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Protein

WD repeat-containing protein 13

Gene

WDR13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ9H1Z4.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 13
Gene namesi
Name:WDR13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:14352. WDR13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37876.

Polymorphism and mutation databases

BioMutaiWDR13.
DMDMi296453034.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 485485WD repeat-containing protein 13PRO_0000051361Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701PhosphoserineCombined sources
Isoform 2 (identifier: Q9H1Z4-2)
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H1Z4.
MaxQBiQ9H1Z4.
PaxDbiQ9H1Z4.
PRIDEiQ9H1Z4.

PTM databases

iPTMnetiQ9H1Z4.
PhosphoSiteiQ9H1Z4.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiQ9H1Z4.
CleanExiHS_WDR13.
ExpressionAtlasiQ9H1Z4. baseline and differential.
GenevisibleiQ9H1Z4. HS.

Organism-specific databases

HPAiHPA000913.

Interactioni

Protein-protein interaction databases

BioGridi122259. 2 interactions.
IntActiQ9H1Z4. 2 interactions.
STRINGi9606.ENSP00000218056.

Structurei

3D structure databases

ProteinModelPortaliQ9H1Z4.
SMRiQ9H1Z4. Positions 192-471.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati162 – 20241WD 1Add
BLAST
Repeati208 – 24639WD 2Add
BLAST
Repeati250 – 29041WD 3Add
BLAST
Repeati295 – 33541WD 4Add
BLAST
Repeati341 – 38949WD 5Add
BLAST
Repeati394 – 43845WD 6Add
BLAST
Repeati444 – 48239WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQ13. Eukaryota.
ENOG410Y3SD. LUCA.
HOVERGENiHBG055362.
InParanoidiQ9H1Z4.
OrthoDBiEOG7ZWD1P.
PhylomeDBiQ9H1Z4.
TreeFamiTF329058.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H1Z4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVWQQVLA VDARYNAYRT PTFPQFRTQY IRRRSQLLRE NAKAGHPPAL
60 70 80 90 100
RRQYLRLRGQ LLGQRYGPLS EPGSARAYSN SIVRSSRTTL DRMEDFEDDP
110 120 130 140 150
RALGARGHRR SVSRGSYQLQ AQMNRAVYED RPPGSVVPTS AAEASRAMAG
160 170 180 190 200
DTSLSENYAF AGMYHVFDQH VDEAVPRVRF ANDDRHRLAC CSLDGSISLC
210 220 230 240 250
QLVPAPPTVL RVLRGHTRGV SDFAWSLSND ILVSTSLDAT MRIWASEDGR
260 270 280 290 300
CIREIPDPDS AELLCCTFQP VNNNLTVVGN AKHNVHVMNI STGKKVKGGS
310 320 330 340 350
SKLTGRVLAL SFDAPGRLLW AGDDHGSVFS FLFDMATGKL TKAKRLVVHE
360 370 380 390 400
GSPVTSISAR SWVSREARDP SLLINACLNK LLLYRVVDNE GTLQLKRSFP
410 420 430 440 450
IEQSSHPVRS IFCPLMSFRQ GACVVTGSED MCVHFFDVER AAKAAVNKLQ
460 470 480
GHSAPVLDVS FNCDESLLAS SDASGMVIVW RREQK
Length:485
Mass (Da):53,696
Last modified:May 18, 2010 - v2
Checksum:i9F2CC02B1B2ED1D6
GO
Isoform 2 (identifier: Q9H1Z4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:393
Mass (Da):43,037
Checksum:i8B475B77161D342F
GO

Sequence cautioni

The sequence BAA91261.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti353 – 3531P → L in BAA91261 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti325 – 3251H → R.4 Publications
Corresponds to variant rs235842 [ dbSNP | Ensembl ].
VAR_060284

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9292Missing in isoform 2. 1 PublicationVSP_054010Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329819 mRNA. Translation: AAG47845.3.
DQ907252 mRNA. Translation: ABI93266.1.
DQ907253 mRNA. Translation: ABI93267.1.
DQ907255 mRNA. Translation: ABI93269.1.
AF149817 Genomic DNA. Translation: AAK13247.1.
AC115618 Genomic DNA. No translation available.
CH471224 Genomic DNA. Translation: EAW50760.1.
BC002507 mRNA. Translation: AAH02507.2.
BC080579 mRNA. Translation: AAH80579.1.
AK000570 mRNA. Translation: BAA91261.1. Different initiation.
RefSeqiNP_001159898.1. NM_001166426.1.
NP_060353.2. NM_017883.4.
XP_006724602.1. XM_006724539.1.
XP_011542249.1. XM_011543947.1.
UniGeneiHs.521973.

Genome annotation databases

EnsembliENST00000218056; ENSP00000218056; ENSG00000101940.
ENST00000376729; ENSP00000365919; ENSG00000101940.
GeneIDi64743.
KEGGihsa:64743.
UCSCiuc004dkj.3. human. [Q9H1Z4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329819 mRNA. Translation: AAG47845.3.
DQ907252 mRNA. Translation: ABI93266.1.
DQ907253 mRNA. Translation: ABI93267.1.
DQ907255 mRNA. Translation: ABI93269.1.
AF149817 Genomic DNA. Translation: AAK13247.1.
AC115618 Genomic DNA. No translation available.
CH471224 Genomic DNA. Translation: EAW50760.1.
BC002507 mRNA. Translation: AAH02507.2.
BC080579 mRNA. Translation: AAH80579.1.
AK000570 mRNA. Translation: BAA91261.1. Different initiation.
RefSeqiNP_001159898.1. NM_001166426.1.
NP_060353.2. NM_017883.4.
XP_006724602.1. XM_006724539.1.
XP_011542249.1. XM_011543947.1.
UniGeneiHs.521973.

3D structure databases

ProteinModelPortaliQ9H1Z4.
SMRiQ9H1Z4. Positions 192-471.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122259. 2 interactions.
IntActiQ9H1Z4. 2 interactions.
STRINGi9606.ENSP00000218056.

PTM databases

iPTMnetiQ9H1Z4.
PhosphoSiteiQ9H1Z4.

Polymorphism and mutation databases

BioMutaiWDR13.
DMDMi296453034.

Proteomic databases

EPDiQ9H1Z4.
MaxQBiQ9H1Z4.
PaxDbiQ9H1Z4.
PRIDEiQ9H1Z4.

Protocols and materials databases

DNASUi64743.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000218056; ENSP00000218056; ENSG00000101940.
ENST00000376729; ENSP00000365919; ENSG00000101940.
GeneIDi64743.
KEGGihsa:64743.
UCSCiuc004dkj.3. human. [Q9H1Z4-1]

Organism-specific databases

CTDi64743.
GeneCardsiWDR13.
HGNCiHGNC:14352. WDR13.
HPAiHPA000913.
MIMi300512. gene.
neXtProtiNX_Q9H1Z4.
PharmGKBiPA37876.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ13. Eukaryota.
ENOG410Y3SD. LUCA.
HOVERGENiHBG055362.
InParanoidiQ9H1Z4.
OrthoDBiEOG7ZWD1P.
PhylomeDBiQ9H1Z4.
TreeFamiTF329058.

Enzyme and pathway databases

SignaLinkiQ9H1Z4.

Miscellaneous databases

ChiTaRSiWDR13. human.
GenomeRNAii64743.
NextBioi66683.
PROiQ9H1Z4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H1Z4.
CleanExiHS_WDR13.
ExpressionAtlasiQ9H1Z4. baseline and differential.
GenevisibleiQ9H1Z4. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A highly conserved human gene encoding a novel member of WD-repeat family of proteins (WDR13)."
    Singh B.N., Suresh A., UmaPrasad G., Subramanian S., Sultana M., Goel S., Kumar S., Singh L.
    Genomics 81:315-328(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, VARIANT ARG-325.
    Tissue: Brain, Stomach and Testis.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-325.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-325.
    Tissue: Colon and Ovary.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 284-485 (ISOFORM 1/2), VARIANT ARG-325.
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiWDR13_HUMAN
AccessioniPrimary (citable) accession number: Q9H1Z4
Secondary accession number(s): Q06DW8
, Q06DX0, Q06DX1, Q9BUL7, Q9NWW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 18, 2010
Last modified: May 11, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.