Q9H208 (O10A2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 10A2

Alternative name(s):
HP4
Olfactory receptor OR11-86

Gene names

Name:	OR10A2
Synonyms:	OR10A2P

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence AAG45207.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Olfactory receptor 10A2		PRO_0000261139
Regions
	Topological domain	1 – 12	12	Extracellular Potential
	Transmembrane	13 – 33	21	Helical; Name=1; Potential
	Topological domain	34 – 41	8	Cytoplasmic Potential
	Transmembrane	42 – 62	21	Helical; Name=2; Potential
	Topological domain	63 – 86	24	Extracellular Potential
	Transmembrane	87 – 107	21	Helical; Name=3; Potential
	Topological domain	108 – 126	19	Cytoplasmic Potential
	Transmembrane	127 – 147	21	Helical; Name=4; Potential
	Topological domain	148 – 184	37	Extracellular Potential
	Transmembrane	185 – 204	20	Helical; Name=5; Potential
	Topological domain	205 – 224	20	Cytoplasmic Potential
	Transmembrane	225 – 245	21	Helical; Name=6; Potential
	Topological domain	246 – 258	13	Extracellular Potential
	Transmembrane	259 – 279	21	Helical; Name=7; Potential
	Topological domain	280 – 301	22	Cytoplasmic Potential
Amino acid modifications
	Disulfide bond	84 ↔ 176		By similarity
Natural variations
	Natural variant	43	1	H → R. Corresponds to variant rs3930075 [ dbSNP | Ensembl ].		VAR_060022
	Natural variant	134	1	A → T. Ref.1 Ref.3 Corresponds to variant rs2741764 [ dbSNP | Ensembl ].		VAR_053261
	Natural variant	207	1	H → R. Ref.4 Corresponds to variant rs10839631 [ dbSNP | Ensembl ].		VAR_034277
	Natural variant	240	1	I → T. Corresponds to variant rs10839632 [ dbSNP | Ensembl ].		VAR_034278
	Natural variant	258	1	K → T. Corresponds to variant rs7926083 [ dbSNP | Ensembl ].		VAR_034279
Experimental info
	Sequence conflict	173	1	R → K in AAK95109. Ref.4
	Sequence conflict	222	1	N → H in AAK95109. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q9H208 [UniParc]. Last modified November 28, 2006. Version 2. Checksum: 6B7A103BBB8ED190	FASTA	303	33,817
	10 20 30 40 50 60 MSFSSLPTEI QSLLFLTFLT IYLVTLMGNC LIILVTLADP MLHSPMYFFL RNLSFLEIGF 70 80 90 100 110 120 NLVIVPKMLG TLLAQDTTIS FLGCATQMYF FFFFGVAECF LLATMAYDRY VAICSPLHYP 130 140 150 160 170 180 VIMNQRTRAK LAAASWFPGF PVATVQTTWL FSFPFCGTNK VNHFFCDSPP VLRLVCADTA 190 200 210 220 230 240 LFEIYAIVGT ILVVMIPCLL ILCSYTHIAA AILKIPSAKG KNKAFSTCSS HLLVVSLFYI 250 260 270 280 290 300 SLSLTYFRPK SNNSPEGKKL LSLSYTVMTP MLNPIIYSLR NNEVKNALSR TVSKALALRN CIP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic analysis of orthologous mouse and human olfactory receptor loci." Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L., Evans G., Axel R., Hood L., Trask B.J. Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-134.
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-134.
[4]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 55-270, VARIANT ARG-207.
[5]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[6]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+	Additional computationally mapped references.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF321237 Genomic DNA. Translation: AAG45207.1. Different initiation. AC017103 Genomic DNA. No translation available. BC136955 mRNA. Translation: AAI36956.1. AF399624 Genomic DNA. Translation: AAK95109.1. BK004293 Genomic DNA. Translation: DAA04691.1.
IPI	IPI00300587.
RefSeq	NP_001004460.1. NM_001004460.1.
UniGene	Hs.371762. Hs.447478.
3D structure databases
ProteinModelPortal	Q9H208.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000303862.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9H208.
Polymorphism databases
DMDM	118573088.
Proteomic databases
PRIDE	Q9H208.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000307322; ENSP00000303862; ENSG00000170790.
GeneID	341276.
KEGG	hsa:341276.
UCSC	uc001meu.1. human.
Organism-specific databases
CTD	341276.
GeneCards	GC11P006890.
HGNC	HGNC:8161. OR10A2.
neXtProt	NX_Q9H208.
PharmGKB	PA31950.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG148577.
HOGENOM	HOG000041365.
HOVERGEN	HBG017625.
InParanoid	Q9H208.
KO	K04257.
OMA	VTLMGNC.
OrthoDB	EOG434W6M.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR10A2.
Genevestigator	Q9H208.
GermOnline	ENSG00000170790. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	341276.
NextBio	98098.

Entry information

Entry name

O10A2_HUMAN

Accession

Primary (citable) accession number: Q9H208
Secondary accession number(s): B2RNL9, Q6IFG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	November 28, 2006
Last modified:	May 1, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.