Q9H254 (SPTN4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Spectrin beta chain, non-erythrocytic 4

Alternative name(s):
Beta-IV spectrin
Spectrin, non-erythroid beta chain 3

Gene names

Name:	SPTBN4
Synonyms:	KIAA1642, SPTBN3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2564 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm › cytoskeleton By similarity. Cytoplasm › cell cortex By similarity.
Tissue specificity	Abundantly expressed in brain and pancreatic islets.
Sequence similarities	Belongs to the spectrin family. Contains 2 CH (calponin-homology) domains. Contains 1 PH domain. Contains 18 spectrin repeats.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	Actin-binding
Molecular function	Actin capping
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin filament capping Inferred from electronic annotation. Source: UniProtKB-KW adult walking behavior Inferred from sequence or structural similarity. Source: BHF-UCL axon guidance Traceable author statement. Source: Reactome cardiac conduction Inferred from sequence or structural similarity. Source: BHF-UCL central nervous system projection neuron axonogenesis Inferred from sequence or structural similarity. Source: BHF-UCL clustering of voltage-gated sodium channels Inferred from sequence or structural similarity. Source: BHF-UCL cytoskeletal anchoring at plasma membrane Traceable author statement Ref.2. Source: UniProtKB establishment of protein localization to plasma membrane Inferred from sequence or structural similarity. Source: BHF-UCL fertilization Inferred from electronic annotation. Source: Compara negative regulation of heart rate Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of multicellular organism growth Inferred from electronic annotation. Source: Compara regulation of peptidyl-serine phosphorylation Inferred from sequence or structural similarity. Source: BHF-UCL regulation of sodium ion transport Inferred from sequence or structural similarity. Source: BHF-UCL sensory perception of sound Inferred from sequence or structural similarity. Source: BHF-UCL transmission of nerve impulse Inferred from sequence or structural similarity. Source: BHF-UCL vesicle-mediated transport Traceable author statement Ref.1. Source: UniProtKB
Cellular_component	PML body Inferred from direct assay Ref.1. Source: UniProtKB adherens junction Inferred from sequence or structural similarity. Source: BHF-UCL axon hillock Inferred from sequence or structural similarity. Source: BHF-UCL axon initial segment Inferred from sequence or structural similarity. Source: BHF-UCL cell body fiber Inferred from sequence or structural similarity. Source: BHF-UCL cytosol Traceable author statement. Source: Reactome node of Ranvier Inferred from sequence or structural similarity. Source: BHF-UCL nuclear matrix Inferred from direct assay Ref.1. Source: UniProtKB plasma membrane Inferred from sequence or structural similarity. Source: BHF-UCL spectrin Inferred from direct assay Ref.2. Source: UniProtKB
Molecular_function	actin binding Traceable author statement Ref.2. Source: UniProtKB ankyrin binding Inferred from direct assay Ref.1. Source: UniProtKB phospholipid binding Inferred from electronic annotation. Source: InterPro spectrin binding Inferred from sequence or structural similarity. Source: BHF-UCL structural constituent of cytoskeleton Traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DISC1	Q9NRI5	3	EBI-308543,EBI-529989

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H254-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H254-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1287-1309: NQENQLRAQQWMQKLHDQLELQH → CLIIHPALLHPPWEPPYLPRSSS
     1310-2564: Missing.

Isoform 3 (identifier: Q9H254-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1257: Missing.
     1258-1286: AVQAAEGLLRQGNIYGEQAQEAVTRLLEK → MPHYPSCSSAPSLGTPIPPQIQQLEARHR

Isoform 4 (identifier: Q9H254-4)

The sequence of this isoform differs from the canonical sequence as follows:
     2113-2154: IEKIKAEQSK...APLLRPGGYE → PRREDHLNPG...KTARRDGTCL
     2155-2564: Missing.

Isoform 5 (identifier: Q9H254-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1324: Missing.
     1973-2002: DVSSVEVLMNYHQGLKTELEARVPELTTCQ → CPSSLLGLPASPWWPTPATPSPLTAPFSME
     2003-2564: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2564	2564	Spectrin beta chain, non-erythrocytic 4		PRO_0000073465
Regions
	Domain	1 – 282	282	Actin-binding
	Domain	61 – 165	105	CH 1
	Domain	180 – 282	103	CH 2
	Repeat	309 – 354	46	Spectrin 1
	Repeat	398 – 419	22	Spectrin 2
	Repeat	429 – 533	105	Spectrin 3
	Repeat	535 – 642	108	Spectrin 4
	Repeat	644 – 771	128	Spectrin 5
	Repeat	773 – 879	107	Spectrin 6
	Repeat	881 – 985	105	Spectrin 7
	Repeat	1019 – 1086	68	Spectrin 8
	Repeat	1088 – 1197	110	Spectrin 9
	Repeat	1199 – 1303	105	Spectrin 10
	Repeat	1305 – 1408	104	Spectrin 11
	Repeat	1410 – 1513	104	Spectrin 12
	Repeat	1515 – 1619	105	Spectrin 13
	Repeat	1621 – 1725	105	Spectrin 14
	Repeat	1727 – 1832	106	Spectrin 15
	Repeat	1834 – 1940	107	Spectrin 16
	Repeat	1942 – 2046	105	Spectrin 17
	Repeat	2048 – 2107	60	Spectrin 18
	Domain	2418 – 2527	110	PH
Natural variations
	Alternative sequence	1 – 1324	1324	Missing in isoform 5.		VSP_046383
	Alternative sequence	1 – 1257	1257	Missing in isoform 3.		VSP_000723
	Alternative sequence	1258 – 1286	29	AVQAA…RLLEK → MPHYPSCSSAPSLGTPIPPQ IQQLEARHR in isoform 3.		VSP_000724
	Alternative sequence	1287 – 1309	23	NQENQ…LELQH → CLIIHPALLHPPWEPPYLPR SSS in isoform 2.		VSP_000725
	Alternative sequence	1310 – 2564	1255	Missing in isoform 2.		VSP_000726
	Alternative sequence	1973 – 2002	30	DVSSV…LTTCQ → CPSSLLGLPASPWWPTPATP SPLTAPFSME in isoform 5.		VSP_046384
	Alternative sequence	2003 – 2564	562	Missing in isoform 5.		VSP_046385
	Alternative sequence	2113 – 2154	42	IEKIK…PGGYE → PRREDHLNPGVQDQPWQHTE KPSLPKPKANKEKTARRDGT CL in isoform 4.		VSP_000727
	Alternative sequence	2155 – 2564	410	Missing in isoform 4.		VSP_000728
	Natural variant	1331	1	G → S. Ref.1 Corresponds to variant rs814501 [ dbSNP | Ensembl ].		VAR_048632
Experimental info
	Sequence conflict	604 – 608	5	Missing in AAG38874. Ref.2
	Sequence conflict	604 – 608	5	Missing in AAF93171. Ref.2
	Sequence conflict	714	1	L → S in AAG38874. Ref.2
	Sequence conflict	714	1	L → S in AAF93171. Ref.2
	Sequence conflict	714	1	L → S in AAF93173. Ref.2
	Sequence conflict	1189	1	E → K in AAG38874. Ref.2
	Sequence conflict	1189	1	E → K in AAF93171. Ref.2
	Sequence conflict	1189	1	E → K in AAF93173. Ref.2
	Sequence conflict	1193	1	E → K in AAG38874. Ref.2
	Sequence conflict	1193	1	E → K in AAF93171. Ref.2
	Sequence conflict	1193	1	E → K in AAF93173. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 16, 2001. Version 2. Checksum: 52CDE7D11D601ECC	FASTA	2,564	288,985
	10 20 30 40 50 60 MAQVPGEVDN MEGLPAPNNN PAARWESPDR GWEREQPAAS TAAASLFECS RIKALADERE 70 80 90 100 110 120 AVQKKTFTKW VNSHLARVGC HIGDLYVDLR DGFVLTRLLE VLSGEQLPRP TRGRMRIHSL 130 140 150 160 170 180 ENVDKALQFL KEQRVHLENV GSHDIVDGNH RLTLGLVWTI ILRFQIQVIK IETEDNRETR 190 200 210 220 230 240 SAKDALLLWC QMKTAGYPEV NIQNFTTSWR DGLAFNALIH RHRPDLVDFS KLTKSNANYN 250 260 270 280 290 300 LQRAFRTAEQ HLGLARLLDP EDVNMEAPDE KSIITYVVSF YHYFSKMKAL AVEGKRIGKV 310 320 330 340 350 360 LDQVLEVGKI IERYEELAAE LLAWIHRTVG LISNQKFANS LSGVQQQLQA FTAYCTLEKP 370 380 390 400 410 420 VKFQEKGNLE VLLFSIQSKL RACNRRLFVP REGCGIWDID KAWGELEKAE HEREAALRAE 430 440 450 460 470 480 LIRQEKLELL AQRFDHKVAM RESWLNENQR LVSQDNFGYE LPAVEAAMKK HEAIEADIAA 490 500 510 520 530 540 YEERVQGVAE LAQALAAEGY YDIRRVAAQR DSVLRQWALL TGLVGARRTR LEQNLALQKV 550 560 570 580 590 600 FQEMVYMVDW MEEMQAQLLS RECGQHLVEA DDLLQKHGLL EGDIAAQSER VEALNAAALR 610 620 630 640 650 660 FSQLQGYQPC DPQVICNRVN HVHGCLAELQ EQAARRRAEL EASRSLWALL QELEEAESWA 670 680 690 700 710 720 RDKERLLEAA GGGGAAGAAG AAGTAGGAHD LSSTARLLAQ HKILQGELGG RRALLQQALR 730 740 750 760 770 780 CGEELVAAGG AVGPGADTVH LVGLAERAAS ARRRWQRLEE AAARRERRLQ EARALHQFGA 790 800 810 820 830 840 DLDGLLDWLR DAYRLAAAGD FGHDEASSRR LARQHRALTG EVEAHRGPVS GLRRQLATLG 850 860 870 880 890 900 GASGAGPLVV ALQVRVVEAE QLFAEVTEVA ALRRQWLRDA LAVYRMFGEV HACELWIGEK 910 920 930 940 950 960 EQWLLSMRVP DSLDDVEVVQ HRFESLDQEM NSLMGRVLDV NHTVQELVEG GHPSSDEVRS 970 980 990 1000 1010 1020 CQDHLNSRWN RIVELVEQRK EEMSAVLLVE NHVLEVAEVR AQVREKRRAV ESAPRAGGAL 1030 1040 1050 1060 1070 1080 QWRLSGLEAA LQALEPRQAA LLEEAALLAE RFPAQAARLH QGAEELGAEW GALASAAQAC 1090 1100 1110 1120 1130 1140 GEAVAAAGRL QRFLHDLDAF LDWLVRAQEA AGGSEGPLPN SLEEADALLA RHAALKEEVD 1150 1160 1170 1180 1190 1200 QREEDYARIV AASEALLAAD GAELGPGLAL DEWLPHLELG WHKLLGLWEA RREALVQAHI 1210 1220 1230 1240 1250 1260 YQLFLRDLRQ ALVVLRNQEM ALSGAELPGT VESVEEALKQ HRDFLTTMEL SQQKMQVAVQ 1270 1280 1290 1300 1310 1320 AAEGLLRQGN IYGEQAQEAV TRLLEKNQEN QLRAQQWMQK LHDQLELQHF LRDCHELDGW 1330 1340 1350 1360 1370 1380 IHEKMLMARD GTREDNHKLH KRWLRHQAFM AELAQNKEWL EKIEREGQQL MQEKPELAAS 1390 1400 1410 1420 1430 1440 VRKKLGEIRQ CWAELESTTQ AKARQLFEAS KADQLVQSFA ELDKKLLHME SQLQDVDPGG 1450 1460 1470 1480 1490 1500 DLATVNSQLK KLQSMESQVE EWYREVGELQ AQTAALPLEP ASKELVGERQ NAVGERLVRL 1510 1520 1530 1540 1550 1560 LEPLQERRRL LLASKELHQV AHDLDDELAW VQERLPLAMQ TERGNGLQAV QQHIKKNQGL 1570 1580 1590 1600 1610 1620 RREIQAHGPR LEEVLERAGA LASLRSPEAE AVRRGLEQLQ SAWAGLREAA ERRQQVLDAA 1630 1640 1650 1660 1670 1680 FQVEQYYFDV AEVEAWLGEQ ELLMMSEDKG KDEQSTLQLL KKHLQLEQGV ENYEESIAQL 1690 1700 1710 1720 1730 1740 SRQCRALLEM GHPDSEQISR RQSQVDRLYV ALKELGEERR VALEQQYWLY QLSRQVSELE 1750 1760 1770 1780 1790 1800 HWIAEKEVVA GSPELGQDFE HVSVLQEKFS EFASETGMAG RERLAAVNQM VDELIECGHT 1810 1820 1830 1840 1850 1860 AAATMAEWKD GLNEAWAELL ELMGTRAQLL AASRELHKFF SDARELQGQI EEKRRRLPRL 1870 1880 1890 1900 1910 1920 TTPPEPRPSA SSMQRTLRAF EHDLQLLVSQ VRQLQEGAAQ LRTVYAGEHA EAIASREQEV 1930 1940 1950 1960 1970 1980 LQGWKELLSA CEDARLHVSS TADALRFHSQ VRDLLSWMDG IASQIGAADK PRDVSSVEVL 1990 2000 2010 2020 2030 2040 MNYHQGLKTE LEARVPELTT CQELGRSLLL NKSAMADEIQ AQLDKLGTRK EEVSEKWDRH 2050 2060 2070 2080 2090 2100 WEWLQQMLEV HQFAQEAVVA DAWLTAQEPL LQSRELGSSV DEVEQLIRRH EAFRKAAAAW 2110 2120 2130 2140 2150 2160 EERFSSLRRL TTIEKIKAEQ SKQPPTPLLG RKFFGDPTEL AAKAAPLLRP GGYERGLEPL 2170 2180 2190 2200 2210 2220 ARRASDTLSA EVRTRVGYVR QELKPERLQP RIDRLPEIPG RVEPAALPAA PEDAAETPAT 2230 2240 2250 2260 2270 2280 PAAAEQVRPR PERQESADRA EELPRRRRPE RQESVDQSEE AARRRRPERQ ESAEHEAAHS 2290 2300 2310 2320 2330 2340 LTLGRYEQME RRRERRERRL ERQESSEQEM PIRGDLVKGK ATLADIVEQL QEKEAGPGLP 2350 2360 2370 2380 2390 2400 AGPSLPQPRE LPPGRLPNGL ELPERTPRPD RPRARDRPKP RRRPRPREGG EGGGSRRSRS 2410 2420 2430 2440 2450 2460 APAQGGSAPA PPPPPTHTVQ HEGFLLRKRE LDANRKSSNR SWVSLYCVLS KGELGFYKDS 2470 2480 2490 2500 2510 2520 KGPASGSTHG GEPLLSLHKA TSEVASDYKK KKHVFKLQTQ DGSEFLLQAK DEEEMNGWLE 2530 2540 2550 2560 AVASSVAEHA EIARWGQTLP TTSSTDEGNP KREGGDRRAS GRRK
	Isoform 2 [UniParc]. Checksum: 7EC61D92DAC5479C	FASTA	1,309	146,169
	10 20 30 40 50 60 MAQVPGEVDN MEGLPAPNNN PAARWESPDR GWEREQPAAS TAAASLFECS RIKALADERE 70 80 90 100 110 120 AVQKKTFTKW VNSHLARVGC HIGDLYVDLR DGFVLTRLLE VLSGEQLPRP TRGRMRIHSL 130 140 150 160 170 180 ENVDKALQFL KEQRVHLENV GSHDIVDGNH RLTLGLVWTI ILRFQIQVIK IETEDNRETR 190 200 210 220 230 240 SAKDALLLWC QMKTAGYPEV NIQNFTTSWR DGLAFNALIH RHRPDLVDFS KLTKSNANYN 250 260 270 280 290 300 LQRAFRTAEQ HLGLARLLDP EDVNMEAPDE KSIITYVVSF YHYFSKMKAL AVEGKRIGKV 310 320 330 340 350 360 LDQVLEVGKI IERYEELAAE LLAWIHRTVG LISNQKFANS LSGVQQQLQA FTAYCTLEKP 370 380 390 400 410 420 VKFQEKGNLE VLLFSIQSKL RACNRRLFVP REGCGIWDID KAWGELEKAE HEREAALRAE 430 440 450 460 470 480 LIRQEKLELL AQRFDHKVAM RESWLNENQR LVSQDNFGYE LPAVEAAMKK HEAIEADIAA 490 500 510 520 530 540 YEERVQGVAE LAQALAAEGY YDIRRVAAQR DSVLRQWALL TGLVGARRTR LEQNLALQKV 550 560 570 580 590 600 FQEMVYMVDW MEEMQAQLLS RECGQHLVEA DDLLQKHGLL EGDIAAQSER VEALNAAALR 610 620 630 640 650 660 FSQLQGYQPC DPQVICNRVN HVHGCLAELQ EQAARRRAEL EASRSLWALL QELEEAESWA 670 680 690 700 710 720 RDKERLLEAA GGGGAAGAAG AAGTAGGAHD LSSTARLLAQ HKILQGELGG RRALLQQALR 730 740 750 760 770 780 CGEELVAAGG AVGPGADTVH LVGLAERAAS ARRRWQRLEE AAARRERRLQ EARALHQFGA 790 800 810 820 830 840 DLDGLLDWLR DAYRLAAAGD FGHDEASSRR LARQHRALTG EVEAHRGPVS GLRRQLATLG 850 860 870 880 890 900 GASGAGPLVV ALQVRVVEAE QLFAEVTEVA ALRRQWLRDA LAVYRMFGEV HACELWIGEK 910 920 930 940 950 960 EQWLLSMRVP DSLDDVEVVQ HRFESLDQEM NSLMGRVLDV NHTVQELVEG GHPSSDEVRS 970 980 990 1000 1010 1020 CQDHLNSRWN RIVELVEQRK EEMSAVLLVE NHVLEVAEVR AQVREKRRAV ESAPRAGGAL 1030 1040 1050 1060 1070 1080 QWRLSGLEAA LQALEPRQAA LLEEAALLAE RFPAQAARLH QGAEELGAEW GALASAAQAC 1090 1100 1110 1120 1130 1140 GEAVAAAGRL QRFLHDLDAF LDWLVRAQEA AGGSEGPLPN SLEEADALLA RHAALKEEVD 1150 1160 1170 1180 1190 1200 QREEDYARIV AASEALLAAD GAELGPGLAL DEWLPHLELG WHKLLGLWEA RREALVQAHI 1210 1220 1230 1240 1250 1260 YQLFLRDLRQ ALVVLRNQEM ALSGAELPGT VESVEEALKQ HRDFLTTMEL SQQKMQVAVQ 1270 1280 1290 1300 AAEGLLRQGN IYGEQAQEAV TRLLEKCLII HPALLHPPWE PPYLPRSSS
	Isoform 3 [UniParc]. Checksum: 1CE0DB8C9686B90E	FASTA	1,307	148,622
	10 20 30 40 50 60 MPHYPSCSSA PSLGTPIPPQ IQQLEARHRN QENQLRAQQW MQKLHDQLEL QHFLRDCHEL 70 80 90 100 110 120 DGWIHEKMLM ARDGTREDNH KLHKRWLRHQ AFMAELAQNK EWLEKIEREG QQLMQEKPEL 130 140 150 160 170 180 AASVRKKLGE IRQCWAELES TTQAKARQLF EASKADQLVQ SFAELDKKLL HMESQLQDVD 190 200 210 220 230 240 PGGDLATVNS QLKKLQSMES QVEEWYREVG ELQAQTAALP LEPASKELVG ERQNAVGERL 250 260 270 280 290 300 VRLLEPLQER RRLLLASKEL HQVAHDLDDE LAWVQERLPL AMQTERGNGL QAVQQHIKKN 310 320 330 340 350 360 QGLRREIQAH GPRLEEVLER AGALASLRSP EAEAVRRGLE QLQSAWAGLR EAAERRQQVL 370 380 390 400 410 420 DAAFQVEQYY FDVAEVEAWL GEQELLMMSE DKGKDEQSTL QLLKKHLQLE QGVENYEESI 430 440 450 460 470 480 AQLSRQCRAL LEMGHPDSEQ ISRRQSQVDR LYVALKELGE ERRVALEQQY WLYQLSRQVS 490 500 510 520 530 540 ELEHWIAEKE VVAGSPELGQ DFEHVSVLQE KFSEFASETG MAGRERLAAV NQMVDELIEC 550 560 570 580 590 600 GHTAAATMAE WKDGLNEAWA ELLELMGTRA QLLAASRELH KFFSDARELQ GQIEEKRRRL 610 620 630 640 650 660 PRLTTPPEPR PSASSMQRTL RAFEHDLQLL VSQVRQLQEG AAQLRTVYAG EHAEAIASRE 670 680 690 700 710 720 QEVLQGWKEL LSACEDARLH VSSTADALRF HSQVRDLLSW MDGIASQIGA ADKPRDVSSV 730 740 750 760 770 780 EVLMNYHQGL KTELEARVPE LTTCQELGRS LLLNKSAMAD EIQAQLDKLG TRKEEVSEKW 790 800 810 820 830 840 DRHWEWLQQM LEVHQFAQEA VVADAWLTAQ EPLLQSRELG SSVDEVEQLI RRHEAFRKAA 850 860 870 880 890 900 AAWEERFSSL RRLTTIEKIK AEQSKQPPTP LLGRKFFGDP TELAAKAAPL LRPGGYERGL 910 920 930 940 950 960 EPLARRASDT LSAEVRTRVG YVRQELKPER LQPRIDRLPE IPGRVEPAAL PAAPEDAAET 970 980 990 1000 1010 1020 PATPAAAEQV RPRPERQESA DRAEELPRRR RPERQESVDQ SEEAARRRRP ERQESAEHEA 1030 1040 1050 1060 1070 1080 AHSLTLGRYE QMERRRERRE RRLERQESSE QEMPIRGDLV KGKATLADIV EQLQEKEAGP 1090 1100 1110 1120 1130 1140 GLPAGPSLPQ PRELPPGRLP NGLELPERTP RPDRPRARDR PKPRRRPRPR EGGEGGGSRR 1150 1160 1170 1180 1190 1200 SRSAPAQGGS APAPPPPPTH TVQHEGFLLR KRELDANRKS SNRSWVSLYC VLSKGELGFY 1210 1220 1230 1240 1250 1260 KDSKGPASGS THGGEPLLSL HKATSEVASD YKKKKHVFKL QTQDGSEFLL QAKDEEEMNG 1270 1280 1290 1300 WLEAVASSVA EHAEIARWGQ TLPTTSSTDE GNPKREGGDR RASGRRK
	Isoform 4 [UniParc]. Checksum: B36417A996D80609	FASTA	2,154	243,424
	10 20 30 40 50 60 MAQVPGEVDN MEGLPAPNNN PAARWESPDR GWEREQPAAS TAAASLFECS RIKALADERE 70 80 90 100 110 120 AVQKKTFTKW VNSHLARVGC HIGDLYVDLR DGFVLTRLLE VLSGEQLPRP TRGRMRIHSL 130 140 150 160 170 180 ENVDKALQFL KEQRVHLENV GSHDIVDGNH RLTLGLVWTI ILRFQIQVIK IETEDNRETR 190 200 210 220 230 240 SAKDALLLWC QMKTAGYPEV NIQNFTTSWR DGLAFNALIH RHRPDLVDFS KLTKSNANYN 250 260 270 280 290 300 LQRAFRTAEQ HLGLARLLDP EDVNMEAPDE KSIITYVVSF YHYFSKMKAL AVEGKRIGKV 310 320 330 340 350 360 LDQVLEVGKI IERYEELAAE LLAWIHRTVG LISNQKFANS LSGVQQQLQA FTAYCTLEKP 370 380 390 400 410 420 VKFQEKGNLE VLLFSIQSKL RACNRRLFVP REGCGIWDID KAWGELEKAE HEREAALRAE 430 440 450 460 470 480 LIRQEKLELL AQRFDHKVAM RESWLNENQR LVSQDNFGYE LPAVEAAMKK HEAIEADIAA 490 500 510 520 530 540 YEERVQGVAE LAQALAAEGY YDIRRVAAQR DSVLRQWALL TGLVGARRTR LEQNLALQKV 550 560 570 580 590 600 FQEMVYMVDW MEEMQAQLLS RECGQHLVEA DDLLQKHGLL EGDIAAQSER VEALNAAALR 610 620 630 640 650 660 FSQLQGYQPC DPQVICNRVN HVHGCLAELQ EQAARRRAEL EASRSLWALL QELEEAESWA 670 680 690 700 710 720 RDKERLLEAA GGGGAAGAAG AAGTAGGAHD LSSTARLLAQ HKILQGELGG RRALLQQALR 730 740 750 760 770 780 CGEELVAAGG AVGPGADTVH LVGLAERAAS ARRRWQRLEE AAARRERRLQ EARALHQFGA 790 800 810 820 830 840 DLDGLLDWLR DAYRLAAAGD FGHDEASSRR LARQHRALTG EVEAHRGPVS GLRRQLATLG 850 860 870 880 890 900 GASGAGPLVV ALQVRVVEAE QLFAEVTEVA ALRRQWLRDA LAVYRMFGEV HACELWIGEK 910 920 930 940 950 960 EQWLLSMRVP DSLDDVEVVQ HRFESLDQEM NSLMGRVLDV NHTVQELVEG GHPSSDEVRS 970 980 990 1000 1010 1020 CQDHLNSRWN RIVELVEQRK EEMSAVLLVE NHVLEVAEVR AQVREKRRAV ESAPRAGGAL 1030 1040 1050 1060 1070 1080 QWRLSGLEAA LQALEPRQAA LLEEAALLAE RFPAQAARLH QGAEELGAEW GALASAAQAC 1090 1100 1110 1120 1130 1140 GEAVAAAGRL QRFLHDLDAF LDWLVRAQEA AGGSEGPLPN SLEEADALLA RHAALKEEVD 1150 1160 1170 1180 1190 1200 QREEDYARIV AASEALLAAD GAELGPGLAL DEWLPHLELG WHKLLGLWEA RREALVQAHI 1210 1220 1230 1240 1250 1260 YQLFLRDLRQ ALVVLRNQEM ALSGAELPGT VESVEEALKQ HRDFLTTMEL SQQKMQVAVQ 1270 1280 1290 1300 1310 1320 AAEGLLRQGN IYGEQAQEAV TRLLEKNQEN QLRAQQWMQK LHDQLELQHF LRDCHELDGW 1330 1340 1350 1360 1370 1380 IHEKMLMARD GTREDNHKLH KRWLRHQAFM AELAQNKEWL EKIEREGQQL MQEKPELAAS 1390 1400 1410 1420 1430 1440 VRKKLGEIRQ CWAELESTTQ AKARQLFEAS KADQLVQSFA ELDKKLLHME SQLQDVDPGG 1450 1460 1470 1480 1490 1500 DLATVNSQLK KLQSMESQVE EWYREVGELQ AQTAALPLEP ASKELVGERQ NAVGERLVRL 1510 1520 1530 1540 1550 1560 LEPLQERRRL LLASKELHQV AHDLDDELAW VQERLPLAMQ TERGNGLQAV QQHIKKNQGL 1570 1580 1590 1600 1610 1620 RREIQAHGPR LEEVLERAGA LASLRSPEAE AVRRGLEQLQ SAWAGLREAA ERRQQVLDAA 1630 1640 1650 1660 1670 1680 FQVEQYYFDV AEVEAWLGEQ ELLMMSEDKG KDEQSTLQLL KKHLQLEQGV ENYEESIAQL 1690 1700 1710 1720 1730 1740 SRQCRALLEM GHPDSEQISR RQSQVDRLYV ALKELGEERR VALEQQYWLY QLSRQVSELE 1750 1760 1770 1780 1790 1800 HWIAEKEVVA GSPELGQDFE HVSVLQEKFS EFASETGMAG RERLAAVNQM VDELIECGHT 1810 1820 1830 1840 1850 1860 AAATMAEWKD GLNEAWAELL ELMGTRAQLL AASRELHKFF SDARELQGQI EEKRRRLPRL 1870 1880 1890 1900 1910 1920 TTPPEPRPSA SSMQRTLRAF EHDLQLLVSQ VRQLQEGAAQ LRTVYAGEHA EAIASREQEV 1930 1940 1950 1960 1970 1980 LQGWKELLSA CEDARLHVSS TADALRFHSQ VRDLLSWMDG IASQIGAADK PRDVSSVEVL 1990 2000 2010 2020 2030 2040 MNYHQGLKTE LEARVPELTT CQELGRSLLL NKSAMADEIQ AQLDKLGTRK EEVSEKWDRH 2050 2060 2070 2080 2090 2100 WEWLQQMLEV HQFAQEAVVA DAWLTAQEPL LQSRELGSSV DEVEQLIRRH EAFRKAAAAW 2110 2120 2130 2140 2150 EERFSSLRRL TTPRREDHLN PGVQDQPWQH TEKPSLPKPK ANKEKTARRD GTCL
	Isoform 5 [UniParc]. Checksum: 53C7058D7A66F4B9	FASTA	678	77,167
	10 20 30 40 50 60 MLMARDGTRE DNHKLHKRWL RHQAFMAELA QNKEWLEKIE REGQQLMQEK PELAASVRKK 70 80 90 100 110 120 LGEIRQCWAE LESTTQAKAR QLFEASKADQ LVQSFAELDK KLLHMESQLQ DVDPGGDLAT 130 140 150 160 170 180 VNSQLKKLQS MESQVEEWYR EVGELQAQTA ALPLEPASKE LVGERQNAVG ERLVRLLEPL 190 200 210 220 230 240 QERRRLLLAS KELHQVAHDL DDELAWVQER LPLAMQTERG NGLQAVQQHI KKNQGLRREI 250 260 270 280 290 300 QAHGPRLEEV LERAGALASL RSPEAEAVRR GLEQLQSAWA GLREAAERRQ QVLDAAFQVE 310 320 330 340 350 360 QYYFDVAEVE AWLGEQELLM MSEDKGKDEQ STLQLLKKHL QLEQGVENYE ESIAQLSRQC 370 380 390 400 410 420 RALLEMGHPD SEQISRRQSQ VDRLYVALKE LGEERRVALE QQYWLYQLSR QVSELEHWIA 430 440 450 460 470 480 EKEVVAGSPE LGQDFEHVSV LQEKFSEFAS ETGMAGRERL AAVNQMVDEL IECGHTAAAT 490 500 510 520 530 540 MAEWKDGLNE AWAELLELMG TRAQLLAASR ELHKFFSDAR ELQGQIEEKR RRLPRLTTPP 550 560 570 580 590 600 EPRPSASSMQ RTLRAFEHDL QLLVSQVRQL QEGAAQLRTV YAGEHAEAIA SREQEVLQGW 610 620 630 640 650 660 KELLSACEDA RLHVSSTADA LRFHSQVRDL LSWMDGIASQ IGAADKPRCP SSLLGLPASP 670 WWPTPATPSP LTAPFSME

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A new spectrin, beta-IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix." Tse W.T., Tang J., Jin O., Korsgren C., John K.M., Kung A.L., Gwynn B., Peters L.L., Lux S.E. J. Biol. Chem. 276:23974-23985(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 5), VARIANT SER-1331.
[2]	"BetaIV spectrin, a new spectrin localized at axon initial segments and nodes of Ranvier in the central and peripheral nervous system." Berghs S., Aggujaro D., Dirkx R. Jr., Maksimova E., Stabach P., Hermel J.-M., Zhang J.-P., Philbrick W., Slepnev V., Ort T., Solimena M. J. Cell Biol. 151:985-1002(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 386-2382 (ISOFORM 1). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF311855 mRNA. Translation: AAG42473.1. AF311856 mRNA. Translation: AAG42474.1. AF082075 mRNA. Translation: AAG38874.1. AY004226 mRNA. Translation: AAF93171.1. AY004226 mRNA. Translation: AAF93172.1. AY004227 mRNA. Translation: AAF93173.1. AC020929 Genomic DNA. No translation available. AB046862 mRNA. Translation: BAB13468.1.
IPI	IPI00018829. IPI00217044. IPI00217047. IPI00217048. IPI00871486.
RefSeq	NP_066022.2. NM_020971.2.
UniGene	Hs.32706.
3D structure databases
ProteinModelPortal	Q9H254.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H254. 2 interactions.
STRING	9606.ENSP00000263373.
PTM databases
PhosphoSite	Q9H254.
Polymorphism databases
DMDM	17368942.
Proteomic databases
PaxDb	Q9H254.
PRIDE	Q9H254.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000338932; ENSP00000340345; ENSG00000160460. ENST00000352632; ENSP00000263373; ENSG00000160460. ENST00000392023; ENSP00000375877; ENSG00000160460. ENST00000598249; ENSP00000469242; ENSG00000160460.
GeneID	57731.
KEGG	hsa:57731.
UCSC	uc002onx.3. human.
Organism-specific databases
CTD	57731.
GeneCards	GC19P040973.
H-InvDB	HIX0015138.
HGNC	HGNC:14896. SPTBN4.
HPA	HPA043370.
MIM	606214. gene.
neXtProt	NX_Q9H254.
PharmGKB	PA37918.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5069.
HOGENOM	HOG000007281.
HOVERGEN	HBG057912.
InParanoid	Q9H254.
KO	K06115.
OrthoDB	EOG490782.
PhylomeDB	Q9H254.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology. REACT_127416. Developmental Biology.
Gene expression databases
ArrayExpress	Q9H254.
Bgee	Q9H254.
CleanEx	HS_SPTBN4.
Genevestigator	Q9H254.
GermOnline	ENSG00000160460. Homo sapiens.
Family and domain databases
Gene3D	1.10.418.10. 2 hits. 2.30.29.30. 1 hit.
InterPro	IPR001589. Actinin_actin-bd_CS. IPR001715. CH-domain. IPR001605. PH_dom-spectrin-type. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR018159. Spectrin/alpha-actinin. IPR016343. Spectrin_bsu. IPR002017. Spectrin_repeat. [Graphical view]
Pfam	PF00307. CH. 2 hits. PF00169. PH. 1 hit. PF00435. Spectrin. 14 hits. [Graphical view]
PIRSF	PIRSF002297. Spectrin_beta_subunit. 1 hit.
PRINTS	PR00683. SPECTRINPH.
SMART	SM00033. CH. 2 hits. SM00233. PH. 1 hit. SM00150. SPEC. 16 hits. [Graphical view]
SUPFAM	SSF47576. Calponin-homology. 1 hit.
PROSITE	PS00019. ACTININ_1. 1 hit. PS00020. ACTININ_2. 1 hit. PS50021. CH. 2 hits. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	57731.
NextBio	64688.
SOURCE	Search...

Entry information

Entry name

SPTN4_HUMAN

Accession

Primary (citable) accession number: Q9H254
Secondary accession number(s): E9PGQ5 , Q9H1K7, Q9H1K8, Q9H1K9, Q9H253, Q9H3G8, Q9HCD0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	November 16, 2001
Last modified:	May 1, 2013
This is version 115 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.