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Q9H1Y3

- OPN3_HUMAN

UniProt

Q9H1Y3 - OPN3_HUMAN

Protein

Opsin-3

Gene

OPN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    May play a role in encephalic photoreception.

    GO - Molecular functioni

    1. G-protein coupled photoreceptor activity Source: UniProtKB
    2. G-protein coupled receptor activity Source: ProtInc
    3. photoreceptor activity Source: UniProtKB

    GO - Biological processi

    1. detection of light stimulus Source: UniProtKB
    2. detection of visible light Source: GOC
    3. G-protein coupled receptor signaling pathway Source: ProtInc
    4. phototransduction Source: UniProtKB
    5. protein-chromophore linkage Source: UniProtKB-KW
    6. regulation of circadian rhythm Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer

    Keywords - Biological processi

    Keywords - Ligandi

    Chromophore

    Enzyme and pathway databases

    ReactomeiREACT_18426. Opsins.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Opsin-3
    Alternative name(s):
    Encephalopsin
    Panopsin
    Gene namesi
    Name:OPN3
    Synonyms:ECPN
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:14007. OPN3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31939.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 402402Opsin-3PRO_0000197813Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi114 ↔ 188PROSITE-ProRule annotation
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
    Modified residuei299 – 2991N6-(retinylidene)lysine
    Lipidationi325 – 3251S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiQ9H1Y3.
    PRIDEiQ9H1Y3.

    PTM databases

    PhosphoSiteiQ9H1Y3.

    Expressioni

    Tissue specificityi

    Strongly expressed in brain. Highly expressed in the preoptic area and paraventricular nucleus of the hypothalamus. Shows highly patterned expression in other regions of the brain, being enriched in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons, selected thalamic nuclei, and a subset of interneurons in the ventral horn of the spinal cord.

    Gene expression databases

    BgeeiQ9H1Y3.
    CleanExiHS_OPN3.
    GenevestigatoriQ9H1Y3.

    Organism-specific databases

    HPAiCAB013682.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000355512.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H1Y3.
    SMRiQ9H1Y3. Positions 35-332.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4040ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini66 – 7712CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini103 – 11715ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini138 – 15316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini178 – 20124ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini230 – 25526CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini280 – 2878ExtracellularSequence Analysis
    Topological domaini313 – 40290CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6525Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei78 – 10225Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei118 – 13720Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei154 – 17724Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei202 – 22928Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei256 – 27924Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 31225Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG250907.
    HOGENOMiHOG000029042.
    HOVERGENiHBG100337.
    InParanoidiQ9H1Y3.
    KOiK04256.
    OMAiHLVTPTV.
    OrthoDBiEOG7FBRHZ.
    PhylomeDBiQ9H1Y3.
    TreeFamiTF324998.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR027430. Retinal_BS.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS00238. OPSIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H1Y3-1) [UniParc]FASTAAdd to Basket

    Also known as: 1-4b-5-6

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYSGNRSGGH GYWDGGGAAG AEGPAPAGTL SPAPLFSPGT YERLALLLGS    50
    IGLLGVGNNL LVLVLYYKFQ RLRTPTHLLL VNISLSDLLV SLFGVTFTFV 100
    SCLRNGWVWD TVGCVWDGFS GSLFGIVSIA TLTVLAYERY IRVVHARVIN 150
    FSWAWRAITY IWLYSLAWAG APLLGWNRYI LDVHGLGCTV DWKSKDANDS 200
    SFVLFLFLGC LVVPLGVIAH CYGHILYSIR MLRCVEDLQT IQVIKILKYE 250
    KKLAKMCFLM IFTFLVCWMP YIVICFLVVN GHGHLVTPTI SIVSYLFAKS 300
    NTVYNPVIYV FMIRKFRRSL LQLLCLRLLR CQRPAKDLPA AGSEMQIRPI 350
    VMSQKDGDRP KKKVTFNSSS IIFIITSDES LSVDDSDKTN GSKVDVIQVR 400
    PL 402
    Length:402
    Mass (Da):44,873
    Last modified:March 1, 2001 - v1
    Checksum:i370F64C19F834A71
    GO
    Isoform 2 (identifier: Q9H1Y3-2) [UniParc]FASTAAdd to Basket

    Also known as: 1-2-5-6

    The sequence of this isoform differs from the canonical sequence as follows:
         126-231: IVSIATLTVL...YGHILYSIRM → WISQLQAATREARASMGPVQQGTICMQ

    Show »
    Length:323
    Mass (Da):35,730
    Checksum:iBA9734383981FF2F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti390 – 3967NGSKVDV → IGVQSLML in AAD32671. (PubMed:10234000)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti167 – 1671A → V.
    Corresponds to variant rs12072790 [ dbSNP | Ensembl ].
    VAR_050613
    Natural varianti183 – 1831V → I.
    Corresponds to variant rs2273712 [ dbSNP | Ensembl ].
    VAR_050614

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei126 – 231106IVSIA…YSIRM → WISQLQAATREARASMGPVQ QGTICMQ in isoform 2. CuratedVSP_010209Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF140242 mRNA. Translation: AAD32671.1.
    AF303588 mRNA. Translation: AAK37447.1.
    AF482426 Genomic DNA. Translation: AAO15715.1.
    AF482426 Genomic DNA. Translation: AAO15717.1.
    AL133390 Genomic DNA. No translation available.
    BC036773 mRNA. Translation: AAH36773.1.
    CCDSiCCDS31072.1. [Q9H1Y3-1]
    RefSeqiNP_055137.2. NM_014322.2. [Q9H1Y3-1]
    UniGeneiHs.409081.

    Genome annotation databases

    EnsembliENST00000366554; ENSP00000355512; ENSG00000054277. [Q9H1Y3-1]
    GeneIDi23596.
    KEGGihsa:23596.
    UCSCiuc001hza.3. human. [Q9H1Y3-1]

    Polymorphism databases

    DMDMi17380172.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF140242 mRNA. Translation: AAD32671.1 .
    AF303588 mRNA. Translation: AAK37447.1 .
    AF482426 Genomic DNA. Translation: AAO15715.1 .
    AF482426 Genomic DNA. Translation: AAO15717.1 .
    AL133390 Genomic DNA. No translation available.
    BC036773 mRNA. Translation: AAH36773.1 .
    CCDSi CCDS31072.1. [Q9H1Y3-1 ]
    RefSeqi NP_055137.2. NM_014322.2. [Q9H1Y3-1 ]
    UniGenei Hs.409081.

    3D structure databases

    ProteinModelPortali Q9H1Y3.
    SMRi Q9H1Y3. Positions 35-332.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000355512.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9H1Y3.

    Polymorphism databases

    DMDMi 17380172.

    Proteomic databases

    PaxDbi Q9H1Y3.
    PRIDEi Q9H1Y3.

    Protocols and materials databases

    DNASUi 23596.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366554 ; ENSP00000355512 ; ENSG00000054277 . [Q9H1Y3-1 ]
    GeneIDi 23596.
    KEGGi hsa:23596.
    UCSCi uc001hza.3. human. [Q9H1Y3-1 ]

    Organism-specific databases

    CTDi 23596.
    GeneCardsi GC01M241753.
    HGNCi HGNC:14007. OPN3.
    HPAi CAB013682.
    MIMi 606695. gene.
    neXtProti NX_Q9H1Y3.
    PharmGKBi PA31939.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG250907.
    HOGENOMi HOG000029042.
    HOVERGENi HBG100337.
    InParanoidi Q9H1Y3.
    KOi K04256.
    OMAi HLVTPTV.
    OrthoDBi EOG7FBRHZ.
    PhylomeDBi Q9H1Y3.
    TreeFami TF324998.

    Enzyme and pathway databases

    Reactomei REACT_18426. Opsins.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii OPN3.
    GenomeRNAii 23596.
    NextBioi 46258.
    PROi Q9H1Y3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H1Y3.
    CleanExi HS_OPN3.
    Genevestigatori Q9H1Y3.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR027430. Retinal_BS.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS00238. OPSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain."
      Blackshaw S., Snyder S.H.
      J. Neurosci. 19:3681-3690(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43."
      Halford S., Freedman M.S., Bellingham J., Inglis S.L., Poopalasundaram S., Soni B.G., Foster R.G., Hunt D.M.
      Genomics 72:203-208(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Different structural organization of the encephalopsin gene in man and mouse."
      Kasper G., Taudien S., Staub E., Mennerich D., Rieder M., Hinzmann B., Dahl E., Schwidetzky U., Rosenthal A., Rump A.
      Gene 295:27-32(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Ovary.

    Entry informationi

    Entry nameiOPN3_HUMAN
    AccessioniPrimary (citable) accession number: Q9H1Y3
    Secondary accession number(s): Q8IX08, Q9Y344
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3