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Protein

Olfactory receptor 2D2

Gene

OR2D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GO_Central
  • sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166368-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2D2
Alternative name(s):
HB2
Olfactory receptor 11-610
Short name:
OR11-610
Olfactory receptor 2D1
Olfactory receptor OR11-88
Gene namesi
Name:OR2D2
Synonyms:OR2D1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8244. OR2D2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 270ExtracellularSequence analysisAdd BLAST11
Transmembranei271 – 290Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini291 – 308CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166368.
PharmGKBiPA32152.

Polymorphism and mutation databases

BioMutaiOR2D2.
DMDMi209572777.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504671 – 308Olfactory receptor 2D2Add BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9H210.
PeptideAtlasiQ9H210.
PRIDEiQ9H210.

PTM databases

iPTMnetiQ9H210.
PhosphoSitePlusiQ9H210.

Expressioni

Gene expression databases

CleanExiHS_OR2D2.
ExpressionAtlasiQ9H210. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000299459.

Structurei

3D structure databases

ProteinModelPortaliQ9H210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8YG. Eukaryota.
ENOG411194F. LUCA.
GeneTreeiENSGT00820000126998.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ9H210.
KOiK04257.
OMAiQINQTQV.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9H210.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H210-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQINQTQVT EFLLLGLSDG PHTEQLLFIV LLGVYLVTVL GNLLLISLVH
60 70 80 90 100
VDSQLHTPMY FFLCNLSLAD LCFSTNIVPQ ALVHLLSRKK VIAFTLCAAR
110 120 130 140 150
LLFFLIFGCT QCALLAVMSY DRYVAICNPL RYPNIMTWKV CVQLATGSWT
160 170 180 190 200
SGILVSVVDT TFILRLPYRG SNSIAHFFCE APALLILAST DTHASEMAIF
210 220 230 240 250
LMGVVILLIP VFLILVSYGR IIVTVVKMKS TVGSLKAFST CGSHLMVVIL
260 270 280 290 300
FYGSAIITYM TPKSSKQQEK SVSVFYAIVT PMLNPLIYSL RNKDVKAALR

KVATRNFP
Length:308
Mass (Da):34,172
Last modified:October 14, 2008 - v4
Checksum:iE3A7471570625CE4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134N → D in AAC70020 (PubMed:9787077).Curated1
Sequence conflicti134N → D in AAK95076 (PubMed:12213199).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06201784H → Y.Corresponds to variant rs57896484dbSNPEnsembl.1
Natural variantiVAR_046723148S → P.Corresponds to variant rs1965209dbSNPEnsembl.1
Natural variantiVAR_046724163I → M.Corresponds to variant rs1965207dbSNPEnsembl.1
Natural variantiVAR_046725163I → T.5 PublicationsCorresponds to variant rs1965208dbSNPEnsembl.1
Natural variantiVAR_046726202M → T.3 PublicationsCorresponds to variant rs2741804dbSNPEnsembl.1
Natural variantiVAR_062018220R → G.Corresponds to variant rs60116285dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321237 Genomic DNA. Translation: AAG45204.1.
AB065824 Genomic DNA. Translation: BAC06043.1.
CH471064 Genomic DNA. Translation: EAW68673.1.
BC140729 mRNA. Translation: AAI40730.1.
AF065876 Genomic DNA. Translation: AAC70020.1.
AF399591 Genomic DNA. Translation: AAK95076.1.
BK004434 Genomic DNA. Translation: DAA04832.1.
CCDSiCCDS31416.1.
RefSeqiNP_003691.1. NM_003700.1.
UniGeneiHs.690210.

Genome annotation databases

EnsembliENST00000299459; ENSP00000299459; ENSG00000166368.
GeneIDi120776.
KEGGihsa:120776.
UCSCiuc010rau.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321237 Genomic DNA. Translation: AAG45204.1.
AB065824 Genomic DNA. Translation: BAC06043.1.
CH471064 Genomic DNA. Translation: EAW68673.1.
BC140729 mRNA. Translation: AAI40730.1.
AF065876 Genomic DNA. Translation: AAC70020.1.
AF399591 Genomic DNA. Translation: AAK95076.1.
BK004434 Genomic DNA. Translation: DAA04832.1.
CCDSiCCDS31416.1.
RefSeqiNP_003691.1. NM_003700.1.
UniGeneiHs.690210.

3D structure databases

ProteinModelPortaliQ9H210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000299459.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9H210.
PhosphoSitePlusiQ9H210.

Polymorphism and mutation databases

BioMutaiOR2D2.
DMDMi209572777.

Proteomic databases

PaxDbiQ9H210.
PeptideAtlasiQ9H210.
PRIDEiQ9H210.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299459; ENSP00000299459; ENSG00000166368.
GeneIDi120776.
KEGGihsa:120776.
UCSCiuc010rau.3. human.

Organism-specific databases

CTDi120776.
GeneCardsiOR2D2.
HGNCiHGNC:8244. OR2D2.
MIMi608494. gene.
neXtProtiNX_Q9H210.
OpenTargetsiENSG00000166368.
PharmGKBiPA32152.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J8YG. Eukaryota.
ENOG411194F. LUCA.
GeneTreeiENSGT00820000126998.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ9H210.
KOiK04257.
OMAiQINQTQV.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ9H210.
TreeFamiTF337251.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166368-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2D2.
GenomeRNAii120776.
PROiQ9H210.
SOURCEiSearch...

Gene expression databases

CleanExiHS_OR2D2.
ExpressionAtlasiQ9H210. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2D2_HUMAN
AccessioniPrimary (citable) accession number: Q9H210
Secondary accession number(s): B9EIL5
, O95224, Q6IF28, Q8NGH4, Q96R52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 14, 2008
Last modified: November 30, 2016
This is version 132 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.