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Q9H1Z9

- TSN10_HUMAN

UniProt

Q9H1Z9 - TSN10_HUMAN

Protein

Tetraspanin-10

Gene

TSPAN10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. enzyme binding Source: UniProt

    GO - Biological processi

    1. establishment of protein localization to organelle Source: UniProt

    Protein family/group databases

    TCDBi8.A.40.1.10. the tetraspanin (tetraspanin) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetraspanin-10
    Short name:
    Tspan-10
    Alternative name(s):
    Oculospanin
    Gene namesi
    Name:TSPAN10
    Synonyms:OCSP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:29942. TSPAN10.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670686.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 355355Tetraspanin-10PRO_0000219255Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9H1Z9.
    PRIDEiQ9H1Z9.

    PTM databases

    PhosphoSiteiQ9H1Z9.

    Expressioni

    Tissue specificityi

    Expressed in the eye, including iris, ciliary body, retinal pigment epithelium, but not lens (protein level).1 Publication

    Gene expression databases

    BgeeiQ9H1Z9.
    CleanExiHS_TSPAN10.
    GenevestigatoriQ9H1Z9.

    Interactioni

    Protein-protein interaction databases

    BioGridi123795. 1 interaction.
    IntActiQ9H1Z9. 1 interaction.
    MINTiMINT-8415327.
    STRINGi9606.ENSP00000331620.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H1Z9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei79 – 9921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei121 – 14121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei156 – 17621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei291 – 31121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG271540.
    HOGENOMiHOG000133009.
    HOVERGENiHBG030259.
    InParanoidiQ9H1Z9.
    KOiK17351.
    PhylomeDBiQ9H1Z9.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.
    PROSITEiPS00421. TM4_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H1Z9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEGERSPLL SQETAGQKPL SVHRPPTSGC LGPVPREDQA EAWGCSCCPP    50
    ETKHQALSGT PKKGPAPSLS PGSSCVKYLI FLSNFPFSLL GLLALAIGLW 100
    GLAVKGSLGS DLGGPLPTDP MLGLALGGLV VSAASLAGCL GALCENTCLL 150
    RGFSGGILAF LVLEAVAGAL VVALWGPLQD SLEHTLRVAI AHYQDDPDLR 200
    FLLDQVQLGL RCCGAASYQD WQQNLYFNCS SPGVQACSLP ASCCIDPRED 250
    GASVNDQCGF GVLRLDADAA QRVVYLEGCG PPLRRWLRAN LAASGGYAIA 300
    VVLLQGAELL LAARLLGALA ARSGAAYGPG AHGEDRAGPQ SPSPGAPPAA 350
    KPARG 355
    Length:355
    Mass (Da):36,498
    Last modified:March 1, 2001 - v1
    Checksum:i1F9AEE3FAE7ABE7A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti332 – 3321H → R in AAH32802. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti187 – 1871R → H.
    Corresponds to variant rs34896443 [ dbSNP | Ensembl ].
    VAR_057277
    Natural varianti218 – 2181Y → H.
    Corresponds to variant rs34379910 [ dbSNP | Ensembl ].
    VAR_061849

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF325213 mRNA. Translation: AAG42857.1.
    BC032802 mRNA. Translation: AAH32802.1.
    RefSeqiNP_001277141.1. NM_001290212.1.
    NP_114151.3. NM_031945.4.
    UniGeneiHs.740811.

    Genome annotation databases

    EnsembliENST00000328585; ENSP00000331620; ENSG00000182612.
    GeneIDi83882.
    KEGGihsa:83882.

    Polymorphism databases

    DMDMi34222702.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF325213 mRNA. Translation: AAG42857.1 .
    BC032802 mRNA. Translation: AAH32802.1 .
    RefSeqi NP_001277141.1. NM_001290212.1.
    NP_114151.3. NM_031945.4.
    UniGenei Hs.740811.

    3D structure databases

    ProteinModelPortali Q9H1Z9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123795. 1 interaction.
    IntActi Q9H1Z9. 1 interaction.
    MINTi MINT-8415327.
    STRINGi 9606.ENSP00000331620.

    Protein family/group databases

    TCDBi 8.A.40.1.10. the tetraspanin (tetraspanin) family.

    PTM databases

    PhosphoSitei Q9H1Z9.

    Polymorphism databases

    DMDMi 34222702.

    Proteomic databases

    PaxDbi Q9H1Z9.
    PRIDEi Q9H1Z9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328585 ; ENSP00000331620 ; ENSG00000182612 .
    GeneIDi 83882.
    KEGGi hsa:83882.

    Organism-specific databases

    CTDi 83882.
    GeneCardsi GC17P079609.
    HGNCi HGNC:29942. TSPAN10.
    neXtProti NX_Q9H1Z9.
    PharmGKBi PA142670686.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG271540.
    HOGENOMi HOG000133009.
    HOVERGENi HBG030259.
    InParanoidi Q9H1Z9.
    KOi K17351.
    PhylomeDBi Q9H1Z9.

    Miscellaneous databases

    GenomeRNAii 83882.
    NextBioi 72949.
    PROi Q9H1Z9.

    Gene expression databases

    Bgeei Q9H1Z9.
    CleanExi HS_TSPAN10.
    Genevestigatori Q9H1Z9.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    PROSITEi PS00421. TM4_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants."
      Wistow G., Bernstein S.L., Wyatt M.K., Fariss R.N., Behal A., Touchman J.W., Bouffard G., Smith D., Peterson K.
      Mol. Vis. 8:205-220(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Eye.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiTSN10_HUMAN
    AccessioniPrimary (citable) accession number: Q9H1Z9
    Secondary accession number(s): Q8N548
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 22, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3