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Q9H1Y3

- OPN3_HUMAN

UniProt

Q9H1Y3 - OPN3_HUMAN

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Protein

Opsin-3

Gene

OPN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in encephalic photoreception.

GO - Molecular functioni

  1. G-protein coupled photoreceptor activity Source: UniProtKB
  2. G-protein coupled receptor activity Source: ProtInc
  3. photoreceptor activity Source: UniProtKB

GO - Biological processi

  1. detection of light stimulus Source: UniProtKB
  2. detection of visible light Source: GOC
  3. G-protein coupled receptor signaling pathway Source: ProtInc
  4. phototransduction Source: UniProtKB
  5. protein-chromophore linkage Source: UniProtKB-KW
  6. regulation of circadian rhythm Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

Keywords - Biological processi

Keywords - Ligandi

Chromophore

Enzyme and pathway databases

ReactomeiREACT_18426. Opsins.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Opsin-3
Alternative name(s):
Encephalopsin
Panopsin
Gene namesi
Name:OPN3
Synonyms:ECPN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:14007. OPN3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31939.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Opsin-3PRO_0000197813Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi114 ↔ 188PROSITE-ProRule annotation
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
Modified residuei299 – 2991N6-(retinylidene)lysine
Lipidationi325 – 3251S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiQ9H1Y3.
PaxDbiQ9H1Y3.
PRIDEiQ9H1Y3.

PTM databases

PhosphoSiteiQ9H1Y3.

Expressioni

Tissue specificityi

Strongly expressed in brain. Highly expressed in the preoptic area and paraventricular nucleus of the hypothalamus. Shows highly patterned expression in other regions of the brain, being enriched in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons, selected thalamic nuclei, and a subset of interneurons in the ventral horn of the spinal cord.

Gene expression databases

BgeeiQ9H1Y3.
CleanExiHS_OPN3.
GenevestigatoriQ9H1Y3.

Organism-specific databases

HPAiCAB013682.

Interactioni

Protein-protein interaction databases

BioGridi117131. 4 interactions.
STRINGi9606.ENSP00000355512.

Structurei

3D structure databases

ProteinModelPortaliQ9H1Y3.
SMRiQ9H1Y3. Positions 65-332.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040ExtracellularSequence AnalysisAdd
BLAST
Topological domaini66 – 7712CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini103 – 11715ExtracellularSequence AnalysisAdd
BLAST
Topological domaini138 – 15316CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini178 – 20124ExtracellularSequence AnalysisAdd
BLAST
Topological domaini230 – 25526CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini280 – 2878ExtracellularSequence Analysis
Topological domaini313 – 40290CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 6525Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei78 – 10225Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei118 – 13720Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei154 – 17724Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei202 – 22928Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei256 – 27924Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei288 – 31225Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG250907.
GeneTreeiENSGT00760000118977.
HOGENOMiHOG000029042.
HOVERGENiHBG100337.
InParanoidiQ9H1Y3.
KOiK04256.
OMAiHLVTPTV.
OrthoDBiEOG7FBRHZ.
PhylomeDBiQ9H1Y3.
TreeFamiTF324998.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027430. Retinal_BS.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H1Y3-1) [UniParc]FASTAAdd to Basket

Also known as: 1-4b-5-6

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYSGNRSGGH GYWDGGGAAG AEGPAPAGTL SPAPLFSPGT YERLALLLGS
60 70 80 90 100
IGLLGVGNNL LVLVLYYKFQ RLRTPTHLLL VNISLSDLLV SLFGVTFTFV
110 120 130 140 150
SCLRNGWVWD TVGCVWDGFS GSLFGIVSIA TLTVLAYERY IRVVHARVIN
160 170 180 190 200
FSWAWRAITY IWLYSLAWAG APLLGWNRYI LDVHGLGCTV DWKSKDANDS
210 220 230 240 250
SFVLFLFLGC LVVPLGVIAH CYGHILYSIR MLRCVEDLQT IQVIKILKYE
260 270 280 290 300
KKLAKMCFLM IFTFLVCWMP YIVICFLVVN GHGHLVTPTI SIVSYLFAKS
310 320 330 340 350
NTVYNPVIYV FMIRKFRRSL LQLLCLRLLR CQRPAKDLPA AGSEMQIRPI
360 370 380 390 400
VMSQKDGDRP KKKVTFNSSS IIFIITSDES LSVDDSDKTN GSKVDVIQVR

PL
Length:402
Mass (Da):44,873
Last modified:March 1, 2001 - v1
Checksum:i370F64C19F834A71
GO
Isoform 2 (identifier: Q9H1Y3-2) [UniParc]FASTAAdd to Basket

Also known as: 1-2-5-6

The sequence of this isoform differs from the canonical sequence as follows:
     126-231: IVSIATLTVL...YGHILYSIRM → WISQLQAATREARASMGPVQQGTICMQ

Show »
Length:323
Mass (Da):35,730
Checksum:iBA9734383981FF2F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti390 – 3967NGSKVDV → IGVQSLML in AAD32671. (PubMed:10234000)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti167 – 1671A → V.
Corresponds to variant rs12072790 [ dbSNP | Ensembl ].
VAR_050613
Natural varianti183 – 1831V → I.
Corresponds to variant rs2273712 [ dbSNP | Ensembl ].
VAR_050614

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei126 – 231106IVSIA…YSIRM → WISQLQAATREARASMGPVQ QGTICMQ in isoform 2. CuratedVSP_010209Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF140242 mRNA. Translation: AAD32671.1.
AF303588 mRNA. Translation: AAK37447.1.
AF482426 Genomic DNA. Translation: AAO15715.1.
AF482426 Genomic DNA. Translation: AAO15717.1.
AL133390 Genomic DNA. No translation available.
BC036773 mRNA. Translation: AAH36773.1.
CCDSiCCDS31072.1. [Q9H1Y3-1]
RefSeqiNP_055137.2. NM_014322.2. [Q9H1Y3-1]
UniGeneiHs.409081.

Genome annotation databases

EnsembliENST00000366554; ENSP00000355512; ENSG00000054277. [Q9H1Y3-1]
GeneIDi23596.
KEGGihsa:23596.
UCSCiuc001hza.3. human. [Q9H1Y3-1]

Polymorphism databases

DMDMi17380172.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF140242 mRNA. Translation: AAD32671.1 .
AF303588 mRNA. Translation: AAK37447.1 .
AF482426 Genomic DNA. Translation: AAO15715.1 .
AF482426 Genomic DNA. Translation: AAO15717.1 .
AL133390 Genomic DNA. No translation available.
BC036773 mRNA. Translation: AAH36773.1 .
CCDSi CCDS31072.1. [Q9H1Y3-1 ]
RefSeqi NP_055137.2. NM_014322.2. [Q9H1Y3-1 ]
UniGenei Hs.409081.

3D structure databases

ProteinModelPortali Q9H1Y3.
SMRi Q9H1Y3. Positions 65-332.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117131. 4 interactions.
STRINGi 9606.ENSP00000355512.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9H1Y3.

Polymorphism databases

DMDMi 17380172.

Proteomic databases

MaxQBi Q9H1Y3.
PaxDbi Q9H1Y3.
PRIDEi Q9H1Y3.

Protocols and materials databases

DNASUi 23596.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000366554 ; ENSP00000355512 ; ENSG00000054277 . [Q9H1Y3-1 ]
GeneIDi 23596.
KEGGi hsa:23596.
UCSCi uc001hza.3. human. [Q9H1Y3-1 ]

Organism-specific databases

CTDi 23596.
GeneCardsi GC01M241753.
HGNCi HGNC:14007. OPN3.
HPAi CAB013682.
MIMi 606695. gene.
neXtProti NX_Q9H1Y3.
PharmGKBi PA31939.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG250907.
GeneTreei ENSGT00760000118977.
HOGENOMi HOG000029042.
HOVERGENi HBG100337.
InParanoidi Q9H1Y3.
KOi K04256.
OMAi HLVTPTV.
OrthoDBi EOG7FBRHZ.
PhylomeDBi Q9H1Y3.
TreeFami TF324998.

Enzyme and pathway databases

Reactomei REACT_18426. Opsins.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii OPN3.
GenomeRNAii 23596.
NextBioi 46258.
PROi Q9H1Y3.
SOURCEi Search...

Gene expression databases

Bgeei Q9H1Y3.
CleanExi HS_OPN3.
Genevestigatori Q9H1Y3.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR027430. Retinal_BS.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain."
    Blackshaw S., Snyder S.H.
    J. Neurosci. 19:3681-3690(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43."
    Halford S., Freedman M.S., Bellingham J., Inglis S.L., Poopalasundaram S., Soni B.G., Foster R.G., Hunt D.M.
    Genomics 72:203-208(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Different structural organization of the encephalopsin gene in man and mouse."
    Kasper G., Taudien S., Staub E., Mennerich D., Rieder M., Hinzmann B., Dahl E., Schwidetzky U., Rosenthal A., Rump A.
    Gene 295:27-32(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Ovary.

Entry informationi

Entry nameiOPN3_HUMAN
AccessioniPrimary (citable) accession number: Q9H1Y3
Secondary accession number(s): Q8IX08, Q9Y344
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3