Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 10A2

Gene

OR10A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170790-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10A2
Alternative name(s):
HP4
Olfactory receptor OR11-86
Gene namesi
Name:OR10A2
Synonyms:OR10A2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8161. OR10A2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12ExtracellularSequence analysisAdd BLAST12
Transmembranei13 – 33Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini34 – 41CytoplasmicSequence analysis8
Transmembranei42 – 62Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini63 – 86ExtracellularSequence analysisAdd BLAST24
Transmembranei87 – 107Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini108 – 126CytoplasmicSequence analysisAdd BLAST19
Transmembranei127 – 147Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini148 – 184ExtracellularSequence analysisAdd BLAST37
Transmembranei185 – 204Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini205 – 224CytoplasmicSequence analysisAdd BLAST20
Transmembranei225 – 245Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini246 – 258ExtracellularSequence analysisAdd BLAST13
Transmembranei259 – 279Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini280 – 301CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi341276.
OpenTargetsiENSG00000170790.
PharmGKBiPA31950.

Polymorphism and mutation databases

BioMutaiOR10A2.
DMDMi118573088.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002611391 – 303Olfactory receptor 10A2Add BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi84 ↔ 176PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9H208.
PRIDEiQ9H208.
TopDownProteomicsiQ9H208.

PTM databases

iPTMnetiQ9H208.
PhosphoSitePlusiQ9H208.

Expressioni

Gene expression databases

CleanExiHS_OR10A2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303862.

Structurei

3D structure databases

ProteinModelPortaliQ9H208.
SMRiQ9H208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKK8. Eukaryota.
ENOG410YDA3. LUCA.
GeneTreeiENSGT00760000119002.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ9H208.
KOiK04257.
OMAiVTLMGNC.
OrthoDBiEOG091G0FFM.
PhylomeDBiQ9H208.
TreeFamiTF337350.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSSLPTEI QSLLFLTFLT IYLVTLMGNC LIILVTLADP MLHSPMYFFL
60 70 80 90 100
RNLSFLEIGF NLVIVPKMLG TLLAQDTTIS FLGCATQMYF FFFFGVAECF
110 120 130 140 150
LLATMAYDRY VAICSPLHYP VIMNQRTRAK LAAASWFPGF PVATVQTTWL
160 170 180 190 200
FSFPFCGTNK VNHFFCDSPP VLRLVCADTA LFEIYAIVGT ILVVMIPCLL
210 220 230 240 250
ILCSYTHIAA AILKIPSAKG KNKAFSTCSS HLLVVSLFYI SLSLTYFRPK
260 270 280 290 300
SNNSPEGKKL LSLSYTVMTP MLNPIIYSLR NNEVKNALSR TVSKALALRN

CIP
Length:303
Mass (Da):33,817
Last modified:November 28, 2006 - v2
Checksum:i6B7A103BBB8ED190
GO

Sequence cautioni

The sequence AAG45207 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173R → K in AAK95109 (PubMed:12213199).Curated1
Sequence conflicti222N → H in AAK95109 (PubMed:12213199).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06002243H → R.Corresponds to variant rs3930075dbSNPEnsembl.1
Natural variantiVAR_053261134A → T.2 PublicationsCorresponds to variant rs2741764dbSNPEnsembl.1
Natural variantiVAR_034277207H → R.1 PublicationCorresponds to variant rs10839631dbSNPEnsembl.1
Natural variantiVAR_034278240I → T.Corresponds to variant rs10839632dbSNPEnsembl.1
Natural variantiVAR_034279258K → T.Corresponds to variant rs7926083dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321237 Genomic DNA. Translation: AAG45207.1. Different initiation.
AC017103 Genomic DNA. No translation available.
BC136955 mRNA. Translation: AAI36956.1.
AF399624 Genomic DNA. Translation: AAK95109.1.
BK004293 Genomic DNA. Translation: DAA04691.1.
CCDSiCCDS31415.1.
RefSeqiNP_001004460.1. NM_001004460.1.
UniGeneiHs.371762.
Hs.447478.

Genome annotation databases

EnsembliENST00000307322; ENSP00000303862; ENSG00000170790.
GeneIDi341276.
KEGGihsa:341276.
UCSCiuc001meu.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321237 Genomic DNA. Translation: AAG45207.1. Different initiation.
AC017103 Genomic DNA. No translation available.
BC136955 mRNA. Translation: AAI36956.1.
AF399624 Genomic DNA. Translation: AAK95109.1.
BK004293 Genomic DNA. Translation: DAA04691.1.
CCDSiCCDS31415.1.
RefSeqiNP_001004460.1. NM_001004460.1.
UniGeneiHs.371762.
Hs.447478.

3D structure databases

ProteinModelPortaliQ9H208.
SMRiQ9H208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000303862.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9H208.
PhosphoSitePlusiQ9H208.

Polymorphism and mutation databases

BioMutaiOR10A2.
DMDMi118573088.

Proteomic databases

PaxDbiQ9H208.
PRIDEiQ9H208.
TopDownProteomicsiQ9H208.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307322; ENSP00000303862; ENSG00000170790.
GeneIDi341276.
KEGGihsa:341276.
UCSCiuc001meu.2. human.

Organism-specific databases

CTDi341276.
DisGeNETi341276.
GeneCardsiOR10A2.
HGNCiHGNC:8161. OR10A2.
neXtProtiNX_Q9H208.
OpenTargetsiENSG00000170790.
PharmGKBiPA31950.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKK8. Eukaryota.
ENOG410YDA3. LUCA.
GeneTreeiENSGT00760000119002.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ9H208.
KOiK04257.
OMAiVTLMGNC.
OrthoDBiEOG091G0FFM.
PhylomeDBiQ9H208.
TreeFamiTF337350.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170790-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii341276.
PROiQ9H208.

Gene expression databases

CleanExiHS_OR10A2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO10A2_HUMAN
AccessioniPrimary (citable) accession number: Q9H208
Secondary accession number(s): B2RNL9, Q6IFG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: November 2, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.