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Protein

Olfactory receptor 51E2

Gene

OR51E2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probable G protein-coupled receptor that is activated by the short chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). May also function as an olfactory receptor being activated by beta-ionone (PubMed:19389702).2 Publications

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: UniProtKB
  • signaling receptor activity Source: UniProtKB
  • steroid hormone receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51E2
Alternative name(s):
HPRAJ
Olfactory receptor OR11-16
Prostate-specific G-protein coupled receptor
Gene namesi
Name:OR51E2
Synonyms:PSGR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15195. OR51E2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence analysisAdd
BLAST
Transmembranei25 – 4521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini46 – 538CytoplasmicSequence analysis
Transmembranei54 – 7421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini75 – 9824ExtracellularSequence analysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence analysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini160 – 19536ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini217 – 23620CytoplasmicSequence analysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini258 – 27215ExtracellularSequence analysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini294 – 32027CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32372.

Polymorphism and mutation databases

BioMutaiOR51E2.
DMDMi18202936.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Olfactory receptor 51E2PRO_0000150751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi96 ↔ 178PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H255.
PeptideAtlasiQ9H255.
PRIDEiQ9H255.

PTM databases

PhosphoSiteiQ9H255.

Expressioni

Tissue specificityi

Mainly expressed in the prostate. Also expressed in spleen, liver, olfactory epithelium and medulla oblongata.2 Publications

Gene expression databases

BgeeiQ9H255.
CleanExiHS_OR51E2.
ExpressionAtlasiQ9H255. baseline and differential.
GenevisibleiQ9H255. HS.

Interactioni

Protein-protein interaction databases

BioGridi123434. 9 interactions.
STRINGi9606.ENSP00000380153.

Structurei

3D structure databases

ProteinModelPortaliQ9H255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGD6. Eukaryota.
ENOG41120HT. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H255.
KOiK04257.
OMAiHFWFGFP.
OrthoDBiEOG754HPV.
PhylomeDBiQ9H255.
TreeFamiTF342735.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSCNFTHAT FVLIGIPGLE KAHFWVGFPL LSMYVVAMFG NCIVVFIVRT
60 70 80 90 100
ERSLHAPMYL FLCMLAAIDL ALSTSTMPKI LALFWFDSRE ISFEACLTQM
110 120 130 140 150
FFIHALSAIE STILLAMAFD RYVAICHPLR HAAVLNNTVT AQIGIVAVVR
160 170 180 190 200
GSLFFFPLPL LIKRLAFCHS NVLSHSYCVH QDVMKLAYAD TLPNVVYGLT
210 220 230 240 250
AILLVMGVDV MFISLSYFLI IRTVLQLPSK SERAKAFGTC VSHIGVVLAF
260 270 280 290 300
YVPLIGLSVV HRFGNSLHPI VRVVMGDIYL LLPPVINPII YGAKTKQIRT
310 320
RVLAMFKISC DKDLQAVGGK
Length:320
Mass (Da):35,493
Last modified:March 1, 2001 - v1
Checksum:i03582CC2AAB6E2C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311306 Genomic DNA. Translation: AAG40776.1.
AF369708 mRNA. Translation: AAK38728.1.
AY033942 mRNA. Translation: AAK57550.1.
AK314051 mRNA. Translation: BAG36760.1.
CH471064 Genomic DNA. Translation: EAW68829.1.
BC020768 mRNA. Translation: AAH20768.1.
BK004368 Genomic DNA. Translation: DAA04766.1.
CCDSiCCDS7751.1.
RefSeqiNP_110401.1. NM_030774.3.
UniGeneiHs.501758.
Hs.606330.

Genome annotation databases

EnsembliENST00000396950; ENSP00000380153; ENSG00000167332.
GeneIDi81285.
KEGGihsa:81285.
UCSCiuc001lzk.3. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311306 Genomic DNA. Translation: AAG40776.1.
AF369708 mRNA. Translation: AAK38728.1.
AY033942 mRNA. Translation: AAK57550.1.
AK314051 mRNA. Translation: BAG36760.1.
CH471064 Genomic DNA. Translation: EAW68829.1.
BC020768 mRNA. Translation: AAH20768.1.
BK004368 Genomic DNA. Translation: DAA04766.1.
CCDSiCCDS7751.1.
RefSeqiNP_110401.1. NM_030774.3.
UniGeneiHs.501758.
Hs.606330.

3D structure databases

ProteinModelPortaliQ9H255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123434. 9 interactions.
STRINGi9606.ENSP00000380153.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9H255.

Polymorphism and mutation databases

BioMutaiOR51E2.
DMDMi18202936.

Proteomic databases

PaxDbiQ9H255.
PeptideAtlasiQ9H255.
PRIDEiQ9H255.

Protocols and materials databases

DNASUi81285.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396950; ENSP00000380153; ENSG00000167332.
GeneIDi81285.
KEGGihsa:81285.
UCSCiuc001lzk.3. human.

Organism-specific databases

CTDi81285.
GeneCardsiOR51E2.
H-InvDBHIX0171324.
HGNCiHGNC:15195. OR51E2.
MIMi611268. gene.
neXtProtiNX_Q9H255.
PharmGKBiPA32372.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGD6. Eukaryota.
ENOG41120HT. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ9H255.
KOiK04257.
OMAiHFWFGFP.
OrthoDBiEOG754HPV.
PhylomeDBiQ9H255.
TreeFamiTF342735.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

ChiTaRSiOR51E2. human.
GeneWikiiOR51E2.
GenomeRNAii81285.
PROiQ9H255.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H255.
CleanExiHS_OR51E2.
ExpressionAtlasiQ9H255. baseline and differential.
GenevisibleiQ9H255. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer."
    Xu L.L., Stackhouse B.G., Florence K., Zhang W., Shanmugam N., Sesterhenn I.A., Zou Z., Srikantan V., Augustus M., Roschke V., Carter K., McLeod D.G., Moul J.W., Soppet D., Srivastava S.
    Cancer Res. 60:6568-6572(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Identification of a prostate-specific G-protein coupled receptor (PSGR) that interacts with G alpha subunit in yeast two hybrid assay."
    Xia C., Ma W., Liu M.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning and genetic characterization of an evolutionarily conserved human olfactory receptor that is differentially expressed across species."
    Yuan T.T., Toy P., McClary J.A., Lin R.J., Miyamoto N.G., Kretschmer P.J.
    Gene 278:41-51(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  7. Cited for: IDENTIFICATION.
  8. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
  9. "The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase."
    Wang J., Weng J., Cai Y., Penland R., Liu M., Ittmann M.
    Prostate 66:847-857(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  10. "Activation of an olfactory receptor inhibits proliferation of prostate cancer cells."
    Neuhaus E.M., Zhang W., Gelis L., Deng Y., Noldus J., Hatt H.
    J. Biol. Chem. 284:16218-16225(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation."
    Pluznick J.L., Protzko R.J., Gevorgyan H., Peterlin Z., Sipos A., Han J., Brunet I., Wan L.X., Rey F., Wang T., Firestein S.J., Yanagisawa M., Gordon J.I., Eichmann A., Peti-Peterdi J., Caplan M.J.
    Proc. Natl. Acad. Sci. U.S.A. 110:4410-4415(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiO51E2_HUMAN
AccessioniPrimary (citable) accession number: Q9H255
Secondary accession number(s): B2RA63, Q6IF94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.