Reviewed, UniProtKB/Swiss-Prot Q9H255 (O51E2_HUMAN)

Names and origin

Protein names

Recommended name:
    Olfactory receptor 51E2
Alternative name(s):
    Olfactory receptor OR11-16
    Prostate-specific G-protein coupled receptor
    HPRAJ

Gene names

Name:	OR51E2
Synonyms:	PSGR

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Exclusively expressed in the prostate. Up-regulated in prostate cancers. Ref.7
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of smell Non-traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Non-traceable author statement. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	olfactory receptor activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 320	320	Olfactory receptor 51E2		PRO_0000150751
Regions
	Topological domain	1 – 24	24	Extracellular Potential
	Transmembrane	25 – 45	21	1 Potential
	Topological domain	46 – 53	8	Cytoplasmic Potential
	Transmembrane	54 – 74	21	2 Potential
	Topological domain	75 – 98	24	Extracellular Potential
	Transmembrane	99 – 119	21	3 Potential
	Topological domain	120 – 138	19	Cytoplasmic Potential
	Transmembrane	139 – 159	21	4 Potential
	Topological domain	160 – 195	36	Extracellular Potential
	Transmembrane	196 – 216	21	5 Potential
	Topological domain	217 – 236	20	Cytoplasmic Potential
	Transmembrane	237 – 257	21	6 Potential
	Topological domain	258 – 272	15	Extracellular Potential
	Transmembrane	273 – 293	21	7 Potential
	Topological domain	294 – 320	27	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	96 ↔ 178		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9H255-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 03582CC2AAB6E2C6	FASTA	320	35,493
	10 20 30 40 50 60 MSSCNFTHAT FVLIGIPGLE KAHFWVGFPL LSMYVVAMFG NCIVVFIVRT ERSLHAPMYL 70 80 90 100 110 120 FLCMLAAIDL ALSTSTMPKI LALFWFDSRE ISFEACLTQM FFIHALSAIE STILLAMAFD 130 140 150 160 170 180 RYVAICHPLR HAAVLNNTVT AQIGIVAVVR GSLFFFPLPL LIKRLAFCHS NVLSHSYCVH 190 200 210 220 230 240 QDVMKLAYAD TLPNVVYGLT AILLVMGVDV MFISLSYFLI IRTVLQLPSK SERAKAFGTC 250 260 270 280 290 300 VSHIGVVLAF YVPLIGLSVV HRFGNSLHPI VRVVMGDIYL LLPPVINPII YGAKTKQIRT 310 320 RVLAMFKISC DKDLQAVGGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer." Xu L.L., Stackhouse B.G., Florence K., Zhang W., Shanmugam N., Sesterhenn I.A., Zou Z., Srikantan V., Augustus M., Roschke V., Carter K., McLeod D.G., Moul J.W., Soppet D., Srivastava S. Cancer Res. 60:6568-6572(2000) [PubMed: 11118034] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Identification of a prostate-specific G-protein coupled receptor (PSGR) that interacts with G alpha subunit in yeast two hybrid assay." Xia C., Ma W., Liu M. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning and genetic characterization of an evolutionarily conserved human olfactory receptor that is differentially expressed across species." Yuan T.T., Toy P., McClary J.A., Lin R.J., Miyamoto N.G., Kretschmer P.J. Gene 278:41-51(2001) [PubMed: 11707321] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[5]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed: 14983052] [Abstract] Cited for: IDENTIFICATION.
[6]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
[7]	"The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase." Wang J., Weng J., Cai Y., Penland R., Liu M., Ittmann M. Prostate 66:847-857(2006) [PubMed: 16491480] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF311306 Genomic DNA. Translation: AAG40776.1. AF369708 mRNA. Translation: AAK38728.1. AY033942 mRNA. Translation: AAK57550.1. BC020768 mRNA. Translation: AAH20768.1. BK004368 Genomic DNA. Translation: DAA04766.1.
IPI	IPI00022441.
RefSeq	NP_110401.1.
UniGene	Hs.501758 Hs.606330
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	Q9H255.
Genome annotation databases
Ensembl	ENSG00000167332. Homo sapiens. [Contig view]
GeneID	81285.
KEGG	hsa:81285.
Organism-specific databases
GeneCards	GC11M004657.
H-InvDB	HIX0009385.
HGNC	HGNC:15195. OR51E2.
MIM	611268. gene.
PharmGKB	PA32372.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9H255.
HOVERGEN	Q9H255.
Gene expression databases
ArrayExpress	Q9H255.
Bgee	Q9H255.
CleanEx	HS_OR51E2.
GermOnline	ENSG00000167332. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR11398. Olfact_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	71556.
SOURCE	Search...

Entry information

Entry name

O51E2_HUMAN

Accession

Primary (citable) accession number: Q9H255
Secondary accession number(s): Q6IF94

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2001
Last sequence update:	March 1, 2001
Last modified:	June 16, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)