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Q9H1Z9 (TSN10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tetraspanin-10

Short name=Tspan-10
Alternative name(s):
Oculospanin
Gene names
Name:TSPAN10
Synonyms:OCSP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Expressed in the eye, including iris, ciliary body, retinal pigment epithelium, but not lens (protein level). Ref.1

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355Tetraspanin-10
PRO_0000219255

Regions

Transmembrane79 – 9921Helical; Potential
Transmembrane121 – 14121Helical; Potential
Transmembrane156 – 17621Helical; Potential
Transmembrane291 – 31121Helical; Potential

Amino acid modifications

Glycosylation2281N-linked (GlcNAc...) Potential

Natural variations

Natural variant1871R → H.
Corresponds to variant rs34896443 [ dbSNP | Ensembl ].
VAR_057277
Natural variant2181Y → H.
Corresponds to variant rs34379910 [ dbSNP | Ensembl ].
VAR_061849

Experimental info

Sequence conflict3321H → R in AAH32802. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9H1Z9 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 1F9AEE3FAE7ABE7A

FASTA35536,498
        10         20         30         40         50         60 
MEEGERSPLL SQETAGQKPL SVHRPPTSGC LGPVPREDQA EAWGCSCCPP ETKHQALSGT 

        70         80         90        100        110        120 
PKKGPAPSLS PGSSCVKYLI FLSNFPFSLL GLLALAIGLW GLAVKGSLGS DLGGPLPTDP 

       130        140        150        160        170        180 
MLGLALGGLV VSAASLAGCL GALCENTCLL RGFSGGILAF LVLEAVAGAL VVALWGPLQD 

       190        200        210        220        230        240 
SLEHTLRVAI AHYQDDPDLR FLLDQVQLGL RCCGAASYQD WQQNLYFNCS SPGVQACSLP 

       250        260        270        280        290        300 
ASCCIDPRED GASVNDQCGF GVLRLDADAA QRVVYLEGCG PPLRRWLRAN LAASGGYAIA 

       310        320        330        340        350 
VVLLQGAELL LAARLLGALA ARSGAAYGPG AHGEDRAGPQ SPSPGAPPAA KPARG 

« Hide

References

« Hide 'large scale' references
[1]"Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants."
Wistow G., Bernstein S.L., Wyatt M.K., Fariss R.N., Behal A., Touchman J.W., Bouffard G., Smith D., Peterson K.
Mol. Vis. 8:205-220(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Eye.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF325213 mRNA. Translation: AAG42857.1.
BC032802 mRNA. Translation: AAH32802.1.
RefSeqNP_114151.3. NM_031945.3.
UniGeneHs.740811.

3D structure databases

ProteinModelPortalQ9H1Z9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123795. 1 interaction.
IntActQ9H1Z9. 1 interaction.
MINTMINT-8415327.
STRING9606.ENSP00000331620.

Protein family/group databases

TCDB8.A.40.1.10. the tetraspanin (tetraspanin) family.

PTM databases

PhosphoSiteQ9H1Z9.

Polymorphism databases

DMDM34222702.

Proteomic databases

PaxDbQ9H1Z9.
PRIDEQ9H1Z9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000328585; ENSP00000331620; ENSG00000182612.
GeneID83882.
KEGGhsa:83882.

Organism-specific databases

CTD83882.
GeneCardsGC17P079609.
HGNCHGNC:29942. TSPAN10.
neXtProtNX_Q9H1Z9.
PharmGKBPA142670686.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG271540.
HOGENOMHOG000133009.
HOVERGENHBG030259.
InParanoidQ9H1Z9.
KOK17351.
PhylomeDBQ9H1Z9.

Gene expression databases

BgeeQ9H1Z9.
CleanExHS_TSPAN10.
GenevestigatorQ9H1Z9.

Family and domain databases

InterProIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PRINTSPR00259. TMFOUR.
SUPFAMSSF48652. SSF48652. 1 hit.
PROSITEPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi83882.
NextBio72949.
PROQ9H1Z9.

Entry information

Entry nameTSN10_HUMAN
AccessionPrimary (citable) accession number: Q9H1Z9
Secondary accession number(s): Q8N548
Entry history
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM