VPS16

Functionⁱ

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for recruitment of VPS33A to the HOPS complex (PubMed:23901104). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS33A but not VPS33B (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770).4 Publications3 Publications

GO - Molecular functionⁱ

actin binding Source: GO_Central
actin filament binding Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

autophagosome maturation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25783203
endosome to lysosome transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25783203
intracellular protein transport Source: InterPro
regulation of SNARE complex assembly Source: GO_Central
regulation of vacuole fusion, non-autophagic Source: GO_Central

Complete GO annotation...

Keywordsⁱ

Biological process	Autophagy, Protein transport, Transport

Biological process

Autophagy, Protein transport, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Vacuolar protein sorting-associated protein 16 homolog Short name: hVPS16
Gene namesⁱ	Name:VPS16
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14584. VPS16.

HGNCⁱ

HGNC:14584. VPS16.

Subcellular locationⁱ

Note:

Colocalizes with AP-3, clathrin, Rab5 and Rab7b (By similarity). Cytoplasmic, peripheral membrane protein associated with early endosomes and late endosomes/lysosomes.By similarityCurated

GO - Cellular componentⁱ

autophagosome Source: UniProtKB-SubCell
axon Source: Ensembl
clathrin-coated vesicle Source: UniProtKB-SubCell
early endosome
Source: UniProtKB
Inferred from direct assayⁱ
- 19109425
HOPS complex
Source: UniProtKB
Inferred from direct assayⁱ
late endosome
Source: UniProtKB
Inferred from direct assayⁱ
- 19109425
- 11382755
late endosome membrane Source: UniProtKB-SubCell
lysosomal membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 17897319
lysosome
Source: UniProtKB
Inferred from direct assayⁱ
- 11382755
neuronal cell body Source: Ensembl
recycling endosome
Source: UniProtKB
Inferred from direct assayⁱ
- 19109425

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasmic vesicle, Endosome, Lysosome, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

VSP16 mutation have been found in one familly with adolescent-onset primary dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.1 Publication

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	669	A → D: Disrupts interaction with VPS33A, no effect on interaction with VPS18 and impairs endosome-lysosome fusion; when associated with E-725. 2 Publications		1
Mutagenesisⁱ	725	R → E: Disrupts interaction with VPS33A, no effect on interaction with VPS18 and impairs endosome-lysosome fusion; when associated with D-669. 2 Publications		1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

PharmGKBⁱ	PA37903.

PharmGKBⁱ

PA37903.

Polymorphism and mutation databases

DMDMⁱ	23396927.

DMDMⁱ

23396927.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000065888	1 – 839	Vacuolar protein sorting-associated protein 16 homologAdd BLAST		839

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	4	Nitrated tyrosineBy similarity		1

Keywords - PTMⁱ

Nitration

Proteomic databases

EPDⁱ	Q9H269.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H269.
PaxDbⁱ	Q9H269.
PeptideAtlas More...PeptideAtlasⁱ	Q9H269.
PRIDEⁱ	Q9H269.

PTM databases

iPTMnetⁱ	Q9H269.
PhosphoSitePlusⁱ	Q9H269.

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000215305.
ExpressionAtlasⁱ	Q9H269. baseline and differential.
Genevisibleⁱ	Q9H269. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043229. HPA048661.

HPAⁱ

HPA043229.
HPA048661.

Interactionⁱ

Subunit structureⁱ

Core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuole/endosome tethering (CORVET) complex. Their common core is composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, which in HOPS further associates with VPS39 and VPS41 and in CORVET with VPS8 and TGFBRAP1 (PubMed:11382755, PubMed:25783203, PubMed:23901104, PubMed:25266290). Interacts with RAB5C (By similarity). Interacts with STX17, MON1B (PubMed:20434987, PubMed:24554770). Associates with adaptor protein complex 3 (AP-3) and clathrin:AP-3 complexes (By similarity).By similarity2 Publications4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
STX17	P56962	3	EBI-2655929,EBI-2797775
TGFBRAP1	Q8WUH2	3	EBI-2655929,EBI-2954829
VPS11	Q9H270	6	EBI-2655929,EBI-373380
VPS18	Q9P253	15	EBI-2655929,EBI-1053363
VPS33A	Q96AX1	13	EBI-2655929,EBI-2527283

Show more details

GO - Molecular functionⁱ

actin binding Source: GO_Central
actin filament binding Source: Ensembl

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	122220. 58 interactors.
IntActⁱ	Q9H269. 30 interactors.
STRINGⁱ	9606.ENSP00000369810.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	645 – 660	Combined sources	16
Helixⁱ	664 – 687	Combined sources	24
Helixⁱ	696 – 705	Combined sources	10
Helixⁱ	709 – 718	Combined sources	10
Helixⁱ	723 – 734	Combined sources	12

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4BX9	X-ray	2.60	C	642-736	[»]
ProteinModelPortalⁱ	Q9H269.
SMRⁱ	Q9H269.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	642 – 736	Interaction with VPS33A1 PublicationAdd BLAST		95

Sequence similaritiesⁱ

Belongs to the VPS16 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2280. Eukaryota. ENOG410XQ8X. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003896.
HOVERGENⁱ	HBG056306.
InParanoidⁱ	Q9H269.
KEGG Orthology (KO) More...KOⁱ	K20180.
OMAⁱ	SYCLLGR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01XD.
PhylomeDBⁱ	Q9H269.
TreeFamⁱ	TF105673.

Family and domain databases

Gene3Dⁱ	2.130.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR016534. VPS16. IPR006925. Vps16_C. IPR006926. Vps16_N. IPR015943. WD40/YVTN_repeat-like_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04840. Vps16_C. 1 hit. PF04841. Vps16_N. 1 hit.
PIRSFⁱ	PIRSF007949. VPS16. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q9H269-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDCYTANWNP LGDSAFYRKY ELYSMDWDLK EELRDCLVAA APYGGPIALL 
        60         70         80         90        100
RNPWRKEKAA SVRPVLDIYS ASGMPLASLL WKSGPVVSLG WSAEEELLCV 
       110        120        130        140        150
QEDGAVLVYG LHGDFRRHFS MGNEVLQNRV LDARIFHTEF GSGVAILTGA 
       160        170        180        190        200
HRFTLSANVG DLKLRRMPEV PGLQSAPSCW TVLCQDRVAH ILLAVGPDLY 
       210        220        230        240        250
LLDHAACSAV TPPGLAPGVS SFLQMAVSFT YRHLALFTDT GYIWMGTASL 
       260        270        280        290        300
KEKLCEFNCN IRAPPKQMVW CSRPRSKERA VVVAWERRLM VVGDAPESIQ 
       310        320        330        340        350
FVLDEDSYLV PELDGVRIFS RSTHEFLHEV PAASEEIFKI ASMAPGALLL 
       360        370        380        390        400
EAQKEYEKES QKADEYLREI QELGQLTQAV QQCIEAAGHE HQPDMQKSLL 
       410        420        430        440        450
RAASFGKCFL DRFPPDSFVH MCQDLRVLNA VRDYHIGIPL TYSQYKQLTI 
       460        470        480        490        500
QVLLDRLVLR RLYPLAIQIC EYLRLPEVQG VSRILAHWAC YKVQQKDVSD 
       510        520        530        540        550
EDVARAINQK LGDTPGVSYS DIAARAYGCG RTELAIKLLE YEPRSGEQVP 
       560        570        580        590        600
LLLKMKRSKL ALSKAIESGD TDLVFTVLLH LKNELNRGDF FMTLRNQPMA 
       610        620        630        640        650
LSLYRQFCKH QELETLKDLY NQDDNHQELG SFHIRASYAA EERIEGRVAA 
       660        670        680        690        700
LQTAADAFYK AKNEFAAKAT EDQMRLLRLQ RRLEDELGGQ FLDLSLHDTV 
       710        720        730        740        750
TTLILGGHNK RAEQLARDFR IPDKRLWWLK LTALADLEDW EELEKFSKSK 
       760        770        780        790        800
KSPIGYLPFV EICMKQHNKY EAKKYASRVG PEQKVKALLL VGDVAQAADV 
       810        820        830 
AIEHRNEAEL SLVLSHCTGA TDGATADKIQ RARAQAQKK

Length:839

Mass (Da):94,694

Last modified:September 19, 2002 - v2

Checksum:ⁱ9C4292D455C19A60

GO

Isoform 2 (identifier: Q9H269-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
300-443: Missing.

« Hide

        10         20         30         40         50
MDCYTANWNP LGDSAFYRKY ELYSMDWDLK EELRDCLVAA APYGGPIALL 
        60         70         80         90        100
RNPWRKEKAA SVRPVLDIYS ASGMPLASLL WKSGPVVSLG WSAEEELLCV 
       110        120        130        140        150
QEDGAVLVYG LHGDFRRHFS MGNEVLQNRV LDARIFHTEF GSGVAILTGA 
       160        170        180        190        200
HRFTLSANVG DLKLRRMPEV PGLQSAPSCW TVLCQDRVAH ILLAVGPDLY 
       210        220        230        240        250
LLDHAACSAV TPPGLAPGVS SFLQMAVSFT YRHLALFTDT GYIWMGTASL 
       260        270        280        290        300
KEKLCEFNCN IRAPPKQMVW CSRPRSKERA VVVAWERRLM VVGDAPESIQ 
       310        320        330        340        350
YKQLTIQVLL DRLVLRRLYP LAIQICEYLR LPEVQGVSRI LAHWACYKVQ 
       360        370        380        390        400
QKDVSDEDVA RAINQKLGDT PGVSYSDIAA RAYGCGRTEL AIKLLEYEPR 
       410        420        430        440        450
SGEQVPLLLK MKRSKLALSK AIESGDTDLV FTVLLHLKNE LNRGDFFMTL 
       460        470        480        490        500
RNQPMALSLY RQFCKHQELE TLKDLYNQDD NHQELGSFHI RASYAAEERI 
       510        520        530        540        550
EGRVAALQTA ADAFYKAKNE FAAKATEDQM RLLRLQRRLE DELGGQFLDL 
       560        570        580        590        600
SLHDTVTTLI LGGHNKRAEQ LARDFRIPDK RLWWLKLTAL ADLEDWEELE 
       610        620        630        640        650
KFSKSKKSPI GYLPFVEICM KQHNKYEAKK YASRVGPEQK VKALLLVGDV 
       660        670        680        690 
AQAADVAIEH RNEAELSLVL SHCTGATDGA TADKIQRARA QAQKK

Note: No experimental confirmation available.

Show »

Length:695

Mass (Da):78,300

Checksum:ⁱ13D27C230E5CFFCD

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	87	V → A in BAB71013 (PubMed:14702039).Curated	1
Sequence conflictⁱ	612	E → G in BAB71013 (PubMed:14702039).Curated	1
Sequence conflictⁱ	690 – 691	QF → LQ in AAH12422 (PubMed:15489334).Curated	2
Sequence conflictⁱ	768	N → T in AAG34678 (PubMed:11250079).Curated	1
Sequence conflictⁱ	809	E → D in AAH12422 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_076520	52	N → K Probable disease associated mutation found in patients with adolescent-onset primary dystonia. 1 PublicationCorresponds to variant dbSNP:rs367642720Ensembl.		1
Natural variantⁱVAR_053776	637	S → I. Corresponds to variant dbSNP:rs35773586Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_004018	300 – 443	Missing in isoform 2. 1 PublicationAdd BLAST		144

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF308801 mRNA. Translation: AAG34678.1. AK055787 mRNA. Translation: BAB71013.1. AL161656 Genomic DNA. Translation: CAC21465.1. AL161656 Genomic DNA. Translation: CAI12120.1. AL834401 mRNA. Translation: CAD39063.1. BC012422 mRNA. Translation: AAH12422.1. BC021291 mRNA. Translation: AAH21291.2. BC064406 mRNA. Translation: AAH64406.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13036.1. [Q9H269-1] CCDS13037.1. [Q9H269-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_072097.2. NM_022575.3. [Q9H269-1] NP_536338.1. NM_080413.2. [Q9H269-2]
UniGeneⁱ	Hs.269577.

Genome annotation databases

Ensemblⁱ	ENST00000380445; ENSP00000369810; ENSG00000215305. [Q9H269-1] ENST00000380469; ENSP00000369836; ENSG00000215305. [Q9H269-2]
GeneIDⁱ	64601.
KEGGⁱ	hsa:64601.
UCSC genome browser More...UCSCⁱ	uc002whe.5. human. [Q9H269-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9H269	H2QJU9	Homo sapiens (Human) Pan troglodytes (Chimpanzee)	839	UniRef100_Q9H269	Cluster: Vacuolar protein sorting-associated protein 16 homolog	2

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9H269	H2QJU9 M3YCA7 G9KXD5 G9KXD6 UPI00094258F2 UPI00057A8DC2 UPI0007A6A9CA UPI000440095A UPI000737EC48 UPI000B507922 +135	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Mustela putorius furo (European domestic ferret) (Mustela furo) Rhinolophus sinicus (Chinese rufous horseshoe bat) Camelus bactrianus (Bactrian camel) Miniopterus natalensis (Natal long-fingered bat) (Miniopterus schreibersii natalensis) Balaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni) Vicugna pacos (Alpaca) (Lama pacos) Neomonachus schauinslandi (Hawaiian monk seal) (Monachus schauinslandi) Ursus maritimus (Polar bear) (Thalarctos maritimus) And more	839	UniRef90_Q9H269	Cluster: Vacuolar protein sorting-associated protein 16 homolog	146
Q9H269-2	UPI0004402C49 UPI00042CC5E8 F7CSI6 A0A1S3AR98 UPI00029D484E UPI0002C47524 UPI0002C5952D UPI00032ADA41 UPI0003315685 UPI000332F18C +13	Balaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni) Bubalus bubalis (Domestic water buffalo) Macaca mulatta (Rhesus macaque) Erinaceus europaeus (Western European hedgehog) Pantholops hodgsonii (Chiru) (Tibetan antelope) Trichechus manatus latirostris (Florida manatee) Odobenus rosmarus divergens (Pacific walrus) Ochotona princeps (Southern American pika) Sorex araneus (Eurasian common shrew) (European shrew) Jaculus jaculus (Lesser Egyptian jerboa) And more	695	UniRef90_Q9H269-2	Cluster: Isoform 2 of Vacuolar protein sorting-associated protein 16 homolog	24

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9H269	H2QJU9 M3YCA7 G9KXD5 G9KXD6 UPI00094258F2 UPI00057A8DC2 UPI0007A6A9CA UPI000737EC48 UPI000440095A UPI000B507922 +166	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Mustela putorius furo (European domestic ferret) (Mustela furo) Rhinolophus sinicus (Chinese rufous horseshoe bat) Camelus bactrianus (Bactrian camel) Miniopterus natalensis (Natal long-fingered bat) (Miniopterus schreibersii natalensis) Vicugna pacos (Alpaca) (Lama pacos) Balaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni) Neomonachus schauinslandi (Hawaiian monk seal) (Monachus schauinslandi) Ursus maritimus (Polar bear) (Thalarctos maritimus) And more	839	UniRef50_Q9H269	Cluster: Vacuolar protein sorting-associated protein 16 homolog	177
Q9H269-2	UPI0004402C49 UPI00042CC5E8 UPI0002C47524 UPI00046B7845 UPI000A313273 UPI00029D484E UPI0003340116 UPI00032ADA41 UPI000B52A3EA A0A1S3AR98 +15	Balaenoptera acutorostrata scammoni (North Pacific minke whale) (Balaenoptera davidsoni) Bubalus bubalis (Domestic water buffalo) Trichechus manatus latirostris (Florida manatee) Eptesicus fuscus (Big brown bat) (Vespertilio fuscus) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Pantholops hodgsonii (Chiru) (Tibetan antelope) Octodon degus (Degu) (Sciurus degus) Ochotona princeps (Southern American pika) Tarsius syrichta (Philippine tarsier) Erinaceus europaeus (Western European hedgehog) And more	695	UniRef50_Q9H269-2	Cluster: Isoform 2 of Vacuolar protein sorting-associated protein 16 homolog	26

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF308801 mRNA. Translation: AAG34678.1. AK055787 mRNA. Translation: BAB71013.1. AL161656 Genomic DNA. Translation: CAC21465.1. AL161656 Genomic DNA. Translation: CAI12120.1. AL834401 mRNA. Translation: CAD39063.1. BC012422 mRNA. Translation: AAH12422.1. BC021291 mRNA. Translation: AAH21291.2. BC064406 mRNA. Translation: AAH64406.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13036.1. [Q9H269-1] CCDS13037.1. [Q9H269-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_072097.2. NM_022575.3. [Q9H269-1] NP_536338.1. NM_080413.2. [Q9H269-2]
UniGeneⁱ	Hs.269577.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4BX9	X-ray	2.60	C	642-736	[»]
ProteinModelPortalⁱ	Q9H269.
SMRⁱ	Q9H269.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122220. 58 interactors.
IntActⁱ	Q9H269. 30 interactors.
STRINGⁱ	9606.ENSP00000369810.

PTM databases

iPTMnetⁱ	Q9H269.
PhosphoSitePlusⁱ	Q9H269.

Polymorphism and mutation databases

DMDMⁱ	23396927.

DMDMⁱ

23396927.

Proteomic databases

EPDⁱ	Q9H269.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H269.
PaxDbⁱ	Q9H269.
PeptideAtlas More...PeptideAtlasⁱ	Q9H269.
PRIDEⁱ	Q9H269.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000380445; ENSP00000369810; ENSG00000215305. [Q9H269-1] ENST00000380469; ENSP00000369836; ENSG00000215305. [Q9H269-2]
GeneIDⁱ	64601.
KEGGⁱ	hsa:64601.
UCSC genome browser More...UCSCⁱ	uc002whe.5. human. [Q9H269-1]

Organism-specific databases

CTDⁱ	64601.
GeneCardsⁱ	VPS16.
H-InvDBⁱ	HIX0213048.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14584. VPS16.
Human Protein Atlas More...HPAⁱ	HPA043229. HPA048661.
MIMⁱ	608550. gene.
neXtProtⁱ	NX_Q9H269.
PharmGKBⁱ	PA37903.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2280. Eukaryota. ENOG410XQ8X. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003896.
HOVERGENⁱ	HBG056306.
InParanoidⁱ	Q9H269.
KEGG Orthology (KO) More...KOⁱ	K20180.
OMAⁱ	SYCLLGR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01XD.
PhylomeDBⁱ	Q9H269.
TreeFamⁱ	TF105673.

Miscellaneous databases

ChiTaRSⁱ	VPS16. human.
GenomeRNAiⁱ	64601.
Protein Ontology More...PROⁱ	PR:Q9H269.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000215305.
ExpressionAtlasⁱ	Q9H269. baseline and differential.
Genevisibleⁱ	Q9H269. HS.

Family and domain databases

Gene3Dⁱ	2.130.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR016534. VPS16. IPR006925. Vps16_C. IPR006926. Vps16_N. IPR015943. WD40/YVTN_repeat-like_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04840. Vps16_C. 1 hit. PF04841. Vps16_N. 1 hit.
PIRSFⁱ	PIRSF007949. VPS16. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VPS16_HUMAN
Accessionⁱ	Q9H269Primary (citable) accession number: Q9H269 Secondary accession number(s): Q5JUB1 , Q8WU31, Q96EE7, Q96N92, Q9H1Q4, Q9H1Q5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
	Last sequence update:	September 19, 2002
	Last modified:	August 30, 2017
	This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

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Proteomes

Annotation systems

Supporting data

UniProtKB - Q9H269 (VPS16_HUMAN)

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Vacuolar protein sorting-associated protein 16 homolog

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (2)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ