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Q9H205

- O2AG1_HUMAN

UniProt

Q9H205 - O2AG1_HUMAN

Protein

Olfactory receptor 2AG1

Gene

OR2AG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (20 Jun 2001)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro
    3. protein binding Source: IntAct

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2AG1
    Alternative name(s):
    HT3
    Olfactory receptor 2AG3
    Olfactory receptor OR11-79
    Gene namesi
    Name:OR2AG1
    Synonyms:OR2AG3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15142. OR2AG1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32126.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Olfactory receptor 2AG1PRO_0000150472Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9H205.

    Expressioni

    Gene expression databases

    CleanExiHS_OR2AG1.
    GenevestigatoriQ9H205.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MPDZO759708EBI-7590304,EBI-821405

    Protein-protein interaction databases

    IntActiQ9H205. 1 interaction.
    MINTiMINT-7289875.
    STRINGi9606.ENSP00000307447.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H205.
    SMRiQ9H205. Positions 26-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31624CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41022.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ9H205.
    KOiK04257.
    OMAiYPFCRAQ.
    OrthoDBiEOG72G17Q.
    PhylomeDBiQ9H205.
    TreeFamiTF337295.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H205-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELWNFTLGS GFILVGILND SGSPELLCAT ITILYLLALI SNGLLLLAIT    50
    MEARLHMPMY LLLGQLSLMD LLFTSVVTPK ALADFLRREN TISFGGCALQ 100
    MFLALTMGGA EDLLLAFMAY DRYVAICHPL TYMTLMSSRA CWLMVATSWI 150
    LASLSALIYT VYTMHYPFCR AQEIRHLLCE IPHLLKVACA DTSRYELMVY 200
    VMGVTFLIPS LAAILASYTQ ILLTVLHMPS NEGRKKALVT CSSHLTVVGM 250
    FYGAATFMYV LPSSFHSTRQ DNIISVFYTI VTPALNPLIY SLRNKEVMRA 300
    LRRVLGKYML PAHSTL 316
    Length:316
    Mass (Da):35,270
    Last modified:June 20, 2001 - v2
    Checksum:i6885161BD606C0AE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti187 – 1871V → L.1 Publication
    Corresponds to variant rs2659880 [ dbSNP | Ensembl ].
    VAR_053140
    Natural varianti299 – 2991R → G.1 Publication
    Corresponds to variant rs2659879 [ dbSNP | Ensembl ].
    VAR_059985
    Natural varianti299 – 2991R → W.
    Corresponds to variant rs2659879 [ dbSNP | Ensembl ].
    VAR_059986

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065823 Genomic DNA. Translation: BAC06042.1.
    CH471064 Genomic DNA. Translation: EAW68677.1.
    BC151143 mRNA. Translation: AAI51144.1.
    AF399618 Genomic DNA. Translation: AAK95103.1.
    AF321237 Genomic DNA. Translation: AAG45209.1.
    BK004295 Genomic DNA. Translation: DAA04693.1.
    CCDSiCCDS31414.1.
    RefSeqiNP_001004489.1. NM_001004489.2.
    UniGeneiHs.553608.

    Genome annotation databases

    EnsembliENST00000307401; ENSP00000307447; ENSG00000170803.
    GeneIDi144125.
    KEGGihsa:144125.
    UCSCiuc001mer.2. human.

    Polymorphism databases

    DMDMi14423804.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065823 Genomic DNA. Translation: BAC06042.1 .
    CH471064 Genomic DNA. Translation: EAW68677.1 .
    BC151143 mRNA. Translation: AAI51144.1 .
    AF399618 Genomic DNA. Translation: AAK95103.1 .
    AF321237 Genomic DNA. Translation: AAG45209.1 .
    BK004295 Genomic DNA. Translation: DAA04693.1 .
    CCDSi CCDS31414.1.
    RefSeqi NP_001004489.1. NM_001004489.2.
    UniGenei Hs.553608.

    3D structure databases

    ProteinModelPortali Q9H205.
    SMRi Q9H205. Positions 26-296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9H205. 1 interaction.
    MINTi MINT-7289875.
    STRINGi 9606.ENSP00000307447.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 14423804.

    Proteomic databases

    PRIDEi Q9H205.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307401 ; ENSP00000307447 ; ENSG00000170803 .
    GeneIDi 144125.
    KEGGi hsa:144125.
    UCSCi uc001mer.2. human.

    Organism-specific databases

    CTDi 144125.
    GeneCardsi GC11P006806.
    HGNCi HGNC:15142. OR2AG1.
    neXtProti NX_Q9H205.
    PharmGKBi PA32126.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41022.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q9H205.
    KOi K04257.
    OMAi YPFCRAQ.
    OrthoDBi EOG72G17Q.
    PhylomeDBi Q9H205.
    TreeFami TF337295.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2AG1.
    GenomeRNAii 144125.
    NextBioi 84842.
    PROi Q9H205.

    Gene expression databases

    CleanExi HS_OR2AG1.
    Genevestigatori Q9H205.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 152-316, VARIANTS LEU-187 AND GLY-299.
    6. Cited for: IDENTIFICATION.
    7. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO2AG1_HUMAN
    AccessioniPrimary (citable) accession number: Q9H205
    Secondary accession number(s): B9EKV7, Q6IFG7, Q96R26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: June 20, 2001
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3