Reviewed, UniProtKB/Swiss-Prot Q9H207 (O10A5_HUMAN)

Names and origin

Protein names

Recommended name:
    Olfactory receptor 10A5
Alternative name(s):
    Olfactory receptor-like protein JCG6
    Olfactory receptor 11-403
      Short name=OR11-403
    HP3

Gene names

Name:	OR10A5
Synonyms:	OR10A1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Odorant receptor Potential. May be involved in taste perception.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in the tongue.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of smell Ref.4 Non-traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Ref.4 Non-traceable author statement. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	olfactory receptor activity Ref.4 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 317	317	Olfactory receptor 10A5		PRO_0000150687
Regions
	Topological domain	1 – 26	26	Extracellular Potential
	Transmembrane	27 – 47	21	1 Potential
	Topological domain	48 – 55	8	Cytoplasmic Potential
	Transmembrane	56 – 76	21	2 Potential
	Topological domain	77 – 100	24	Extracellular Potential
	Transmembrane	101 – 121	21	3 Potential
	Topological domain	122 – 140	19	Cytoplasmic Potential
	Transmembrane	141 – 161	21	4 Potential
	Topological domain	162 – 198	37	Extracellular Potential
	Transmembrane	199 – 218	20	5 Potential
	Topological domain	219 – 238	20	Cytoplasmic Potential
	Transmembrane	239 – 259	21	6 Potential
	Topological domain	260 – 272	13	Extracellular Potential
	Transmembrane	273 – 293	21	7 Potential
	Topological domain	294 – 317	24	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	98 ↔ 190		By similarity
Natural variations
	Natural variant	41	1	K → M: dbSNP rs7949377.		VAR_034282
Experimental info
	Sequence conflict	256	1	S → L in AAC70019. Ref.4
	Sequence conflict	262	1	W → R in AAC70019. Ref.4
	Sequence conflict	271	1	S → G in AAC70019. Ref.4
	Sequence conflict	282	1	V → M in AAC70019. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q9H207-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 464073EFC4EC5B45	FASTA	317	35,519
	10 20 30 40 50 60 MAIGNWTEIS EFILMSFSSL PTEIQSLLFL TFLTIYLVTL KGNSLIILVT LADPMLHSPM 70 80 90 100 110 120 YFFLRNLSFL EIGFNLVIVP KMLGTLLAQD TTISFLGCAT QMYFFFFFGV AECFLLATMA 130 140 150 160 170 180 YDRYVAICSP LHYPVIMNQR TRAKLAAASW FPGFPVATVQ TTWLFSFPFC GTNKVNHFFC 190 200 210 220 230 240 DSPPVLKLVC ADTALFEIYA IVGTILVVMI PCLLILCSYT RIAAAILKIP SAKGKHKAFS 250 260 270 280 290 300 TCSSHLLVVS LFYISSSLTY FWPKSNNSPE SKKLLSLSYT VVTPMLNPII YSLRNSEVKN 310 ALSRTFHKVL ALRNCIP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"New GPCRs from a human lingual cDNA library." Gaudin J.-C., Breuils L., Haertle T. Chem. Senses 26:1157-1166(2001) [PubMed: 11705801] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Tongue.
[2]	"Genomic analysis of orthologous mouse and human olfactory receptor loci." Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L., Evans G., Axel R., Hood L., Trask B.J. Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001) [PubMed: 11416212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Organization and evolution of olfactory receptor genes on human chromosome 11." Buettner J.A., Glusman G., Ben-Arie N., Ramos P., Lancet D., Evans G.A. Genomics 53:56-68(1998) [PubMed: 9787077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-288.
[5]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed: 12213199] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF324499 mRNA. Translation: AAL33005.1. AF321237 Genomic DNA. Translation: AAG45206.1. BC093651 mRNA. Translation: AAH93651.1. BC093653 mRNA. Translation: AAH93653.1. AF065874 Genomic DNA. Translation: AAC70019.1. AF399623 Genomic DNA. Translation: AAK95108.1.
IPI	IPI00744748.
RefSeq	NP_835462.1.
UniGene	Hs.447478
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	Q9H207.
Genome annotation databases
Ensembl	ENSG00000166363. Homo sapiens. [Contig view]
GeneID	144124.
KEGG	hsa:144124.
UCSC	uc001met.1. human.
Organism-specific databases
GeneCards	GC11P006823.
HGNC	HGNC:15131. OR10A5.
MIM	608493. gene.
PharmGKB	PA31953.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9H207.
Enzyme and pathway databases
Reactome	REACT_14797. Signaling by GPCR.
Gene expression databases
CleanEx	HS_OR10A5.
GermOnline	ENSG00000166363. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR11398. Olfact_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	84838.
SOURCE	Search...

Entry information

Entry name

O10A5_HUMAN

Accession

Primary (citable) accession number: Q9H207
Secondary accession number(s): O95223 , Q52M66, Q96R21, Q96R22

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	March 1, 2001
Last modified:	July 7, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)