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Q9H1Z9

- TSN10_HUMAN

UniProt

Q9H1Z9 - TSN10_HUMAN

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Protein

Tetraspanin-10

Gene

TSPAN10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. enzyme binding Source: UniProt

GO - Biological processi

  1. establishment of protein localization to organelle Source: UniProt
Complete GO annotation...

Protein family/group databases

TCDBi8.A.40.1.10. the tetraspanin (tetraspanin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-10
Short name:
Tspan-10
Alternative name(s):
Oculospanin
Gene namesi
Name:TSPAN10
Synonyms:OCSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:29942. TSPAN10.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670686.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355Tetraspanin-10PRO_0000219255Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9H1Z9.
PaxDbiQ9H1Z9.
PRIDEiQ9H1Z9.

PTM databases

PhosphoSiteiQ9H1Z9.

Expressioni

Tissue specificityi

Expressed in the eye, including iris, ciliary body, retinal pigment epithelium, but not lens (protein level).1 Publication

Gene expression databases

BgeeiQ9H1Z9.
CleanExiHS_TSPAN10.
GenevestigatoriQ9H1Z9.

Interactioni

Protein-protein interaction databases

BioGridi123795. 2 interactions.
IntActiQ9H1Z9. 1 interaction.
MINTiMINT-8415327.
STRINGi9606.ENSP00000331620.

Structurei

3D structure databases

ProteinModelPortaliQ9H1Z9.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei79 – 9921HelicalSequence AnalysisAdd
BLAST
Transmembranei121 – 14121HelicalSequence AnalysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence AnalysisAdd
BLAST
Transmembranei291 – 31121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG271540.
HOGENOMiHOG000133009.
HOVERGENiHBG030259.
InParanoidiQ9H1Z9.
KOiK17351.
PhylomeDBiQ9H1Z9.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H1Z9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEGERSPLL SQETAGQKPL SVHRPPTSGC LGPVPREDQA EAWGCSCCPP
60 70 80 90 100
ETKHQALSGT PKKGPAPSLS PGSSCVKYLI FLSNFPFSLL GLLALAIGLW
110 120 130 140 150
GLAVKGSLGS DLGGPLPTDP MLGLALGGLV VSAASLAGCL GALCENTCLL
160 170 180 190 200
RGFSGGILAF LVLEAVAGAL VVALWGPLQD SLEHTLRVAI AHYQDDPDLR
210 220 230 240 250
FLLDQVQLGL RCCGAASYQD WQQNLYFNCS SPGVQACSLP ASCCIDPRED
260 270 280 290 300
GASVNDQCGF GVLRLDADAA QRVVYLEGCG PPLRRWLRAN LAASGGYAIA
310 320 330 340 350
VVLLQGAELL LAARLLGALA ARSGAAYGPG AHGEDRAGPQ SPSPGAPPAA

KPARG
Length:355
Mass (Da):36,498
Last modified:March 1, 2001 - v1
Checksum:i1F9AEE3FAE7ABE7A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti332 – 3321H → R in AAH32802. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti187 – 1871R → H.
Corresponds to variant rs34896443 [ dbSNP | Ensembl ].
VAR_057277
Natural varianti218 – 2181Y → H.
Corresponds to variant rs34379910 [ dbSNP | Ensembl ].
VAR_061849

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF325213 mRNA. Translation: AAG42857.1.
BC032802 mRNA. Translation: AAH32802.1.
RefSeqiNP_001277141.1. NM_001290212.1.
NP_114151.3. NM_031945.4.
UniGeneiHs.740811.

Genome annotation databases

EnsembliENST00000328585; ENSP00000331620; ENSG00000182612.
GeneIDi83882.
KEGGihsa:83882.

Polymorphism databases

DMDMi34222702.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF325213 mRNA. Translation: AAG42857.1 .
BC032802 mRNA. Translation: AAH32802.1 .
RefSeqi NP_001277141.1. NM_001290212.1.
NP_114151.3. NM_031945.4.
UniGenei Hs.740811.

3D structure databases

ProteinModelPortali Q9H1Z9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123795. 2 interactions.
IntActi Q9H1Z9. 1 interaction.
MINTi MINT-8415327.
STRINGi 9606.ENSP00000331620.

Protein family/group databases

TCDBi 8.A.40.1.10. the tetraspanin (tetraspanin) family.

PTM databases

PhosphoSitei Q9H1Z9.

Polymorphism databases

DMDMi 34222702.

Proteomic databases

MaxQBi Q9H1Z9.
PaxDbi Q9H1Z9.
PRIDEi Q9H1Z9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328585 ; ENSP00000331620 ; ENSG00000182612 .
GeneIDi 83882.
KEGGi hsa:83882.

Organism-specific databases

CTDi 83882.
GeneCardsi GC17P079609.
HGNCi HGNC:29942. TSPAN10.
neXtProti NX_Q9H1Z9.
PharmGKBi PA142670686.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG271540.
HOGENOMi HOG000133009.
HOVERGENi HBG030259.
InParanoidi Q9H1Z9.
KOi K17351.
PhylomeDBi Q9H1Z9.

Miscellaneous databases

GenomeRNAii 83882.
NextBioi 72949.
PROi Q9H1Z9.

Gene expression databases

Bgeei Q9H1Z9.
CleanExi HS_TSPAN10.
Genevestigatori Q9H1Z9.

Family and domain databases

InterProi IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PRINTSi PR00259. TMFOUR.
SUPFAMi SSF48652. SSF48652. 1 hit.
PROSITEi PS00421. TM4_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants."
    Wistow G., Bernstein S.L., Wyatt M.K., Fariss R.N., Behal A., Touchman J.W., Bouffard G., Smith D., Peterson K.
    Mol. Vis. 8:205-220(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Eye.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiTSN10_HUMAN
AccessioniPrimary (citable) accession number: Q9H1Z9
Secondary accession number(s): Q8N548
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3