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Protein

Olfactory receptor 2AG1

Gene

OR2AG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170803-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Protein family/group databases

TCDBi9.A.14.8.2. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2AG1
Alternative name(s):
HT3
Olfactory receptor 2AG3
Olfactory receptor OR11-79
Gene namesi
Name:OR2AG1
Synonyms:OR2AG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15142. OR2AG1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 316CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi144125.
OpenTargetsiENSG00000279486.
PharmGKBiPA32126.

Polymorphism and mutation databases

BioMutaiOR2AG1.
DMDMi14423804.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504721 – 316Olfactory receptor 2AG1Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi19N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H205.
PeptideAtlasiQ9H205.
PRIDEiQ9H205.

Expressioni

Gene expression databases

CleanExiHS_OR2AG1.
ExpressionAtlasiQ9H205. differential.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MPDZO759708EBI-7590304,EBI-821405

Protein-protein interaction databases

IntActiQ9H205. 1 interactor.
MINTiMINT-7289875.
STRINGi9606.ENSP00000307447.

Structurei

3D structure databases

ProteinModelPortaliQ9H205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGT4. Eukaryota.
ENOG4111C5R. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ9H205.
KOiK04257.
OMAiYPFCRAQ.
OrthoDBiEOG091G0FFK.
PhylomeDBiQ9H205.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
IPR030789. OR2AG1.
[Graphical view]
PANTHERiPTHR26453:SF267. PTHR26453:SF267. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELWNFTLGS GFILVGILND SGSPELLCAT ITILYLLALI SNGLLLLAIT
60 70 80 90 100
MEARLHMPMY LLLGQLSLMD LLFTSVVTPK ALADFLRREN TISFGGCALQ
110 120 130 140 150
MFLALTMGGA EDLLLAFMAY DRYVAICHPL TYMTLMSSRA CWLMVATSWI
160 170 180 190 200
LASLSALIYT VYTMHYPFCR AQEIRHLLCE IPHLLKVACA DTSRYELMVY
210 220 230 240 250
VMGVTFLIPS LAAILASYTQ ILLTVLHMPS NEGRKKALVT CSSHLTVVGM
260 270 280 290 300
FYGAATFMYV LPSSFHSTRQ DNIISVFYTI VTPALNPLIY SLRNKEVMRA
310
LRRVLGKYML PAHSTL
Length:316
Mass (Da):35,270
Last modified:June 20, 2001 - v2
Checksum:i6885161BD606C0AE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053140187V → L.1 PublicationCorresponds to variant rs2659880dbSNPEnsembl.1
Natural variantiVAR_059985299R → G.1 PublicationCorresponds to variant rs2659879dbSNPEnsembl.1
Natural variantiVAR_059986299R → W.Corresponds to variant rs2659879dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065823 Genomic DNA. Translation: BAC06042.1.
CH471064 Genomic DNA. Translation: EAW68677.1.
BC151143 mRNA. Translation: AAI51144.1.
AF399618 Genomic DNA. Translation: AAK95103.1.
AF321237 Genomic DNA. Translation: AAG45209.1.
BK004295 Genomic DNA. Translation: DAA04693.1.
CCDSiCCDS31414.1.
RefSeqiNP_001004489.1. NM_001004489.2.
UniGeneiHs.553608.

Genome annotation databases

EnsembliENST00000307401; ENSP00000307447; ENSG00000279486.
GeneIDi144125.
KEGGihsa:144125.
UCSCiuc001mer.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065823 Genomic DNA. Translation: BAC06042.1.
CH471064 Genomic DNA. Translation: EAW68677.1.
BC151143 mRNA. Translation: AAI51144.1.
AF399618 Genomic DNA. Translation: AAK95103.1.
AF321237 Genomic DNA. Translation: AAG45209.1.
BK004295 Genomic DNA. Translation: DAA04693.1.
CCDSiCCDS31414.1.
RefSeqiNP_001004489.1. NM_001004489.2.
UniGeneiHs.553608.

3D structure databases

ProteinModelPortaliQ9H205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9H205. 1 interactor.
MINTiMINT-7289875.
STRINGi9606.ENSP00000307447.

Protein family/group databases

TCDBi9.A.14.8.2. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR2AG1.
DMDMi14423804.

Proteomic databases

PaxDbiQ9H205.
PeptideAtlasiQ9H205.
PRIDEiQ9H205.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307401; ENSP00000307447; ENSG00000279486.
GeneIDi144125.
KEGGihsa:144125.
UCSCiuc001mer.2. human.

Organism-specific databases

CTDi144125.
DisGeNETi144125.
GeneCardsiOR2AG1.
HGNCiHGNC:15142. OR2AG1.
neXtProtiNX_Q9H205.
OpenTargetsiENSG00000279486.
PharmGKBiPA32126.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGT4. Eukaryota.
ENOG4111C5R. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ9H205.
KOiK04257.
OMAiYPFCRAQ.
OrthoDBiEOG091G0FFK.
PhylomeDBiQ9H205.
TreeFamiTF337295.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170803-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2AG1.
GenomeRNAii144125.
PROiQ9H205.

Gene expression databases

CleanExiHS_OR2AG1.
ExpressionAtlasiQ9H205. differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
IPR030789. OR2AG1.
[Graphical view]
PANTHERiPTHR26453:SF267. PTHR26453:SF267. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO2AG1_HUMAN
AccessioniPrimary (citable) accession number: Q9H205
Secondary accession number(s): B9EKV7, Q6IFG7, Q96R26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.