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Q9H208 (O10A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10A2
Alternative name(s):
HP4
Olfactory receptor OR11-86
Gene names
Name:OR10A2
Synonyms:OR10A2P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence AAG45207.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303Olfactory receptor 10A2
PRO_0000261139

Regions

Topological domain1 – 1212Extracellular Potential
Transmembrane13 – 3321Helical; Name=1; Potential
Topological domain34 – 418Cytoplasmic Potential
Transmembrane42 – 6221Helical; Name=2; Potential
Topological domain63 – 8624Extracellular Potential
Transmembrane87 – 10721Helical; Name=3; Potential
Topological domain108 – 12619Cytoplasmic Potential
Transmembrane127 – 14721Helical; Name=4; Potential
Topological domain148 – 18437Extracellular Potential
Transmembrane185 – 20420Helical; Name=5; Potential
Topological domain205 – 22420Cytoplasmic Potential
Transmembrane225 – 24521Helical; Name=6; Potential
Topological domain246 – 25813Extracellular Potential
Transmembrane259 – 27921Helical; Name=7; Potential
Topological domain280 – 30122Cytoplasmic Potential

Amino acid modifications

Disulfide bond84 ↔ 176 By similarity

Natural variations

Natural variant431H → R.
Corresponds to variant rs3930075 [ dbSNP | Ensembl ].
VAR_060022
Natural variant1341A → T. Ref.1 Ref.3
Corresponds to variant rs2741764 [ dbSNP | Ensembl ].
VAR_053261
Natural variant2071H → R. Ref.4
Corresponds to variant rs10839631 [ dbSNP | Ensembl ].
VAR_034277
Natural variant2401I → T.
Corresponds to variant rs10839632 [ dbSNP | Ensembl ].
VAR_034278
Natural variant2581K → T.
Corresponds to variant rs7926083 [ dbSNP | Ensembl ].
VAR_034279

Experimental info

Sequence conflict1731R → K in AAK95109. Ref.4
Sequence conflict2221N → H in AAK95109. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9H208 [UniParc].

Last modified November 28, 2006. Version 2.
Checksum: 6B7A103BBB8ED190

FASTA30333,817
        10         20         30         40         50         60 
MSFSSLPTEI QSLLFLTFLT IYLVTLMGNC LIILVTLADP MLHSPMYFFL RNLSFLEIGF 

        70         80         90        100        110        120 
NLVIVPKMLG TLLAQDTTIS FLGCATQMYF FFFFGVAECF LLATMAYDRY VAICSPLHYP 

       130        140        150        160        170        180 
VIMNQRTRAK LAAASWFPGF PVATVQTTWL FSFPFCGTNK VNHFFCDSPP VLRLVCADTA 

       190        200        210        220        230        240 
LFEIYAIVGT ILVVMIPCLL ILCSYTHIAA AILKIPSAKG KNKAFSTCSS HLLVVSLFYI 

       250        260        270        280        290        300 
SLSLTYFRPK SNNSPEGKKL LSLSYTVMTP MLNPIIYSLR NNEVKNALSR TVSKALALRN 


CIP 

« Hide

References

« Hide 'large scale' references
[1]"Genomic analysis of orthologous mouse and human olfactory receptor loci."
Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L., Evans G., Axel R., Hood L., Trask B.J.
Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-134.
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-134.
[4]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 55-270, VARIANT ARG-207.
[5]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF321237 Genomic DNA. Translation: AAG45207.1. Different initiation.
AC017103 Genomic DNA. No translation available.
BC136955 mRNA. Translation: AAI36956.1.
AF399624 Genomic DNA. Translation: AAK95109.1.
BK004293 Genomic DNA. Translation: DAA04691.1.
CCDSCCDS31415.1.
RefSeqNP_001004460.1. NM_001004460.1.
UniGeneHs.371762.
Hs.447478.

3D structure databases

ProteinModelPortalQ9H208.
SMRQ9H208. Positions 19-292.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000303862.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9H208.

Polymorphism databases

DMDM118573088.

Proteomic databases

PRIDEQ9H208.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000307322; ENSP00000303862; ENSG00000170790.
GeneID341276.
KEGGhsa:341276.
UCSCuc001meu.1. human.

Organism-specific databases

CTD341276.
GeneCardsGC11P006890.
HGNCHGNC:8161. OR10A2.
neXtProtNX_Q9H208.
PharmGKBPA31950.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG148577.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ9H208.
KOK04257.
OMAVTLMGNC.
OrthoDBEOG7SXW3S.
PhylomeDBQ9H208.
TreeFamTF337350.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR10A2.
GenevestigatorQ9H208.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi341276.
NextBio98098.
PROQ9H208.

Entry information

Entry nameO10A2_HUMAN
AccessionPrimary (citable) accession number: Q9H208
Secondary accession number(s): B2RNL9, Q6IFG9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries