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Q9H207

- O10A5_HUMAN

UniProt

Q9H207 - O10A5_HUMAN

Protein

Olfactory receptor 10A5

Gene

OR10A5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Odorant receptor Potential. May be involved in taste perception.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
    2. sensory perception of smell Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10A5
    Alternative name(s):
    HP3
    Olfactory receptor 10A1
    Olfactory receptor 11-403
    Short name:
    OR11-403
    Olfactory receptor-like protein JCG6
    Gene namesi
    Name:OR10A5
    Synonyms:OR10A1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15131. OR10A5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31953.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317Olfactory receptor 10A5PRO_0000150687Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 190PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9H207.

    Expressioni

    Tissue specificityi

    Expressed in the tongue.

    Gene expression databases

    ArrayExpressiQ9H207.
    BgeeiQ9H207.
    CleanExiHS_OR10A5.
    GenevestigatoriQ9H207.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000299454.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H207.
    SMRiQ9H207. Positions 33-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 558CytoplasmicSequence Analysis
    Topological domaini77 – 10024ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini162 – 19837ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23820CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini294 – 31724CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 21820Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148577.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ9H207.
    KOiK04257.
    OrthoDBiEOG7SXW3S.
    PhylomeDBiQ9H207.
    TreeFamiTF337350.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H207-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIGNWTEIS EFILMSFSSL PTEIQSLLFL TFLTIYLVTL KGNSLIILVT    50
    LADPMLHSPM YFFLRNLSFL EIGFNLVIVP KMLGTLLAQD TTISFLGCAT 100
    QMYFFFFFGV AECFLLATMA YDRYVAICSP LHYPVIMNQR TRAKLAAASW 150
    FPGFPVATVQ TTWLFSFPFC GTNKVNHFFC DSPPVLKLVC ADTALFEIYA 200
    IVGTILVVMI PCLLILCSYT RIAAAILKIP SAKGKHKAFS TCSSHLLVVS 250
    LFYISSSLTY FWPKSNNSPE SKKLLSLSYT VVTPMLNPII YSLRNSEVKN 300
    ALSRTFHKVL ALRNCIP 317
    Length:317
    Mass (Da):35,519
    Last modified:March 1, 2001 - v1
    Checksum:i464073EFC4EC5B45
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti256 – 2561S → L in AAC70019. (PubMed:9787077)Curated
    Sequence conflicti262 – 2621W → R in AAC70019. (PubMed:9787077)Curated
    Sequence conflicti271 – 2711S → G in AAC70019. (PubMed:9787077)Curated
    Sequence conflicti282 – 2821V → M in AAC70019. (PubMed:9787077)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti41 – 411K → M.
    Corresponds to variant rs7949377 [ dbSNP | Ensembl ].
    VAR_034282

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF324499 mRNA. Translation: AAL33005.1.
    AF321237 Genomic DNA. Translation: AAG45206.1.
    BC093651 mRNA. Translation: AAH93651.1.
    BC093653 mRNA. Translation: AAH93653.1.
    AF065874 Genomic DNA. Translation: AAC70019.1.
    AF399623 Genomic DNA. Translation: AAK95108.1.
    CCDSiCCDS7773.1.
    RefSeqiNP_835462.1. NM_178168.1.
    UniGeneiHs.447478.

    Genome annotation databases

    EnsembliENST00000299454; ENSP00000299454; ENSG00000166363.
    GeneIDi144124.
    KEGGihsa:144124.
    UCSCiuc001met.1. human.

    Polymorphism databases

    DMDMi14423805.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF324499 mRNA. Translation: AAL33005.1 .
    AF321237 Genomic DNA. Translation: AAG45206.1 .
    BC093651 mRNA. Translation: AAH93651.1 .
    BC093653 mRNA. Translation: AAH93653.1 .
    AF065874 Genomic DNA. Translation: AAC70019.1 .
    AF399623 Genomic DNA. Translation: AAK95108.1 .
    CCDSi CCDS7773.1.
    RefSeqi NP_835462.1. NM_178168.1.
    UniGenei Hs.447478.

    3D structure databases

    ProteinModelPortali Q9H207.
    SMRi Q9H207. Positions 33-310.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000299454.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 14423805.

    Proteomic databases

    PRIDEi Q9H207.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000299454 ; ENSP00000299454 ; ENSG00000166363 .
    GeneIDi 144124.
    KEGGi hsa:144124.
    UCSCi uc001met.1. human.

    Organism-specific databases

    CTDi 144124.
    GeneCardsi GC11P006866.
    HGNCi HGNC:15131. OR10A5.
    MIMi 608493. gene.
    neXtProti NX_Q9H207.
    PharmGKBi PA31953.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148577.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q9H207.
    KOi K04257.
    OrthoDBi EOG7SXW3S.
    PhylomeDBi Q9H207.
    TreeFami TF337350.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10A5.
    GenomeRNAii 144124.
    NextBioi 84838.
    PROi Q9H207.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H207.
    Bgeei Q9H207.
    CleanExi HS_OR10A5.
    Genevestigatori Q9H207.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "New GPCRs from a human lingual cDNA library."
      Gaudin J.-C., Breuils L., Haertle T.
      Chem. Senses 26:1157-1166(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Tongue.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Organization and evolution of olfactory receptor genes on human chromosome 11."
      Buettner J.A., Glusman G., Ben-Arie N., Ramos P., Lancet D., Evans G.A.
      Genomics 53:56-68(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-288.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284.

    Entry informationi

    Entry nameiO10A5_HUMAN
    AccessioniPrimary (citable) accession number: Q9H207
    Secondary accession number(s): O95223
    , Q52M66, Q96R21, Q96R22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3