UniProtKB - Q9H223 (EHD4_HUMAN)
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Protein
EH domain-containing protein 4
Gene
EHD4
Organism
Homo sapiens (Human)
Status
Functioni
ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport.2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 223 | ATPBy similarity | 1 | |
Binding sitei | 261 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 68 – 75 | ATPBy similarity | 8 | |
Calcium bindingi | 492 – 503 | PROSITE-ProRule annotationBy similarityAdd BLAST | 12 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cadherin binding Source: BHF-UCL
- calcium ion binding Source: InterPro
- GTP binding Source: InterPro
- nucleic acid binding Source: ProtInc
GO - Biological processi
- cellular response to growth factor stimulus Source: Ensembl
- endocytic recycling Source: UniProtKB
- pinocytosis Source: Ensembl
- positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
- protein homooligomerization Source: UniProtKB
- regulation of endocytosis Source: Ensembl
Keywordsi
Ligand | ATP-binding, Calcium, Metal-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: EH domain-containing protein 4CuratedAlternative name(s): Hepatocellular carcinoma-associated protein 10/111 Publication PAST homolog 4Curated |
Gene namesi | ORF Names:FKSG7Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000103966.9 |
HGNCi | HGNC:3245 EHD4 |
MIMi | 605892 gene |
neXtProti | NX_Q9H223 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000103966 |
PharmGKBi | PA27680 |
Polymorphism and mutation databases
BioMutai | EHD4 |
DMDMi | 18202935 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000146114 | 1 – 541 | EH domain-containing protein 4Add BLAST | 541 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 162 | PhosphoserineCombined sources | 1 | |
Modified residuei | 451 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 459 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9H223 |
MaxQBi | Q9H223 |
PaxDbi | Q9H223 |
PeptideAtlasi | Q9H223 |
PRIDEi | Q9H223 |
PTM databases
iPTMneti | Q9H223 |
PhosphoSitePlusi | Q9H223 |
Expressioni
Tissue specificityi
Highly expressed in pancreas and heart.1 Publication
Gene expression databases
Bgeei | ENSG00000103966 |
CleanExi | HS_EHD4 |
ExpressionAtlasi | Q9H223 baseline and differential |
Genevisiblei | Q9H223 HS |
Organism-specific databases
HPAi | HPA049890 HPA049986 HPA052729 HPA066751 |
Interactioni
Subunit structurei
Homooligomer, and heterooligomer with EHD1, EHD2 and EHD3.1 Publication
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
Protein-protein interaction databases
BioGridi | 11905461 interactors. |
IntActi | Q9H223 15 interactors. |
MINTi | Q9H223 |
STRINGi | 9606.ENSP00000220325 |
Structurei
3D structure databases
ProteinModelPortali | Q9H223 |
SMRi | Q9H223 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 58 – 289 | Dynamin-type GAdd BLAST | 232 | |
Domaini | 447 – 535 | EHPROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 479 – 514 | EF-handPROSITE-ProRule annotationAdd BLAST | 36 |
Domaini
The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.By similarity
Sequence similaritiesi
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily.Curated
Phylogenomic databases
eggNOGi | KOG1954 Eukaryota ENOG410XYGB LUCA |
GeneTreei | ENSGT00760000118985 |
HOGENOMi | HOG000242040 |
HOVERGENi | HBG018183 |
InParanoidi | Q9H223 |
KOi | K12477 |
OMAi | GEMYQTV |
OrthoDBi | EOG091G04KA |
PhylomeDBi | Q9H223 |
TreeFami | TF314429 |
Family and domain databases
InterProi | View protein in InterPro IPR022812 Dynamin_SF IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR000261 EH_dom IPR029952 EHD4 IPR031692 EHD_N IPR030381 G_DYNAMIN_dom IPR027417 P-loop_NTPase |
PANTHERi | PTHR11216:SF57 PTHR11216:SF57, 1 hit |
Pfami | View protein in Pfam PF00350 Dynamin_N, 1 hit PF12763 EF-hand_4, 1 hit PF16880 EHD_N, 1 hit |
SMARTi | View protein in SMART SM00027 EH, 1 hit |
SUPFAMi | SSF47473 SSF47473, 1 hit SSF52540 SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00018 EF_HAND_1, 1 hit PS50222 EF_HAND_2, 1 hit PS50031 EH, 1 hit PS51718 G_DYNAMIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9H223-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFSWMGRQAG GRERAGGADA VQTVTGGLRS LYLRKVLPLE EAYRFHEFHS
60 70 80 90 100
PALEDADFEN KPMILLVGQY STGKTTFIRY LLEQDFPGMR IGPEPTTDSF
110 120 130 140 150
IAVMYGETEG STPGNALVVD PKKPFRKLSR FGNAFLNRFM CSQLPNQVLK
160 170 180 190 200
SISVIDSPGI LSGEKQRISR GYDFCQVLQW FAERVDRIIL LFDAHKLDIS
210 220 230 240 250
DEFSEAIKAF RGQDDKIRVV LNKADQVDTQ QLMRVYGALM WSLGKVINTP
260 270 280 290 300
EVLRVYIGSF WAQPLQNTDN RRLFEAEAQD LFRDIQSLPQ KAAVRKLNDL
310 320 330 340 350
IKRARLAKVH AYIISYLKKE MPSVFGKENK KRELISRLPE IYIQLQREYQ
360 370 380 390 400
ISAGDFPEVK AMQEQLENYD FTKFHSLKPK LIEAVDNMLS NKISPLMNLI
410 420 430 440 450
SQEETSTPTQ LVQGGAFDGT TEGPFNQGYG EGAKEGADEE EWVVAKDKPV
460 470 480 490 500
YDELFYTLSP INGKISGVNA KKEMVTSKLP NSVLGKIWKL ADCDCDGMLD
510 520 530 540
EEEFALAKHL IKIKLDGYEL PSSLPPHLVP PSHRKSLPKA D
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 297 | L → I in AAG28784 (Ref. 2) Curated | 1 | |
Sequence conflicti | 421 – 433 | TEGPF…YGEGA → PRAPSTRATGRVP in AAG28784 (Ref. 2) CuratedAdd BLAST | 13 | |
Sequence conflicti | 439 | E → Q in AAG28784 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053070 | 154 | V → I. Corresponds to variant dbSNP:rs11549015Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF323924 mRNA Translation: AAK11599.1 AF307137 mRNA Translation: AAG28784.1 AF454953 mRNA Translation: AAL51079.1 BC006287 mRNA Translation: AAH06287.1 BC051823 mRNA Translation: AAH51823.1 AF181265 mRNA Translation: AAF40472.1 |
CCDSi | CCDS10081.1 |
RefSeqi | NP_644670.1, NM_139265.3 |
UniGenei | Hs.143703 |
Genome annotation databases
Ensembli | ENST00000220325; ENSP00000220325; ENSG00000103966 |
GeneIDi | 30844 |
KEGGi | hsa:30844 |
UCSCi | uc001zot.4 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | EHD4_HUMAN | |
Accessioni | Q9H223Primary (citable) accession number: Q9H223 Secondary accession number(s): Q9HAR1, Q9NZN2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | March 28, 2018 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |