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Protein

Sphingosine 1-phosphate receptor 5

Gene

S1PR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-419408. Lysosphingolipid and LPA receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 5
Short name:
S1P receptor 5
Short name:
S1P5
Alternative name(s):
Endothelial differentiation G-protein-coupled receptor 8
Sphingosine 1-phosphate receptor Edg-8
Short name:
S1P receptor Edg-8
Gene namesi
Name:S1PR5
Synonyms:EDG8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:14299. S1PR5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040ExtracellularBy similarityAdd
BLAST
Transmembranei41 – 6121Helical; Name=1By similarityAdd
BLAST
Topological domaini62 – 709CytoplasmicBy similarity
Transmembranei71 – 9121Helical; Name=2By similarityAdd
BLAST
Topological domaini92 – 11120ExtracellularBy similarityAdd
BLAST
Transmembranei112 – 13221Helical; Name=3By similarityAdd
BLAST
Topological domaini133 – 15119CytoplasmicBy similarityAdd
BLAST
Transmembranei152 – 17221Helical; Name=4By similarityAdd
BLAST
Topological domaini173 – 19220ExtracellularBy similarityAdd
BLAST
Transmembranei193 – 21321Helical; Name=5By similarityAdd
BLAST
Topological domaini214 – 25239CytoplasmicBy similarityAdd
BLAST
Transmembranei253 – 27321Helical; Name=6By similarityAdd
BLAST
Topological domaini274 – 28714ExtracellularBy similarityAdd
BLAST
Transmembranei288 – 30821Helical; Name=7By similarityAdd
BLAST
Topological domaini309 – 39890CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162402378.

Chemistry

ChEMBLiCHEMBL2363041.
DrugBankiDB08868. Fingolimod.
GuidetoPHARMACOLOGYi279.

Polymorphism and mutation databases

BioMutaiS1PR5.
DMDMi62510663.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Sphingosine 1-phosphate receptor 5PRO_0000069436Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi20 – 201N-linked (GlcNAc...)Sequence analysis
Lipidationi323 – 3231S-palmitoyl cysteineBy similarity
Modified residuei381 – 3811PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ9H228.
PaxDbiQ9H228.
PeptideAtlasiQ9H228.
PRIDEiQ9H228.

PTM databases

iPTMnetiQ9H228.
PhosphoSiteiQ9H228.

Expressioni

Tissue specificityi

Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes.3 Publications

Developmental stagei

At 24 weeks of gestation, fragments of radial glial fibers are positive within the cortical plate and subplate of allocortical areas. These positive fragments often appear enlarged as varicosities and some of them terminate at blood vessels. Between 28 and 30 weeks of gestation, all iso- and allocortical areas contain immunolabeled radial glial fibers revealing curvature next to sulci. After 32 weeks of gestation, radial glial fibers gradually disappear; instead positive transitional stages between radial glia and astrocytes were found.1 Publication

Gene expression databases

BgeeiENSG00000180739.
CleanExiHS_S1PR5.
ExpressionAtlasiQ9H228. baseline and differential.
GenevisibleiQ9H228. HS.

Organism-specific databases

HPAiHPA029683.

Interactioni

Protein-protein interaction databases

BioGridi119793. 6 interactions.
IntActiQ9H228. 1 interaction.
STRINGi9606.ENSP00000328472.

Chemistry

BindingDBiQ9H228.

Structurei

3D structure databases

ProteinModelPortaliQ9H228.
SMRiQ9H228. Positions 13-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIK8. Eukaryota.
ENOG4111FBV. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ9H228.
KOiK04295.
OMAiYMANILM.
OrthoDBiEOG091G0DD4.
PhylomeDBiQ9H228.
TreeFamiTF330052.

Family and domain databases

InterProiIPR005386. EDG8_S1P_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01561. EDG8RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H228-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESGLLRPAP VSEVIVLHYN YTGKLRGARY QPGAGLRADA VVCLAVCAFI
60 70 80 90 100
VLENLAVLLV LGRHPRFHAP MFLLLGSLTL SDLLAGAAYA ANILLSGPLT
110 120 130 140 150
LKLSPALWFA REGGVFVALT ASVLSLLAIA LERSLTMARR GPAPVSSRGR
160 170 180 190 200
TLAMAAAAWG VSLLLGLLPA LGWNCLGRLD ACSTVLPLYA KAYVLFCVLA
210 220 230 240 250
FVGILAAICA LYARIYCQVR ANARRLPARP GTAGTTSTRA RRKPRSLALL
260 270 280 290 300
RTLSVVLLAF VACWGPLFLL LLLDVACPAR TCPVLLQADP FLGLAMANSL
310 320 330 340 350
LNPIIYTLTN RDLRHALLRL VCCGRHSCGR DPSGSQQSAS AAEASGGLRR
360 370 380 390
CLPPGLDGSF SGSERSSPQR DGLDTSGSTG SPGAPTAART LVSEPAAD
Length:398
Mass (Da):41,775
Last modified:March 1, 2001 - v1
Checksum:i34ADC6C40D8250BF
GO
Isoform 2 (identifier: Q9H228-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-310: RIYCQVRANA...LNPIIYTLTN → LAGLAAHAQR...EWLPAVGERG
     311-398: Missing.

Show »
Length:310
Mass (Da):32,279
Checksum:i906D2B43EC85A8AB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti318 – 3181L → Q.
Corresponds to variant rs35483143 [ dbSNP | Ensembl ].
VAR_033466

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei214 – 31097RIYCQ…YTLTN → LAGLAAHAQRGAPGLCGMLG PPHPAAVARRGVPGAHLSCT PAGRSLPGTGHGQLTSEPHH LHAHQPRPAPRAPAPGLLRT PLLRQRPEWLPAVGERG in isoform 2. 1 PublicationVSP_013369Add
BLAST
Alternative sequencei311 – 39888Missing in isoform 2. 1 PublicationVSP_013370Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331840 mRNA. Translation: AAL57041.1.
AK074661 mRNA. Translation: BAC11119.1.
AF317676 Genomic DNA. Translation: AAG38113.1.
AY262689 Genomic DNA. Translation: AAP20653.1.
AB083602 Genomic DNA. Translation: BAB89315.1.
AC011461 Genomic DNA. No translation available.
BC034703 mRNA. Translation: AAH34703.1.
BC067781 mRNA. Translation: AAH67781.1.
CCDSiCCDS12240.1. [Q9H228-1]
RefSeqiNP_001159687.1. NM_001166215.1. [Q9H228-1]
NP_110387.1. NM_030760.4. [Q9H228-1]
UniGeneiHs.501561.

Genome annotation databases

EnsembliENST00000333430; ENSP00000328472; ENSG00000180739. [Q9H228-1]
ENST00000439028; ENSP00000416915; ENSG00000180739. [Q9H228-1]
GeneIDi53637.
KEGGihsa:53637.
UCSCiuc002mot.2. human. [Q9H228-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331840 mRNA. Translation: AAL57041.1.
AK074661 mRNA. Translation: BAC11119.1.
AF317676 Genomic DNA. Translation: AAG38113.1.
AY262689 Genomic DNA. Translation: AAP20653.1.
AB083602 Genomic DNA. Translation: BAB89315.1.
AC011461 Genomic DNA. No translation available.
BC034703 mRNA. Translation: AAH34703.1.
BC067781 mRNA. Translation: AAH67781.1.
CCDSiCCDS12240.1. [Q9H228-1]
RefSeqiNP_001159687.1. NM_001166215.1. [Q9H228-1]
NP_110387.1. NM_030760.4. [Q9H228-1]
UniGeneiHs.501561.

3D structure databases

ProteinModelPortaliQ9H228.
SMRiQ9H228. Positions 13-321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119793. 6 interactions.
IntActiQ9H228. 1 interaction.
STRINGi9606.ENSP00000328472.

Chemistry

BindingDBiQ9H228.
ChEMBLiCHEMBL2363041.
DrugBankiDB08868. Fingolimod.
GuidetoPHARMACOLOGYi279.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9H228.
PhosphoSiteiQ9H228.

Polymorphism and mutation databases

BioMutaiS1PR5.
DMDMi62510663.

Proteomic databases

MaxQBiQ9H228.
PaxDbiQ9H228.
PeptideAtlasiQ9H228.
PRIDEiQ9H228.

Protocols and materials databases

DNASUi53637.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333430; ENSP00000328472; ENSG00000180739. [Q9H228-1]
ENST00000439028; ENSP00000416915; ENSG00000180739. [Q9H228-1]
GeneIDi53637.
KEGGihsa:53637.
UCSCiuc002mot.2. human. [Q9H228-1]

Organism-specific databases

CTDi53637.
GeneCardsiS1PR5.
H-InvDBHIX0174397.
HGNCiHGNC:14299. S1PR5.
HPAiHPA029683.
MIMi605146. gene.
neXtProtiNX_Q9H228.
PharmGKBiPA162402378.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIK8. Eukaryota.
ENOG4111FBV. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ9H228.
KOiK04295.
OMAiYMANILM.
OrthoDBiEOG091G0DD4.
PhylomeDBiQ9H228.
TreeFamiTF330052.

Enzyme and pathway databases

ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-419408. Lysosphingolipid and LPA receptors.

Miscellaneous databases

ChiTaRSiS1PR5. human.
GeneWikiiS1PR5.
GenomeRNAii53637.
PROiQ9H228.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180739.
CleanExiHS_S1PR5.
ExpressionAtlasiQ9H228. baseline and differential.
GenevisibleiQ9H228. HS.

Family and domain databases

InterProiIPR005386. EDG8_S1P_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01561. EDG8RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS1PR5_HUMAN
AccessioniPrimary (citable) accession number: Q9H228
Secondary accession number(s): Q6NW11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.