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Q9H267

- VP33B_HUMAN

UniProt

Q9H267 - VP33B_HUMAN

Protein

Vacuolar protein sorting-associated protein 33B

Gene

VPS33B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. lysosome localization Source: UniProtKB
    2. melanosome localization Source: UniProtKB
    3. membrane fusion Source: UniProtKB
    4. platelet alpha granule organization Source: UniProtKB
    5. protein transport Source: UniProtKB
    6. vesicle docking involved in exocytosis Source: InterPro
    7. vesicle-mediated transport Source: MGI

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vacuolar protein sorting-associated protein 33B
    Short name:
    hVPS33B
    Gene namesi
    Name:VPS33B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:12712. VPS33B.

    Subcellular locationi

    Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side
    Note: Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes. Colocalizes with M.tuberculosis PtpA in the cytosol of tuberculosis-infected macrophages and associates with phagosomes. Colocalizes in clusters with VIPAS39 at cytoplasmic organelles.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. late endosome Source: UniProtKB
    3. late endosome membrane Source: UniProtKB-SubCell
    4. lysosomal membrane Source: UniProtKB-SubCell
    5. lysosome Source: UniProtKB
    6. perinuclear region of cytoplasm Source: UniProtKB
    7. platelet alpha granule Source: UniProtKB

    Keywords - Cellular componenti

    Endosome, Lysosome, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Arthrogryposis, renal dysfunction and cholestasis syndrome 1 (ARCS1) [MIM:208085]: A multisystem disorder, characterized by neurogenic arthrogryposis multiplex congenita, renal tubular dysfunction and neonatal cholestasis with bile duct hypoplasia and low gamma glutamyl transpeptidase activity. Platelet dysfunction is common.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti30 – 301L → P in ARCS1; interacts with VIPAS39 but does not colocalize with VIPAS39 at cytoplasmic organelles. 1 Publication
    VAR_018983
    Natural varianti243 – 2431S → F in ARCS1. 1 Publication
    VAR_057901

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi133 – 1331Y → E: Reduces phosphorylation activity, but does not impair phagolysosomal fusion in M.tuberculosis-infected macrophages; when associated with E-382; E-511 and E-517. 1 Publication
    Mutagenesisi382 – 3821Y → E: Reduces phosphorylation activity, but does not impair phagolysosomal fusion in M.tuberculosis-infected macrophages; when associated with E-133; E-511 and E-517. 1 Publication
    Mutagenesisi511 – 5111Y → E: Reduces phosphorylation activity, but does not impair phagolysosomal fusion in M.tuberculosis-infected macrophages; when associated with E-133; E-382 and E-517. 1 Publication
    Mutagenesisi517 – 5171Y → E: Reduces phosphorylation activity, but does not impair phagolysosomal fusion in M.tuberculosis-infected macrophages; when associated with E-133; E-382 and E-511. 1 Publication

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi208085. phenotype.
    Orphaneti2697. Arthrogryposis - renal dysfunction - cholestasis.
    PharmGKBiPA37327.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 617616Vacuolar protein sorting-associated protein 33BPRO_0000206305Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Post-translational modificationi

    Phosphorylated on tyrosine residues. Dephosphorylation by M.tuberculosis PtpA is necessary to induce the reduction of host phagolysosome fusion in M.tuberculosis-infected macrophages.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9H267.
    PaxDbiQ9H267.
    PRIDEiQ9H267.

    PTM databases

    PhosphoSiteiQ9H267.

    Expressioni

    Tissue specificityi

    Ubiquitous; highly expressed in testis and low expression in the lung.

    Gene expression databases

    ArrayExpressiQ9H267.
    BgeeiQ9H267.
    CleanExiHS_VPS33B.
    GenevestigatoriQ9H267.

    Organism-specific databases

    HPAiHPA040415.

    Interactioni

    Subunit structurei

    Interacts with RAB11A and VIPAS39. Interacts with M.tuberculosis PtpA.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    VIPAS39Q9H9C120EBI-749072,EBI-749080

    Protein-protein interaction databases

    BioGridi117659. 22 interactions.
    IntActiQ9H267. 8 interactions.
    MINTiMINT-1451069.
    STRINGi9606.ENSP00000327650.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H267.
    SMRiQ9H267. Positions 14-614.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the STXBP/unc-18/SEC1 family.Curated

    Phylogenomic databases

    eggNOGiCOG5158.
    HOGENOMiHOG000166771.
    HOVERGENiHBG106182.
    InParanoidiQ9H267.
    OMAiKGYRFIF.
    OrthoDBiEOG722J85.
    PhylomeDBiQ9H267.
    TreeFamiTF315126.

    Family and domain databases

    Gene3Di3.40.50.1910. 2 hits.
    InterProiIPR027482. Sec-1-like_dom2.
    IPR001619. Sec1-like.
    IPR027121. VPS33.
    [Graphical view]
    PANTHERiPTHR11679. PTHR11679. 1 hit.
    PTHR11679:SF1. PTHR11679:SF1. 1 hit.
    PfamiPF00995. Sec1. 1 hit.
    [Graphical view]
    SUPFAMiSSF56815. SSF56815. 2 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H267-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAFPHRPDAP ELPDFSMLKR LARDQLIYLL EQLPGKKDLF IEADLMSPLD    50
    RIANVSILKQ HEVDKLYKVE NKPALSSNEQ LCFLVRPRIK NMRYIASLVN 100
    ADKLAGRTRK YKVIFSPQKF YACEMVLEEE GIYGDVSCDE WAFSLLPLDV 150
    DLLSMELPEF FRDYFLEGDQ RWINTVAQAL HLLSTLYGPF PNCYGIGRCA 200
    KMAYELWRNL EEEEDGETKG RRPEIGHIFL LDRDVDFVTA LCSQVVYEGL 250
    VDDTFRIKCG SVDFGPEVTS SDKSLKVLLN AEDKVFNEIR NEHFSNVFGF 300
    LSQKARNLQA QYDRRRGMDI KQMKNFVSQE LKGLKQEHRL LSLHIGACES 350
    IMKKKTKQDF QELIKTEHAL LEGFNIREST SYIEEHIDRQ VSPIESLRLM 400
    CLLSITENGL IPKDYRSLKT QYLQSYGPEH LLTFSNLRRA GLLTEQAPGD 450
    TLTAVESKVS KLVTDKAAGK ITDAFSSLAK RSNFRAISKK LNLIPRVDGE 500
    YDLKVPRDMA YVFGGAYVPL SCRIIEQVLE RRSWQGLDEV VRLLNCSDFA 550
    FTDMTKEDKA SSESLRLILV VFLGGCTFSE ISALRFLGRE KGYRFIFLTT 600
    AVTNSARLME AMSEVKA 617
    Length:617
    Mass (Da):70,585
    Last modified:November 30, 2010 - v2
    Checksum:iBD7DB97E1FEB1D32
    GO
    Isoform 2 (identifier: Q9H267-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-91: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:526
    Mass (Da):60,032
    Checksum:iA614FE0EFCBF8BE2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti293 – 2931H → Y in BAB55345. (PubMed:14702039)Curated
    Sequence conflicti466 – 4661K → E in BAB55345. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti30 – 301L → P in ARCS1; interacts with VIPAS39 but does not colocalize with VIPAS39 at cytoplasmic organelles. 1 Publication
    VAR_018983
    Natural varianti243 – 2431S → F in ARCS1. 1 Publication
    VAR_057901
    Natural varianti513 – 5131F → S.
    Corresponds to variant rs3177428 [ dbSNP | Ensembl ].
    VAR_057330
    Natural varianti514 – 5141G → S.3 Publications
    Corresponds to variant rs11073964 [ dbSNP | Ensembl ].
    VAR_013828

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9191Missing in isoform 2. 1 PublicationVSP_056567Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF201694 mRNA. Translation: AAF91174.1.
    AL357472 mRNA. Translation: CAB93109.1.
    AF308803 mRNA. Translation: AAG34680.1.
    AK027754 mRNA. Translation: BAB55345.1.
    AK074863 mRNA. Translation: BAG52018.1.
    AC068831 Genomic DNA. No translation available.
    CH471101 Genomic DNA. Translation: EAX02140.1.
    BC016445 mRNA. Translation: AAH16445.1.
    CCDSiCCDS10369.1.
    RefSeqiNP_001276077.1. NM_001289148.1.
    NP_061138.3. NM_018668.4.
    UniGeneiHs.745007.

    Genome annotation databases

    EnsembliENST00000333371; ENSP00000327650; ENSG00000184056.
    ENST00000535843; ENSP00000446267; ENSG00000184056.
    GeneIDi26276.
    KEGGihsa:26276.
    UCSCiuc002bqp.1. human.

    Polymorphism databases

    DMDMi313104046.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF201694 mRNA. Translation: AAF91174.1 .
    AL357472 mRNA. Translation: CAB93109.1 .
    AF308803 mRNA. Translation: AAG34680.1 .
    AK027754 mRNA. Translation: BAB55345.1 .
    AK074863 mRNA. Translation: BAG52018.1 .
    AC068831 Genomic DNA. No translation available.
    CH471101 Genomic DNA. Translation: EAX02140.1 .
    BC016445 mRNA. Translation: AAH16445.1 .
    CCDSi CCDS10369.1.
    RefSeqi NP_001276077.1. NM_001289148.1.
    NP_061138.3. NM_018668.4.
    UniGenei Hs.745007.

    3D structure databases

    ProteinModelPortali Q9H267.
    SMRi Q9H267. Positions 14-614.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117659. 22 interactions.
    IntActi Q9H267. 8 interactions.
    MINTi MINT-1451069.
    STRINGi 9606.ENSP00000327650.

    PTM databases

    PhosphoSitei Q9H267.

    Polymorphism databases

    DMDMi 313104046.

    Proteomic databases

    MaxQBi Q9H267.
    PaxDbi Q9H267.
    PRIDEi Q9H267.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333371 ; ENSP00000327650 ; ENSG00000184056 .
    ENST00000535843 ; ENSP00000446267 ; ENSG00000184056 .
    GeneIDi 26276.
    KEGGi hsa:26276.
    UCSCi uc002bqp.1. human.

    Organism-specific databases

    CTDi 26276.
    GeneCardsi GC15M091541.
    H-InvDB HIX0202153.
    HGNCi HGNC:12712. VPS33B.
    HPAi HPA040415.
    MIMi 208085. phenotype.
    608552. gene.
    neXtProti NX_Q9H267.
    Orphaneti 2697. Arthrogryposis - renal dysfunction - cholestasis.
    PharmGKBi PA37327.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5158.
    HOGENOMi HOG000166771.
    HOVERGENi HBG106182.
    InParanoidi Q9H267.
    OMAi KGYRFIF.
    OrthoDBi EOG722J85.
    PhylomeDBi Q9H267.
    TreeFami TF315126.

    Miscellaneous databases

    GeneWikii VPS33B.
    GenomeRNAii 26276.
    NextBioi 48583.
    PROi Q9H267.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H267.
    Bgeei Q9H267.
    CleanExi HS_VPS33B.
    Genevestigatori Q9H267.

    Family and domain databases

    Gene3Di 3.40.50.1910. 2 hits.
    InterProi IPR027482. Sec-1-like_dom2.
    IPR001619. Sec1-like.
    IPR027121. VPS33.
    [Graphical view ]
    PANTHERi PTHR11679. PTHR11679. 1 hit.
    PTHR11679:SF1. PTHR11679:SF1. 1 hit.
    Pfami PF00995. Sec1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56815. SSF56815. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, mapping and expression analysis of VPS33B, the human orthologue of rat Vps33b."
      Carim-Todd L., Sumoy L., Andreu N., Estivill X., Escarceller M.
      Cytogenet. Cell Genet. 89:92-95(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-514.
    2. "Molecular cloning and characterization of human VPS18, VPS11, VPS16, and VPS33."
      Huizing M., Didier A., Walenta J., Anikster Y., Gahl W.A., Kraemer H.
      Gene 264:241-247(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT SER-514.
      Tissue: Placenta.
    4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-514.
      Tissue: Placenta.
    7. "Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B."
      Bach H., Papavinasasundaram K.G., Wong D., Hmama Z., Av-Gay Y.
      Cell Host Microbe 3:316-322(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEPHOSPHORYLATION, PHOSPHORYLATION, INTERACTION WITH MYCOBACTERIUM TUBERCULOSIS PTPA, MUTAGENESIS OF TYR-133; TYR-382; TYR-511 AND TYR-517, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    9. Cited for: INTERACTION WITH RAB11A AND VIPAS39, CHARACTERIZATION OF VARIANT ARCS1 PRO-30, SUBCELLULAR LOCATION.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: VARIANT ARCS1 PRO-30, SUBCELLULAR LOCATION.
    12. Cited for: VARIANT ARCS1 PHE-243.

    Entry informationi

    Entry nameiVP33B_HUMAN
    AccessioniPrimary (citable) accession number: Q9H267
    Secondary accession number(s): B3KQF6
    , Q96K14, Q9NRP6, Q9NSF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3