069565 mRNA. Translation: AAH69565.1.
    BC104929 mRNA. Translation: AAI04930.1.
    BC104931 mRNA. Translation: AAI04932.1.
    CCDSiCCDS45086.1. [Q9H293-2]
    CCDS9597.1. [Q9H293-1]
    RefSeqiNP_073626.1. NM_022789.3. [Q9H293-1]
    NP_758525.1. NM_172314.1. [Q9H293-2]
    UniGeneiHs.302036.

    Genome annotation databases

    EnsembliENST00000329715; ENSP00000328111; ENSG00000166090. [Q9H293-1]
    ENST00000397242; ENSP00000380417; ENSG00000166090. [Q9H293-2]
    GeneIDi64806.
    KEGGihsa:64806.
    UCSCiuc001wjq.3. human. [Q9H293-2]
    uc001wjr.3. human. [Q9H293-1]

    Polymorphism databases

    DMDMi20138730.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Interleukin-17 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF305200 mRNA. Translation: AAG40848.1 .
    AF458059 mRNA. Translation: AAL57622.1 .
    AF461739 mRNA. Translation: AAN39038.1 .
    AY359127 mRNA. Translation: AAQ89484.1 .
    CH471078 Genomic DNA. Translation: EAW66162.1 .
    BC069565 mRNA. Translation: AAH69565.1 .
    BC104929 mRNA. Translation: AAI04930.1 .
    BC104931 mRNA. Translation: AAI04932.1 .
    CCDSi CCDS45086.1. [Q9H293-2 ]
    CCDS9597.1. [Q9H293-1 ]
    RefSeqi NP_073626.1. NM_022789.3. [Q9H293-1 ]
    NP_758525.1. NM_172314.1. [Q9H293-2 ]
    UniGenei Hs.302036.

    3D structure databases

    ProteinModelPortali Q9H293.
    SMRi Q9H293. Positions 31-175.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122310. 2 interactions.
    IntActi Q9H293. 1 interaction.
    STRINGi 9606.ENSP00000328111.

    PTM databases

    PhosphoSitei Q9H293.

    Polymorphism databases

    DMDMi 20138730.

    Proteomic databases

    PaxDbi Q9H293.
    PRIDEi Q9H293.

    Protocols and materials databases

    DNASUi 64806.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329715 ; ENSP00000328111 ; ENSG00000166090 . [Q9H293-1 ]
    ENST00000397242 ; ENSP00000380417 ; ENSG00000166090 . [Q9H293-2 ]
    GeneIDi 64806.
    KEGGi hsa:64806.
    UCSCi uc001wjq.3. human. [Q9H293-2 ]
    uc001wjr.3. human. [Q9H293-1 ]

    Organism-specific databases

    CTDi 64806.
    GeneCardsi GC14P023843.
    HGNCi HGNC:13765. IL25.
    HPAi CAB024864.
    MIMi 605658. gene.
    neXtProti NX_Q9H293.
    PharmGKBi PA29799.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45274.
    HOGENOMi HOG000113041.
    HOVERGENi HBG052097.
    KOi K05493.
    OMAi KGYCLER.
    OrthoDBi EOG7KSX9Z.
    PhylomeDBi Q9H293.
    TreeFami TF314701.

    Miscellaneous databases

    GeneWikii Interleukin_25.
    GenomeRNAii 64806.
    NextBioi 66902.
    PROi Q9H293.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H293.
    CleanExi HS_IL25.
    Genevestigatori Q9H293.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR010345. IL-17_fam.
    [Graphical view ]
    PANTHERi PTHR21295. PTHR21295. 1 hit.
    Pfami PF06083. IL17. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production."
      Kim M.R., Manoukian R., Yeh R., Silbiger S.M., Danilenko D.M., Scully S., Sun J., DeRose M.L., Stolina M., Chang D., Van G.Y., Clarkin K., Nguyen H.Q., Yu Y.B., Jing S., Senaldi G., Elliott G., Medlock E.S.
      Blood 100:2330-2340(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 33-47.

    Entry informationi

    Entry nameiIL25_HUMAN
    AccessioniPrimary (citable) accession number: Q9H293
    Secondary accession number(s): Q2M3F0, Q8IZV3, Q8WXB0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3