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Q9H1Y3 (OPN3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Opsin-3
Alternative name(s):
Encephalopsin
Panopsin
Gene names
Name:OPN3
Synonyms:ECPN
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in encephalic photoreception.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Strongly expressed in brain. Highly expressed in the preoptic area and paraventricular nucleus of the hypothalamus. Shows highly patterned expression in other regions of the brain, being enriched in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons, selected thalamic nuclei, and a subset of interneurons in the ventral horn of the spinal cord.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H1Y3-1)

Also known as: 1-4b-5-6;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H1Y3-2)

Also known as: 1-2-5-6;

The sequence of this isoform differs from the canonical sequence as follows:
     126-231: IVSIATLTVL...YGHILYSIRM → WISQLQAATREARASMGPVQQGTICMQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 402402Opsin-3
PRO_0000197813

Regions

Topological domain1 – 4040Extracellular Potential
Transmembrane41 – 6525Helical; Name=1; Potential
Topological domain66 – 7712Cytoplasmic Potential
Transmembrane78 – 10225Helical; Name=2; Potential
Topological domain103 – 11715Extracellular Potential
Transmembrane118 – 13720Helical; Name=3; Potential
Topological domain138 – 15316Cytoplasmic Potential
Transmembrane154 – 17724Helical; Name=4; Potential
Topological domain178 – 20124Extracellular Potential
Transmembrane202 – 22928Helical; Name=5; Potential
Topological domain230 – 25526Cytoplasmic Potential
Transmembrane256 – 27924Helical; Name=6; Potential
Topological domain280 – 2878Extracellular Potential
Transmembrane288 – 31225Helical; Name=7; Potential
Topological domain313 – 40290Cytoplasmic Potential

Amino acid modifications

Modified residue2991N6-(retinylidene)lysine
Lipidation3251S-palmitoyl cysteine By similarity
Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation1981N-linked (GlcNAc...) Potential
Disulfide bond114 ↔ 188 By similarity

Natural variations

Alternative sequence126 – 231106IVSIA…YSIRM → WISQLQAATREARASMGPVQ QGTICMQ in isoform 2.
VSP_010209
Natural variant1671A → V.
Corresponds to variant rs12072790 [ dbSNP | Ensembl ].
VAR_050613
Natural variant1831V → I.
Corresponds to variant rs2273712 [ dbSNP | Ensembl ].
VAR_050614

Experimental info

Sequence conflict390 – 3967NGSKVDV → IGVQSLML in AAD32671. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (1-4b-5-6) [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 370F64C19F834A71

FASTA40244,873
        10         20         30         40         50         60 
MYSGNRSGGH GYWDGGGAAG AEGPAPAGTL SPAPLFSPGT YERLALLLGS IGLLGVGNNL 

        70         80         90        100        110        120 
LVLVLYYKFQ RLRTPTHLLL VNISLSDLLV SLFGVTFTFV SCLRNGWVWD TVGCVWDGFS 

       130        140        150        160        170        180 
GSLFGIVSIA TLTVLAYERY IRVVHARVIN FSWAWRAITY IWLYSLAWAG APLLGWNRYI 

       190        200        210        220        230        240 
LDVHGLGCTV DWKSKDANDS SFVLFLFLGC LVVPLGVIAH CYGHILYSIR MLRCVEDLQT 

       250        260        270        280        290        300 
IQVIKILKYE KKLAKMCFLM IFTFLVCWMP YIVICFLVVN GHGHLVTPTI SIVSYLFAKS 

       310        320        330        340        350        360 
NTVYNPVIYV FMIRKFRRSL LQLLCLRLLR CQRPAKDLPA AGSEMQIRPI VMSQKDGDRP 

       370        380        390        400 
KKKVTFNSSS IIFIITSDES LSVDDSDKTN GSKVDVIQVR PL 

« Hide

Isoform 2 (1-2-5-6) [UniParc].

Checksum: BA9734383981FF2F
Show »

FASTA32335,730

References

« Hide 'large scale' references
[1]"Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain."
Blackshaw S., Snyder S.H.
J. Neurosci. 19:3681-3690(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43."
Halford S., Freedman M.S., Bellingham J., Inglis S.L., Poopalasundaram S., Soni B.G., Foster R.G., Hunt D.M.
Genomics 72:203-208(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Different structural organization of the encephalopsin gene in man and mouse."
Kasper G., Taudien S., Staub E., Mennerich D., Rieder M., Hinzmann B., Dahl E., Schwidetzky U., Rosenthal A., Rump A.
Gene 295:27-32(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF140242 mRNA. Translation: AAD32671.1.
AF303588 mRNA. Translation: AAK37447.1.
AF482426 Genomic DNA. Translation: AAO15715.1.
AF482426 Genomic DNA. Translation: AAO15717.1.
AL133390 Genomic DNA. No translation available.
BC036773 mRNA. Translation: AAH36773.1.
RefSeqNP_055137.2. NM_014322.2.
UniGeneHs.409081.

3D structure databases

ProteinModelPortalQ9H1Y3.
SMRQ9H1Y3. Positions 5-332.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000355512.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9H1Y3.

Polymorphism databases

DMDM17380172.

Proteomic databases

PaxDbQ9H1Y3.
PRIDEQ9H1Y3.

Protocols and materials databases

DNASU23596.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000331838; ENSP00000328018; ENSG00000054277. [Q9H1Y3-2]
ENST00000366554; ENSP00000355512; ENSG00000054277. [Q9H1Y3-1]
GeneID23596.
KEGGhsa:23596.
UCSCuc001hza.3. human. [Q9H1Y3-1]

Organism-specific databases

CTD23596.
GeneCardsGC01M241753.
HGNCHGNC:14007. OPN3.
HPACAB013682.
MIM606695. gene.
neXtProtNX_Q9H1Y3.
PharmGKBPA31939.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG250907.
HOGENOMHOG000029042.
HOVERGENHBG100337.
InParanoidQ9H1Y3.
KOK04256.
OMAHLVTPTV.
OrthoDBEOG7FBRHZ.
PhylomeDBQ9H1Y3.
TreeFamTF324998.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ9H1Y3.
CleanExHS_OPN3.
GenevestigatorQ9H1Y3.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027430. Retinal_BS.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOPN3.
GenomeRNAi23596.
NextBio46258.
PROQ9H1Y3.
SOURCESearch...

Entry information

Entry nameOPN3_HUMAN
AccessionPrimary (citable) accession number: Q9H1Y3
Secondary accession number(s): Q8IX08, Q9Y344
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries