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Protein

Olfactory receptor 2AG1

Gene

OR2AG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Protein family/group databases

TCDBi9.A.14.8.2 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2AG1
Alternative name(s):
HT3
Olfactory receptor 2AG3
Olfactory receptor OR11-79
Gene namesi
Name:OR2AG1
Synonyms:OR2AG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000170803.5
HostDB:ENSG00000279486.3
HGNCiHGNC:15142 OR2AG1
neXtProtiNX_Q9H205

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 236CytoplasmicSequence analysisAdd BLAST17
Transmembranei237 – 259Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini260 – 272ExtracellularSequence analysisAdd BLAST13
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 316CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi144125
OpenTargetsiENSG00000279486
PharmGKBiPA32126

Polymorphism and mutation databases

BioMutaiOR2AG1
DMDMi14423804

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504721 – 316Olfactory receptor 2AG1Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H205
PeptideAtlasiQ9H205
PRIDEiQ9H205

Expressioni

Gene expression databases

BgeeiENSG00000170803
CleanExiHS_OR2AG1
ExpressionAtlasiQ9H205 baseline and differential

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MPDZO759708EBI-7590304,EBI-821405

Protein-protein interaction databases

IntActiQ9H205, 1 interactor
MINTiQ9H205
STRINGi9606.ENSP00000307447

Structurei

3D structure databases

ProteinModelPortaliQ9H205
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGT4 Eukaryota
ENOG4111C5R LUCA
GeneTreeiENSGT00760000118850
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ9H205
KOiK04257
OMAiYPFCRAQ
OrthoDBiEOG091G0FFK
PhylomeDBiQ9H205
TreeFamiTF337295

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
IPR030789 OR2AG1
PANTHERiPTHR26453:SF183 PTHR26453:SF183, 1 hit
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELWNFTLGS GFILVGILND SGSPELLCAT ITILYLLALI SNGLLLLAIT
60 70 80 90 100
MEARLHMPMY LLLGQLSLMD LLFTSVVTPK ALADFLRREN TISFGGCALQ
110 120 130 140 150
MFLALTMGGA EDLLLAFMAY DRYVAICHPL TYMTLMSSRA CWLMVATSWI
160 170 180 190 200
LASLSALIYT VYTMHYPFCR AQEIRHLLCE IPHLLKVACA DTSRYELMVY
210 220 230 240 250
VMGVTFLIPS LAAILASYTQ ILLTVLHMPS NEGRKKALVT CSSHLTVVGM
260 270 280 290 300
FYGAATFMYV LPSSFHSTRQ DNIISVFYTI VTPALNPLIY SLRNKEVMRA
310
LRRVLGKYML PAHSTL
Length:316
Mass (Da):35,270
Last modified:June 20, 2001 - v2
Checksum:i6885161BD606C0AE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053140187V → L1 PublicationCorresponds to variant dbSNP:rs2659880Ensembl.1
Natural variantiVAR_059985299R → G1 PublicationCorresponds to variant dbSNP:rs2659879Ensembl.1
Natural variantiVAR_059986299R → W. Corresponds to variant dbSNP:rs2659879Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065823 Genomic DNA Translation: BAC06042.1
CH471064 Genomic DNA Translation: EAW68677.1
BC151143 mRNA Translation: AAI51144.1
AF399618 Genomic DNA Translation: AAK95103.1
AF321237 Genomic DNA Translation: AAG45209.1
BK004295 Genomic DNA Translation: DAA04693.1
CCDSiCCDS31414.1
RefSeqiNP_001004489.1, NM_001004489.2
UniGeneiHs.553608

Genome annotation databases

EnsembliENST00000307401; ENSP00000307447; ENSG00000279486
ENST00000641258; ENSP00000493074; ENSG00000279486
GeneIDi144125
KEGGihsa:144125
UCSCiuc001mer.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO2AG1_HUMAN
AccessioniPrimary (citable) accession number: Q9H205
Secondary accession number(s): B9EKV7, Q6IFG7, Q96R26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: May 23, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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