ID   O2AG1_HUMAN             Reviewed;         316 AA.
AC   Q9H205; B9EKV7; Q6IFG7; Q96R26;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2001, sequence version 2.
DT   24-JAN-2024, entry version 173.
DE   RecName: Full=Olfactory receptor 2AG1;
DE   AltName: Full=HT3;
DE   AltName: Full=Olfactory receptor 2AG3;
DE   AltName: Full=Olfactory receptor OR11-79;
GN   Name=OR2AG1; Synonyms=OR2AG3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 152-316, AND VARIANTS LEU-187 AND
RP   GLY-299.
RX   PubMed=11416212; DOI=10.1073/pnas.131215398;
RA   Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L.,
RA   Evans G., Axel R., Hood L., Trask B.J.;
RT   "Genomic analysis of orthologous mouse and human olfactory receptor loci.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001).
RN   [6]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [7]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- INTERACTION:
CC       Q9H205; O75970: MPDZ; NbExp=8; IntAct=EBI-7590304, EBI-821405;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2AG1";
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DR   EMBL; AB065823; BAC06042.1; -; Genomic_DNA.
DR   EMBL; CH471064; EAW68677.1; -; Genomic_DNA.
DR   EMBL; BC151143; AAI51144.1; -; mRNA.
DR   EMBL; AF399618; AAK95103.1; -; Genomic_DNA.
DR   EMBL; AF321237; AAG45209.1; -; Genomic_DNA.
DR   EMBL; BK004295; DAA04693.1; -; Genomic_DNA.
DR   CCDS; CCDS31414.1; -.
DR   RefSeq; NP_001004489.1; NM_001004489.2.
DR   AlphaFoldDB; Q9H205; -.
DR   SMR; Q9H205; -.
DR   IntAct; Q9H205; 1.
DR   MINT; Q9H205; -.
DR   STRING; 9606.ENSP00000493074; -.
DR   TCDB; 9.A.14.8.2; the g-protein-coupled receptor (gpcr) family.
DR   GlyCosmos; Q9H205; 2 sites, No reported glycans.
DR   GlyGen; Q9H205; 2 sites.
DR   BioMuta; OR2AG1; -.
DR   DMDM; 14423804; -.
DR   MassIVE; Q9H205; -.
DR   PaxDb; 9606-ENSP00000485326; -.
DR   PeptideAtlas; Q9H205; -.
DR   ProteomicsDB; 80466; -.
DR   Antibodypedia; 78188; 25 antibodies from 10 providers.
DR   DNASU; 144125; -.
DR   Ensembl; ENST00000641258.1; ENSP00000493074.1; ENSG00000279486.6.
DR   GeneID; 144125; -.
DR   KEGG; hsa:144125; -.
DR   MANE-Select; ENST00000641258.1; ENSP00000493074.1; NM_001004489.3; NP_001004489.1.
DR   UCSC; uc001mer.2; human.
DR   AGR; HGNC:15142; -.
DR   CTD; 144125; -.
DR   DisGeNET; 144125; -.
DR   GeneCards; OR2AG1; -.
DR   HGNC; HGNC:15142; OR2AG1.
DR   HPA; ENSG00000279486; Not detected.
DR   neXtProt; NX_Q9H205; -.
DR   OpenTargets; ENSG00000279486; -.
DR   PharmGKB; PA32126; -.
DR   VEuPathDB; HostDB:ENSG00000279486; -.
DR   eggNOG; ENOG502SIEP; Eukaryota.
DR   GeneTree; ENSGT01090000259995; -.
DR   HOGENOM; CLU_012526_0_1_1; -.
DR   InParanoid; Q9H205; -.
DR   OMA; YELFVYV; -.
DR   OrthoDB; 3784606at2759; -.
DR   PhylomeDB; Q9H205; -.
DR   TreeFam; TF337295; -.
DR   PathwayCommons; Q9H205; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; Q9H205; -.
DR   BioGRID-ORCS; 144125; 4 hits in 734 CRISPR screens.
DR   GeneWiki; OR2AG1; -.
DR   GenomeRNAi; 144125; -.
DR   Pharos; Q9H205; Tdark.
DR   PRO; PR:Q9H205; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9H205; Protein.
DR   Bgee; ENSG00000279486; Expressed in bone marrow cell and 5 other cell types or tissues.
DR   ExpressionAtlas; Q9H205; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15421; 7tmA_OR2T-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF183; OLFACTORY RECEPTOR 2AG1; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..316
FT                   /note="Olfactory receptor 2AG1"
FT                   /id="PRO_0000150472"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..316
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        19
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         187
FT                   /note="V -> L (in dbSNP:rs2659880)"
FT                   /evidence="ECO:0000269|PubMed:11416212"
FT                   /id="VAR_053140"
FT   VARIANT         299
FT                   /note="R -> G (in dbSNP:rs2659879)"
FT                   /evidence="ECO:0000269|PubMed:11416212"
FT                   /id="VAR_059985"
FT   VARIANT         299
FT                   /note="R -> W (in dbSNP:rs2659879)"
FT                   /id="VAR_059986"
SQ   SEQUENCE   316 AA;  35270 MW;  6885161BD606C0AE CRC64;
     MELWNFTLGS GFILVGILND SGSPELLCAT ITILYLLALI SNGLLLLAIT MEARLHMPMY
     LLLGQLSLMD LLFTSVVTPK ALADFLRREN TISFGGCALQ MFLALTMGGA EDLLLAFMAY
     DRYVAICHPL TYMTLMSSRA CWLMVATSWI LASLSALIYT VYTMHYPFCR AQEIRHLLCE
     IPHLLKVACA DTSRYELMVY VMGVTFLIPS LAAILASYTQ ILLTVLHMPS NEGRKKALVT
     CSSHLTVVGM FYGAATFMYV LPSSFHSTRQ DNIISVFYTI VTPALNPLIY SLRNKEVMRA
     LRRVLGKYML PAHSTL
//