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Protein

WD repeat-containing protein 13

Gene

WDR13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ9H1Z4

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 13
Gene namesi
Name:WDR13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000101940.17
HGNCiHGNC:14352 WDR13
MIMi300512 gene
neXtProtiNX_Q9H1Z4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37876

Polymorphism and mutation databases

BioMutaiWDR13
DMDMi296453034

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513611 – 485WD repeat-containing protein 13Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70PhosphoserineCombined sources1
Modified residuei74PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei114Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei114Omega-N-methylarginine; alternateCombined sources1
Isoform 2 (identifier: Q9H1Z4-2)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9H1Z4
MaxQBiQ9H1Z4
PaxDbiQ9H1Z4
PeptideAtlasiQ9H1Z4
PRIDEiQ9H1Z4

PTM databases

iPTMnetiQ9H1Z4
PhosphoSitePlusiQ9H1Z4

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000101940
CleanExiHS_WDR13
ExpressionAtlasiQ9H1Z4 baseline and differential
GenevisibleiQ9H1Z4 HS

Organism-specific databases

HPAiHPA000913

Interactioni

Protein-protein interaction databases

BioGridi122259, 3 interactors
IntActiQ9H1Z4, 2 interactors
STRINGi9606.ENSP00000218056

Structurei

3D structure databases

ProteinModelPortaliQ9H1Z4
SMRiQ9H1Z4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati162 – 202WD 1Add BLAST41
Repeati208 – 246WD 2Add BLAST39
Repeati250 – 290WD 3Add BLAST41
Repeati295 – 335WD 4Add BLAST41
Repeati341 – 389WD 5Add BLAST49
Repeati394 – 438WD 6Add BLAST45
Repeati444 – 482WD 7Add BLAST39

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQ13 Eukaryota
ENOG410Y3SD LUCA
HOVERGENiHBG055362
InParanoidiQ9H1Z4
OrthoDBiEOG091G0C0Z
PhylomeDBiQ9H1Z4
TreeFamiTF329058

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H1Z4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVWQQVLA VDARYNAYRT PTFPQFRTQY IRRRSQLLRE NAKAGHPPAL
60 70 80 90 100
RRQYLRLRGQ LLGQRYGPLS EPGSARAYSN SIVRSSRTTL DRMEDFEDDP
110 120 130 140 150
RALGARGHRR SVSRGSYQLQ AQMNRAVYED RPPGSVVPTS AAEASRAMAG
160 170 180 190 200
DTSLSENYAF AGMYHVFDQH VDEAVPRVRF ANDDRHRLAC CSLDGSISLC
210 220 230 240 250
QLVPAPPTVL RVLRGHTRGV SDFAWSLSND ILVSTSLDAT MRIWASEDGR
260 270 280 290 300
CIREIPDPDS AELLCCTFQP VNNNLTVVGN AKHNVHVMNI STGKKVKGGS
310 320 330 340 350
SKLTGRVLAL SFDAPGRLLW AGDDHGSVFS FLFDMATGKL TKAKRLVVHE
360 370 380 390 400
GSPVTSISAR SWVSREARDP SLLINACLNK LLLYRVVDNE GTLQLKRSFP
410 420 430 440 450
IEQSSHPVRS IFCPLMSFRQ GACVVTGSED MCVHFFDVER AAKAAVNKLQ
460 470 480
GHSAPVLDVS FNCDESLLAS SDASGMVIVW RREQK
Length:485
Mass (Da):53,696
Last modified:May 18, 2010 - v2
Checksum:i9F2CC02B1B2ED1D6
GO
Isoform 2 (identifier: Q9H1Z4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:393
Mass (Da):43,037
Checksum:i8B475B77161D342F
GO

Sequence cautioni

The sequence BAA91261 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti353P → L in BAA91261 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060284325H → R4 PublicationsCorresponds to variant dbSNP:rs235842Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0540101 – 92Missing in isoform 2. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329819 mRNA Translation: AAG47845.3
DQ907252 mRNA Translation: ABI93266.1
DQ907253 mRNA Translation: ABI93267.1
DQ907255 mRNA Translation: ABI93269.1
AF149817 Genomic DNA Translation: AAK13247.1
AC115618 Genomic DNA No translation available.
CH471224 Genomic DNA Translation: EAW50760.1
BC002507 mRNA Translation: AAH02507.2
BC080579 mRNA Translation: AAH80579.1
AK000570 mRNA Translation: BAA91261.1 Different initiation.
RefSeqiNP_001159898.1, NM_001166426.2
NP_001334146.1, NM_001347217.1
NP_001334148.1, NM_001347219.1
NP_060353.2, NM_017883.5
XP_011542249.1, XM_011543947.2
UniGeneiHs.521973
Hs.735778

Genome annotation databases

EnsembliENST00000218056; ENSP00000218056; ENSG00000101940
ENST00000376729; ENSP00000365919; ENSG00000101940
GeneIDi64743
KEGGihsa:64743
UCSCiuc004dkj.3 human [Q9H1Z4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiWDR13_HUMAN
AccessioniPrimary (citable) accession number: Q9H1Z4
Secondary accession number(s): Q06DW8
, Q06DX0, Q06DX1, Q9BUL7, Q9NWW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 18, 2010
Last modified: April 25, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health