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Q9H205

- O2AG1_HUMAN

UniProt

Q9H205 - O2AG1_HUMAN

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Protein

Olfactory receptor 2AG1

Gene

OR2AG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2AG1
Alternative name(s):
HT3
Olfactory receptor 2AG3
Olfactory receptor OR11-79
Gene namesi
Name:OR2AG1
Synonyms:OR2AG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15142. OR2AG1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 31624CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32126.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Olfactory receptor 2AG1PRO_0000150472Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9H205.

Expressioni

Gene expression databases

CleanExiHS_OR2AG1.
GenevestigatoriQ9H205.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MPDZO759708EBI-7590304,EBI-821405

Protein-protein interaction databases

IntActiQ9H205. 1 interaction.
MINTiMINT-7289875.
STRINGi9606.ENSP00000307447.

Structurei

3D structure databases

ProteinModelPortaliQ9H205.
SMRiQ9H205. Positions 26-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41022.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ9H205.
KOiK04257.
OMAiYPFCRAQ.
OrthoDBiEOG72G17Q.
PhylomeDBiQ9H205.
TreeFamiTF337295.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H205-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELWNFTLGS GFILVGILND SGSPELLCAT ITILYLLALI SNGLLLLAIT
60 70 80 90 100
MEARLHMPMY LLLGQLSLMD LLFTSVVTPK ALADFLRREN TISFGGCALQ
110 120 130 140 150
MFLALTMGGA EDLLLAFMAY DRYVAICHPL TYMTLMSSRA CWLMVATSWI
160 170 180 190 200
LASLSALIYT VYTMHYPFCR AQEIRHLLCE IPHLLKVACA DTSRYELMVY
210 220 230 240 250
VMGVTFLIPS LAAILASYTQ ILLTVLHMPS NEGRKKALVT CSSHLTVVGM
260 270 280 290 300
FYGAATFMYV LPSSFHSTRQ DNIISVFYTI VTPALNPLIY SLRNKEVMRA
310
LRRVLGKYML PAHSTL
Length:316
Mass (Da):35,270
Last modified:June 20, 2001 - v2
Checksum:i6885161BD606C0AE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti187 – 1871V → L.1 Publication
Corresponds to variant rs2659880 [ dbSNP | Ensembl ].
VAR_053140
Natural varianti299 – 2991R → G.1 Publication
Corresponds to variant rs2659879 [ dbSNP | Ensembl ].
VAR_059985
Natural varianti299 – 2991R → W.
Corresponds to variant rs2659879 [ dbSNP | Ensembl ].
VAR_059986

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065823 Genomic DNA. Translation: BAC06042.1.
CH471064 Genomic DNA. Translation: EAW68677.1.
BC151143 mRNA. Translation: AAI51144.1.
AF399618 Genomic DNA. Translation: AAK95103.1.
AF321237 Genomic DNA. Translation: AAG45209.1.
BK004295 Genomic DNA. Translation: DAA04693.1.
CCDSiCCDS31414.1.
RefSeqiNP_001004489.1. NM_001004489.2.
UniGeneiHs.553608.

Genome annotation databases

EnsembliENST00000307401; ENSP00000307447; ENSG00000279486.
ENST00000623437; ENSP00000485326; ENSG00000170803.
ENST00000624502; ENSP00000485214; ENSG00000279486.
GeneIDi144125.
KEGGihsa:144125.
UCSCiuc001mer.2. human.

Polymorphism databases

DMDMi14423804.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065823 Genomic DNA. Translation: BAC06042.1 .
CH471064 Genomic DNA. Translation: EAW68677.1 .
BC151143 mRNA. Translation: AAI51144.1 .
AF399618 Genomic DNA. Translation: AAK95103.1 .
AF321237 Genomic DNA. Translation: AAG45209.1 .
BK004295 Genomic DNA. Translation: DAA04693.1 .
CCDSi CCDS31414.1.
RefSeqi NP_001004489.1. NM_001004489.2.
UniGenei Hs.553608.

3D structure databases

ProteinModelPortali Q9H205.
SMRi Q9H205. Positions 26-296.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9H205. 1 interaction.
MINTi MINT-7289875.
STRINGi 9606.ENSP00000307447.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 14423804.

Proteomic databases

PRIDEi Q9H205.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307401 ; ENSP00000307447 ; ENSG00000279486 .
ENST00000623437 ; ENSP00000485326 ; ENSG00000170803 .
ENST00000624502 ; ENSP00000485214 ; ENSG00000279486 .
GeneIDi 144125.
KEGGi hsa:144125.
UCSCi uc001mer.2. human.

Organism-specific databases

CTDi 144125.
GeneCardsi GC11P006806.
HGNCi HGNC:15142. OR2AG1.
neXtProti NX_Q9H205.
PharmGKBi PA32126.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41022.
GeneTreei ENSGT00760000118850.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q9H205.
KOi K04257.
OMAi YPFCRAQ.
OrthoDBi EOG72G17Q.
PhylomeDBi Q9H205.
TreeFami TF337295.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2AG1.
GenomeRNAii 144125.
NextBioi 84842.
PROi Q9H205.

Gene expression databases

CleanExi HS_OR2AG1.
Genevestigatori Q9H205.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 152-316, VARIANTS LEU-187 AND GLY-299.
  6. Cited for: IDENTIFICATION.
  7. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO2AG1_HUMAN
AccessioniPrimary (citable) accession number: Q9H205
Secondary accession number(s): B9EKV7, Q6IFG7, Q96R26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: November 26, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3