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Q9H257

- CARD9_HUMAN

UniProt

Q9H257 - CARD9_HUMAN

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Protein

Caspase recruitment domain-containing protein 9

Gene

CARD9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B By similarity. Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A (dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper (TH-17) cells.By similarity1 Publication

GO - Molecular functioni

  1. CARD domain binding Source: UniProtKB
  2. protein homodimerization activity Source: UniProtKB

GO - Biological processi

  1. defense response to Gram-positive bacterium Source: Ensembl
  2. defense response to virus Source: Ensembl
  3. innate immune response Source: Reactome
  4. nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Source: Reactome
  5. nucleotide-binding oligomerization domain containing signaling pathway Source: Reactome
  6. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  7. positive regulation of interleukin-6 production Source: Ensembl
  8. positive regulation of JNK cascade Source: MGI
  9. positive regulation of stress-activated MAPK cascade Source: MGI
  10. positive regulation of tumor necrosis factor production Source: Ensembl
  11. regulation of apoptotic process Source: InterPro
  12. regulation of interleukin-2 biosynthetic process Source: Ensembl
  13. regulation of interleukin-6 biosynthetic process Source: Ensembl
  14. regulation of tumor necrosis factor biosynthetic process Source: Ensembl
  15. response to drug Source: Ensembl
  16. response to exogenous dsRNA Source: Ensembl
  17. response to fungus Source: Ensembl
  18. response to muramyl dipeptide Source: Ensembl
  19. response to peptidoglycan Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_75776. NOD1/2 Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 9
Short name:
hCARD9
Gene namesi
Name:CARD9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:16391. CARD9.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Candidiasis, familial, 2 (CANDF2) [MIM:212050]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.3 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry. Defects induce reduced numbers of CD4+ Th17 lymphocytes as well as a lack of monocyte-derived cytokines in response to Candida strains. Neutrophils show a selective Candida albicans killing defect with abnormal ultrastructural phagolysosomes and outgrowth of hyphae (PubMed:23335372).1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti72 – 721G → S in CANDF2; loss of protein expression. 1 Publication
VAR_070828
Natural varianti101 – 1011R → C in CANDF2. 1 Publication
VAR_070829
Natural varianti373 – 3731R → P in CANDF2; loss of protein expression. 1 Publication
VAR_070830

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi212050. phenotype.
Orphaneti1334. Chronic mucocutaneous candidosis.
397587. Deep dermatophytosis.
PharmGKBiPA26077.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 536536Caspase recruitment domain-containing protein 9PRO_0000144082Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei460 – 4601Phosphoserine1 Publication
Modified residuei531 – 5311Phosphothreonine; by CK2By similarity
Modified residuei533 – 5331Phosphothreonine; by CK2By similarity

Post-translational modificationi

Phosphorylated at Thr-531 and Thr-533 by CK2 following interaction with VHL, leading to inhibit the ability to activate NF-kappa-B.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H257.
PaxDbiQ9H257.
PRIDEiQ9H257.

PTM databases

PhosphoSiteiQ9H257.

Expressioni

Tissue specificityi

Highly expressed in spleen. Also detected in liver, placenta, lung, peripheral blood leukocytes and in brain.

Gene expression databases

BgeeiQ9H257.
CleanExiHS_CARD9.
GenevestigatoriQ9H257.

Interactioni

Subunit structurei

Interacts with NOD2 and RIPK2. Interacts with VHL; without leading to protein degradation By similarity. Self-associates. Interacts (via CARD domain) with BCL10 (via CARD domain).By similarity1 Publication

Protein-protein interaction databases

BioGridi122094. 11 interactions.
IntActiQ9H257. 6 interactions.
STRINGi9606.ENSP00000360797.

Structurei

3D structure databases

ProteinModelPortaliQ9H257.
SMRiQ9H257. Positions 11-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 9893CARDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili117 – 277161Sequence AnalysisAdd
BLAST
Coiled coili332 – 41988Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 CARD domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG243105.
GeneTreeiENSGT00530000063108.
HOGENOMiHOG000231538.
HOVERGENiHBG058091.
InParanoidiQ9H257.
KOiK12794.
OMAiQLLMSEV.
OrthoDBiEOG747PH5.
PhylomeDBiQ9H257.
TreeFamiTF351139.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H257-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDYENDDEC WSVLEGFRVT LTSVIDPSRI TPYLRQCKVL NPDDEEQVLS
60 70 80 90 100
DPNLVIRKRK VGVLLDILQR TGHKGYVAFL ESLELYYPQL YKKVTGKEPA
110 120 130 140 150
RVFSMIIDAS GESGLTQLLM TEVMKLQKKV QDLTALLSSK DDFIKELRVK
160 170 180 190 200
DSLLRKHQER VQRLKEECEA GSRELKRCKE ENYDLAMRLA HQSEEKGAAL
210 220 230 240 250
MRNRDLQLEI DQLKHSLMKA EDDCKVERKH TLKLRHAMEQ RPSQELLWEL
260 270 280 290 300
QQEKALLQAR VQELEASVQE GKLDRSSPYI QVLEEDWRQA LRDHQEQANT
310 320 330 340 350
IFSLRKDLRQ GEARRLRCME EKEMFELQCL ALRKDSKMYK DRIEAILLQM
360 370 380 390 400
EEVAIERDQA IATREELHAQ HARGLQEKDA LRKQVRELGE KADELQLQVF
410 420 430 440 450
QCEAQLLAVE GRLRRQQLET LVLSSDLEDG SPRRSQELSL PQDLEDTQLS
460 470 480 490 500
DKGCLAGGGS PKQPFAALHQ EQVLRNPHDA GLSSGEPPEK ERRRLKESFE
510 520 530
NYRRKRALRK MQKGWRQGEE DRENTTGSDN TDTEGS
Length:536
Mass (Da):62,241
Last modified:April 3, 2007 - v2
Checksum:i6EB18353112F2BAC
GO
Isoform 2 (identifier: Q9H257-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     482-492: LSSGEPPEKER → PAGLPGIGAVC
     493-536: Missing.

Note: No experimental confirmation available.

Show »
Length:492
Mass (Da):56,667
Checksum:iAADBCF6A5E81125F
GO
Isoform 3 (identifier: Q9H257-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-366: AIATREE → STQMEGL
     367-536: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:366
Mass (Da):42,953
Checksum:iEC1CB0ABCF6C7CF4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121S → N.2 Publications
Corresponds to variant rs4077515 [ dbSNP | Ensembl ].
VAR_048607
Natural varianti72 – 721G → S in CANDF2; loss of protein expression. 1 Publication
VAR_070828
Natural varianti101 – 1011R → C in CANDF2. 1 Publication
VAR_070829
Natural varianti373 – 3731R → P in CANDF2; loss of protein expression. 1 Publication
VAR_070830

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei360 – 3667AIATREE → STQMEGL in isoform 3. 1 PublicationVSP_024390
Alternative sequencei367 – 536170Missing in isoform 3. 1 PublicationVSP_024391Add
BLAST
Alternative sequencei482 – 49211LSSGEPPEKER → PAGLPGIGAVC in isoform 2. 1 PublicationVSP_024392Add
BLAST
Alternative sequencei493 – 53644Missing in isoform 2. 1 PublicationVSP_024393Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF311287 mRNA. Translation: AAG28790.1.
AK024001 mRNA. Translation: BAB14766.1.
AK292081 mRNA. Translation: BAF84770.1.
AL592301 Genomic DNA. Translation: CAI13931.1.
AL592301 Genomic DNA. Translation: CAI13932.1.
CH471090 Genomic DNA. Translation: EAW88220.1.
BC008877 mRNA. Translation: AAH08877.1.
CCDSiCCDS48057.1. [Q9H257-2]
CCDS6997.1. [Q9H257-1]
RefSeqiNP_434700.2. NM_052813.4. [Q9H257-1]
NP_434701.1. NM_052814.3. [Q9H257-2]
UniGeneiHs.694071.

Genome annotation databases

EnsembliENST00000371732; ENSP00000360797; ENSG00000187796. [Q9H257-1]
ENST00000371734; ENSP00000360799; ENSG00000187796. [Q9H257-2]
ENST00000489932; ENSP00000451368; ENSG00000187796. [Q9H257-3]
GeneIDi64170.
KEGGihsa:64170.
UCSCiuc004chg.3. human. [Q9H257-1]
uc010nbj.2. human. [Q9H257-3]
uc022bpo.1. human. [Q9H257-2]

Polymorphism databases

DMDMi143811370.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF311287 mRNA. Translation: AAG28790.1 .
AK024001 mRNA. Translation: BAB14766.1 .
AK292081 mRNA. Translation: BAF84770.1 .
AL592301 Genomic DNA. Translation: CAI13931.1 .
AL592301 Genomic DNA. Translation: CAI13932.1 .
CH471090 Genomic DNA. Translation: EAW88220.1 .
BC008877 mRNA. Translation: AAH08877.1 .
CCDSi CCDS48057.1. [Q9H257-2 ]
CCDS6997.1. [Q9H257-1 ]
RefSeqi NP_434700.2. NM_052813.4. [Q9H257-1 ]
NP_434701.1. NM_052814.3. [Q9H257-2 ]
UniGenei Hs.694071.

3D structure databases

ProteinModelPortali Q9H257.
SMRi Q9H257. Positions 11-98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122094. 11 interactions.
IntActi Q9H257. 6 interactions.
STRINGi 9606.ENSP00000360797.

PTM databases

PhosphoSitei Q9H257.

Polymorphism databases

DMDMi 143811370.

Proteomic databases

MaxQBi Q9H257.
PaxDbi Q9H257.
PRIDEi Q9H257.

Protocols and materials databases

DNASUi 64170.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371732 ; ENSP00000360797 ; ENSG00000187796 . [Q9H257-1 ]
ENST00000371734 ; ENSP00000360799 ; ENSG00000187796 . [Q9H257-2 ]
ENST00000489932 ; ENSP00000451368 ; ENSG00000187796 . [Q9H257-3 ]
GeneIDi 64170.
KEGGi hsa:64170.
UCSCi uc004chg.3. human. [Q9H257-1 ]
uc010nbj.2. human. [Q9H257-3 ]
uc022bpo.1. human. [Q9H257-2 ]

Organism-specific databases

CTDi 64170.
GeneCardsi GC09M139259.
HGNCi HGNC:16391. CARD9.
MIMi 212050. phenotype.
607212. gene.
neXtProti NX_Q9H257.
Orphaneti 1334. Chronic mucocutaneous candidosis.
397587. Deep dermatophytosis.
PharmGKBi PA26077.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG243105.
GeneTreei ENSGT00530000063108.
HOGENOMi HOG000231538.
HOVERGENi HBG058091.
InParanoidi Q9H257.
KOi K12794.
OMAi QLLMSEV.
OrthoDBi EOG747PH5.
PhylomeDBi Q9H257.
TreeFami TF351139.

Enzyme and pathway databases

Reactomei REACT_75776. NOD1/2 Signaling Pathway.

Miscellaneous databases

GeneWikii CARD9.
GenomeRNAii 64170.
NextBioi 66079.
PROi Q9H257.
SOURCEi Search...

Gene expression databases

Bgeei Q9H257.
CleanExi HS_CARD9.
Genevestigatori Q9H257.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
InterProi IPR001315. CARD.
IPR011029. DEATH-like_dom.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50209. CARD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CARD9 is a novel caspase recruitment domain-containing protein that interacts with Bcl10/CLAP and activates NF-kappa B."
    Bertin J., Guo Y., Wang L., Srinivasula S.M., Jacobson M.D., Poyet J.-L., Merriam S., Du M.-Q., Dyer M.J.S., Robison K.E., DiStefano P.S., Alnemri E.S.
    J. Biol. Chem. 275:41082-41086(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASN-12, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BCL10.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ASN-12.
    Tissue: Retinoblastoma and Synovium.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Muscle.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  7. Cited for: INVOLVEMENT IN CANDF2.
  8. Cited for: VARIANTS CANDF2 SER-72 AND PRO-373.
  9. Cited for: VARIANT CANDF2 CYS-101.

Entry informationi

Entry nameiCARD9_HUMAN
AccessioniPrimary (citable) accession number: Q9H257
Secondary accession number(s): Q5SXM5, Q5SXM6, Q9H854
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: April 3, 2007
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3