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Protein

WD repeat-containing protein 13

Gene

WDR13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101940-MONOMER.
SignaLinkiQ9H1Z4.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 13
Gene namesi
Name:WDR13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:14352. WDR13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37876.

Polymorphism and mutation databases

BioMutaiWDR13.
DMDMi296453034.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513611 – 485WD repeat-containing protein 13Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70PhosphoserineCombined sources1
Modified residuei74PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei114Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei114Omega-N-methylarginine; alternateCombined sources1
Isoform 2 (identifier: Q9H1Z4-2)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9H1Z4.
MaxQBiQ9H1Z4.
PaxDbiQ9H1Z4.
PeptideAtlasiQ9H1Z4.
PRIDEiQ9H1Z4.

PTM databases

iPTMnetiQ9H1Z4.
PhosphoSitePlusiQ9H1Z4.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000101940.
CleanExiHS_WDR13.
ExpressionAtlasiQ9H1Z4. baseline and differential.
GenevisibleiQ9H1Z4. HS.

Organism-specific databases

HPAiHPA000913.

Interactioni

Protein-protein interaction databases

BioGridi122259. 2 interactors.
IntActiQ9H1Z4. 2 interactors.
STRINGi9606.ENSP00000218056.

Structurei

3D structure databases

ProteinModelPortaliQ9H1Z4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati162 – 202WD 1Add BLAST41
Repeati208 – 246WD 2Add BLAST39
Repeati250 – 290WD 3Add BLAST41
Repeati295 – 335WD 4Add BLAST41
Repeati341 – 389WD 5Add BLAST49
Repeati394 – 438WD 6Add BLAST45
Repeati444 – 482WD 7Add BLAST39

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQ13. Eukaryota.
ENOG410Y3SD. LUCA.
HOVERGENiHBG055362.
InParanoidiQ9H1Z4.
OrthoDBiEOG091G0C0Z.
PhylomeDBiQ9H1Z4.
TreeFamiTF329058.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H1Z4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVWQQVLA VDARYNAYRT PTFPQFRTQY IRRRSQLLRE NAKAGHPPAL
60 70 80 90 100
RRQYLRLRGQ LLGQRYGPLS EPGSARAYSN SIVRSSRTTL DRMEDFEDDP
110 120 130 140 150
RALGARGHRR SVSRGSYQLQ AQMNRAVYED RPPGSVVPTS AAEASRAMAG
160 170 180 190 200
DTSLSENYAF AGMYHVFDQH VDEAVPRVRF ANDDRHRLAC CSLDGSISLC
210 220 230 240 250
QLVPAPPTVL RVLRGHTRGV SDFAWSLSND ILVSTSLDAT MRIWASEDGR
260 270 280 290 300
CIREIPDPDS AELLCCTFQP VNNNLTVVGN AKHNVHVMNI STGKKVKGGS
310 320 330 340 350
SKLTGRVLAL SFDAPGRLLW AGDDHGSVFS FLFDMATGKL TKAKRLVVHE
360 370 380 390 400
GSPVTSISAR SWVSREARDP SLLINACLNK LLLYRVVDNE GTLQLKRSFP
410 420 430 440 450
IEQSSHPVRS IFCPLMSFRQ GACVVTGSED MCVHFFDVER AAKAAVNKLQ
460 470 480
GHSAPVLDVS FNCDESLLAS SDASGMVIVW RREQK
Length:485
Mass (Da):53,696
Last modified:May 18, 2010 - v2
Checksum:i9F2CC02B1B2ED1D6
GO
Isoform 2 (identifier: Q9H1Z4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:393
Mass (Da):43,037
Checksum:i8B475B77161D342F
GO

Sequence cautioni

The sequence BAA91261 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti353P → L in BAA91261 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060284325H → R.4 PublicationsCorresponds to variant rs235842dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0540101 – 92Missing in isoform 2. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329819 mRNA. Translation: AAG47845.3.
DQ907252 mRNA. Translation: ABI93266.1.
DQ907253 mRNA. Translation: ABI93267.1.
DQ907255 mRNA. Translation: ABI93269.1.
AF149817 Genomic DNA. Translation: AAK13247.1.
AC115618 Genomic DNA. No translation available.
CH471224 Genomic DNA. Translation: EAW50760.1.
BC002507 mRNA. Translation: AAH02507.2.
BC080579 mRNA. Translation: AAH80579.1.
AK000570 mRNA. Translation: BAA91261.1. Different initiation.
RefSeqiNP_001159898.1. NM_001166426.1.
NP_060353.2. NM_017883.4.
XP_006724602.1. XM_006724539.1.
XP_011542249.1. XM_011543947.2.
UniGeneiHs.521973.

Genome annotation databases

EnsembliENST00000218056; ENSP00000218056; ENSG00000101940.
ENST00000376729; ENSP00000365919; ENSG00000101940.
GeneIDi64743.
KEGGihsa:64743.
UCSCiuc004dkj.3. human. [Q9H1Z4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329819 mRNA. Translation: AAG47845.3.
DQ907252 mRNA. Translation: ABI93266.1.
DQ907253 mRNA. Translation: ABI93267.1.
DQ907255 mRNA. Translation: ABI93269.1.
AF149817 Genomic DNA. Translation: AAK13247.1.
AC115618 Genomic DNA. No translation available.
CH471224 Genomic DNA. Translation: EAW50760.1.
BC002507 mRNA. Translation: AAH02507.2.
BC080579 mRNA. Translation: AAH80579.1.
AK000570 mRNA. Translation: BAA91261.1. Different initiation.
RefSeqiNP_001159898.1. NM_001166426.1.
NP_060353.2. NM_017883.4.
XP_006724602.1. XM_006724539.1.
XP_011542249.1. XM_011543947.2.
UniGeneiHs.521973.

3D structure databases

ProteinModelPortaliQ9H1Z4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122259. 2 interactors.
IntActiQ9H1Z4. 2 interactors.
STRINGi9606.ENSP00000218056.

PTM databases

iPTMnetiQ9H1Z4.
PhosphoSitePlusiQ9H1Z4.

Polymorphism and mutation databases

BioMutaiWDR13.
DMDMi296453034.

Proteomic databases

EPDiQ9H1Z4.
MaxQBiQ9H1Z4.
PaxDbiQ9H1Z4.
PeptideAtlasiQ9H1Z4.
PRIDEiQ9H1Z4.

Protocols and materials databases

DNASUi64743.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000218056; ENSP00000218056; ENSG00000101940.
ENST00000376729; ENSP00000365919; ENSG00000101940.
GeneIDi64743.
KEGGihsa:64743.
UCSCiuc004dkj.3. human. [Q9H1Z4-1]

Organism-specific databases

CTDi64743.
GeneCardsiWDR13.
HGNCiHGNC:14352. WDR13.
HPAiHPA000913.
MIMi300512. gene.
neXtProtiNX_Q9H1Z4.
PharmGKBiPA37876.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ13. Eukaryota.
ENOG410Y3SD. LUCA.
HOVERGENiHBG055362.
InParanoidiQ9H1Z4.
OrthoDBiEOG091G0C0Z.
PhylomeDBiQ9H1Z4.
TreeFamiTF329058.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101940-MONOMER.
SignaLinkiQ9H1Z4.

Miscellaneous databases

ChiTaRSiWDR13. human.
GenomeRNAii64743.
PROiQ9H1Z4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101940.
CleanExiHS_WDR13.
ExpressionAtlasiQ9H1Z4. baseline and differential.
GenevisibleiQ9H1Z4. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR13_HUMAN
AccessioniPrimary (citable) accession number: Q9H1Z4
Secondary accession number(s): Q06DW8
, Q06DX0, Q06DX1, Q9BUL7, Q9NWW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.