Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9H209

- O10A4_HUMAN

UniProt

Q9H209 - O10A4_HUMAN

Protein

Olfactory receptor 10A4

Gene

OR10A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Odorant receptor Potential. May be involved in taste perception.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    GO - Biological processi

    1. axon guidance Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10A4
    Alternative name(s):
    HP2
    Olfactory receptor-like protein JCG5
    Gene namesi
    Name:OR10A4
    Synonyms:OR10A4P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15130. OR10A4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31952.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Olfactory receptor 10A4PRO_0000150686Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9H209.
    PRIDEiQ9H209.

    PTM databases

    PhosphoSiteiQ9H209.

    Expressioni

    Tissue specificityi

    Expressed in the tongue.

    Gene expression databases

    BgeeiQ9H209.
    GenevestigatoriQ9H209.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000369157.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H209.
    SMRiQ9H209. Positions 33-306.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 558CytoplasmicSequence Analysis
    Topological domaini77 – 10024ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini162 – 19837ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23820CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini294 – 31522CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 21820Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150795.
    HOVERGENiHBG017625.
    InParanoidiQ9H209.
    KOiK04257.
    OMAiTTWIFSF.
    OrthoDBiEOG7X9G79.
    PhylomeDBiQ9H209.
    TreeFamiTF337350.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H209-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMWENWTIVS EFVLVSFSAL STELQALLFL LFLTIYLVTL MGNVLIILVT    50
    IADSALQSPM YFFLRNLSFL EIGFNLVIVP KMLGTLIIQD TTISFLGCAT 100
    QMYFFFFFGA AECCLLATMA YDRYVAICDP LHYPVIMGHI SCAQLAAASW 150
    FSGFSVATVQ TTWIFSFPFC GPNRVNHFFC DSPPVIALVC ADTSVFELEA 200
    LTATVLFILF PFLLILGSYV RILSTIFRMP SAEGKHQAFS TCSAHLLVVS 250
    LFYSTAILTY FRPQSSASSE SKKLLSLSST VVTPMLNPII YSSRNKEVKA 300
    ALKRLIHRTL GSQKL 315
    Length:315
    Mass (Da):35,117
    Last modified:May 18, 2010 - v2
    Checksum:iC8DF67959FDACBFC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti206 – 2061L → P.3 Publications
    Corresponds to variant rs2595453 [ dbSNP | Ensembl ].
    VAR_060023
    Natural varianti221 – 2211R → H.
    Corresponds to variant rs7938371 [ dbSNP | Ensembl ].
    VAR_034280
    Natural varianti246 – 2461L → F.
    Corresponds to variant rs16919049 [ dbSNP | Ensembl ].
    VAR_034281
    Natural varianti262 – 2621R → Q.1 Publication
    Corresponds to variant rs10839635 [ dbSNP | Ensembl ].
    VAR_024124

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF321237 Genomic DNA. Translation: AAG45205.1.
    AF209506 mRNA. Translation: AAL32993.1.
    AC087280 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68674.1.
    BC137024 mRNA. Translation: AAI37025.1.
    BC137027 mRNA. Translation: AAI37028.1.
    AF399625 Genomic DNA. Translation: AAK95110.1.
    CCDSiCCDS7774.1.
    RefSeqiNP_997069.2. NM_207186.2.
    UniGeneiHs.448685.

    Genome annotation databases

    EnsembliENST00000379829; ENSP00000369157; ENSG00000170782.
    GeneIDi283297.
    KEGGihsa:283297.
    UCSCiuc010rat.2. human.

    Polymorphism databases

    DMDMi296439244.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF321237 Genomic DNA. Translation: AAG45205.1 .
    AF209506 mRNA. Translation: AAL32993.1 .
    AC087280 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68674.1 .
    BC137024 mRNA. Translation: AAI37025.1 .
    BC137027 mRNA. Translation: AAI37028.1 .
    AF399625 Genomic DNA. Translation: AAK95110.1 .
    CCDSi CCDS7774.1.
    RefSeqi NP_997069.2. NM_207186.2.
    UniGenei Hs.448685.

    3D structure databases

    ProteinModelPortali Q9H209.
    SMRi Q9H209. Positions 33-306.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000369157.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9H209.

    Polymorphism databases

    DMDMi 296439244.

    Proteomic databases

    PaxDbi Q9H209.
    PRIDEi Q9H209.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379829 ; ENSP00000369157 ; ENSG00000170782 .
    GeneIDi 283297.
    KEGGi hsa:283297.
    UCSCi uc010rat.2. human.

    Organism-specific databases

    CTDi 283297.
    GeneCardsi GC11P006897.
    HGNCi HGNC:15130. OR10A4.
    neXtProti NX_Q9H209.
    PharmGKBi PA31952.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150795.
    HOVERGENi HBG017625.
    InParanoidi Q9H209.
    KOi K04257.
    OMAi TTWIFSF.
    OrthoDBi EOG7X9G79.
    PhylomeDBi Q9H209.
    TreeFami TF337350.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10A4.
    GenomeRNAii 283297.
    NextBioi 93786.
    PROi Q9H209.

    Gene expression databases

    Bgeei Q9H209.
    Genevestigatori Q9H209.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-206.
    2. "New GPCRs from a human lingual cDNA library."
      Gaudin J.-C., Breuils L., Haertle T.
      Chem. Senses 26:1157-1166(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-206.
      Tissue: Tongue.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-262.
      Tissue: Testis.
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284, VARIANT PRO-206.

    Entry informationi

    Entry nameiO10A4_HUMAN
    AccessioniPrimary (citable) accession number: Q9H209
    Secondary accession number(s): B2RNP5, B9EH36, Q96R20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3