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Protein

Tetraspanin-10

Gene

TSPAN10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates maturation of the transmembrane metalloprotease ADAM10.By similarity

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

GO - Biological processi

Protein family/group databases

TCDBi8.A.40.1.10 the tetraspanin (tetraspanin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-10
Short name:
Tspan-10
Alternative name(s):
Oculospanin
Gene namesi
Name:TSPAN10
Synonyms:OCSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:29942 TSPAN10
neXtProtiNX_Q9H1Z9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 78CytoplasmicCuratedAdd BLAST78
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 120ExtracellularCuratedAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 154CytoplasmicCuratedAdd BLAST13
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 355ExtracellularCuratedAdd BLAST180

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi83882
PharmGKBiPA142670686

Polymorphism and mutation databases

BioMutaiTSPAN10
DMDMi34222702

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192551 – 355Tetraspanin-10Add BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9H1Z9
PeptideAtlasiQ9H1Z9
PRIDEiQ9H1Z9
ProteomicsDBi80462

PTM databases

iPTMnetiQ9H1Z9
PhosphoSitePlusiQ9H1Z9
SwissPalmiQ9H1Z9

Expressioni

Tissue specificityi

Expressed in the eye, including iris, ciliary body, retinal pigment epithelium, but not lens (protein level).1 Publication

Gene expression databases

CleanExiHS_TSPAN10

Interactioni

Subunit structurei

Interacts with ADAM10.By similarity

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123795, 5 interactors
IntActiQ9H1Z9, 1 interactor
MINTiQ9H1Z9

Structurei

3D structure databases

ProteinModelPortaliQ9H1Z9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000133009
HOVERGENiHBG030259
InParanoidiQ9H1Z9
KOiK17351
PhylomeDBiQ9H1Z9

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H1Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEGERSPLL SQETAGQKPL SVHRPPTSGC LGPVPREDQA EAWGCSCCPP
60 70 80 90 100
ETKHQALSGT PKKGPAPSLS PGSSCVKYLI FLSNFPFSLL GLLALAIGLW
110 120 130 140 150
GLAVKGSLGS DLGGPLPTDP MLGLALGGLV VSAASLAGCL GALCENTCLL
160 170 180 190 200
RGFSGGILAF LVLEAVAGAL VVALWGPLQD SLEHTLRVAI AHYQDDPDLR
210 220 230 240 250
FLLDQVQLGL RCCGAASYQD WQQNLYFNCS SPGVQACSLP ASCCIDPRED
260 270 280 290 300
GASVNDQCGF GVLRLDADAA QRVVYLEGCG PPLRRWLRAN LAASGGYAIA
310 320 330 340 350
VVLLQGAELL LAARLLGALA ARSGAAYGPG AHGEDRAGPQ SPSPGAPPAA

KPARG
Length:355
Mass (Da):36,498
Last modified:March 1, 2001 - v1
Checksum:i1F9AEE3FAE7ABE7A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti332H → R in AAH32802 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057277187R → H. Corresponds to variant dbSNP:rs34896443Ensembl.1
Natural variantiVAR_061849218Y → H. Corresponds to variant dbSNP:rs34379910Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325213 mRNA Translation: AAG42857.1
BC032802 mRNA Translation: AAH32802.1
RefSeqiNP_001277141.1, NM_001290212.1
NP_114151.3, NM_031945.4
UniGeneiHs.208219
Hs.740811

Genome annotation databases

EnsembliENST00000328585; ENSP00000331620; ENSG00000182612
GeneIDi83882
KEGGihsa:83882

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTSN10_HUMAN
AccessioniPrimary (citable) accession number: Q9H1Z9
Secondary accession number(s): Q8N548
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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