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Q9H208

- O10A2_HUMAN

UniProt

Q9H208 - O10A2_HUMAN

Protein

Olfactory receptor 10A2

Gene

OR10A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10A2
    Alternative name(s):
    HP4
    Olfactory receptor OR11-86
    Gene namesi
    Name:OR10A2
    Synonyms:OR10A2P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:8161. OR10A2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31950.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303Olfactory receptor 10A2PRO_0000261139Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi84 ↔ 176PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ9H208.

    PTM databases

    PhosphoSiteiQ9H208.

    Expressioni

    Gene expression databases

    CleanExiHS_OR10A2.
    GenevestigatoriQ9H208.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000303862.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H208.
    SMRiQ9H208. Positions 19-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini34 – 418CytoplasmicSequence Analysis
    Topological domaini63 – 8624ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini108 – 12619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini148 – 18437ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini205 – 22420CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini246 – 25813ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini280 – 30122CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei42 – 6221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei185 – 20420Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei259 – 27921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148577.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ9H208.
    KOiK04257.
    OMAiVTLMGNC.
    OrthoDBiEOG7SXW3S.
    PhylomeDBiQ9H208.
    TreeFamiTF337350.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H208-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFSSLPTEI QSLLFLTFLT IYLVTLMGNC LIILVTLADP MLHSPMYFFL    50
    RNLSFLEIGF NLVIVPKMLG TLLAQDTTIS FLGCATQMYF FFFFGVAECF 100
    LLATMAYDRY VAICSPLHYP VIMNQRTRAK LAAASWFPGF PVATVQTTWL 150
    FSFPFCGTNK VNHFFCDSPP VLRLVCADTA LFEIYAIVGT ILVVMIPCLL 200
    ILCSYTHIAA AILKIPSAKG KNKAFSTCSS HLLVVSLFYI SLSLTYFRPK 250
    SNNSPEGKKL LSLSYTVMTP MLNPIIYSLR NNEVKNALSR TVSKALALRN 300
    CIP 303
    Length:303
    Mass (Da):33,817
    Last modified:November 28, 2006 - v2
    Checksum:i6B7A103BBB8ED190
    GO

    Sequence cautioni

    The sequence AAG45207.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti173 – 1731R → K in AAK95109. (PubMed:12213199)Curated
    Sequence conflicti222 – 2221N → H in AAK95109. (PubMed:12213199)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti43 – 431H → R.
    Corresponds to variant rs3930075 [ dbSNP | Ensembl ].
    VAR_060022
    Natural varianti134 – 1341A → T.2 Publications
    Corresponds to variant rs2741764 [ dbSNP | Ensembl ].
    VAR_053261
    Natural varianti207 – 2071H → R.1 Publication
    Corresponds to variant rs10839631 [ dbSNP | Ensembl ].
    VAR_034277
    Natural varianti240 – 2401I → T.
    Corresponds to variant rs10839632 [ dbSNP | Ensembl ].
    VAR_034278
    Natural varianti258 – 2581K → T.
    Corresponds to variant rs7926083 [ dbSNP | Ensembl ].
    VAR_034279

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF321237 Genomic DNA. Translation: AAG45207.1. Different initiation.
    AC017103 Genomic DNA. No translation available.
    BC136955 mRNA. Translation: AAI36956.1.
    AF399624 Genomic DNA. Translation: AAK95109.1.
    BK004293 Genomic DNA. Translation: DAA04691.1.
    CCDSiCCDS31415.1.
    RefSeqiNP_001004460.1. NM_001004460.1.
    UniGeneiHs.371762.
    Hs.447478.

    Genome annotation databases

    EnsembliENST00000307322; ENSP00000303862; ENSG00000170790.
    GeneIDi341276.
    KEGGihsa:341276.
    UCSCiuc001meu.1. human.

    Polymorphism databases

    DMDMi118573088.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF321237 Genomic DNA. Translation: AAG45207.1 . Different initiation.
    AC017103 Genomic DNA. No translation available.
    BC136955 mRNA. Translation: AAI36956.1 .
    AF399624 Genomic DNA. Translation: AAK95109.1 .
    BK004293 Genomic DNA. Translation: DAA04691.1 .
    CCDSi CCDS31415.1.
    RefSeqi NP_001004460.1. NM_001004460.1.
    UniGenei Hs.371762.
    Hs.447478.

    3D structure databases

    ProteinModelPortali Q9H208.
    SMRi Q9H208. Positions 19-292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000303862.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9H208.

    Polymorphism databases

    DMDMi 118573088.

    Proteomic databases

    PRIDEi Q9H208.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307322 ; ENSP00000303862 ; ENSG00000170790 .
    GeneIDi 341276.
    KEGGi hsa:341276.
    UCSCi uc001meu.1. human.

    Organism-specific databases

    CTDi 341276.
    GeneCardsi GC11P006890.
    HGNCi HGNC:8161. OR10A2.
    neXtProti NX_Q9H208.
    PharmGKBi PA31950.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148577.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q9H208.
    KOi K04257.
    OMAi VTLMGNC.
    OrthoDBi EOG7SXW3S.
    PhylomeDBi Q9H208.
    TreeFami TF337350.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GenomeRNAii 341276.
    NextBioi 98098.
    PROi Q9H208.

    Gene expression databases

    CleanExi HS_OR10A2.
    Genevestigatori Q9H208.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-134.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-134.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 55-270, VARIANT ARG-207.
    5. Cited for: IDENTIFICATION.
    6. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10A2_HUMAN
    AccessioniPrimary (citable) accession number: Q9H208
    Secondary accession number(s): B2RNL9, Q6IFG9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3