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Q9H209 (O10A4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10A4
Alternative name(s):
HP2
Olfactory receptor-like protein JCG5
Gene names
Name:OR10A4
Synonyms:OR10A4P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential. May be involved in taste perception.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in the tongue.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Olfactory receptor 10A4
PRO_0000150686

Regions

Topological domain1 – 2626Extracellular Potential
Transmembrane27 – 4721Helical; Name=1; Potential
Topological domain48 – 558Cytoplasmic Potential
Transmembrane56 – 7621Helical; Name=2; Potential
Topological domain77 – 10024Extracellular Potential
Transmembrane101 – 12121Helical; Name=3; Potential
Topological domain122 – 14019Cytoplasmic Potential
Transmembrane141 – 16121Helical; Name=4; Potential
Topological domain162 – 19837Extracellular Potential
Transmembrane199 – 21820Helical; Name=5; Potential
Topological domain219 – 23820Cytoplasmic Potential
Transmembrane239 – 25921Helical; Name=6; Potential
Topological domain260 – 27213Extracellular Potential
Transmembrane273 – 29321Helical; Name=7; Potential
Topological domain294 – 31522Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 190 By similarity

Natural variations

Natural variant2061L → P. Ref.1 Ref.2 Ref.6
Corresponds to variant rs2595453 [ dbSNP | Ensembl ].
VAR_060023
Natural variant2211R → H.
Corresponds to variant rs7938371 [ dbSNP | Ensembl ].
VAR_034280
Natural variant2461L → F.
Corresponds to variant rs16919049 [ dbSNP | Ensembl ].
VAR_034281
Natural variant2621R → Q. Ref.5
Corresponds to variant rs10839635 [ dbSNP | Ensembl ].
VAR_024124

Sequences

Sequence LengthMass (Da)Tools
Q9H209 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: C8DF67959FDACBFC

FASTA31535,117
        10         20         30         40         50         60 
MMWENWTIVS EFVLVSFSAL STELQALLFL LFLTIYLVTL MGNVLIILVT IADSALQSPM 

        70         80         90        100        110        120 
YFFLRNLSFL EIGFNLVIVP KMLGTLIIQD TTISFLGCAT QMYFFFFFGA AECCLLATMA 

       130        140        150        160        170        180 
YDRYVAICDP LHYPVIMGHI SCAQLAAASW FSGFSVATVQ TTWIFSFPFC GPNRVNHFFC 

       190        200        210        220        230        240 
DSPPVIALVC ADTSVFELEA LTATVLFILF PFLLILGSYV RILSTIFRMP SAEGKHQAFS 

       250        260        270        280        290        300 
TCSAHLLVVS LFYSTAILTY FRPQSSASSE SKKLLSLSST VVTPMLNPII YSSRNKEVKA 

       310 
ALKRLIHRTL GSQKL 

« Hide

References

« Hide 'large scale' references
[1]"Genomic analysis of orthologous mouse and human olfactory receptor loci."
Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L., Evans G., Axel R., Hood L., Trask B.J.
Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-206.
[2]"New GPCRs from a human lingual cDNA library."
Gaudin J.-C., Breuils L., Haertle T.
Chem. Senses 26:1157-1166(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PRO-206.
Tissue: Tongue.
[3]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-262.
Tissue: Testis.
[6]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284, VARIANT PRO-206.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF321237 Genomic DNA. Translation: AAG45205.1.
AF209506 mRNA. Translation: AAL32993.1.
AC087280 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68674.1.
BC137024 mRNA. Translation: AAI37025.1.
BC137027 mRNA. Translation: AAI37028.1.
AF399625 Genomic DNA. Translation: AAK95110.1.
RefSeqNP_997069.2. NM_207186.2.
UniGeneHs.448685.

3D structure databases

ProteinModelPortalQ9H209.
SMRQ9H209. Positions 33-308.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000369157.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9H209.

Polymorphism databases

DMDM296439244.

Proteomic databases

PaxDbQ9H209.
PRIDEQ9H209.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000379829; ENSP00000369157; ENSG00000170782.
GeneID283297.
KEGGhsa:283297.
UCSCuc010rat.2. human.

Organism-specific databases

CTD283297.
GeneCardsGC11P006897.
HGNCHGNC:15130. OR10A4.
neXtProtNX_Q9H209.
PharmGKBPA31952.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG150795.
HOVERGENHBG017625.
InParanoidQ9H209.
KOK04257.
OMATTWIFSF.
OrthoDBEOG7X9G79.
PhylomeDBQ9H209.
TreeFamTF337350.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ9H209.
GenevestigatorQ9H209.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10A4.
GenomeRNAi283297.
NextBio93786.
PROQ9H209.

Entry information

Entry nameO10A4_HUMAN
AccessionPrimary (citable) accession number: Q9H209
Secondary accession number(s): B2RNP5, B9EH36, Q96R20
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries