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Protein

Olfactory receptor 10A4

Gene

OR10A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor (Potential). May be involved in taste perception.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170782-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10A4
Alternative name(s):
HP2
Olfactory receptor-like protein JCG5
Gene namesi
Name:OR10A4
Synonyms:OR10A4P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15130. OR10A4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 100ExtracellularSequence analysisAdd BLAST24
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 198ExtracellularSequence analysisAdd BLAST37
Transmembranei199 – 218Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini219 – 238CytoplasmicSequence analysisAdd BLAST20
Transmembranei239 – 259Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 293Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini294 – 315CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi283297.
OpenTargetsiENSG00000170782.
PharmGKBiPA31952.

Polymorphism and mutation databases

BioMutaiOR10A4.
DMDMi296439244.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506861 – 315Olfactory receptor 10A4Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H209.
PeptideAtlasiQ9H209.
PRIDEiQ9H209.

Expressioni

Tissue specificityi

Expressed in the tongue.

Gene expression databases

BgeeiENSG00000170782.
GenevisibleiQ9H209. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369157.

Structurei

3D structure databases

ProteinModelPortaliQ9H209.
SMRiQ9H209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKK8. Eukaryota.
ENOG410YDA3. LUCA.
GeneTreeiENSGT00760000119002.
HOVERGENiHBG017625.
InParanoidiQ9H209.
KOiK04257.
OMAiTTWIFSF.
OrthoDBiEOG091G0FFM.
PhylomeDBiQ9H209.
TreeFamiTF337350.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMWENWTIVS EFVLVSFSAL STELQALLFL LFLTIYLVTL MGNVLIILVT
60 70 80 90 100
IADSALQSPM YFFLRNLSFL EIGFNLVIVP KMLGTLIIQD TTISFLGCAT
110 120 130 140 150
QMYFFFFFGA AECCLLATMA YDRYVAICDP LHYPVIMGHI SCAQLAAASW
160 170 180 190 200
FSGFSVATVQ TTWIFSFPFC GPNRVNHFFC DSPPVIALVC ADTSVFELEA
210 220 230 240 250
LTATVLFILF PFLLILGSYV RILSTIFRMP SAEGKHQAFS TCSAHLLVVS
260 270 280 290 300
LFYSTAILTY FRPQSSASSE SKKLLSLSST VVTPMLNPII YSSRNKEVKA
310
ALKRLIHRTL GSQKL
Length:315
Mass (Da):35,117
Last modified:May 18, 2010 - v2
Checksum:iC8DF67959FDACBFC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060023206L → P.3 PublicationsCorresponds to variant rs2595453dbSNPEnsembl.1
Natural variantiVAR_034280221R → H.Corresponds to variant rs7938371dbSNPEnsembl.1
Natural variantiVAR_034281246L → F.Corresponds to variant rs16919049dbSNPEnsembl.1
Natural variantiVAR_024124262R → Q.1 PublicationCorresponds to variant rs10839635dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321237 Genomic DNA. Translation: AAG45205.1.
AF209506 mRNA. Translation: AAL32993.1.
AC087280 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68674.1.
BC137024 mRNA. Translation: AAI37025.1.
BC137027 mRNA. Translation: AAI37028.1.
AF399625 Genomic DNA. Translation: AAK95110.1.
CCDSiCCDS7774.1.
RefSeqiNP_997069.2. NM_207186.2.
UniGeneiHs.448685.

Genome annotation databases

EnsembliENST00000379829; ENSP00000369157; ENSG00000170782.
GeneIDi283297.
KEGGihsa:283297.
UCSCiuc010rat.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321237 Genomic DNA. Translation: AAG45205.1.
AF209506 mRNA. Translation: AAL32993.1.
AC087280 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68674.1.
BC137024 mRNA. Translation: AAI37025.1.
BC137027 mRNA. Translation: AAI37028.1.
AF399625 Genomic DNA. Translation: AAK95110.1.
CCDSiCCDS7774.1.
RefSeqiNP_997069.2. NM_207186.2.
UniGeneiHs.448685.

3D structure databases

ProteinModelPortaliQ9H209.
SMRiQ9H209.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000369157.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR10A4.
DMDMi296439244.

Proteomic databases

PaxDbiQ9H209.
PeptideAtlasiQ9H209.
PRIDEiQ9H209.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379829; ENSP00000369157; ENSG00000170782.
GeneIDi283297.
KEGGihsa:283297.
UCSCiuc010rat.2. human.

Organism-specific databases

CTDi283297.
DisGeNETi283297.
GeneCardsiOR10A4.
HGNCiHGNC:15130. OR10A4.
neXtProtiNX_Q9H209.
OpenTargetsiENSG00000170782.
PharmGKBiPA31952.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKK8. Eukaryota.
ENOG410YDA3. LUCA.
GeneTreeiENSGT00760000119002.
HOVERGENiHBG017625.
InParanoidiQ9H209.
KOiK04257.
OMAiTTWIFSF.
OrthoDBiEOG091G0FFM.
PhylomeDBiQ9H209.
TreeFamiTF337350.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170782-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10A4.
GenomeRNAii283297.
PROiQ9H209.

Gene expression databases

BgeeiENSG00000170782.
GenevisibleiQ9H209. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO10A4_HUMAN
AccessioniPrimary (citable) accession number: Q9H209
Secondary accession number(s): B2RNP5, B9EH36, Q96R20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.