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Protein

Olfactory receptor 10A2

Gene

OR10A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10A2
Alternative name(s):
HP4
Olfactory receptor OR11-86
Gene namesi
Name:OR10A2
Synonyms:OR10A2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8161. OR10A2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12ExtracellularSequence analysisAdd BLAST12
Transmembranei13 – 33Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini34 – 41CytoplasmicSequence analysis8
Transmembranei42 – 62Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini63 – 86ExtracellularSequence analysisAdd BLAST24
Transmembranei87 – 107Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini108 – 126CytoplasmicSequence analysisAdd BLAST19
Transmembranei127 – 147Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini148 – 184ExtracellularSequence analysisAdd BLAST37
Transmembranei185 – 204Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini205 – 224CytoplasmicSequence analysisAdd BLAST20
Transmembranei225 – 245Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini246 – 258ExtracellularSequence analysisAdd BLAST13
Transmembranei259 – 279Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini280 – 301CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi341276.
PharmGKBiPA31950.

Polymorphism and mutation databases

BioMutaiOR10A2.
DMDMi118573088.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002611391 – 303Olfactory receptor 10A2Add BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi84 ↔ 176PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9H208.
PRIDEiQ9H208.
TopDownProteomicsiQ9H208.

PTM databases

iPTMnetiQ9H208.
PhosphoSitePlusiQ9H208.

Expressioni

Gene expression databases

BgeeiENSG00000170790.
CleanExiHS_OR10A2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000303862.

Structurei

3D structure databases

ProteinModelPortaliQ9H208.
SMRiQ9H208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKK8. Eukaryota.
ENOG410YDA3. LUCA.
GeneTreeiENSGT00760000119002.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ9H208.
KOiK04257.
OMAiVTLMGNC.
OrthoDBiEOG091G0FFM.
PhylomeDBiQ9H208.
TreeFamiTF337350.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSSLPTEI QSLLFLTFLT IYLVTLMGNC LIILVTLADP MLHSPMYFFL
60 70 80 90 100
RNLSFLEIGF NLVIVPKMLG TLLAQDTTIS FLGCATQMYF FFFFGVAECF
110 120 130 140 150
LLATMAYDRY VAICSPLHYP VIMNQRTRAK LAAASWFPGF PVATVQTTWL
160 170 180 190 200
FSFPFCGTNK VNHFFCDSPP VLRLVCADTA LFEIYAIVGT ILVVMIPCLL
210 220 230 240 250
ILCSYTHIAA AILKIPSAKG KNKAFSTCSS HLLVVSLFYI SLSLTYFRPK
260 270 280 290 300
SNNSPEGKKL LSLSYTVMTP MLNPIIYSLR NNEVKNALSR TVSKALALRN

CIP
Length:303
Mass (Da):33,817
Last modified:November 28, 2006 - v2
Checksum:i6B7A103BBB8ED190
GO

Sequence cautioni

The sequence AAG45207 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173R → K in AAK95109 (PubMed:12213199).Curated1
Sequence conflicti222N → H in AAK95109 (PubMed:12213199).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06002243H → R. Corresponds to variant dbSNP:rs3930075Ensembl.1
Natural variantiVAR_053261134A → T2 PublicationsCorresponds to variant dbSNP:rs2741764Ensembl.1
Natural variantiVAR_034277207H → R1 PublicationCorresponds to variant dbSNP:rs10839631Ensembl.1
Natural variantiVAR_034278240I → T. Corresponds to variant dbSNP:rs10839632Ensembl.1
Natural variantiVAR_034279258K → T. Corresponds to variant dbSNP:rs7926083Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321237 Genomic DNA. Translation: AAG45207.1. Different initiation.
AC017103 Genomic DNA. No translation available.
BC136955 mRNA. Translation: AAI36956.1.
AF399624 Genomic DNA. Translation: AAK95109.1.
BK004293 Genomic DNA. Translation: DAA04691.1.
CCDSiCCDS31415.1.
RefSeqiNP_001004460.1. NM_001004460.1.
UniGeneiHs.371762.
Hs.447478.

Genome annotation databases

EnsembliENST00000307322; ENSP00000303862; ENSG00000170790.
GeneIDi341276.
KEGGihsa:341276.
UCSCiuc001meu.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO10A2_HUMAN
AccessioniPrimary (citable) accession number: Q9H208
Secondary accession number(s): B2RNL9, Q6IFG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: August 30, 2017
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families