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Q9H205 (O2AG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2AG1
Alternative name(s):
HT3
Olfactory receptor 2AG3
Olfactory receptor OR11-79
Gene names
Name:OR2AG1
Synonyms:OR2AG3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MPDZO759708EBI-7590304,EBI-821405

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Olfactory receptor 2AG1
PRO_0000150472

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4924Helical; Name=1; Potential
Topological domain50 – 578Cytoplasmic Potential
Transmembrane58 – 7922Helical; Name=2; Potential
Topological domain80 – 10021Extracellular Potential
Transmembrane101 – 12020Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 15819Helical; Name=4; Potential
Topological domain159 – 19537Extracellular Potential
Transmembrane196 – 21924Helical; Name=5; Potential
Topological domain220 – 23617Cytoplasmic Potential
Transmembrane237 – 25923Helical; Name=6; Potential
Topological domain260 – 27213Extracellular Potential
Transmembrane273 – 29220Helical; Name=7; Potential
Topological domain293 – 31624Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation191N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant1871V → L. Ref.5
Corresponds to variant rs2659880 [ dbSNP | Ensembl ].
VAR_053140
Natural variant2991R → G. Ref.5
Corresponds to variant rs2659879 [ dbSNP | Ensembl ].
VAR_059985
Natural variant2991R → W.
Corresponds to variant rs2659879 [ dbSNP | Ensembl ].
VAR_059986

Sequences

Sequence LengthMass (Da)Tools
Q9H205 [UniParc].

Last modified June 20, 2001. Version 2.
Checksum: 6885161BD606C0AE

FASTA31635,270
        10         20         30         40         50         60 
MELWNFTLGS GFILVGILND SGSPELLCAT ITILYLLALI SNGLLLLAIT MEARLHMPMY 

        70         80         90        100        110        120 
LLLGQLSLMD LLFTSVVTPK ALADFLRREN TISFGGCALQ MFLALTMGGA EDLLLAFMAY 

       130        140        150        160        170        180 
DRYVAICHPL TYMTLMSSRA CWLMVATSWI LASLSALIYT VYTMHYPFCR AQEIRHLLCE 

       190        200        210        220        230        240 
IPHLLKVACA DTSRYELMVY VMGVTFLIPS LAAILASYTQ ILLTVLHMPS NEGRKKALVT 

       250        260        270        280        290        300 
CSSHLTVVGM FYGAATFMYV LPSSFHSTRQ DNIISVFYTI VTPALNPLIY SLRNKEVMRA 

       310 
LRRVLGKYML PAHSTL 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
[5]"Genomic analysis of orthologous mouse and human olfactory receptor loci."
Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L., Evans G., Axel R., Hood L., Trask B.J.
Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 152-316, VARIANTS LEU-187 AND GLY-299.
[6]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065823 Genomic DNA. Translation: BAC06042.1.
CH471064 Genomic DNA. Translation: EAW68677.1.
BC151143 mRNA. Translation: AAI51144.1.
AF399618 Genomic DNA. Translation: AAK95103.1.
AF321237 Genomic DNA. Translation: AAG45209.1.
BK004295 Genomic DNA. Translation: DAA04693.1.
CCDSCCDS31414.1.
RefSeqNP_001004489.1. NM_001004489.2.
UniGeneHs.553608.

3D structure databases

ProteinModelPortalQ9H205.
SMRQ9H205. Positions 26-296.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9H205. 1 interaction.
MINTMINT-7289875.
STRING9606.ENSP00000307447.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM14423804.

Proteomic databases

PRIDEQ9H205.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000307401; ENSP00000307447; ENSG00000170803.
GeneID144125.
KEGGhsa:144125.
UCSCuc001mer.2. human.

Organism-specific databases

CTD144125.
GeneCardsGC11P006806.
HGNCHGNC:15142. OR2AG1.
neXtProtNX_Q9H205.
PharmGKBPA32126.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41022.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ9H205.
KOK04257.
OMAYPFCRAQ.
OrthoDBEOG72G17Q.
PhylomeDBQ9H205.
TreeFamTF337295.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR2AG1.
GenevestigatorQ9H205.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2AG1.
GenomeRNAi144125.
NextBio84842.
PROQ9H205.

Entry information

Entry nameO2AG1_HUMAN
AccessionPrimary (citable) accession number: Q9H205
Secondary accession number(s): B9EKV7, Q6IFG7, Q96R26
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries