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Q9H1Y0

- ATG5_HUMAN

UniProt

Q9H1Y0 - ATG5_HUMAN

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Protein

Autophagy protein 5

Gene
ATG5, APG5L, ASP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.6 Publications
May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.6 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. autophagic vacuole assembly Source: UniProtKB
  3. autophagy Source: UniProtKB
  4. blood vessel remodeling Source: Ensembl
  5. C-terminal protein lipidation Source: RefGenome
  6. heart contraction Source: Ensembl
  7. innate immune response Source: Reactome
  8. late nucleophagy Source: RefGenome
  9. mitochondrion degradation Source: RefGenome
  10. negative regulation of apoptotic process Source: Ensembl
  11. negative regulation of protein ubiquitination Source: Ensembl
  12. negative regulation of type I interferon production Source: Reactome
  13. otolith development Source: Ensembl
  14. piecemeal microautophagy of nucleus Source: RefGenome
  15. post-translational protein modification Source: UniProtKB
  16. regulation of cilium assembly Source: UniProtKB
  17. regulation of cytokine secretion involved in immune response Source: Ensembl
  18. response to drug Source: Ensembl
  19. response to fungus Source: Ensembl
  20. sporulation resulting in formation of a cellular spore Source: RefGenome
  21. vasodilation Source: Ensembl
  22. ventricular cardiac muscle cell development Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Autophagy, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_25271. Negative regulators of RIG-I/MDA5 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy protein 5
Alternative name(s):
APG5-like
Apoptosis-specific protein
Gene namesi
Name:ATG5
Synonyms:APG5L, ASP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:589. ATG5.

Subcellular locationi

Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein
Note: Colocalizes with nonmuscle actin. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed By similarity. Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme.3 Publications

GO - Cellular componenti

  1. Atg12-Atg5-Atg16 complex Source: RefGenome
  2. autophagic vacuole Source: MGI
  3. axoneme Source: UniProtKB
  4. cytoplasm Source: UniProtKB
  5. membrane Source: MGI
  6. pre-autophagosomal structure membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi130 – 1301K → R: Loss of conjugation. 1 Publication

Organism-specific databases

PharmGKBiPA24880.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275Autophagy protein 5PRO_0000218994Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Cross-linki130 – 130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12) Inferred

Post-translational modificationi

Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.
Acetylated by EP300.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ9H1Y0.
PaxDbiQ9H1Y0.
PRIDEiQ9H1Y0.

PTM databases

PhosphoSiteiQ9H1Y0.

Expressioni

Tissue specificityi

Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.

Inductioni

By apoptotic stimuli.

Gene expression databases

ArrayExpressiQ9H1Y0.
BgeeiQ9H1Y0.
CleanExiHS_ATG5.
GenevestigatoriQ9H1Y0.

Organism-specific databases

HPAiCAB034432.
CAB037309.
HPA042973.

Interactioni

Subunit structurei

Forms a conjugate with ATG12. The ATG5-ATG12 conjugate forms a complex with several units of ATG16L. Interacts with TECPR1; the interaction is direct and does not take place when ATG16L is associated with the ATG5-ATG12 conjugate. ATG12-ATG5 interacts with MAVS, MGA and RARRES3. Interacts with ATG3, ATG7 and ATG10. Interacts with FADD. Interacts transiently interacts with hepatitis C virus (HCV) protein NS5B during HCV infection.7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GABARAPO951662EBI-1047414,EBI-712001
MAP1LC3BQ9GZQ82EBI-1047414,EBI-373144
TECPR1Q7Z6L16EBI-1047414,EBI-2946676
WDFY3Q8IZQ17EBI-1047414,EBI-1569256

Protein-protein interaction databases

BioGridi114859. 18 interactions.
DIPiDIP-29758N.
IntActiQ9H1Y0. 33 interactions.
STRINGi9606.ENSP00000343313.

Structurei

Secondary structure

1
275
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1210
Beta strandi15 – 228
Beta strandi28 – 303
Beta strandi35 – 406
Helixi45 – 484
Helixi50 – 578
Helixi62 – 643
Beta strandi69 – 724
Helixi83 – 908
Turni91 – 933
Beta strandi96 – 1038
Turni109 – 1113
Helixi118 – 13720
Helixi140 – 1445
Helixi147 – 15812
Helixi162 – 17211
Beta strandi179 – 1813
Beta strandi187 – 1904
Beta strandi194 – 1974
Beta strandi208 – 2103
Helixi215 – 2228
Helixi224 – 2263
Beta strandi236 – 2405
Helixi251 – 2577
Beta strandi265 – 2717

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GDKX-ray2.70B/E1-275[»]
4GDLX-ray2.88B1-275[»]
4NAWX-ray2.20B/F/J/N1-275[»]
ProteinModelPortaliQ9H1Y0.
SMRiQ9H1Y0. Positions 3-275.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG5 family.

Phylogenomic databases

eggNOGiNOG271554.
HOGENOMiHOG000007893.
HOVERGENiHBG018731.
InParanoidiQ9H1Y0.
KOiK08339.
OMAiHYPIGVL.
OrthoDBiEOG72C50T.
PhylomeDBiQ9H1Y0.
TreeFamiTF314415.

Family and domain databases

InterProiIPR007239. Atg5.
[Graphical view]
PANTHERiPTHR13040. PTHR13040. 1 hit.
PfamiPF04106. APG5. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: Q9H1Y0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTDDKDVLRD VWFGRIPTCF TLYQDEITER EAEPYYLLLP RVSYLTLVTD    50
KVKKHFQKVM RQEDISEIWF EYEGTPLKWH YPIGLLFDLL ASSSALPWNI 100
TVHFKSFPEK DLLHCPSKDA IEAHFMSCMK EADALKHKSQ VINEMQKKDH 150
KQLWMGLQND RFDQFWAINR KLMEYPAEEN GFRYIPFRIY QTTTERPFIQ 200
KLFRPVAADG QLHTLGDLLK EVCPSAIDPE DGEKKNQVMI HGIEPMLETP 250
LQWLSEHLSY PDNFLHISII PQPTD 275
Length:275
Mass (Da):32,447
Last modified:November 16, 2001 - v2
Checksum:iC33A1E0B3C1DBE5C
GO
Isoform Short (identifier: Q9H1Y0-2) [UniParc]FASTAAdd to Basket

Also known as: APG5beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: MTDDKDVLRD...FEYEGTPLKW → M

Show »
Length:197
Mass (Da):22,931
Checksum:i05FC581F6EABB753
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti58 – 581K → M in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036243

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7979MTDDK…TPLKW → M in isoform Short. VSP_003791Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791W → M in CAC19459. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y11588 mRNA. Translation: CAA72327.1.
AF293841 mRNA. Translation: AAG44955.1.
CR749386 mRNA. Translation: CAH18236.1.
AL022067, AL133509, AL138917 Genomic DNA. Translation: CAI42297.1.
AL022067, AL133509, AL138917 Genomic DNA. Translation: CAI42298.1.
AL133509, AL022067, AL138917 Genomic DNA. Translation: CAC19459.2.
AL133509, AL022067, AL138917 Genomic DNA. Translation: CAI42831.1.
AL138917, AL133509, AL022067 Genomic DNA. Translation: CAI20313.1.
AL138917, AL022067, AL133509 Genomic DNA. Translation: CAI20314.1.
BC002699 mRNA. Translation: AAH02699.1.
BC093011 mRNA. Translation: AAH93011.1.
CCDSiCCDS5055.1. [Q9H1Y0-1]
CCDS69159.1. [Q9H1Y0-2]
RefSeqiNP_001273035.1. NM_001286106.1. [Q9H1Y0-1]
NP_001273036.1. NM_001286107.1. [Q9H1Y0-2]
NP_001273037.1. NM_001286108.1.
NP_001273040.1. NM_001286111.1.
NP_004840.1. NM_004849.3. [Q9H1Y0-1]
UniGeneiHs.486063.

Genome annotation databases

EnsembliENST00000343245; ENSP00000343313; ENSG00000057663. [Q9H1Y0-1]
ENST00000369070; ENSP00000358066; ENSG00000057663. [Q9H1Y0-2]
ENST00000369076; ENSP00000358072; ENSG00000057663. [Q9H1Y0-1]
GeneIDi9474.
KEGGihsa:9474.
UCSCiuc003prf.3. human. [Q9H1Y0-1]
uc003prg.3. human. [Q9H1Y0-2]

Polymorphism databases

DMDMi17366828.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y11588 mRNA. Translation: CAA72327.1 .
AF293841 mRNA. Translation: AAG44955.1 .
CR749386 mRNA. Translation: CAH18236.1 .
AL022067 , AL133509 , AL138917 Genomic DNA. Translation: CAI42297.1 .
AL022067 , AL133509 , AL138917 Genomic DNA. Translation: CAI42298.1 .
AL133509 , AL022067 , AL138917 Genomic DNA. Translation: CAC19459.2 .
AL133509 , AL022067 , AL138917 Genomic DNA. Translation: CAI42831.1 .
AL138917 , AL133509 , AL022067 Genomic DNA. Translation: CAI20313.1 .
AL138917 , AL022067 , AL133509 Genomic DNA. Translation: CAI20314.1 .
BC002699 mRNA. Translation: AAH02699.1 .
BC093011 mRNA. Translation: AAH93011.1 .
CCDSi CCDS5055.1. [Q9H1Y0-1 ]
CCDS69159.1. [Q9H1Y0-2 ]
RefSeqi NP_001273035.1. NM_001286106.1. [Q9H1Y0-1 ]
NP_001273036.1. NM_001286107.1. [Q9H1Y0-2 ]
NP_001273037.1. NM_001286108.1.
NP_001273040.1. NM_001286111.1.
NP_004840.1. NM_004849.3. [Q9H1Y0-1 ]
UniGenei Hs.486063.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GDK X-ray 2.70 B/E 1-275 [» ]
4GDL X-ray 2.88 B 1-275 [» ]
4NAW X-ray 2.20 B/F/J/N 1-275 [» ]
ProteinModelPortali Q9H1Y0.
SMRi Q9H1Y0. Positions 3-275.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114859. 18 interactions.
DIPi DIP-29758N.
IntActi Q9H1Y0. 33 interactions.
STRINGi 9606.ENSP00000343313.

PTM databases

PhosphoSitei Q9H1Y0.

Polymorphism databases

DMDMi 17366828.

Proteomic databases

MaxQBi Q9H1Y0.
PaxDbi Q9H1Y0.
PRIDEi Q9H1Y0.

Protocols and materials databases

DNASUi 9474.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343245 ; ENSP00000343313 ; ENSG00000057663 . [Q9H1Y0-1 ]
ENST00000369070 ; ENSP00000358066 ; ENSG00000057663 . [Q9H1Y0-2 ]
ENST00000369076 ; ENSP00000358072 ; ENSG00000057663 . [Q9H1Y0-1 ]
GeneIDi 9474.
KEGGi hsa:9474.
UCSCi uc003prf.3. human. [Q9H1Y0-1 ]
uc003prg.3. human. [Q9H1Y0-2 ]

Organism-specific databases

CTDi 9474.
GeneCardsi GC06M106632.
HGNCi HGNC:589. ATG5.
HPAi CAB034432.
CAB037309.
HPA042973.
MIMi 604261. gene.
neXtProti NX_Q9H1Y0.
PharmGKBi PA24880.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG271554.
HOGENOMi HOG000007893.
HOVERGENi HBG018731.
InParanoidi Q9H1Y0.
KOi K08339.
OMAi HYPIGVL.
OrthoDBi EOG72C50T.
PhylomeDBi Q9H1Y0.
TreeFami TF314415.

Enzyme and pathway databases

Reactomei REACT_25271. Negative regulators of RIG-I/MDA5 signaling.

Miscellaneous databases

ChiTaRSi ATG5. human.
GeneWikii ATG5.
GenomeRNAii 9474.
NextBioi 35504.
PROi Q9H1Y0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9H1Y0.
Bgeei Q9H1Y0.
CleanExi HS_ATG5.
Genevestigatori Q9H1Y0.

Family and domain databases

InterProi IPR007239. Atg5.
[Graphical view ]
PANTHERi PTHR13040. PTHR13040. 1 hit.
Pfami PF04106. APG5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy in yeast."
    Hammond E.M., Brunet C.L., Johnson G.D., Parkhill J., Milner A.E., Brady G., Gregory C.D., Grand R.J.A.
    FEBS Lett. 425:391-395(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
    Tissue: Fetal liver.
  2. "A novel splicing isoform of human APG5."
    Chen Y., Piao Y.J., Jiang Y.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
    Tissue: Fetal brain.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
    Tissue: Endometrium and Placenta.
  6. "A novel protein expressed in mammalian cells undergoing apoptosis."
    Grand R.J.A., Milner A.E., Mustoe T., Johnson G.D., Owen D., Grant M.L., Gregory C.D.
    Exp. Cell Res. 218:439-451(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN APOPTOSIS.
  7. "A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy."
    Mizushima N., Sugita H., Yoshimori T., Ohsumi Y.
    J. Biol. Chem. 273:33889-33892(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CONJUGATION TO ATG12 AT LYS-130, MUTAGENESIS OF LYS-130.
  8. "The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3."
    Tanida I., Tanida-Miyake E., Ueno T., Kominami E.
    J. Biol. Chem. 276:1701-1706(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CONJUGATION TO ATG12.
  9. "Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells."
    Mizushima N., Yamamoto A., Hatano M., Kobayashi Y., Kabeya Y., Suzuki K., Tokuhisa T., Ohsumi Y., Yoshimori T.
    J. Cell Biol. 152:657-668(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CONJUGATION TO ATG12, SUBCELLULAR LOCATION.
    Tissue: Embryonic stem cell.
  10. "Mammalian Apg12p, but not the Apg12p.Apg5p conjugate, facilitates LC3 processing."
    Tanida I., Nishitani T., Nemoto T., Ueno T., Kominami E.
    Biochem. Biophys. Res. Commun. 296:1164-1170(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATG3, CONJUGATION TO ATG12, FUNCTION.
  11. "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p."
    Tanida I., Tanida-Miyake E., Komatsu M., Ueno T., Kominami E.
    J. Biol. Chem. 277:13739-13744(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ATG3, CONJUGATION TO ATG12.
  12. "Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death."
    Pyo J.O., Jang M.H., Kwon Y.K., Lee H.J., Jun J.I., Woo H.N., Cho D.H., Choi B., Lee H., Kim J.H., Mizushima N., Oshumi Y., Jung Y.K.
    J. Biol. Chem. 280:20722-20729(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH FADD.
  13. "Stimulation of ATG12-ATG5 conjugation by ribonucleic acid."
    Shao Y., Gao Z., Feldman T., Jiang X.
    Autophagy 3:10-16(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: CONJUGATION TO ATG12.
  14. Cited for: FUNCTION IN INNATE IMMUNE RESPONSE, INTERACTION WITH MAVS; MGA AND RARRES3.
  15. "Regulation of autophagy by the p300 acetyltransferase."
    Lee I.H., Finkel T.
    J. Biol. Chem. 284:6322-6328(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION BY EP300.
  16. "Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infection."
    Guevin C., Manna D., Belanger C., Konan K.V., Mak P., Labonte P.
    Virology 405:1-7(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH HEPATITIS C VIRUS PROTEIN NS5B.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. Cited for: INTERACTION WITH TECPR1.
  19. "Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan."
    Mai S., Muster B., Bereiter-Hahn J., Jendrach M.
    Autophagy 8:47-62(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  20. "A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate."
    Chen D., Fan W., Lu Y., Ding X., Chen S., Zhong Q.
    Mol. Cell 45:629-641(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TECPR1.
  21. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  22. "Structure of the human ATG12-ATG5 conjugate required for LC3 lipidation in autophagy."
    Otomo C., Metlagel Z., Takaesu G., Otomo T.
    Nat. Struct. Mol. Biol. 20:59-66(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) IN CONJUGATION WITH ATG12.
  23. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-58.

Entry informationi

Entry nameiATG5_HUMAN
AccessioniPrimary (citable) accession number: Q9H1Y0
Secondary accession number(s): O60875
, Q5JVR2, Q68DI4, Q9H2B8, Q9HCZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: September 3, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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