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Q9H257

- CARD9_HUMAN

UniProt

Q9H257 - CARD9_HUMAN

Protein

Caspase recruitment domain-containing protein 9

Gene

CARD9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B By similarity. Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A (dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper (TH-17) cells.By similarity1 Publication

    GO - Molecular functioni

    1. CARD domain binding Source: UniProtKB
    2. protein homodimerization activity Source: UniProtKB

    GO - Biological processi

    1. defense response to Gram-positive bacterium Source: Ensembl
    2. defense response to virus Source: Ensembl
    3. innate immune response Source: Reactome
    4. nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Source: Reactome
    5. nucleotide-binding oligomerization domain containing signaling pathway Source: Reactome
    6. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    7. positive regulation of interleukin-6 production Source: Ensembl
    8. positive regulation of JNK cascade Source: MGI
    9. positive regulation of stress-activated MAPK cascade Source: MGI
    10. positive regulation of tumor necrosis factor production Source: Ensembl
    11. regulation of apoptotic process Source: InterPro
    12. regulation of interleukin-2 biosynthetic process Source: Ensembl
    13. regulation of interleukin-6 biosynthetic process Source: Ensembl
    14. regulation of tumor necrosis factor biosynthetic process Source: Ensembl
    15. response to drug Source: Ensembl
    16. response to exogenous dsRNA Source: Ensembl
    17. response to fungus Source: Ensembl
    18. response to muramyl dipeptide Source: Ensembl
    19. response to peptidoglycan Source: Ensembl

    Keywords - Biological processi

    Immunity, Innate immunity

    Enzyme and pathway databases

    ReactomeiREACT_75776. NOD1/2 Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caspase recruitment domain-containing protein 9
    Short name:
    hCARD9
    Gene namesi
    Name:CARD9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:16391. CARD9.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Involvement in diseasei

    Candidiasis, familial, 2 (CANDF2) [MIM:212050]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.3 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry. Defects induce reduced numbers of CD4+ Th17 lymphocytes as well as a lack of monocyte-derived cytokines in response to Candida strains. Neutrophils show a selective Candida albicans killing defect with abnormal ultrastructural phagolysosomes and outgrowth of hyphae (PubMed:23335372).1 Publication
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti72 – 721G → S in CANDF2; loss of protein expression. 1 Publication
    VAR_070828
    Natural varianti101 – 1011R → C in CANDF2. 1 Publication
    VAR_070829
    Natural varianti373 – 3731R → P in CANDF2; loss of protein expression. 1 Publication
    VAR_070830

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi212050. phenotype.
    Orphaneti1334. Chronic mucocutaneous candidiasis.
    397587. Deep dermatophytosis.
    PharmGKBiPA26077.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 536536Caspase recruitment domain-containing protein 9PRO_0000144082Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei460 – 4601Phosphoserine1 Publication
    Modified residuei531 – 5311Phosphothreonine; by CK2By similarity
    Modified residuei533 – 5331Phosphothreonine; by CK2By similarity

    Post-translational modificationi

    Phosphorylated at Thr-531 and Thr-533 by CK2 following interaction with VHL, leading to inhibit the ability to activate NF-kappa-B.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9H257.
    PaxDbiQ9H257.
    PRIDEiQ9H257.

    PTM databases

    PhosphoSiteiQ9H257.

    Expressioni

    Tissue specificityi

    Highly expressed in spleen. Also detected in liver, placenta, lung, peripheral blood leukocytes and in brain.

    Gene expression databases

    BgeeiQ9H257.
    CleanExiHS_CARD9.
    GenevestigatoriQ9H257.

    Interactioni

    Subunit structurei

    Interacts with NOD2 and RIPK2. Interacts with VHL; without leading to protein degradation By similarity. Self-associates. Interacts (via CARD domain) with BCL10 (via CARD domain).By similarity1 Publication

    Protein-protein interaction databases

    BioGridi122094. 6 interactions.
    IntActiQ9H257. 6 interactions.
    STRINGi9606.ENSP00000360797.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H257.
    SMRiQ9H257. Positions 11-98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 9893CARDPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili117 – 277161Sequence AnalysisAdd
    BLAST
    Coiled coili332 – 41988Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CARD domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG243105.
    HOGENOMiHOG000231538.
    HOVERGENiHBG058091.
    InParanoidiQ9H257.
    KOiK12794.
    OMAiQLLMSEV.
    OrthoDBiEOG747PH5.
    PhylomeDBiQ9H257.
    TreeFamiTF351139.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    InterProiIPR001315. CARD.
    IPR011029. DEATH-like_dom.
    [Graphical view]
    PfamiPF00619. CARD. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50209. CARD. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H257-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDYENDDEC WSVLEGFRVT LTSVIDPSRI TPYLRQCKVL NPDDEEQVLS    50
    DPNLVIRKRK VGVLLDILQR TGHKGYVAFL ESLELYYPQL YKKVTGKEPA 100
    RVFSMIIDAS GESGLTQLLM TEVMKLQKKV QDLTALLSSK DDFIKELRVK 150
    DSLLRKHQER VQRLKEECEA GSRELKRCKE ENYDLAMRLA HQSEEKGAAL 200
    MRNRDLQLEI DQLKHSLMKA EDDCKVERKH TLKLRHAMEQ RPSQELLWEL 250
    QQEKALLQAR VQELEASVQE GKLDRSSPYI QVLEEDWRQA LRDHQEQANT 300
    IFSLRKDLRQ GEARRLRCME EKEMFELQCL ALRKDSKMYK DRIEAILLQM 350
    EEVAIERDQA IATREELHAQ HARGLQEKDA LRKQVRELGE KADELQLQVF 400
    QCEAQLLAVE GRLRRQQLET LVLSSDLEDG SPRRSQELSL PQDLEDTQLS 450
    DKGCLAGGGS PKQPFAALHQ EQVLRNPHDA GLSSGEPPEK ERRRLKESFE 500
    NYRRKRALRK MQKGWRQGEE DRENTTGSDN TDTEGS 536
    Length:536
    Mass (Da):62,241
    Last modified:April 3, 2007 - v2
    Checksum:i6EB18353112F2BAC
    GO
    Isoform 2 (identifier: Q9H257-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         482-492: LSSGEPPEKER → PAGLPGIGAVC
         493-536: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:492
    Mass (Da):56,667
    Checksum:iAADBCF6A5E81125F
    GO
    Isoform 3 (identifier: Q9H257-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         360-366: AIATREE → STQMEGL
         367-536: Missing.

    Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:366
    Mass (Da):42,953
    Checksum:iEC1CB0ABCF6C7CF4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti12 – 121S → N.2 Publications
    Corresponds to variant rs4077515 [ dbSNP | Ensembl ].
    VAR_048607
    Natural varianti72 – 721G → S in CANDF2; loss of protein expression. 1 Publication
    VAR_070828
    Natural varianti101 – 1011R → C in CANDF2. 1 Publication
    VAR_070829
    Natural varianti373 – 3731R → P in CANDF2; loss of protein expression. 1 Publication
    VAR_070830

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei360 – 3667AIATREE → STQMEGL in isoform 3. 1 PublicationVSP_024390
    Alternative sequencei367 – 536170Missing in isoform 3. 1 PublicationVSP_024391Add
    BLAST
    Alternative sequencei482 – 49211LSSGEPPEKER → PAGLPGIGAVC in isoform 2. 1 PublicationVSP_024392Add
    BLAST
    Alternative sequencei493 – 53644Missing in isoform 2. 1 PublicationVSP_024393Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF311287 mRNA. Translation: AAG28790.1.
    AK024001 mRNA. Translation: BAB14766.1.
    AK292081 mRNA. Translation: BAF84770.1.
    AL592301 Genomic DNA. Translation: CAI13931.1.
    AL592301 Genomic DNA. Translation: CAI13932.1.
    CH471090 Genomic DNA. Translation: EAW88220.1.
    BC008877 mRNA. Translation: AAH08877.1.
    CCDSiCCDS48057.1. [Q9H257-2]
    CCDS6997.1. [Q9H257-1]
    RefSeqiNP_434700.2. NM_052813.4. [Q9H257-1]
    NP_434701.1. NM_052814.3. [Q9H257-2]
    UniGeneiHs.694071.

    Genome annotation databases

    EnsembliENST00000371732; ENSP00000360797; ENSG00000187796. [Q9H257-1]
    ENST00000371734; ENSP00000360799; ENSG00000187796. [Q9H257-2]
    ENST00000489932; ENSP00000451368; ENSG00000187796. [Q9H257-3]
    GeneIDi64170.
    KEGGihsa:64170.
    UCSCiuc004chg.3. human. [Q9H257-1]
    uc010nbj.2. human. [Q9H257-3]
    uc022bpo.1. human. [Q9H257-2]

    Polymorphism databases

    DMDMi143811370.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF311287 mRNA. Translation: AAG28790.1 .
    AK024001 mRNA. Translation: BAB14766.1 .
    AK292081 mRNA. Translation: BAF84770.1 .
    AL592301 Genomic DNA. Translation: CAI13931.1 .
    AL592301 Genomic DNA. Translation: CAI13932.1 .
    CH471090 Genomic DNA. Translation: EAW88220.1 .
    BC008877 mRNA. Translation: AAH08877.1 .
    CCDSi CCDS48057.1. [Q9H257-2 ]
    CCDS6997.1. [Q9H257-1 ]
    RefSeqi NP_434700.2. NM_052813.4. [Q9H257-1 ]
    NP_434701.1. NM_052814.3. [Q9H257-2 ]
    UniGenei Hs.694071.

    3D structure databases

    ProteinModelPortali Q9H257.
    SMRi Q9H257. Positions 11-98.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122094. 6 interactions.
    IntActi Q9H257. 6 interactions.
    STRINGi 9606.ENSP00000360797.

    PTM databases

    PhosphoSitei Q9H257.

    Polymorphism databases

    DMDMi 143811370.

    Proteomic databases

    MaxQBi Q9H257.
    PaxDbi Q9H257.
    PRIDEi Q9H257.

    Protocols and materials databases

    DNASUi 64170.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371732 ; ENSP00000360797 ; ENSG00000187796 . [Q9H257-1 ]
    ENST00000371734 ; ENSP00000360799 ; ENSG00000187796 . [Q9H257-2 ]
    ENST00000489932 ; ENSP00000451368 ; ENSG00000187796 . [Q9H257-3 ]
    GeneIDi 64170.
    KEGGi hsa:64170.
    UCSCi uc004chg.3. human. [Q9H257-1 ]
    uc010nbj.2. human. [Q9H257-3 ]
    uc022bpo.1. human. [Q9H257-2 ]

    Organism-specific databases

    CTDi 64170.
    GeneCardsi GC09M139259.
    HGNCi HGNC:16391. CARD9.
    MIMi 212050. phenotype.
    607212. gene.
    neXtProti NX_Q9H257.
    Orphaneti 1334. Chronic mucocutaneous candidiasis.
    397587. Deep dermatophytosis.
    PharmGKBi PA26077.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG243105.
    HOGENOMi HOG000231538.
    HOVERGENi HBG058091.
    InParanoidi Q9H257.
    KOi K12794.
    OMAi QLLMSEV.
    OrthoDBi EOG747PH5.
    PhylomeDBi Q9H257.
    TreeFami TF351139.

    Enzyme and pathway databases

    Reactomei REACT_75776. NOD1/2 Signaling Pathway.

    Miscellaneous databases

    GeneWikii CARD9.
    NextBioi 66079.
    PROi Q9H257.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H257.
    CleanExi HS_CARD9.
    Genevestigatori Q9H257.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    InterProi IPR001315. CARD.
    IPR011029. DEATH-like_dom.
    [Graphical view ]
    Pfami PF00619. CARD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50209. CARD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CARD9 is a novel caspase recruitment domain-containing protein that interacts with Bcl10/CLAP and activates NF-kappa B."
      Bertin J., Guo Y., Wang L., Srinivasula S.M., Jacobson M.D., Poyet J.-L., Merriam S., Du M.-Q., Dyer M.J.S., Robison K.E., DiStefano P.S., Alnemri E.S.
      J. Biol. Chem. 275:41082-41086(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASN-12, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH BCL10.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ASN-12.
      Tissue: Retinoblastoma and Synovium.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Muscle.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-460, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    7. Cited for: INVOLVEMENT IN CANDF2.
    8. Cited for: VARIANTS CANDF2 SER-72 AND PRO-373.
    9. Cited for: VARIANT CANDF2 CYS-101.

    Entry informationi

    Entry nameiCARD9_HUMAN
    AccessioniPrimary (citable) accession number: Q9H257
    Secondary accession number(s): Q5SXM5, Q5SXM6, Q9H854
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3