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Q9H208

- O10A2_HUMAN

UniProt

Q9H208 - O10A2_HUMAN

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Protein

Olfactory receptor 10A2

Gene

OR10A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10A2
Alternative name(s):
HP4
Olfactory receptor OR11-86
Gene namesi
Name:OR10A2
Synonyms:OR10A2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:8161. OR10A2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31950.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Olfactory receptor 10A2PRO_0000261139Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi84 ↔ 176PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9H208.

PTM databases

PhosphoSiteiQ9H208.

Expressioni

Gene expression databases

CleanExiHS_OR10A2.
GenevestigatoriQ9H208.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303862.

Structurei

3D structure databases

ProteinModelPortaliQ9H208.
SMRiQ9H208. Positions 19-292.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212ExtracellularSequence AnalysisAdd
BLAST
Topological domaini34 – 418CytoplasmicSequence Analysis
Topological domaini63 – 8624ExtracellularSequence AnalysisAdd
BLAST
Topological domaini108 – 12619CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini148 – 18437ExtracellularSequence AnalysisAdd
BLAST
Topological domaini205 – 22420CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini246 – 25813ExtracellularSequence AnalysisAdd
BLAST
Topological domaini280 – 30122CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei42 – 6221Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei87 – 10721Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei127 – 14721Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei185 – 20420Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei225 – 24521Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei259 – 27921Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148577.
GeneTreeiENSGT00760000119002.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ9H208.
KOiK04257.
OMAiVTLMGNC.
OrthoDBiEOG7SXW3S.
PhylomeDBiQ9H208.
TreeFamiTF337350.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H208-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFSSLPTEI QSLLFLTFLT IYLVTLMGNC LIILVTLADP MLHSPMYFFL
60 70 80 90 100
RNLSFLEIGF NLVIVPKMLG TLLAQDTTIS FLGCATQMYF FFFFGVAECF
110 120 130 140 150
LLATMAYDRY VAICSPLHYP VIMNQRTRAK LAAASWFPGF PVATVQTTWL
160 170 180 190 200
FSFPFCGTNK VNHFFCDSPP VLRLVCADTA LFEIYAIVGT ILVVMIPCLL
210 220 230 240 250
ILCSYTHIAA AILKIPSAKG KNKAFSTCSS HLLVVSLFYI SLSLTYFRPK
260 270 280 290 300
SNNSPEGKKL LSLSYTVMTP MLNPIIYSLR NNEVKNALSR TVSKALALRN

CIP
Length:303
Mass (Da):33,817
Last modified:November 28, 2006 - v2
Checksum:i6B7A103BBB8ED190
GO

Sequence cautioni

The sequence AAG45207.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731R → K in AAK95109. (PubMed:12213199)Curated
Sequence conflicti222 – 2221N → H in AAK95109. (PubMed:12213199)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431H → R.
Corresponds to variant rs3930075 [ dbSNP | Ensembl ].
VAR_060022
Natural varianti134 – 1341A → T.2 Publications
Corresponds to variant rs2741764 [ dbSNP | Ensembl ].
VAR_053261
Natural varianti207 – 2071H → R.1 Publication
Corresponds to variant rs10839631 [ dbSNP | Ensembl ].
VAR_034277
Natural varianti240 – 2401I → T.
Corresponds to variant rs10839632 [ dbSNP | Ensembl ].
VAR_034278
Natural varianti258 – 2581K → T.
Corresponds to variant rs7926083 [ dbSNP | Ensembl ].
VAR_034279

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF321237 Genomic DNA. Translation: AAG45207.1. Different initiation.
AC017103 Genomic DNA. No translation available.
BC136955 mRNA. Translation: AAI36956.1.
AF399624 Genomic DNA. Translation: AAK95109.1.
BK004293 Genomic DNA. Translation: DAA04691.1.
CCDSiCCDS31415.1.
RefSeqiNP_001004460.1. NM_001004460.1.
UniGeneiHs.371762.
Hs.447478.

Genome annotation databases

EnsembliENST00000307322; ENSP00000303862; ENSG00000170790.
GeneIDi341276.
KEGGihsa:341276.
UCSCiuc001meu.1. human.

Polymorphism databases

DMDMi118573088.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF321237 Genomic DNA. Translation: AAG45207.1 . Different initiation.
AC017103 Genomic DNA. No translation available.
BC136955 mRNA. Translation: AAI36956.1 .
AF399624 Genomic DNA. Translation: AAK95109.1 .
BK004293 Genomic DNA. Translation: DAA04691.1 .
CCDSi CCDS31415.1.
RefSeqi NP_001004460.1. NM_001004460.1.
UniGenei Hs.371762.
Hs.447478.

3D structure databases

ProteinModelPortali Q9H208.
SMRi Q9H208. Positions 19-292.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000303862.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9H208.

Polymorphism databases

DMDMi 118573088.

Proteomic databases

PRIDEi Q9H208.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307322 ; ENSP00000303862 ; ENSG00000170790 .
GeneIDi 341276.
KEGGi hsa:341276.
UCSCi uc001meu.1. human.

Organism-specific databases

CTDi 341276.
GeneCardsi GC11P006890.
HGNCi HGNC:8161. OR10A2.
neXtProti NX_Q9H208.
PharmGKBi PA31950.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148577.
GeneTreei ENSGT00760000119002.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q9H208.
KOi K04257.
OMAi VTLMGNC.
OrthoDBi EOG7SXW3S.
PhylomeDBi Q9H208.
TreeFami TF337350.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii 341276.
NextBioi 98098.
PROi Q9H208.

Gene expression databases

CleanExi HS_OR10A2.
Genevestigatori Q9H208.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-134.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-134.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 55-270, VARIANT ARG-207.
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10A2_HUMAN
AccessioniPrimary (citable) accession number: Q9H208
Secondary accession number(s): B2RNL9, Q6IFG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: October 29, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3