ID   O10A4_HUMAN             Reviewed;         315 AA.
AC   Q9H209; B2RNP5; B9EH36; Q96R20;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   24-JAN-2024, entry version 161.
DE   RecName: Full=Olfactory receptor 10A4;
DE   AltName: Full=HP2;
DE   AltName: Full=Olfactory receptor-like protein JCG5;
GN   Name=OR10A4; Synonyms=OR10A4P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT PRO-206.
RX   PubMed=11416212; DOI=10.1073/pnas.131215398;
RA   Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L.,
RA   Evans G., Axel R., Hood L., Trask B.J.;
RT   "Genomic analysis of orthologous mouse and human olfactory receptor loci.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT PRO-206.
RC   TISSUE=Tongue;
RX   PubMed=11705801; DOI=10.1093/chemse/26.9.1157;
RA   Gaudin J.-C., Breuils L., Haertle T.;
RT   "New GPCRs from a human lingual cDNA library.";
RL   Chem. Senses 26:1157-1166(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-262.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284, AND VARIANT PRO-206.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
CC   -!- FUNCTION: Odorant receptor (Potential). May be involved in taste
CC       perception. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in the tongue.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10A4";
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DR   EMBL; AF321237; AAG45205.1; -; Genomic_DNA.
DR   EMBL; AF209506; AAL32993.1; -; mRNA.
DR   EMBL; AC087280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471064; EAW68674.1; -; Genomic_DNA.
DR   EMBL; BC137024; AAI37025.1; -; mRNA.
DR   EMBL; BC137027; AAI37028.1; -; mRNA.
DR   EMBL; AF399625; AAK95110.1; -; Genomic_DNA.
DR   CCDS; CCDS7774.1; -.
DR   RefSeq; NP_997069.2; NM_207186.2.
DR   AlphaFoldDB; Q9H209; -.
DR   SMR; Q9H209; -.
DR   BioGRID; 129519; 5.
DR   STRING; 9606.ENSP00000369157; -.
DR   GlyCosmos; Q9H209; 1 site, No reported glycans.
DR   GlyGen; Q9H209; 1 site.
DR   BioMuta; OR10A4; -.
DR   DMDM; 296439244; -.
DR   PaxDb; 9606-ENSP00000369157; -.
DR   Antibodypedia; 54733; 104 antibodies from 19 providers.
DR   DNASU; 283297; -.
DR   Ensembl; ENST00000379829.2; ENSP00000369157.2; ENSG00000170782.3.
DR   GeneID; 283297; -.
DR   KEGG; hsa:283297; -.
DR   MANE-Select; ENST00000379829.2; ENSP00000369157.2; NM_207186.2; NP_997069.2.
DR   UCSC; uc010rat.2; human.
DR   AGR; HGNC:15130; -.
DR   CTD; 283297; -.
DR   DisGeNET; 283297; -.
DR   GeneCards; OR10A4; -.
DR   HGNC; HGNC:15130; OR10A4.
DR   HPA; ENSG00000170782; Not detected.
DR   neXtProt; NX_Q9H209; -.
DR   OpenTargets; ENSG00000170782; -.
DR   PharmGKB; PA31952; -.
DR   VEuPathDB; HostDB:ENSG00000170782; -.
DR   eggNOG; ENOG502QVH7; Eukaryota.
DR   GeneTree; ENSGT01050000244815; -.
DR   HOGENOM; CLU_012526_1_2_1; -.
DR   InParanoid; Q9H209; -.
DR   OMA; MMWENWT; -.
DR   OrthoDB; 4631716at2759; -.
DR   PhylomeDB; Q9H209; -.
DR   TreeFam; TF337350; -.
DR   PathwayCommons; Q9H209; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 283297; 6 hits in 744 CRISPR screens.
DR   GeneWiki; OR10A4; -.
DR   GenomeRNAi; 283297; -.
DR   Pharos; Q9H209; Tbio.
DR   PRO; PR:Q9H209; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9H209; Protein.
DR   Bgee; ENSG00000170782; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 3 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15225; 7tmA_OR10A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF9; OLFACTORY RECEPTOR 10A4; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q9H209; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..315
FT                   /note="Olfactory receptor 10A4"
FT                   /id="PRO_0000150686"
FT   TOPO_DOM        1..26
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        77..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        122..140
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162..198
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..315
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        98..190
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         206
FT                   /note="L -> P (in dbSNP:rs2595453)"
FT                   /evidence="ECO:0000269|PubMed:11416212,
FT                   ECO:0000269|PubMed:11705801, ECO:0000269|PubMed:12213199"
FT                   /id="VAR_060023"
FT   VARIANT         221
FT                   /note="R -> H (in dbSNP:rs7938371)"
FT                   /id="VAR_034280"
FT   VARIANT         246
FT                   /note="L -> F (in dbSNP:rs16919049)"
FT                   /id="VAR_034281"
FT   VARIANT         262
FT                   /note="R -> Q (in dbSNP:rs10839635)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_024124"
SQ   SEQUENCE   315 AA;  35117 MW;  C8DF67959FDACBFC CRC64;
     MMWENWTIVS EFVLVSFSAL STELQALLFL LFLTIYLVTL MGNVLIILVT IADSALQSPM
     YFFLRNLSFL EIGFNLVIVP KMLGTLIIQD TTISFLGCAT QMYFFFFFGA AECCLLATMA
     YDRYVAICDP LHYPVIMGHI SCAQLAAASW FSGFSVATVQ TTWIFSFPFC GPNRVNHFFC
     DSPPVIALVC ADTSVFELEA LTATVLFILF PFLLILGSYV RILSTIFRMP SAEGKHQAFS
     TCSAHLLVVS LFYSTAILTY FRPQSSASSE SKKLLSLSST VVTPMLNPII YSSRNKEVKA
     ALKRLIHRTL GSQKL
//