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Protein

Opsin-3

Gene

OPN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in encephalic photoreception.

GO - Molecular functioni

  • G-protein coupled photoreceptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: ProtInc
  • photoreceptor activity Source: UniProtKB

GO - Biological processi

  • cellular response to light stimulus Source: GO_Central
  • detection of light stimulus Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • phototransduction Source: UniProtKB
  • protein-chromophore linkage Source: UniProtKB-KW
  • regulation of circadian rhythm Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Keywords - Ligandi

Chromophore

Enzyme and pathway databases

BioCyciZFISH:ENSG00000054277-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-419771. Opsins.

Names & Taxonomyi

Protein namesi
Recommended name:
Opsin-3
Alternative name(s):
Encephalopsin
Panopsin
Gene namesi
Name:OPN3
Synonyms:ECPN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14007. OPN3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40ExtracellularSequence analysisAdd BLAST40
Transmembranei41 – 65Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini66 – 77CytoplasmicSequence analysisAdd BLAST12
Transmembranei78 – 102Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini103 – 117ExtracellularSequence analysisAdd BLAST15
Transmembranei118 – 137Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini138 – 153CytoplasmicSequence analysisAdd BLAST16
Transmembranei154 – 177Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini178 – 201ExtracellularSequence analysisAdd BLAST24
Transmembranei202 – 229Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini230 – 255CytoplasmicSequence analysisAdd BLAST26
Transmembranei256 – 279Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini280 – 287ExtracellularSequence analysis8
Transmembranei288 – 312Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini313 – 402CytoplasmicSequence analysisAdd BLAST90

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23596.
OpenTargetsiENSG00000054277.
PharmGKBiPA31939.

Polymorphism and mutation databases

BioMutaiOPN3.
DMDMi17380172.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001978131 – 402Opsin-3Add BLAST402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi114 ↔ 188PROSITE-ProRule annotation
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1
Modified residuei299N6-(retinylidene)lysine1
Lipidationi325S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ9H1Y3.
PaxDbiQ9H1Y3.
PeptideAtlasiQ9H1Y3.
PRIDEiQ9H1Y3.

PTM databases

iPTMnetiQ9H1Y3.
PhosphoSitePlusiQ9H1Y3.

Expressioni

Tissue specificityi

Strongly expressed in brain. Highly expressed in the preoptic area and paraventricular nucleus of the hypothalamus. Shows highly patterned expression in other regions of the brain, being enriched in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons, selected thalamic nuclei, and a subset of interneurons in the ventral horn of the spinal cord.

Gene expression databases

BgeeiENSG00000054277.
CleanExiHS_OPN3.
ExpressionAtlasiQ9H1Y3. baseline and differential.
GenevisibleiQ9H1Y3. HS.

Organism-specific databases

HPAiCAB013682.
HPA064443.

Interactioni

Protein-protein interaction databases

BioGridi117131. 4 interactors.
STRINGi9606.ENSP00000355512.

Structurei

3D structure databases

ProteinModelPortaliQ9H1Y3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000029042.
HOVERGENiHBG100337.
InParanoidiQ9H1Y3.
KOiK04256.
OMAiVNGYGHL.
OrthoDBiEOG091G0ALC.
PhylomeDBiQ9H1Y3.
TreeFamiTF324998.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H1Y3-1) [UniParc]FASTAAdd to basket
Also known as: 1-4b-5-6

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYSGNRSGGH GYWDGGGAAG AEGPAPAGTL SPAPLFSPGT YERLALLLGS
60 70 80 90 100
IGLLGVGNNL LVLVLYYKFQ RLRTPTHLLL VNISLSDLLV SLFGVTFTFV
110 120 130 140 150
SCLRNGWVWD TVGCVWDGFS GSLFGIVSIA TLTVLAYERY IRVVHARVIN
160 170 180 190 200
FSWAWRAITY IWLYSLAWAG APLLGWNRYI LDVHGLGCTV DWKSKDANDS
210 220 230 240 250
SFVLFLFLGC LVVPLGVIAH CYGHILYSIR MLRCVEDLQT IQVIKILKYE
260 270 280 290 300
KKLAKMCFLM IFTFLVCWMP YIVICFLVVN GHGHLVTPTI SIVSYLFAKS
310 320 330 340 350
NTVYNPVIYV FMIRKFRRSL LQLLCLRLLR CQRPAKDLPA AGSEMQIRPI
360 370 380 390 400
VMSQKDGDRP KKKVTFNSSS IIFIITSDES LSVDDSDKTN GSKVDVIQVR

PL
Length:402
Mass (Da):44,873
Last modified:March 1, 2001 - v1
Checksum:i370F64C19F834A71
GO
Isoform 2 (identifier: Q9H1Y3-2) [UniParc]FASTAAdd to basket
Also known as: 1-2-5-6

The sequence of this isoform differs from the canonical sequence as follows:
     126-231: IVSIATLTVL...YGHILYSIRM → WISQLQAATREARASMGPVQQGTICMQ

Show »
Length:323
Mass (Da):35,730
Checksum:iBA9734383981FF2F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti390 – 396NGSKVDV → IGVQSLML in AAD32671 (PubMed:10234000).Curated7

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050613167A → V.Corresponds to variant rs12072790dbSNPEnsembl.1
Natural variantiVAR_050614183V → I.Corresponds to variant rs2273712dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010209126 – 231IVSIA…YSIRM → WISQLQAATREARASMGPVQ QGTICMQ in isoform 2. CuratedAdd BLAST106

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140242 mRNA. Translation: AAD32671.1.
AF303588 mRNA. Translation: AAK37447.1.
AF482426 Genomic DNA. Translation: AAO15715.1.
AF482426 Genomic DNA. Translation: AAO15717.1.
AL133390 Genomic DNA. No translation available.
BC036773 mRNA. Translation: AAH36773.1.
CCDSiCCDS31072.1. [Q9H1Y3-1]
RefSeqiNP_055137.2. NM_014322.2. [Q9H1Y3-1]
UniGeneiHs.409081.

Genome annotation databases

EnsembliENST00000366554; ENSP00000355512; ENSG00000054277. [Q9H1Y3-1]
GeneIDi23596.
KEGGihsa:23596.
UCSCiuc001hza.4. human. [Q9H1Y3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140242 mRNA. Translation: AAD32671.1.
AF303588 mRNA. Translation: AAK37447.1.
AF482426 Genomic DNA. Translation: AAO15715.1.
AF482426 Genomic DNA. Translation: AAO15717.1.
AL133390 Genomic DNA. No translation available.
BC036773 mRNA. Translation: AAH36773.1.
CCDSiCCDS31072.1. [Q9H1Y3-1]
RefSeqiNP_055137.2. NM_014322.2. [Q9H1Y3-1]
UniGeneiHs.409081.

3D structure databases

ProteinModelPortaliQ9H1Y3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117131. 4 interactors.
STRINGi9606.ENSP00000355512.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9H1Y3.
PhosphoSitePlusiQ9H1Y3.

Polymorphism and mutation databases

BioMutaiOPN3.
DMDMi17380172.

Proteomic databases

MaxQBiQ9H1Y3.
PaxDbiQ9H1Y3.
PeptideAtlasiQ9H1Y3.
PRIDEiQ9H1Y3.

Protocols and materials databases

DNASUi23596.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366554; ENSP00000355512; ENSG00000054277. [Q9H1Y3-1]
GeneIDi23596.
KEGGihsa:23596.
UCSCiuc001hza.4. human. [Q9H1Y3-1]

Organism-specific databases

CTDi23596.
DisGeNETi23596.
GeneCardsiOPN3.
HGNCiHGNC:14007. OPN3.
HPAiCAB013682.
HPA064443.
MIMi606695. gene.
neXtProtiNX_Q9H1Y3.
OpenTargetsiENSG00000054277.
PharmGKBiPA31939.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000029042.
HOVERGENiHBG100337.
InParanoidiQ9H1Y3.
KOiK04256.
OMAiVNGYGHL.
OrthoDBiEOG091G0ALC.
PhylomeDBiQ9H1Y3.
TreeFamiTF324998.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000054277-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-419771. Opsins.

Miscellaneous databases

GeneWikiiOPN3.
GenomeRNAii23596.
PROiQ9H1Y3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000054277.
CleanExiHS_OPN3.
ExpressionAtlasiQ9H1Y3. baseline and differential.
GenevisibleiQ9H1Y3. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOPN3_HUMAN
AccessioniPrimary (citable) accession number: Q9H1Y3
Secondary accession number(s): Q8IX08, Q9Y344
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.