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Q9H209

- O10A4_HUMAN

UniProt

Q9H209 - O10A4_HUMAN

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Protein

Olfactory receptor 10A4

Gene

OR10A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor (Potential). May be involved in taste perception.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro

GO - Biological processi

  1. axon guidance Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10A4
Alternative name(s):
HP2
Olfactory receptor-like protein JCG5
Gene namesi
Name:OR10A4
Synonyms:OR10A4P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15130. OR10A4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence Analysis
Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini77 – 10024ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini162 – 19837ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 21820Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 23820CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini294 – 31522CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31952.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Olfactory receptor 10A4PRO_0000150686Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H209.
PRIDEiQ9H209.

PTM databases

PhosphoSiteiQ9H209.

Expressioni

Tissue specificityi

Expressed in the tongue.

Gene expression databases

BgeeiQ9H209.
GenevestigatoriQ9H209.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369157.

Structurei

3D structure databases

ProteinModelPortaliQ9H209.
SMRiQ9H209. Positions 33-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150795.
GeneTreeiENSGT00760000119002.
HOVERGENiHBG017625.
InParanoidiQ9H209.
KOiK04257.
OMAiTTWIFSF.
OrthoDBiEOG7X9G79.
PhylomeDBiQ9H209.
TreeFamiTF337350.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H209-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMWENWTIVS EFVLVSFSAL STELQALLFL LFLTIYLVTL MGNVLIILVT
60 70 80 90 100
IADSALQSPM YFFLRNLSFL EIGFNLVIVP KMLGTLIIQD TTISFLGCAT
110 120 130 140 150
QMYFFFFFGA AECCLLATMA YDRYVAICDP LHYPVIMGHI SCAQLAAASW
160 170 180 190 200
FSGFSVATVQ TTWIFSFPFC GPNRVNHFFC DSPPVIALVC ADTSVFELEA
210 220 230 240 250
LTATVLFILF PFLLILGSYV RILSTIFRMP SAEGKHQAFS TCSAHLLVVS
260 270 280 290 300
LFYSTAILTY FRPQSSASSE SKKLLSLSST VVTPMLNPII YSSRNKEVKA
310
ALKRLIHRTL GSQKL
Length:315
Mass (Da):35,117
Last modified:May 18, 2010 - v2
Checksum:iC8DF67959FDACBFC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti206 – 2061L → P.3 Publications
Corresponds to variant rs2595453 [ dbSNP | Ensembl ].
VAR_060023
Natural varianti221 – 2211R → H.
Corresponds to variant rs7938371 [ dbSNP | Ensembl ].
VAR_034280
Natural varianti246 – 2461L → F.
Corresponds to variant rs16919049 [ dbSNP | Ensembl ].
VAR_034281
Natural varianti262 – 2621R → Q.1 Publication
Corresponds to variant rs10839635 [ dbSNP | Ensembl ].
VAR_024124

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321237 Genomic DNA. Translation: AAG45205.1.
AF209506 mRNA. Translation: AAL32993.1.
AC087280 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68674.1.
BC137024 mRNA. Translation: AAI37025.1.
BC137027 mRNA. Translation: AAI37028.1.
AF399625 Genomic DNA. Translation: AAK95110.1.
CCDSiCCDS7774.1.
RefSeqiNP_997069.2. NM_207186.2.
UniGeneiHs.448685.

Genome annotation databases

EnsembliENST00000379829; ENSP00000369157; ENSG00000170782.
GeneIDi283297.
KEGGihsa:283297.
UCSCiuc010rat.2. human.

Polymorphism databases

DMDMi296439244.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321237 Genomic DNA. Translation: AAG45205.1 .
AF209506 mRNA. Translation: AAL32993.1 .
AC087280 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68674.1 .
BC137024 mRNA. Translation: AAI37025.1 .
BC137027 mRNA. Translation: AAI37028.1 .
AF399625 Genomic DNA. Translation: AAK95110.1 .
CCDSi CCDS7774.1.
RefSeqi NP_997069.2. NM_207186.2.
UniGenei Hs.448685.

3D structure databases

ProteinModelPortali Q9H209.
SMRi Q9H209. Positions 33-306.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000369157.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9H209.

Polymorphism databases

DMDMi 296439244.

Proteomic databases

PaxDbi Q9H209.
PRIDEi Q9H209.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000379829 ; ENSP00000369157 ; ENSG00000170782 .
GeneIDi 283297.
KEGGi hsa:283297.
UCSCi uc010rat.2. human.

Organism-specific databases

CTDi 283297.
GeneCardsi GC11P006897.
HGNCi HGNC:15130. OR10A4.
neXtProti NX_Q9H209.
PharmGKBi PA31952.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG150795.
GeneTreei ENSGT00760000119002.
HOVERGENi HBG017625.
InParanoidi Q9H209.
KOi K04257.
OMAi TTWIFSF.
OrthoDBi EOG7X9G79.
PhylomeDBi Q9H209.
TreeFami TF337350.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10A4.
GenomeRNAii 283297.
NextBioi 93786.
PROi Q9H209.

Gene expression databases

Bgeei Q9H209.
Genevestigatori Q9H209.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-206.
  2. "New GPCRs from a human lingual cDNA library."
    Gaudin J.-C., Breuils L., Haertle T.
    Chem. Senses 26:1157-1166(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-206.
    Tissue: Tongue.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-262.
    Tissue: Testis.
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284, VARIANT PRO-206.

Entry informationi

Entry nameiO10A4_HUMAN
AccessioniPrimary (citable) accession number: Q9H209
Secondary accession number(s): B2RNP5, B9EH36, Q96R20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3