ID   O10A5_HUMAN             Reviewed;         317 AA.
AC   Q9H207; O95223; Q52M66; Q96R21; Q96R22;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   24-JAN-2024, entry version 164.
DE   RecName: Full=Olfactory receptor 10A5;
DE   AltName: Full=HP3;
DE   AltName: Full=Olfactory receptor 10A1;
DE   AltName: Full=Olfactory receptor 11-403;
DE            Short=OR11-403;
DE   AltName: Full=Olfactory receptor-like protein JCG6;
GN   Name=OR10A5; Synonyms=OR10A1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Tongue;
RX   PubMed=11705801; DOI=10.1093/chemse/26.9.1157;
RA   Gaudin J.-C., Breuils L., Haertle T.;
RT   "New GPCRs from a human lingual cDNA library.";
RL   Chem. Senses 26:1157-1166(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11416212; DOI=10.1073/pnas.131215398;
RA   Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L.,
RA   Evans G., Axel R., Hood L., Trask B.J.;
RT   "Genomic analysis of orthologous mouse and human olfactory receptor loci.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-288.
RX   PubMed=9787077; DOI=10.1006/geno.1998.5422;
RA   Buettner J.A., Glusman G., Ben-Arie N., Ramos P., Lancet D., Evans G.A.;
RT   "Organization and evolution of olfactory receptor genes on human chromosome
RT   11.";
RL   Genomics 53:56-68(1998).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
CC   -!- FUNCTION: Odorant receptor (Potential). May be involved in taste
CC       perception. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in the tongue.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10A5";
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DR   EMBL; AF324499; AAL33005.1; -; mRNA.
DR   EMBL; AF321237; AAG45206.1; -; Genomic_DNA.
DR   EMBL; BC093651; AAH93651.1; -; mRNA.
DR   EMBL; BC093653; AAH93653.1; -; mRNA.
DR   EMBL; AF065874; AAC70019.1; -; Genomic_DNA.
DR   EMBL; AF399623; AAK95108.1; -; Genomic_DNA.
DR   CCDS; CCDS7773.1; -.
DR   RefSeq; NP_835462.1; NM_178168.1.
DR   AlphaFoldDB; Q9H207; -.
DR   SMR; Q9H207; -.
DR   BioGRID; 126832; 1.
DR   STRING; 9606.ENSP00000299454; -.
DR   GlyCosmos; Q9H207; 1 site, No reported glycans.
DR   GlyGen; Q9H207; 1 site.
DR   iPTMnet; Q9H207; -.
DR   PhosphoSitePlus; Q9H207; -.
DR   BioMuta; OR10A5; -.
DR   DMDM; 14423805; -.
DR   MassIVE; Q9H207; -.
DR   PaxDb; 9606-ENSP00000299454; -.
DR   PeptideAtlas; Q9H207; -.
DR   ProteomicsDB; 80467; -.
DR   TopDownProteomics; Q9H207; -.
DR   Antibodypedia; 56597; 65 antibodies from 14 providers.
DR   DNASU; 144124; -.
DR   Ensembl; ENST00000299454.5; ENSP00000299454.4; ENSG00000166363.6.
DR   GeneID; 144124; -.
DR   KEGG; hsa:144124; -.
DR   MANE-Select; ENST00000299454.5; ENSP00000299454.4; NM_178168.1; NP_835462.1.
DR   UCSC; uc001met.2; human.
DR   AGR; HGNC:15131; -.
DR   CTD; 144124; -.
DR   GeneCards; OR10A5; -.
DR   HGNC; HGNC:15131; OR10A5.
DR   HPA; ENSG00000166363; Not detected.
DR   MIM; 608493; gene.
DR   neXtProt; NX_Q9H207; -.
DR   OpenTargets; ENSG00000166363; -.
DR   PharmGKB; PA31953; -.
DR   VEuPathDB; HostDB:ENSG00000166363; -.
DR   eggNOG; ENOG502QVH7; Eukaryota.
DR   GeneTree; ENSGT01050000244815; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q9H207; -.
DR   OMA; WTEISEF; -.
DR   OrthoDB; 4631716at2759; -.
DR   PhylomeDB; Q9H207; -.
DR   TreeFam; TF337350; -.
DR   PathwayCommons; Q9H207; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 144124; 6 hits in 693 CRISPR screens.
DR   GeneWiki; OR10A5; -.
DR   GenomeRNAi; 144124; -.
DR   Pharos; Q9H207; Tdark.
DR   PRO; PR:Q9H207; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9H207; Protein.
DR   Bgee; ENSG00000166363; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 1 other cell type or tissue.
DR   ExpressionAtlas; Q9H207; baseline and differential.
DR   GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR   CDD; cd15225; 7tmA_OR10A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF148; OLFACTORY RECEPTOR 10A5; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q9H207; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..317
FT                   /note="Olfactory receptor 10A5"
FT                   /id="PRO_0000150687"
FT   TOPO_DOM        1..26
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        77..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        122..140
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        162..198
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..317
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        98..190
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         41
FT                   /note="K -> M (in dbSNP:rs7949377)"
FT                   /id="VAR_034282"
FT   CONFLICT        256
FT                   /note="S -> L (in Ref. 4; AAC70019)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        262
FT                   /note="W -> R (in Ref. 4; AAC70019)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        271
FT                   /note="S -> G (in Ref. 4; AAC70019)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        282
FT                   /note="V -> M (in Ref. 4; AAC70019)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   317 AA;  35519 MW;  464073EFC4EC5B45 CRC64;
     MAIGNWTEIS EFILMSFSSL PTEIQSLLFL TFLTIYLVTL KGNSLIILVT LADPMLHSPM
     YFFLRNLSFL EIGFNLVIVP KMLGTLLAQD TTISFLGCAT QMYFFFFFGV AECFLLATMA
     YDRYVAICSP LHYPVIMNQR TRAKLAAASW FPGFPVATVQ TTWLFSFPFC GTNKVNHFFC
     DSPPVLKLVC ADTALFEIYA IVGTILVVMI PCLLILCSYT RIAAAILKIP SAKGKHKAFS
     TCSSHLLVVS LFYISSSLTY FWPKSNNSPE SKKLLSLSYT VVTPMLNPII YSLRNSEVKN
     ALSRTFHKVL ALRNCIP
//