Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q9H207 (O10A5_HUMAN)

Last modified July 7, 2009. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Olfactory receptor 10A5
Alternative name(s):
    Olfactory receptor-like protein JCG6
    Olfactory receptor 11-403
      Short name=OR11-403
    HP3
Gene names
Name: OR10A5
Synonyms: OR10A1
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Odorant receptor Potential. May be involved in taste perception.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in the tongue.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Biological processOlfaction
Sensory transduction
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processG-protein coupled receptor protein signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

response to stimulus

Inferred from electronic annotation. Source: UniProtKB-KW

sensory perception of smell Ref.4

Non-traceable author statement. Source: UniProtKB

   Cellular componentintegral to membrane Ref.4

Non-traceable author statement. Source: UniProtKB

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionolfactory receptor activity Ref.4

Non-traceable author statement. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 317317Olfactory receptor 10A5
PRO_0000150687

Regions

Topological domain1 – 2626Extracellular Potential
Transmembrane27 – 47211 Potential
Topological domain48 – 558Cytoplasmic Potential
Transmembrane56 – 76212 Potential
Topological domain77 – 10024Extracellular Potential
Transmembrane101 – 121213 Potential
Topological domain122 – 14019Cytoplasmic Potential
Transmembrane141 – 161214 Potential
Topological domain162 – 19837Extracellular Potential
Transmembrane199 – 218205 Potential
Topological domain219 – 23820Cytoplasmic Potential
Transmembrane239 – 259216 Potential
Topological domain260 – 27213Extracellular Potential
Transmembrane273 – 293217 Potential
Topological domain294 – 31724Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 190 By similarity

Natural variations

Natural variant411K → M: dbSNP rs7949377.
VAR_034282

Experimental info

Sequence conflict2561S → L in AAC70019. Ref.4
Sequence conflict2621W → R in AAC70019. Ref.4
Sequence conflict2711S → G in AAC70019. Ref.4
Sequence conflict2821V → M in AAC70019. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9H207-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 464073EFC4EC5B45

FASTA31735,519
        10         20         30         40         50         60 
MAIGNWTEIS EFILMSFSSL PTEIQSLLFL TFLTIYLVTL KGNSLIILVT LADPMLHSPM 

        70         80         90        100        110        120 
YFFLRNLSFL EIGFNLVIVP KMLGTLLAQD TTISFLGCAT QMYFFFFFGV AECFLLATMA 

       130        140        150        160        170        180 
YDRYVAICSP LHYPVIMNQR TRAKLAAASW FPGFPVATVQ TTWLFSFPFC GTNKVNHFFC 

       190        200        210        220        230        240 
DSPPVLKLVC ADTALFEIYA IVGTILVVMI PCLLILCSYT RIAAAILKIP SAKGKHKAFS 

       250        260        270        280        290        300 
TCSSHLLVVS LFYISSSLTY FWPKSNNSPE SKKLLSLSYT VVTPMLNPII YSLRNSEVKN 

       310 
ALSRTFHKVL ALRNCIP 

« Hide

References

« Hide 'large scale' references
[1]"New GPCRs from a human lingual cDNA library."
Gaudin J.-C., Breuils L., Haertle T.
Chem. Senses 26:1157-1166(2001) [PubMed: 11705801] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Tongue.
[2]"Genomic analysis of orthologous mouse and human olfactory receptor loci."
Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L., Evans G., Axel R., Hood L., Trask B.J.
Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001) [PubMed: 11416212] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Organization and evolution of olfactory receptor genes on human chromosome 11."
Buettner J.A., Glusman G., Ben-Arie N., Ramos P., Lancet D., Evans G.A.
Genomics 53:56-68(1998) [PubMed: 9787077] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-288.
[5]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed: 12213199] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284.

Cross-references

Sequence databases

AF324499 mRNA. Translation: AAL33005.1.
AF321237 Genomic DNA. Translation: AAG45206.1.
BC093651 mRNA. Translation: AAH93651.1.
BC093653 mRNA. Translation: AAH93653.1.
AF065874 Genomic DNA. Translation: AAC70019.1.
AF399623 Genomic DNA. Translation: AAK95108.1.
IPIIPI00744748.
RefSeqNP_835462.1.
UniGeneHs.447478

3D structure databases

ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEQ9H207.

Genome annotation databases

EnsemblENSG00000166363. Homo sapiens. [Contig view]
GeneID144124.
KEGGhsa:144124.
UCSCuc001met.1. human.

Organism-specific databases

GeneCardsGC11P006823.
HGNCHGNC:15131. OR10A5.
MIM608493. gene.
PharmGKBPA31953.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ9H207.

Enzyme and pathway databases

ReactomeREACT_14797. Signaling by GPCR.

Gene expression databases

CleanExHS_OR10A5.
GermOnlineENSG00000166363. Homo sapiens.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
IPR000725. Olfact_rcpt.
[Graphical view]
PANTHERPTHR11398. Olfact_rcpt. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio84838.
SOURCESearch...

Entry information

Entry nameO10A5_HUMAN
AccessionPrimary (citable) accession number: Q9H207
Secondary accession number(s): O95223 expand/collapse secondary AC list , Q52M66, Q96R21, Q96R22
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: July 7, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents