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Q9H207

- O10A5_HUMAN

UniProt

Q9H207 - O10A5_HUMAN

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Protein
Olfactory receptor 10A5
Gene
OR10A5, OR10A1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction. May be involved in taste perception.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
  2. sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10A5
Alternative name(s):
HP3
Olfactory receptor 10A1
Olfactory receptor 11-403
Short name:
OR11-403
Olfactory receptor-like protein JCG6
Gene namesi
Name:OR10A5
Synonyms:OR10A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15131. OR10A5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Extracellular Reviewed prediction
Add
BLAST
Transmembranei27 – 4721Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini48 – 558Cytoplasmic Reviewed prediction
Transmembranei56 – 7621Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini77 – 10024Extracellular Reviewed prediction
Add
BLAST
Transmembranei101 – 12121Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini122 – 14019Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei141 – 16121Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini162 – 19837Extracellular Reviewed prediction
Add
BLAST
Transmembranei199 – 21820Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini219 – 23820Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei239 – 25921Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini260 – 27213Extracellular Reviewed prediction
Add
BLAST
Transmembranei273 – 29321Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini294 – 31724Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31953.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Olfactory receptor 10A5
PRO_0000150687Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi98 ↔ 190 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9H207.

Expressioni

Tissue specificityi

Expressed in the tongue.

Gene expression databases

ArrayExpressiQ9H207.
BgeeiQ9H207.
CleanExiHS_OR10A5.
GenevestigatoriQ9H207.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000299454.

Structurei

3D structure databases

ProteinModelPortaliQ9H207.
SMRiQ9H207. Positions 33-310.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148577.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ9H207.
KOiK04257.
OrthoDBiEOG7SXW3S.
PhylomeDBiQ9H207.
TreeFamiTF337350.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H207-1 [UniParc]FASTAAdd to Basket

« Hide

MAIGNWTEIS EFILMSFSSL PTEIQSLLFL TFLTIYLVTL KGNSLIILVT    50
LADPMLHSPM YFFLRNLSFL EIGFNLVIVP KMLGTLLAQD TTISFLGCAT 100
QMYFFFFFGV AECFLLATMA YDRYVAICSP LHYPVIMNQR TRAKLAAASW 150
FPGFPVATVQ TTWLFSFPFC GTNKVNHFFC DSPPVLKLVC ADTALFEIYA 200
IVGTILVVMI PCLLILCSYT RIAAAILKIP SAKGKHKAFS TCSSHLLVVS 250
LFYISSSLTY FWPKSNNSPE SKKLLSLSYT VVTPMLNPII YSLRNSEVKN 300
ALSRTFHKVL ALRNCIP 317
Length:317
Mass (Da):35,519
Last modified:March 1, 2001 - v1
Checksum:i464073EFC4EC5B45
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411K → M.
Corresponds to variant rs7949377 [ dbSNP | Ensembl ].
VAR_034282

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti256 – 2561S → L in AAC70019. 1 Publication
Sequence conflicti262 – 2621W → R in AAC70019. 1 Publication
Sequence conflicti271 – 2711S → G in AAC70019. 1 Publication
Sequence conflicti282 – 2821V → M in AAC70019. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF324499 mRNA. Translation: AAL33005.1.
AF321237 Genomic DNA. Translation: AAG45206.1.
BC093651 mRNA. Translation: AAH93651.1.
BC093653 mRNA. Translation: AAH93653.1.
AF065874 Genomic DNA. Translation: AAC70019.1.
AF399623 Genomic DNA. Translation: AAK95108.1.
CCDSiCCDS7773.1.
RefSeqiNP_835462.1. NM_178168.1.
UniGeneiHs.447478.

Genome annotation databases

EnsembliENST00000299454; ENSP00000299454; ENSG00000166363.
GeneIDi144124.
KEGGihsa:144124.
UCSCiuc001met.1. human.

Polymorphism databases

DMDMi14423805.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF324499 mRNA. Translation: AAL33005.1 .
AF321237 Genomic DNA. Translation: AAG45206.1 .
BC093651 mRNA. Translation: AAH93651.1 .
BC093653 mRNA. Translation: AAH93653.1 .
AF065874 Genomic DNA. Translation: AAC70019.1 .
AF399623 Genomic DNA. Translation: AAK95108.1 .
CCDSi CCDS7773.1.
RefSeqi NP_835462.1. NM_178168.1.
UniGenei Hs.447478.

3D structure databases

ProteinModelPortali Q9H207.
SMRi Q9H207. Positions 33-310.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000299454.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 14423805.

Proteomic databases

PRIDEi Q9H207.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000299454 ; ENSP00000299454 ; ENSG00000166363 .
GeneIDi 144124.
KEGGi hsa:144124.
UCSCi uc001met.1. human.

Organism-specific databases

CTDi 144124.
GeneCardsi GC11P006866.
HGNCi HGNC:15131. OR10A5.
MIMi 608493. gene.
neXtProti NX_Q9H207.
PharmGKBi PA31953.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148577.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q9H207.
KOi K04257.
OrthoDBi EOG7SXW3S.
PhylomeDBi Q9H207.
TreeFami TF337350.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10A5.
GenomeRNAii 144124.
NextBioi 84838.
PROi Q9H207.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9H207.
Bgeei Q9H207.
CleanExi HS_OR10A5.
Genevestigatori Q9H207.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "New GPCRs from a human lingual cDNA library."
    Gaudin J.-C., Breuils L., Haertle T.
    Chem. Senses 26:1157-1166(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Tongue.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Organization and evolution of olfactory receptor genes on human chromosome 11."
    Buettner J.A., Glusman G., Ben-Arie N., Ramos P., Lancet D., Evans G.A.
    Genomics 53:56-68(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-288.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284.

Entry informationi

Entry nameiO10A5_HUMAN
AccessioniPrimary (citable) accession number: Q9H207
Secondary accession number(s): O95223
, Q52M66, Q96R21, Q96R22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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