Q9H207 (O10A5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 10A5

Alternative name(s):
HP3
Olfactory receptor 10A1
Olfactory receptor 11-403
Short name=OR11-403
Olfactory receptor-like protein JCG6

Gene names

Name:	OR10A5
Synonyms:	OR10A1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential. May be involved in taste perception.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in the tongue.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Non-traceable author statement Ref.4. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Non-traceable author statement Ref.4. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 317	317	Olfactory receptor 10A5		PRO_0000150687
Regions
	Topological domain	1 – 26	26	Extracellular Potential
	Transmembrane	27 – 47	21	Helical; Name=1; Potential
	Topological domain	48 – 55	8	Cytoplasmic Potential
	Transmembrane	56 – 76	21	Helical; Name=2; Potential
	Topological domain	77 – 100	24	Extracellular Potential
	Transmembrane	101 – 121	21	Helical; Name=3; Potential
	Topological domain	122 – 140	19	Cytoplasmic Potential
	Transmembrane	141 – 161	21	Helical; Name=4; Potential
	Topological domain	162 – 198	37	Extracellular Potential
	Transmembrane	199 – 218	20	Helical; Name=5; Potential
	Topological domain	219 – 238	20	Cytoplasmic Potential
	Transmembrane	239 – 259	21	Helical; Name=6; Potential
	Topological domain	260 – 272	13	Extracellular Potential
	Transmembrane	273 – 293	21	Helical; Name=7; Potential
	Topological domain	294 – 317	24	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	98 ↔ 190		By similarity
Natural variations
	Natural variant	41	1	K → M. Corresponds to variant rs7949377 [ dbSNP | Ensembl ].		VAR_034282
Experimental info
	Sequence conflict	256	1	S → L in AAC70019. Ref.4
	Sequence conflict	262	1	W → R in AAC70019. Ref.4
	Sequence conflict	271	1	S → G in AAC70019. Ref.4
	Sequence conflict	282	1	V → M in AAC70019. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q9H207 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 464073EFC4EC5B45	FASTA	317	35,519
	10 20 30 40 50 60 MAIGNWTEIS EFILMSFSSL PTEIQSLLFL TFLTIYLVTL KGNSLIILVT LADPMLHSPM 70 80 90 100 110 120 YFFLRNLSFL EIGFNLVIVP KMLGTLLAQD TTISFLGCAT QMYFFFFFGV AECFLLATMA 130 140 150 160 170 180 YDRYVAICSP LHYPVIMNQR TRAKLAAASW FPGFPVATVQ TTWLFSFPFC GTNKVNHFFC 190 200 210 220 230 240 DSPPVLKLVC ADTALFEIYA IVGTILVVMI PCLLILCSYT RIAAAILKIP SAKGKHKAFS 250 260 270 280 290 300 TCSSHLLVVS LFYISSSLTY FWPKSNNSPE SKKLLSLSYT VVTPMLNPII YSLRNSEVKN 310 ALSRTFHKVL ALRNCIP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"New GPCRs from a human lingual cDNA library." Gaudin J.-C., Breuils L., Haertle T. Chem. Senses 26:1157-1166(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Tongue.
[2]	"Genomic analysis of orthologous mouse and human olfactory receptor loci." Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L., Evans G., Axel R., Hood L., Trask B.J. Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Organization and evolution of olfactory receptor genes on human chromosome 11." Buettner J.A., Glusman G., Ben-Arie N., Ramos P., Lancet D., Evans G.A. Genomics 53:56-68(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-288.
[5]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284.
+	Additional computationally mapped references.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF324499 mRNA. Translation: AAL33005.1. AF321237 Genomic DNA. Translation: AAG45206.1. BC093651 mRNA. Translation: AAH93651.1. BC093653 mRNA. Translation: AAH93653.1. AF065874 Genomic DNA. Translation: AAC70019.1. AF399623 Genomic DNA. Translation: AAK95108.1.
IPI	IPI00744748.
RefSeq	NP_835462.1. NM_178168.1.
UniGene	Hs.447478.
3D structure databases
ProteinModelPortal	Q9H207.
SMR	Q9H207. Positions 33-310.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000299454.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	14423805.
Proteomic databases
PRIDE	Q9H207.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000299454; ENSP00000299454; ENSG00000166363.
GeneID	144124.
KEGG	hsa:144124.
UCSC	uc001met.1. human.
Organism-specific databases
CTD	144124.
GeneCards	GC11P006866.
HGNC	HGNC:15131. OR10A5.
MIM	608493. gene.
neXtProt	NX_Q9H207.
PharmGKB	PA31953.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG148577.
HOGENOM	HOG000041365.
HOVERGEN	HBG017625.
InParanoid	Q9H207.
KO	K04257.
OrthoDB	EOG4HDSTX.
PhylomeDB	Q9H207.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q9H207.
Bgee	Q9H207.
CleanEx	HS_OR10A5.
Genevestigator	Q9H207.
GermOnline	ENSG00000166363. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	144124.
NextBio	84838.
SOURCE	Search...

Entry information

Entry name

O10A5_HUMAN

Accession

Primary (citable) accession number: Q9H207
Secondary accession number(s): O95223 , Q52M66, Q96R21, Q96R22

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.