Reviewed, UniProtKB/Swiss-Prot Q9H209 (O10A4_HUMAN)

Names and origin

Protein names

Recommended name:
    Olfactory receptor 10A4
Alternative name(s):
    Olfactory receptor-like protein JCG5
    HP2

Gene names

Name:	OR10A4
Synonyms:	OR10A4P

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Odorant receptor Potential. May be involved in taste perception.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in the tongue.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of smell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Olfactory receptor 10A4		PRO_0000150686
Regions
	Topological domain	1 – 26	26	Extracellular Potential
	Transmembrane	27 – 47	21	1 Potential
	Topological domain	48 – 55	8	Cytoplasmic Potential
	Transmembrane	56 – 76	21	2 Potential
	Topological domain	77 – 100	24	Extracellular Potential
	Transmembrane	101 – 121	21	3 Potential
	Topological domain	122 – 140	19	Cytoplasmic Potential
	Transmembrane	141 – 161	21	4 Potential
	Topological domain	162 – 198	37	Extracellular Potential
	Transmembrane	199 – 218	20	5 Potential
	Topological domain	219 – 238	20	Cytoplasmic Potential
	Transmembrane	239 – 259	21	6 Potential
	Topological domain	260 – 272	13	Extracellular Potential
	Transmembrane	273 – 293	21	7 Potential
	Topological domain	294 – 315	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	98 ↔ 190		By similarity
Natural variations
	Natural variant	221	1	R → H: dbSNP rs7938371.		VAR_034280
	Natural variant	246	1	L → F: dbSNP rs16919049.		VAR_034281
	Natural variant	262	1	R → Q: dbSNP rs10839635.		VAR_024124

Sequences

	Sequence		Length	Mass (Da)
	Q9H209-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 68DF6780CA800A4A	FASTA	315	35,101
	10 20 30 40 50 60 MMWENWTIVS EFVLVSFSAL STELQALLFL LFLTIYLVTL MGNVLIILVT IADSALQSPM 70 80 90 100 110 120 YFFLRNLSFL EIGFNLVIVP KMLGTLIIQD TTISFLGCAT QMYFFFFFGA AECCLLATMA 130 140 150 160 170 180 YDRYVAICDP LHYPVIMGHI SCAQLAAASW FSGFSVATVQ TTWIFSFPFC GPNRVNHFFC 190 200 210 220 230 240 DSPPVIALVC ADTSVFELEA LTATVPFILF PFLLILGSYV RILSTIFRMP SAEGKHQAFS 250 260 270 280 290 300 TCSAHLLVVS LFYSTAILTY FRPQSSASSE SKKLLSLSST VVTPMLNPII YSSRNKEVKA 310 ALKRLIHRTL GSQKL

References

[1]	"Genomic analysis of orthologous mouse and human olfactory receptor loci." Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L., Evans G., Axel R., Hood L., Trask B.J. Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001) [PubMed: 11416212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"New GPCRs from a human lingual cDNA library." Gaudin J.-C., Breuils L., Haertle T. Chem. Senses 26:1157-1166(2001) [PubMed: 11705801] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Tongue.
[3]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed: 12213199] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF321237 Genomic DNA. Translation: AAG45205.1. AF209506 mRNA. Translation: AAL32993.1. AF399625 Genomic DNA. Translation: AAK95110.1.
IPI	IPI00022330.
RefSeq	NP_997069.1.
UniGene	Hs.448685
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	ENSG00000170782. Homo sapiens. [Contig view]
GeneID	283297.
KEGG	hsa:283297.
UCSC	uc001mev.1. human.
Organism-specific databases
GeneCards	GC11P006854.
HGNC	HGNC:15130. OR10A4.
PharmGKB	PA31952.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9H209.
Enzyme and pathway databases
Reactome	REACT_14797. Signaling by GPCR.
Gene expression databases
ArrayExpress	Q9H209.
GermOnline	ENSG00000170782. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR11398. Olfact_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	93786.

Entry information

Entry name

O10A4_HUMAN

Accession

Primary (citable) accession number: Q9H209
Secondary accession number(s): Q96R20

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	March 1, 2001
Last modified:	July 7, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)