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Protein

Augurin

Gene

C2orf40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable hormone that may induce senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Augurin
Alternative name(s):
Esophageal cancer-related gene 4 protein
Gene namesi
Name:C2orf40
Synonyms:ECRG4
ORF Names:UNQ761/PRO1508
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24642. C2orf40.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147358728.

Polymorphism and mutation databases

BioMutaiC2orf40.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Propeptidei32 – 7039Sequence analysisPRO_0000363237Add
BLAST
Peptidei71 – 13262AugurinPRO_0000250514Add
BLAST
Propeptidei133 – 14816Sequence analysisPRO_0000363238Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ9H1Z8.
PeptideAtlasiQ9H1Z8.
PRIDEiQ9H1Z8.

PTM databases

iPTMnetiQ9H1Z8.
PhosphoSiteiQ9H1Z8.

Expressioni

Gene expression databases

BgeeiQ9H1Z8.
CleanExiHS_C2orf40.
ExpressionAtlasiQ9H1Z8. baseline and differential.
GenevisibleiQ9H1Z8. HS.

Organism-specific databases

HPAiHPA008546.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000238044.

Structurei

3D structure databases

ProteinModelPortaliQ9H1Z8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the augurin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXRD. Eukaryota.
ENOG4111P5H. LUCA.
GeneTreeiENSGT00390000000145.
HOGENOMiHOG000034231.
HOVERGENiHBG054353.
InParanoidiQ9H1Z8.
OMAiHSFRHGA.
PhylomeDBiQ9H1Z8.
TreeFamiTF336161.

Family and domain databases

InterProiIPR028173. Augurin.
[Graphical view]
PANTHERiPTHR31613. PTHR31613. 1 hit.
PfamiPF15187. Augurin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H1Z8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASPARPAV LALTGLALLL LLCWGPGGIS GNKLKLMLQK REAPVPTKTK
60 70 80 90 100
VAVDENKAKE FLGSLKRQKR QLWDRTRPEV QQWYQQFLYM GFDEAKFEDD
110 120 130 140
ITYWLNRDRN GHEYYGDYYQ RHYDEDSAIG PRSPYGFRHG ASVNYDDY
Length:148
Mass (Da):17,183
Last modified:March 1, 2001 - v1
Checksum:i021529FA4BDD863A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti52 – 521A → T.
Corresponds to variant rs10187689 [ dbSNP | Ensembl ].
VAR_050962

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325503 mRNA. Translation: AAG42321.1.
AY358601 mRNA. Translation: AAQ88964.1.
AC018878 Genomic DNA. Translation: AAY15084.1.
CH471127 Genomic DNA. Translation: EAX01751.1.
CH471127 Genomic DNA. Translation: EAX01752.1.
BC021742 mRNA. Translation: AAH21742.1.
CCDSiCCDS2072.1.
RefSeqiNP_115787.1. NM_032411.2.
UniGeneiHs.43125.

Genome annotation databases

EnsembliENST00000238044; ENSP00000238044; ENSG00000119147.
GeneIDi84417.
KEGGihsa:84417.
UCSCiuc010fjf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325503 mRNA. Translation: AAG42321.1.
AY358601 mRNA. Translation: AAQ88964.1.
AC018878 Genomic DNA. Translation: AAY15084.1.
CH471127 Genomic DNA. Translation: EAX01751.1.
CH471127 Genomic DNA. Translation: EAX01752.1.
BC021742 mRNA. Translation: AAH21742.1.
CCDSiCCDS2072.1.
RefSeqiNP_115787.1. NM_032411.2.
UniGeneiHs.43125.

3D structure databases

ProteinModelPortaliQ9H1Z8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000238044.

PTM databases

iPTMnetiQ9H1Z8.
PhosphoSiteiQ9H1Z8.

Polymorphism and mutation databases

BioMutaiC2orf40.

Proteomic databases

PaxDbiQ9H1Z8.
PeptideAtlasiQ9H1Z8.
PRIDEiQ9H1Z8.

Protocols and materials databases

DNASUi84417.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000238044; ENSP00000238044; ENSG00000119147.
GeneIDi84417.
KEGGihsa:84417.
UCSCiuc010fjf.4. human.

Organism-specific databases

CTDi84417.
GeneCardsiC2orf40.
HGNCiHGNC:24642. C2orf40.
HPAiHPA008546.
MIMi611752. gene.
neXtProtiNX_Q9H1Z8.
PharmGKBiPA147358728.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXRD. Eukaryota.
ENOG4111P5H. LUCA.
GeneTreeiENSGT00390000000145.
HOGENOMiHOG000034231.
HOVERGENiHBG054353.
InParanoidiQ9H1Z8.
OMAiHSFRHGA.
PhylomeDBiQ9H1Z8.
TreeFamiTF336161.

Miscellaneous databases

GenomeRNAii84417.
NextBioi74152.
PROiQ9H1Z8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H1Z8.
CleanExiHS_C2orf40.
ExpressionAtlasiQ9H1Z8. baseline and differential.
GenevisibleiQ9H1Z8. HS.

Family and domain databases

InterProiIPR028173. Augurin.
[Graphical view]
PANTHERiPTHR31613. PTHR31613. 1 hit.
PfamiPF15187. Augurin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of esophageal cancer related gene 4 (ECRG4)."
    Bi M., Lu S.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "Identification of novel peptide hormones in the human proteome by hidden Markov model screening."
    Mirabeau O., Perlas E., Severini C., Audero E., Gascuel O., Possenti R., Birney E., Rosenthal N., Gross C.
    Genome Res. 17:320-327(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiAUGN_HUMAN
AccessioniPrimary (citable) accession number: Q9H1Z8
Secondary accession number(s): D3DVK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2001
Last modified: March 16, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.