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Protein

Olfactory receptor 2D2

Gene

OR2D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2D2
Alternative name(s):
HB2
Olfactory receptor 11-610
Short name:
OR11-610
Olfactory receptor 2D1
Olfactory receptor OR11-88
Gene namesi
Name:OR2D2
Synonyms:OR2D1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166368.2
HGNCiHGNC:8244 OR2D2
MIMi608494 gene
neXtProtiNX_Q9H210

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 270ExtracellularSequence analysisAdd BLAST11
Transmembranei271 – 290Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini291 – 308CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166368
PharmGKBiPA32152

Polymorphism and mutation databases

BioMutaiOR2D2
DMDMi209572777

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504671 – 308Olfactory receptor 2D2Add BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9H210
PeptideAtlasiQ9H210
PRIDEiQ9H210
ProteomicsDBi80470

PTM databases

iPTMnetiQ9H210
PhosphoSitePlusiQ9H210

Expressioni

Gene expression databases

BgeeiENSG00000166368
CleanExiHS_OR2D2
ExpressionAtlasiQ9H210 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000299459

Structurei

3D structure databases

ProteinModelPortaliQ9H210
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8YG Eukaryota
ENOG411194F LUCA
GeneTreeiENSGT00820000126998
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ9H210
KOiK04257
OMAiFGCTQCV
OrthoDBiEOG091G0AZH
PhylomeDBiQ9H210
TreeFamiTF337251

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H210-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQINQTQVT EFLLLGLSDG PHTEQLLFIV LLGVYLVTVL GNLLLISLVH
60 70 80 90 100
VDSQLHTPMY FFLCNLSLAD LCFSTNIVPQ ALVHLLSRKK VIAFTLCAAR
110 120 130 140 150
LLFFLIFGCT QCALLAVMSY DRYVAICNPL RYPNIMTWKV CVQLATGSWT
160 170 180 190 200
SGILVSVVDT TFILRLPYRG SNSIAHFFCE APALLILAST DTHASEMAIF
210 220 230 240 250
LMGVVILLIP VFLILVSYGR IIVTVVKMKS TVGSLKAFST CGSHLMVVIL
260 270 280 290 300
FYGSAIITYM TPKSSKQQEK SVSVFYAIVT PMLNPLIYSL RNKDVKAALR

KVATRNFP
Length:308
Mass (Da):34,172
Last modified:October 14, 2008 - v4
Checksum:iE3A7471570625CE4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134N → D in AAC70020 (PubMed:9787077).Curated1
Sequence conflicti134N → D in AAK95076 (PubMed:12213199).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06201784H → Y. Corresponds to variant dbSNP:rs57896484Ensembl.1
Natural variantiVAR_046723148S → P. Corresponds to variant dbSNP:rs1965209Ensembl.1
Natural variantiVAR_046724163I → M. Corresponds to variant dbSNP:rs1965207Ensembl.1
Natural variantiVAR_046725163I → T5 PublicationsCorresponds to variant dbSNP:rs1965208Ensembl.1
Natural variantiVAR_046726202M → T3 PublicationsCorresponds to variant dbSNP:rs2741804Ensembl.1
Natural variantiVAR_062018220R → G. Corresponds to variant dbSNP:rs60116285Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321237 Genomic DNA Translation: AAG45204.1
AB065824 Genomic DNA Translation: BAC06043.1
CH471064 Genomic DNA Translation: EAW68673.1
BC140729 mRNA Translation: AAI40730.1
AF065876 Genomic DNA Translation: AAC70020.1
AF399591 Genomic DNA Translation: AAK95076.1
BK004434 Genomic DNA Translation: DAA04832.1
CCDSiCCDS31416.1
RefSeqiNP_003691.1, NM_003700.1
UniGeneiHs.690210

Genome annotation databases

EnsembliENST00000299459; ENSP00000299459; ENSG00000166368
GeneIDi120776
KEGGihsa:120776
UCSCiuc010rau.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR2D2_HUMAN
AccessioniPrimary (citable) accession number: Q9H210
Secondary accession number(s): B9EIL5
, O95224, Q6IF28, Q8NGH4, Q96R52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 14, 2008
Last modified: June 20, 2018
This is version 140 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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