Q9H209 (O10A4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 10A4

Alternative name(s):
HP2
Olfactory receptor-like protein JCG5

Gene names

Name:	OR10A4
Synonyms:	OR10A4P

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential. May be involved in taste perception.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in the tongue.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Olfactory receptor 10A4		PRO_0000150686
Regions
	Topological domain	1 – 26	26	Extracellular Potential
	Transmembrane	27 – 47	21	Helical; Name=1; Potential
	Topological domain	48 – 55	8	Cytoplasmic Potential
	Transmembrane	56 – 76	21	Helical; Name=2; Potential
	Topological domain	77 – 100	24	Extracellular Potential
	Transmembrane	101 – 121	21	Helical; Name=3; Potential
	Topological domain	122 – 140	19	Cytoplasmic Potential
	Transmembrane	141 – 161	21	Helical; Name=4; Potential
	Topological domain	162 – 198	37	Extracellular Potential
	Transmembrane	199 – 218	20	Helical; Name=5; Potential
	Topological domain	219 – 238	20	Cytoplasmic Potential
	Transmembrane	239 – 259	21	Helical; Name=6; Potential
	Topological domain	260 – 272	13	Extracellular Potential
	Transmembrane	273 – 293	21	Helical; Name=7; Potential
	Topological domain	294 – 315	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	98 ↔ 190		By similarity
Natural variations
	Natural variant	206	1	L → P. Ref.1 Ref.2 Ref.6 Corresponds to variant rs2595453 [ dbSNP | Ensembl ].		VAR_060023
	Natural variant	221	1	R → H. Corresponds to variant rs7938371 [ dbSNP | Ensembl ].		VAR_034280
	Natural variant	246	1	L → F. Corresponds to variant rs16919049 [ dbSNP | Ensembl ].		VAR_034281
	Natural variant	262	1	R → Q. Ref.5 Corresponds to variant rs10839635 [ dbSNP | Ensembl ].		VAR_024124

Sequences

	Sequence		Length	Mass (Da)
	Q9H209 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: C8DF67959FDACBFC	FASTA	315	35,117
	10 20 30 40 50 60 MMWENWTIVS EFVLVSFSAL STELQALLFL LFLTIYLVTL MGNVLIILVT IADSALQSPM 70 80 90 100 110 120 YFFLRNLSFL EIGFNLVIVP KMLGTLIIQD TTISFLGCAT QMYFFFFFGA AECCLLATMA 130 140 150 160 170 180 YDRYVAICDP LHYPVIMGHI SCAQLAAASW FSGFSVATVQ TTWIFSFPFC GPNRVNHFFC 190 200 210 220 230 240 DSPPVIALVC ADTSVFELEA LTATVLFILF PFLLILGSYV RILSTIFRMP SAEGKHQAFS 250 260 270 280 290 300 TCSAHLLVVS LFYSTAILTY FRPQSSASSE SKKLLSLSST VVTPMLNPII YSSRNKEVKA 310 ALKRLIHRTL GSQKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic analysis of orthologous mouse and human olfactory receptor loci." Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L., Evans G., Axel R., Hood L., Trask B.J. Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-206.
[2]	"New GPCRs from a human lingual cDNA library." Gaudin J.-C., Breuils L., Haertle T. Chem. Senses 26:1157-1166(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-206. Tissue: Tongue.
[3]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-262. Tissue: Testis.
[6]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284, VARIANT PRO-206.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF321237 Genomic DNA. Translation: AAG45205.1. AF209506 mRNA. Translation: AAL32993.1. AC087280 Genomic DNA. No translation available. CH471064 Genomic DNA. Translation: EAW68674.1. BC137024 mRNA. Translation: AAI37025.1. BC137027 mRNA. Translation: AAI37028.1. AF399625 Genomic DNA. Translation: AAK95110.1.
IPI	IPI00742745.
RefSeq	NP_997069.2. NM_207186.2.
UniGene	Hs.448685.
3D structure databases
ProteinModelPortal	Q9H209.
SMR	Q9H209. Positions 33-306.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000369157.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9H209.
Polymorphism databases
DMDM	296439244.
Proteomic databases
PaxDb	Q9H209.
PRIDE	Q9H209.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000379829; ENSP00000369157; ENSG00000170782.
GeneID	283297.
KEGG	hsa:283297.
UCSC	uc010rat.2. human.
Organism-specific databases
CTD	283297.
GeneCards	GC11P006897.
HGNC	HGNC:15130. OR10A4.
neXtProt	NX_Q9H209.
PharmGKB	PA31952.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG150795.
HOVERGEN	HBG017625.
InParanoid	Q9H209.
KO	K04257.
OMA	IIQDTTI.
OrthoDB	EOG4HDSTX.
PhylomeDB	Q9H209.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	Q9H209.
Genevestigator	Q9H209.
GermOnline	ENSG00000170782. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	283297.
NextBio	93786.

Entry information

Entry name

O10A4_HUMAN

Accession

Primary (citable) accession number: Q9H209
Secondary accession number(s): B2RNP5, B9EH36, Q96R20

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.