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Q9H222

- ABCG5_HUMAN

UniProt

Q9H222 - ABCG5_HUMAN

Protein

ATP-binding cassette sub-family G member 5

Gene

ABCG5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi86 – 938ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. cholesterol transporter activity Source: Ensembl
    4. protein binding Source: IntAct
    5. protein heterodimerization activity Source: BHF-UCL

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. cholesterol efflux Source: BHF-UCL
    3. cholesterol homeostasis Source: BHF-UCL
    4. excretion Source: BHF-UCL
    5. intestinal cholesterol absorption Source: BHF-UCL
    6. negative regulation of intestinal cholesterol absorption Source: BHF-UCL
    7. negative regulation of intestinal phytosterol absorption Source: BHF-UCL
    8. response to drug Source: Ensembl
    9. response to ionizing radiation Source: Ensembl
    10. response to nutrient Source: Ensembl
    11. small molecule metabolic process Source: Reactome
    12. sterol transport Source: Reactome
    13. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_111158. ABCA transporters in lipid homeostasis.
    REACT_13781. Trafficking of dietary sterols.

    Protein family/group databases

    TCDBi3.A.1.204.5. the atp-binding cassette (abc) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-binding cassette sub-family G member 5
    Alternative name(s):
    Sterolin-1
    Gene namesi
    Name:ABCG5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:13886. ABCG5.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: BHF-UCL
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Sitosterolemia (STSL) [MIM:210250]: Rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile. Sitosterolemia patients have hypercholesterolemia, very high levels of plant sterols in the plasma, and frequently develop tendon and tuberous xanthomas, accelerated atherosclerosis and premature coronary artery disease.3 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti146 – 1461E → Q in STSL. 1 Publication
    VAR_012244
    Natural varianti389 – 3891R → H in STSL. 2 Publications
    VAR_012245
    Natural varianti419 – 4191R → H in STSL. 2 Publications
    VAR_012246
    Natural varianti419 – 4191R → P in STSL. 2 Publications
    VAR_012247
    Natural varianti437 – 4371N → K in STSL. 1 Publication
    VAR_020781
    Natural varianti550 – 5501R → S in STSL. 1 Publication
    VAR_012248

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi210250. phenotype.
    Orphaneti2882. Sitosterolemia.
    PharmGKBiPA24411.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 651651ATP-binding cassette sub-family G member 5PRO_0000093393Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi584 – 5841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi591 – 5911N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9H222.
    PRIDEiQ9H222.

    PTM databases

    PhosphoSiteiQ9H222.

    Expressioni

    Tissue specificityi

    Strongly expressed in the liver, lower levels in the small intestine and colon.

    Gene expression databases

    ArrayExpressiQ9H222.
    BgeeiQ9H222.
    CleanExiHS_ABCG5.
    GenevestigatoriQ9H222.

    Organism-specific databases

    HPAiHPA016514.

    Interactioni

    Subunit structurei

    May form heterodimers with ABCG8 or be tightly coupled to ABCG8 along a pathway regulating diatery-sterol absorption and excretion.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ABCG8Q9H2212EBI-1761423,EBI-3908684
    NCK1P163332EBI-1761423,EBI-389883

    Protein-protein interaction databases

    BioGridi122124. 2 interactions.
    IntActiQ9H222. 5 interactions.
    MINTiMINT-2840498.
    STRINGi9606.ENSP00000260645.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H222.
    SMRiQ9H222. Positions 38-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 383383CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini405 – 42117ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini443 – 46220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini484 – 50320ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini525 – 5284CytoplasmicSequence Analysis
    Topological domaini550 – 62374ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini645 – 6517CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei384 – 40421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei422 – 44221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei463 – 48321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei504 – 52421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei529 – 54921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei624 – 64421Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini52 – 293242ABC transporterPROSITE-ProRule annotationAdd
    BLAST
    Domaini388 – 645258ABC transmembrane type-2Add
    BLAST

    Sequence similaritiesi

    Contains 1 ABC transporter domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1131.
    HOGENOMiHOG000033763.
    HOVERGENiHBG050443.
    InParanoidiQ9H222.
    KOiK05683.
    OMAiKSAICHK.
    OrthoDBiEOG7QNVKG.
    PhylomeDBiQ9H222.
    TreeFamiTF105212.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR013525. ABC_2_trans.
    IPR003439. ABC_transporter-like.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01061. ABC2_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H222-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGDLSSLTPG GSMGLQVNRG SQSSLEGAPA TAPEPHSLGI LHASYSVSHR    50
    VRPWWDITSC RQQWTRQILK DVSLYVESGQ IMCILGSSGS GKTTLLDAMS 100
    GRLGRAGTFL GEVYVNGRAL RREQFQDCFS YVLQSDTLLS SLTVRETLHY 150
    TALLAIRRGN PGSFQKKVEA VMAELSLSHV ADRLIGNYSL GGISTGERRR 200
    VSIAAQLLQD PKVMLFDEPT TGLDCMTANQ IVVLLVELAR RNRIVVLTIH 250
    QPRSELFQLF DKIAILSFGE LIFCGTPAEM LDFFNDCGYP CPEHSNPFDF 300
    YMDLTSVDTQ SKEREIETSK RVQMIESAYK KSAICHKTLK NIERMKHLKT 350
    LPMVPFKTKD SPGVFSKLGV LLRRVTRNLV RNKLAVITRL LQNLIMGLFL 400
    LFFVLRVRSN VLKGAIQDRV GLLYQFVGAT PYTGMLNAVN LFPVLRAVSD 450
    QESQDGLYQK WQMMLAYALH VLPFSVVATM IFSSVCYWTL GLHPEVARFG 500
    YFSAALLAPH LIGEFLTLVL LGIVQNPNIV NSVVALLSIA GVLVGSGFLR 550
    NIQEMPIPFK IISYFTFQKY CSEILVVNEF YGLNFTCGSS NVSVTTNPMC 600
    AFTQGIQFIE KTCPGATSRF TMNFLILYSF IPALVILGIV VFKIRDHLIS 650
    R 651
    Length:651
    Mass (Da):72,504
    Last modified:March 1, 2001 - v1
    Checksum:i950BABFCBB6A1536
    GO
    Isoform 2 (identifier: Q9H222-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-395: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:256
    Mass (Da):28,480
    Checksum:iE8AB9B5738CDA01C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501R → C.
    Corresponds to variant rs6756629 [ dbSNP | Ensembl ].
    VAR_048142
    Natural varianti146 – 1461E → Q in STSL. 1 Publication
    VAR_012244
    Natural varianti389 – 3891R → H in STSL. 2 Publications
    VAR_012245
    Natural varianti419 – 4191R → H in STSL. 2 Publications
    VAR_012246
    Natural varianti419 – 4191R → P in STSL. 2 Publications
    VAR_012247
    Natural varianti437 – 4371N → K in STSL. 1 Publication
    VAR_020781
    Natural varianti517 – 5171T → S.
    Corresponds to variant rs17031672 [ dbSNP | Ensembl ].
    VAR_033457
    Natural varianti523 – 5231I → V.1 Publication
    VAR_020782
    Natural varianti550 – 5501R → S in STSL. 1 Publication
    VAR_012248
    Natural varianti600 – 6001C → Y.1 Publication
    VAR_020783
    Natural varianti604 – 6041Q → E.4 Publications
    Corresponds to variant rs6720173 [ dbSNP | Ensembl ].
    VAR_012249
    Natural varianti622 – 6221M → V.1 Publication
    Corresponds to variant rs140374206 [ dbSNP | Ensembl ].
    VAR_020784

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 395395Missing in isoform 2. 1 PublicationVSP_055770Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF320293 mRNA. Translation: AAG40003.1.
    AF312715 mRNA. Translation: AAG53099.1.
    AC011242 Genomic DNA. No translation available.
    AC108476 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAX00286.1.
    BC111541 mRNA. Translation: AAI11542.1.
    AF404106 Genomic DNA. Translation: AAK85387.1.
    AF404107 Genomic DNA. Translation: AAK85388.1.
    CCDSiCCDS1814.1.
    RefSeqiNP_071881.1. NM_022436.2.
    UniGeneiHs.132992.

    Genome annotation databases

    EnsembliENST00000260645; ENSP00000260645; ENSG00000138075. [Q9H222-1]
    GeneIDi64240.
    KEGGihsa:64240.
    UCSCiuc002rtn.3. human.

    Polymorphism databases

    DMDMi17432917.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    ABCMdb

    Database for mutations in ABC proteins

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF320293 mRNA. Translation: AAG40003.1 .
    AF312715 mRNA. Translation: AAG53099.1 .
    AC011242 Genomic DNA. No translation available.
    AC108476 Genomic DNA. No translation available.
    CH471053 Genomic DNA. Translation: EAX00286.1 .
    BC111541 mRNA. Translation: AAI11542.1 .
    AF404106 Genomic DNA. Translation: AAK85387.1 .
    AF404107 Genomic DNA. Translation: AAK85388.1 .
    CCDSi CCDS1814.1.
    RefSeqi NP_071881.1. NM_022436.2.
    UniGenei Hs.132992.

    3D structure databases

    ProteinModelPortali Q9H222.
    SMRi Q9H222. Positions 38-324.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122124. 2 interactions.
    IntActi Q9H222. 5 interactions.
    MINTi MINT-2840498.
    STRINGi 9606.ENSP00000260645.

    Chemistry

    DrugBanki DB00973. Ezetimibe.

    Protein family/group databases

    TCDBi 3.A.1.204.5. the atp-binding cassette (abc) superfamily.

    PTM databases

    PhosphoSitei Q9H222.

    Polymorphism databases

    DMDMi 17432917.

    Proteomic databases

    PaxDbi Q9H222.
    PRIDEi Q9H222.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000260645 ; ENSP00000260645 ; ENSG00000138075 . [Q9H222-1 ]
    GeneIDi 64240.
    KEGGi hsa:64240.
    UCSCi uc002rtn.3. human.

    Organism-specific databases

    CTDi 64240.
    GeneCardsi GC02M044039.
    GeneReviewsi ABCG5.
    HGNCi HGNC:13886. ABCG5.
    HPAi HPA016514.
    MIMi 210250. phenotype.
    605459. gene.
    neXtProti NX_Q9H222.
    Orphaneti 2882. Sitosterolemia.
    PharmGKBi PA24411.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1131.
    HOGENOMi HOG000033763.
    HOVERGENi HBG050443.
    InParanoidi Q9H222.
    KOi K05683.
    OMAi KSAICHK.
    OrthoDBi EOG7QNVKG.
    PhylomeDBi Q9H222.
    TreeFami TF105212.

    Enzyme and pathway databases

    Reactomei REACT_111158. ABCA transporters in lipid homeostasis.
    REACT_13781. Trafficking of dietary sterols.

    Miscellaneous databases

    GeneWikii ABCG5.
    GenomeRNAii 64240.
    NextBioi 66188.
    PROi Q9H222.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H222.
    Bgeei Q9H222.
    CleanExi HS_ABCG5.
    Genevestigatori Q9H222.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR013525. ABC_2_trans.
    IPR003439. ABC_transporter-like.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01061. ABC2_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters."
      Berge K.E., Tian H., Graf G.A., Yu L., Grishin N.V., Schultz J., Kwiterovich P., Shan B., Barnes R., Hobbs H.H.
      Science 290:1771-1775(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLU-604.
      Tissue: Liver.
    2. "Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption."
      Lee M.-H., Lu K., Hazard S., Yu H., Shulenin S., Hidaka H., Kojima H., Allikmets R., Sakuma N., Pegoraro R., Srivastava A.K., Salen G., Dean M., Patel S.B.
      Nat. Genet. 27:79-83(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS STSL HIS-389; HIS-419 AND PRO-419, VARIANT GLU-604.
      Tissue: Liver.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. "Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively."
      Lu K., Lee M.-H., Hazard S., Brooks-Wilson A., Hidaka H., Kojima H., Ose L., Stalenhoef A.F.H., Mietinnen T., Bjorkhem I., Bruckert E., Pandya A., Brewer H.B. Jr., Salen G., Dean M., Srivastava A.K., Patel S.B.
      Am. J. Hum. Genet. 69:278-290(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-88 (ISOFORM 1), VARIANTS STSL GLN-146; HIS-389; PRO-419; HIS-419 AND SER-550, VARIANT GLU-604.
    7. "Role of ABCG1 and other ABCG family members in lipid metabolism."
      Schmitz G., Langmann T., Heimerl S.
      J. Lipid Res. 42:1513-1520(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    8. "Mutations in ATP-cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia."
      Hubacek J.A., Berge K.E., Cohen J.C., Hobbs H.H.
      Hum. Mutat. 18:359-360(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT STSL LYS-437, VARIANTS VAL-523; TYR-600; GLU-604 AND VAL-622.

    Entry informationi

    Entry nameiABCG5_HUMAN
    AccessioniPrimary (citable) accession number: Q9H222
    Secondary accession number(s): Q2T9G2, Q96QZ2, Q96QZ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 5, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3