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Q9H207 (O10A5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10A5
Alternative name(s):
HP3
Olfactory receptor 10A1
Olfactory receptor 11-403
Short name=OR11-403
Olfactory receptor-like protein JCG6
Gene names
Name:OR10A5
Synonyms:OR10A1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential. May be involved in taste perception.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in the tongue.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 317317Olfactory receptor 10A5
PRO_0000150687

Regions

Topological domain1 – 2626Extracellular Potential
Transmembrane27 – 4721Helical; Name=1; Potential
Topological domain48 – 558Cytoplasmic Potential
Transmembrane56 – 7621Helical; Name=2; Potential
Topological domain77 – 10024Extracellular Potential
Transmembrane101 – 12121Helical; Name=3; Potential
Topological domain122 – 14019Cytoplasmic Potential
Transmembrane141 – 16121Helical; Name=4; Potential
Topological domain162 – 19837Extracellular Potential
Transmembrane199 – 21820Helical; Name=5; Potential
Topological domain219 – 23820Cytoplasmic Potential
Transmembrane239 – 25921Helical; Name=6; Potential
Topological domain260 – 27213Extracellular Potential
Transmembrane273 – 29321Helical; Name=7; Potential
Topological domain294 – 31724Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 190 By similarity

Natural variations

Natural variant411K → M.
Corresponds to variant rs7949377 [ dbSNP | Ensembl ].
VAR_034282

Experimental info

Sequence conflict2561S → L in AAC70019. Ref.4
Sequence conflict2621W → R in AAC70019. Ref.4
Sequence conflict2711S → G in AAC70019. Ref.4
Sequence conflict2821V → M in AAC70019. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9H207 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 464073EFC4EC5B45

FASTA31735,519
        10         20         30         40         50         60 
MAIGNWTEIS EFILMSFSSL PTEIQSLLFL TFLTIYLVTL KGNSLIILVT LADPMLHSPM 

        70         80         90        100        110        120 
YFFLRNLSFL EIGFNLVIVP KMLGTLLAQD TTISFLGCAT QMYFFFFFGV AECFLLATMA 

       130        140        150        160        170        180 
YDRYVAICSP LHYPVIMNQR TRAKLAAASW FPGFPVATVQ TTWLFSFPFC GTNKVNHFFC 

       190        200        210        220        230        240 
DSPPVLKLVC ADTALFEIYA IVGTILVVMI PCLLILCSYT RIAAAILKIP SAKGKHKAFS 

       250        260        270        280        290        300 
TCSSHLLVVS LFYISSSLTY FWPKSNNSPE SKKLLSLSYT VVTPMLNPII YSLRNSEVKN 

       310 
ALSRTFHKVL ALRNCIP 

« Hide

References

« Hide 'large scale' references
[1]"New GPCRs from a human lingual cDNA library."
Gaudin J.-C., Breuils L., Haertle T.
Chem. Senses 26:1157-1166(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Tongue.
[2]"Genomic analysis of orthologous mouse and human olfactory receptor loci."
Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L., Evans G., Axel R., Hood L., Trask B.J.
Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Organization and evolution of olfactory receptor genes on human chromosome 11."
Buettner J.A., Glusman G., Ben-Arie N., Ramos P., Lancet D., Evans G.A.
Genomics 53:56-68(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-288.
[5]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF324499 mRNA. Translation: AAL33005.1.
AF321237 Genomic DNA. Translation: AAG45206.1.
BC093651 mRNA. Translation: AAH93651.1.
BC093653 mRNA. Translation: AAH93653.1.
AF065874 Genomic DNA. Translation: AAC70019.1.
AF399623 Genomic DNA. Translation: AAK95108.1.
CCDSCCDS7773.1.
RefSeqNP_835462.1. NM_178168.1.
UniGeneHs.447478.

3D structure databases

ProteinModelPortalQ9H207.
SMRQ9H207. Positions 33-310.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000299454.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM14423805.

Proteomic databases

PRIDEQ9H207.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000299454; ENSP00000299454; ENSG00000166363.
GeneID144124.
KEGGhsa:144124.
UCSCuc001met.1. human.

Organism-specific databases

CTD144124.
GeneCardsGC11P006866.
HGNCHGNC:15131. OR10A5.
MIM608493. gene.
neXtProtNX_Q9H207.
PharmGKBPA31953.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG148577.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ9H207.
KOK04257.
OrthoDBEOG7SXW3S.
PhylomeDBQ9H207.
TreeFamTF337350.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ9H207.
BgeeQ9H207.
CleanExHS_OR10A5.
GenevestigatorQ9H207.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10A5.
GenomeRNAi144124.
NextBio84838.
PROQ9H207.
SOURCESearch...

Entry information

Entry nameO10A5_HUMAN
AccessionPrimary (citable) accession number: Q9H207
Secondary accession number(s): O95223 expand/collapse secondary AC list , Q52M66, Q96R21, Q96R22
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries