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Protein

Interleukin-25

Gene

IL25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.

GO - Molecular functioni

  1. interleukin-17E receptor binding Source: UniProtKB

GO - Biological processi

  1. eosinophil differentiation Source: Ensembl
  2. inflammatory response to antigenic stimulus Source: Ensembl
  3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. response to fungus Source: Ensembl
  5. response to nematode Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-25
Short name:
IL-25
Alternative name(s):
Interleukin-17E
Short name:
IL-17E
Gene namesi
Name:IL25
Synonyms:IL17E
ORF Names:UNQ3120/PRO10272
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:13765. IL25.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29799.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 32321 PublicationAdd
BLAST
Chaini33 – 177145Interleukin-25PRO_0000015431Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi110 ↔ 168By similarity
Disulfide bondi115 ↔ 170By similarity
Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H293.
PRIDEiQ9H293.

PTM databases

PhosphoSiteiQ9H293.

Expressioni

Tissue specificityi

Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea.

Gene expression databases

BgeeiQ9H293.
CleanExiHS_IL25.
GenevestigatoriQ9H293.

Organism-specific databases

HPAiCAB024864.

Interactioni

Protein-protein interaction databases

BioGridi122310. 2 interactions.
IntActiQ9H293. 1 interaction.
STRINGi9606.ENSP00000328111.

Structurei

3D structure databases

ProteinModelPortaliQ9H293.
SMRiQ9H293. Positions 31-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45274.
GeneTreeiENSGT00690000102299.
HOGENOMiHOG000113041.
HOVERGENiHBG052097.
InParanoidiQ9H293.
KOiK05493.
OMAiFYRRPCP.
OrthoDBiEOG7KSX9Z.
PhylomeDBiQ9H293.
TreeFamiTF314701.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H293-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRERPRLGED SSLISLFLQV VAFLAMVMGT HTYSHWPSCC PSKGQDTSEE
60 70 80 90 100
LLRWSTVPVP PLEPARPNRH PESCRASEDG PLNSRAISPW RYELDRDLNR
110 120 130 140 150
LPQDLYHARC LCPHCVSLQT GSHMDPRGNS ELLYHNQTVF YRRPCHGEKG
160 170
THKGYCLERR LYRVSLACVC VRPRVMG
Length:177
Mass (Da):20,330
Last modified:February 28, 2001 - v1
Checksum:i52D895710CD59871
GO
Isoform 2 (identifier: Q9H293-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MRERPRLGEDSSLISLFL → MY

Show »
Length:161
Mass (Da):18,523
Checksum:i37685913FCFE151D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1771G → A in AAL57622 (PubMed:11754819).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1818MRERP…ISLFL → MY in isoform 2. 3 PublicationsVSP_010159Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305200 mRNA. Translation: AAG40848.1.
AF458059 mRNA. Translation: AAL57622.1.
AF461739 mRNA. Translation: AAN39038.1.
AY359127 mRNA. Translation: AAQ89484.1.
CH471078 Genomic DNA. Translation: EAW66162.1.
BC069565 mRNA. Translation: AAH69565.1.
BC104929 mRNA. Translation: AAI04930.1.
BC104931 mRNA. Translation: AAI04932.1.
CCDSiCCDS45086.1. [Q9H293-2]
CCDS9597.1. [Q9H293-1]
RefSeqiNP_073626.1. NM_022789.3. [Q9H293-1]
NP_758525.1. NM_172314.1. [Q9H293-2]
UniGeneiHs.302036.

Genome annotation databases

EnsembliENST00000329715; ENSP00000328111; ENSG00000166090. [Q9H293-1]
ENST00000397242; ENSP00000380417; ENSG00000166090. [Q9H293-2]
GeneIDi64806.
KEGGihsa:64806.
UCSCiuc001wjq.3. human. [Q9H293-2]
uc001wjr.3. human. [Q9H293-1]

Polymorphism databases

DMDMi20138730.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-17 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305200 mRNA. Translation: AAG40848.1.
AF458059 mRNA. Translation: AAL57622.1.
AF461739 mRNA. Translation: AAN39038.1.
AY359127 mRNA. Translation: AAQ89484.1.
CH471078 Genomic DNA. Translation: EAW66162.1.
BC069565 mRNA. Translation: AAH69565.1.
BC104929 mRNA. Translation: AAI04930.1.
BC104931 mRNA. Translation: AAI04932.1.
CCDSiCCDS45086.1. [Q9H293-2]
CCDS9597.1. [Q9H293-1]
RefSeqiNP_073626.1. NM_022789.3. [Q9H293-1]
NP_758525.1. NM_172314.1. [Q9H293-2]
UniGeneiHs.302036.

3D structure databases

ProteinModelPortaliQ9H293.
SMRiQ9H293. Positions 31-175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122310. 2 interactions.
IntActiQ9H293. 1 interaction.
STRINGi9606.ENSP00000328111.

PTM databases

PhosphoSiteiQ9H293.

Polymorphism databases

DMDMi20138730.

Proteomic databases

PaxDbiQ9H293.
PRIDEiQ9H293.

Protocols and materials databases

DNASUi64806.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329715; ENSP00000328111; ENSG00000166090. [Q9H293-1]
ENST00000397242; ENSP00000380417; ENSG00000166090. [Q9H293-2]
GeneIDi64806.
KEGGihsa:64806.
UCSCiuc001wjq.3. human. [Q9H293-2]
uc001wjr.3. human. [Q9H293-1]

Organism-specific databases

CTDi64806.
GeneCardsiGC14P023857.
HGNCiHGNC:13765. IL25.
HPAiCAB024864.
MIMi605658. gene.
neXtProtiNX_Q9H293.
PharmGKBiPA29799.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45274.
GeneTreeiENSGT00690000102299.
HOGENOMiHOG000113041.
HOVERGENiHBG052097.
InParanoidiQ9H293.
KOiK05493.
OMAiFYRRPCP.
OrthoDBiEOG7KSX9Z.
PhylomeDBiQ9H293.
TreeFamiTF314701.

Miscellaneous databases

GeneWikiiInterleukin_25.
GenomeRNAii64806.
NextBioi66902.
PROiQ9H293.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H293.
CleanExiHS_IL25.
GenevestigatoriQ9H293.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production."
    Kim M.R., Manoukian R., Yeh R., Silbiger S.M., Danilenko D.M., Scully S., Sun J., DeRose M.L., Stolina M., Chang D., Van G.Y., Clarkin K., Nguyen H.Q., Yu Y.B., Jing S., Senaldi G., Elliott G., Medlock E.S.
    Blood 100:2330-2340(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 33-47.

Entry informationi

Entry nameiIL25_HUMAN
AccessioniPrimary (citable) accession number: Q9H293
Secondary accession number(s): Q2M3F0, Q8IZV3, Q8WXB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 30, 2002
Last sequence update: February 28, 2001
Last modified: January 6, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.