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Protein

Uncharacterized protein C1orf21

Gene

C1orf21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C1orf21
Alternative name(s):
Cell proliferation-inducing gene 13 protein
Gene namesi
Name:C1orf21
ORF Names:PIG13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15494. C1orf21.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25610.

Polymorphism and mutation databases

BioMutaiC1orf21.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 121121Uncharacterized protein C1orf21PRO_0000089246Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei95 – 951Phosphoserine3 Publications
Modified residuei115 – 1151Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H246.
PaxDbiQ9H246.
PRIDEiQ9H246.

PTM databases

PhosphoSiteiQ9H246.

Expressioni

Tissue specificityi

Expressed in spleen, prostate, testis and uterus.1 Publication

Gene expression databases

BgeeiQ9H246.
CleanExiHS_C1orf21.
ExpressionAtlasiQ9H246. baseline and differential.
GenevisibleiQ9H246. HS.

Organism-specific databases

HPAiHPA026831.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DRAM1Q8N6823EBI-10305393,EBI-10305400

Protein-protein interaction databases

BioGridi123526. 6 interactions.
IntActiQ9H246. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9H246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG44862.
GeneTreeiENSGT00390000014594.
HOGENOMiHOG000237337.
HOVERGENiHBG060374.
InParanoidiQ9H246.
OMAiSYQNGDV.
OrthoDBiEOG7288TB.
PhylomeDBiQ9H246.
TreeFamiTF333178.

Family and domain databases

InterProiIPR027967. DUF4612.
[Graphical view]
PfamiPF15389. DUF4612. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCASAKHVA TVQNEEEAQK GKNYQNGDVF GDEYRIKPVE EVKYMKNGAE
60 70 80 90 100
EEQKIAARNQ ENLEKSASSN VRLKTNKEVP GLVHQPRANM HISESQQEFF
110 120
RMLDEKIEKG RDYCSEEEDI T
Length:121
Mass (Da):13,865
Last modified:March 1, 2001 - v1
Checksum:i86D7F5C93F70903B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312864 mRNA. Translation: AAG45338.1.
AY258286 mRNA. Translation: AAP82231.1.
AK056487 mRNA. Translation: BAB71196.1.
AK312062 mRNA. Translation: BAG34998.1.
AL078645, AL358152 Genomic DNA. Translation: CAI17842.1.
AL358152, AL078645 Genomic DNA. Translation: CAI22695.1.
CH471067 Genomic DNA. Translation: EAW91176.1.
BC028567 mRNA. Translation: AAH28567.1.
CCDSiCCDS1362.1.
RefSeqiNP_110433.1. NM_030806.3.
UniGeneiHs.497159.
Hs.744936.

Genome annotation databases

EnsembliENST00000235307; ENSP00000235307; ENSG00000116667.
GeneIDi81563.
KEGGihsa:81563.
UCSCiuc001gqv.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312864 mRNA. Translation: AAG45338.1.
AY258286 mRNA. Translation: AAP82231.1.
AK056487 mRNA. Translation: BAB71196.1.
AK312062 mRNA. Translation: BAG34998.1.
AL078645, AL358152 Genomic DNA. Translation: CAI17842.1.
AL358152, AL078645 Genomic DNA. Translation: CAI22695.1.
CH471067 Genomic DNA. Translation: EAW91176.1.
BC028567 mRNA. Translation: AAH28567.1.
CCDSiCCDS1362.1.
RefSeqiNP_110433.1. NM_030806.3.
UniGeneiHs.497159.
Hs.744936.

3D structure databases

ProteinModelPortaliQ9H246.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123526. 6 interactions.
IntActiQ9H246. 1 interaction.

PTM databases

PhosphoSiteiQ9H246.

Polymorphism and mutation databases

BioMutaiC1orf21.

Proteomic databases

MaxQBiQ9H246.
PaxDbiQ9H246.
PRIDEiQ9H246.

Protocols and materials databases

DNASUi81563.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000235307; ENSP00000235307; ENSG00000116667.
GeneIDi81563.
KEGGihsa:81563.
UCSCiuc001gqv.1. human.

Organism-specific databases

CTDi81563.
GeneCardsiGC01P184356.
H-InvDBHIX0001416.
HGNCiHGNC:15494. C1orf21.
HPAiHPA026831.
neXtProtiNX_Q9H246.
PharmGKBiPA25610.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG44862.
GeneTreeiENSGT00390000014594.
HOGENOMiHOG000237337.
HOVERGENiHBG060374.
InParanoidiQ9H246.
OMAiSYQNGDV.
OrthoDBiEOG7288TB.
PhylomeDBiQ9H246.
TreeFamiTF333178.

Miscellaneous databases

ChiTaRSiC1orf21. human.
GeneWikiiC1orf21.
C1orf21_(gene).
GenomeRNAii81563.
NextBioi71842.
PROiQ9H246.

Gene expression databases

BgeeiQ9H246.
CleanExiHS_C1orf21.
ExpressionAtlasiQ9H246. baseline and differential.
GenevisibleiQ9H246. HS.

Family and domain databases

InterProiIPR027967. DUF4612.
[Graphical view]
PfamiPF15389. DUF4612. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus."
    Sood R., Bonner T.I., Malakowska I., Stephan D.A., Robbins C.M., Connors T.D., Morgenbesser S.D., Su K., Faruque M.U., Pinkett H., Graham C., Baxevanis A.D., Klinger K.W., Landes G.M., Trent J.M., Carpten J.D.
    Genomics 73:211-222(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Identification of a human cell proliferation gene 13."
    Kim J.W.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95 AND SER-115, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95 AND SER-115, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCA021_HUMAN
AccessioniPrimary (citable) accession number: Q9H246
Secondary accession number(s): B2R551
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2001
Last modified: June 24, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.