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Protein

Sphingosine 1-phosphate receptor 5

Gene

S1PR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-419408 Lysosphingolipid and LPA receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 5
Short name:
S1P receptor 5
Short name:
S1P5
Alternative name(s):
Endothelial differentiation G-protein-coupled receptor 8
Sphingosine 1-phosphate receptor Edg-8
Short name:
S1P receptor Edg-8
Gene namesi
Name:S1PR5
Synonyms:EDG8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000180739.13
HGNCiHGNC:14299 S1PR5
MIMi605146 gene
neXtProtiNX_Q9H228

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40ExtracellularBy similarityAdd BLAST40
Transmembranei41 – 61Helical; Name=1By similarityAdd BLAST21
Topological domaini62 – 70CytoplasmicBy similarity9
Transmembranei71 – 91Helical; Name=2By similarityAdd BLAST21
Topological domaini92 – 111ExtracellularBy similarityAdd BLAST20
Transmembranei112 – 132Helical; Name=3By similarityAdd BLAST21
Topological domaini133 – 151CytoplasmicBy similarityAdd BLAST19
Transmembranei152 – 172Helical; Name=4By similarityAdd BLAST21
Topological domaini173 – 192ExtracellularBy similarityAdd BLAST20
Transmembranei193 – 213Helical; Name=5By similarityAdd BLAST21
Topological domaini214 – 252CytoplasmicBy similarityAdd BLAST39
Transmembranei253 – 273Helical; Name=6By similarityAdd BLAST21
Topological domaini274 – 287ExtracellularBy similarityAdd BLAST14
Transmembranei288 – 308Helical; Name=7By similarityAdd BLAST21
Topological domaini309 – 398CytoplasmicBy similarityAdd BLAST90

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi53637
OpenTargetsiENSG00000180739
PharmGKBiPA162402378

Chemistry databases

ChEMBLiCHEMBL2274
DrugBankiDB08868 Fingolimod
GuidetoPHARMACOLOGYi279

Polymorphism and mutation databases

BioMutaiS1PR5
DMDMi62510663

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694361 – 398Sphingosine 1-phosphate receptor 5Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi323S-palmitoyl cysteineBy similarity1
Modified residuei381PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ9H228
PaxDbiQ9H228
PeptideAtlasiQ9H228
PRIDEiQ9H228

PTM databases

iPTMnetiQ9H228
PhosphoSitePlusiQ9H228

Expressioni

Tissue specificityi

Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes.3 Publications

Developmental stagei

At 24 weeks of gestation, fragments of radial glial fibers are positive within the cortical plate and subplate of allocortical areas. These positive fragments often appear enlarged as varicosities and some of them terminate at blood vessels. Between 28 and 30 weeks of gestation, all iso- and allocortical areas contain immunolabeled radial glial fibers revealing curvature next to sulci. After 32 weeks of gestation, radial glial fibers gradually disappear; instead positive transitional stages between radial glia and astrocytes were found.1 Publication

Gene expression databases

BgeeiENSG00000180739
CleanExiHS_S1PR5
ExpressionAtlasiQ9H228 baseline and differential
GenevisibleiQ9H228 HS

Organism-specific databases

HPAiHPA029683

Interactioni

Protein-protein interaction databases

BioGridi119793, 6 interactors
CORUMiQ9H228
IntActiQ9H228, 1 interactor
STRINGi9606.ENSP00000328472

Chemistry databases

BindingDBiQ9H228

Structurei

3D structure databases

ProteinModelPortaliQ9H228
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIK8 Eukaryota
ENOG4111FBV LUCA
GeneTreeiENSGT00760000118804
HOGENOMiHOG000233501
HOVERGENiHBG103071
InParanoidiQ9H228
KOiK04295
OMAiMVTMRPY
OrthoDBiEOG091G0DD4
PhylomeDBiQ9H228
TreeFamiTF330052

Family and domain databases

InterProiView protein in InterPro
IPR005386 EDG8_S1P_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004061 S1P_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01561 EDG8RECEPTOR
PR00237 GPCRRHODOPSN
PR01523 S1PRECEPTOR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H228-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESGLLRPAP VSEVIVLHYN YTGKLRGARY QPGAGLRADA VVCLAVCAFI
60 70 80 90 100
VLENLAVLLV LGRHPRFHAP MFLLLGSLTL SDLLAGAAYA ANILLSGPLT
110 120 130 140 150
LKLSPALWFA REGGVFVALT ASVLSLLAIA LERSLTMARR GPAPVSSRGR
160 170 180 190 200
TLAMAAAAWG VSLLLGLLPA LGWNCLGRLD ACSTVLPLYA KAYVLFCVLA
210 220 230 240 250
FVGILAAICA LYARIYCQVR ANARRLPARP GTAGTTSTRA RRKPRSLALL
260 270 280 290 300
RTLSVVLLAF VACWGPLFLL LLLDVACPAR TCPVLLQADP FLGLAMANSL
310 320 330 340 350
LNPIIYTLTN RDLRHALLRL VCCGRHSCGR DPSGSQQSAS AAEASGGLRR
360 370 380 390
CLPPGLDGSF SGSERSSPQR DGLDTSGSTG SPGAPTAART LVSEPAAD
Length:398
Mass (Da):41,775
Last modified:March 1, 2001 - v1
Checksum:i34ADC6C40D8250BF
GO
Isoform 2 (identifier: Q9H228-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-310: RIYCQVRANA...LNPIIYTLTN → LAGLAAHAQR...EWLPAVGERG
     311-398: Missing.

Show »
Length:310
Mass (Da):32,279
Checksum:i906D2B43EC85A8AB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033466318L → Q. Corresponds to variant dbSNP:rs35483143Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013369214 – 310RIYCQ…YTLTN → LAGLAAHAQRGAPGLCGMLG PPHPAAVARRGVPGAHLSCT PAGRSLPGTGHGQLTSEPHH LHAHQPRPAPRAPAPGLLRT PLLRQRPEWLPAVGERG in isoform 2. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_013370311 – 398Missing in isoform 2. 1 PublicationAdd BLAST88

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331840 mRNA Translation: AAL57041.1
AK074661 mRNA Translation: BAC11119.1
AF317676 Genomic DNA Translation: AAG38113.1
AY262689 Genomic DNA Translation: AAP20653.1
AB083602 Genomic DNA Translation: BAB89315.1
AC011461 Genomic DNA No translation available.
BC034703 mRNA Translation: AAH34703.1
BC067781 mRNA Translation: AAH67781.1
CCDSiCCDS12240.1 [Q9H228-1]
RefSeqiNP_001159687.1, NM_001166215.1 [Q9H228-1]
NP_110387.1, NM_030760.4 [Q9H228-1]
UniGeneiHs.501561

Genome annotation databases

EnsembliENST00000333430; ENSP00000328472; ENSG00000180739 [Q9H228-1]
ENST00000439028; ENSP00000416915; ENSG00000180739 [Q9H228-1]
GeneIDi53637
KEGGihsa:53637
UCSCiuc002mot.2 human [Q9H228-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS1PR5_HUMAN
AccessioniPrimary (citable) accession number: Q9H228
Secondary accession number(s): Q6NW11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2001
Last modified: December 20, 2017
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health