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Protein

Tetraspanin-10

Gene

TSPAN10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates maturation of the transmembrane metalloprotease ADAM10.By similarity

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

GO - Biological processi

Protein family/group databases

TCDBi8.A.40.1.10. the tetraspanin (tetraspanin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-10
Short name:
Tspan-10
Alternative name(s):
Oculospanin
Gene namesi
Name:TSPAN10
Synonyms:OCSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:29942. TSPAN10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 78CytoplasmicCuratedAdd BLAST78
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 120ExtracellularCuratedAdd BLAST21
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 154CytoplasmicCuratedAdd BLAST13
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 355ExtracellularCuratedAdd BLAST180

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi83882.
PharmGKBiPA142670686.

Polymorphism and mutation databases

BioMutaiTSPAN10.
DMDMi34222702.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192551 – 355Tetraspanin-10Add BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9H1Z9.
PeptideAtlasiQ9H1Z9.
PRIDEiQ9H1Z9.

PTM databases

iPTMnetiQ9H1Z9.
PhosphoSitePlusiQ9H1Z9.
SwissPalmiQ9H1Z9.

Expressioni

Tissue specificityi

Expressed in the eye, including iris, ciliary body, retinal pigment epithelium, but not lens (protein level).1 Publication

Gene expression databases

BgeeiENSG00000182612.
CleanExiHS_TSPAN10.

Interactioni

Subunit structurei

Interacts with ADAM10.By similarity

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123795. 4 interactors.
IntActiQ9H1Z9. 1 interactor.
MINTiMINT-8415327.

Structurei

3D structure databases

ProteinModelPortaliQ9H1Z9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000133009.
HOVERGENiHBG030259.
InParanoidiQ9H1Z9.
KOiK17351.
PhylomeDBiQ9H1Z9.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiView protein in InterPro
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
PfamiView protein in Pfam
PF00335. Tetraspannin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiView protein in PROSITE
PS00421. TM4_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9H1Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEGERSPLL SQETAGQKPL SVHRPPTSGC LGPVPREDQA EAWGCSCCPP
60 70 80 90 100
ETKHQALSGT PKKGPAPSLS PGSSCVKYLI FLSNFPFSLL GLLALAIGLW
110 120 130 140 150
GLAVKGSLGS DLGGPLPTDP MLGLALGGLV VSAASLAGCL GALCENTCLL
160 170 180 190 200
RGFSGGILAF LVLEAVAGAL VVALWGPLQD SLEHTLRVAI AHYQDDPDLR
210 220 230 240 250
FLLDQVQLGL RCCGAASYQD WQQNLYFNCS SPGVQACSLP ASCCIDPRED
260 270 280 290 300
GASVNDQCGF GVLRLDADAA QRVVYLEGCG PPLRRWLRAN LAASGGYAIA
310 320 330 340 350
VVLLQGAELL LAARLLGALA ARSGAAYGPG AHGEDRAGPQ SPSPGAPPAA

KPARG
Length:355
Mass (Da):36,498
Last modified:March 1, 2001 - v1
Checksum:i1F9AEE3FAE7ABE7A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti332H → R in AAH32802 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057277187R → H. Corresponds to variant dbSNP:rs34896443Ensembl.1
Natural variantiVAR_061849218Y → H. Corresponds to variant dbSNP:rs34379910Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325213 mRNA. Translation: AAG42857.1.
BC032802 mRNA. Translation: AAH32802.1.
RefSeqiNP_001277141.1. NM_001290212.1.
NP_114151.3. NM_031945.4.
UniGeneiHs.208219.
Hs.740811.

Genome annotation databases

EnsembliENST00000328585; ENSP00000331620; ENSG00000182612.
GeneIDi83882.
KEGGihsa:83882.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTSN10_HUMAN
AccessioniPrimary (citable) accession number: Q9H1Z9
Secondary accession number(s): Q8N548
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: March 1, 2001
Last modified: May 10, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families