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Protein

DnaJ homolog subfamily C member 25

Gene

DNAJC25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 25
Gene namesi
Name:DNAJC25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:34187. DNAJC25.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence analysisAdd
BLAST
Transmembranei150 – 17021HelicalSequence analysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165585764.

Polymorphism and mutation databases

BioMutaiDNAJC25.
DMDMi74752592.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360DnaJ homolog subfamily C member 25PRO_0000348569Add
BLAST

Proteomic databases

EPDiQ9H1X3.
MaxQBiQ9H1X3.
PaxDbiQ9H1X3.
PRIDEiQ9H1X3.

Expressioni

Gene expression databases

BgeeiQ9H1X3.
ExpressionAtlasiQ9H1X3. baseline and differential.
GenevisibleiQ9H1X3. HS.

Organism-specific databases

HPAiHPA019122.

Interactioni

Protein-protein interaction databases

BioGridi139240. 1 interaction.
IntActiQ9H1X3. 1 interaction.
STRINGi9606.ENSP00000320650.

Structurei

3D structure databases

ProteinModelPortaliQ9H1X3.
SMRiQ9H1X3. Positions 43-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 12476JPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the DNAJC25 family.Curated
Contains 1 J domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0722. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00390000013355.
HOGENOMiHOG000007844.
HOVERGENiHBG054790.
InParanoidiQ9H1X3.
KOiK19371.
OMAiQPYGREQ.
OrthoDBiEOG7FNC7Z.
PhylomeDBiQ9H1X3.
TreeFamiTF313563.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H1X3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAPLLSPGW GAGAAGRRWW MLLAPLLPAL LLVRPAGALV EGLYCGTRDC
60 70 80 90 100
YEVLGVSRSA GKAEIARAYR QLARRYHPDR YRPQPGDEGP GRTPQSAEEA
110 120 130 140 150
FLLVATAYET LKDEETRKDY DYMLDHPEEY YSHYYHYYSR RLAPKVDVRV
160 170 180 190 200
VILVSVCAIS VFQFFSWWNS YNKAISYLAT VPKYRIQATE IAKQQGLLKK
210 220 230 240 250
AKEKGKNKKS KEEIRDEEEN IIKNIIKSKI DIKGGYQKPQ ICDLLLFQII
260 270 280 290 300
LAPFHLCSYI VWYCRWIYNF NIKGKEYGEE ERLYIIRKSM KMSKSQFDSL
310 320 330 340 350
EDHQKETFLK RELWIKENYE VYKQEQEEEL KKKLANDPRW KRYRRWMKNE
360
GPGRLTFVDD
Length:360
Mass (Da):42,404
Last modified:March 1, 2001 - v1
Checksum:i6D6673C4B71ABD19
GO
Isoform 2 (identifier: Q9H1X3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.

Show »
Length:238
Mass (Da):28,940
Checksum:iBF02088AEA95B2EE
GO
Isoform 3 (identifier: Q9H1X3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     113-153: DEETRKDYDY...PKVDVRVVIL → VSQAAAELQQ...FREPRSCALL
     154-360: Missing.

Show »
Length:153
Mass (Da):16,499
Checksum:i95BD5E8660E0FCCA
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 122122Missing in isoform 2. 2 PublicationsVSP_035180Add
BLAST
Alternative sequencei113 – 15341DEETR…RVVIL → VSQAAAELQQYCMQNACKDA LLVGVPAGSNPFREPRSCAL L in isoform 3. 2 PublicationsVSP_035181Add
BLAST
Alternative sequencei154 – 360207Missing in isoform 3. 2 PublicationsVSP_035182Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF447177 mRNA. Translation: AAQ04643.1.
AK095452 mRNA. Translation: BAG53057.1.
BT007068 mRNA. Translation: AAP35731.1.
AL135787 Genomic DNA. Translation: CAC22154.1.
AL135787 Genomic DNA. Translation: CAI12405.1.
CH471105 Genomic DNA. Translation: EAW59082.1.
CH471105 Genomic DNA. Translation: EAW59085.1.
BC015391 mRNA. Translation: AAH15391.1.
BC048318 mRNA. Translation: AAH48318.1.
CCDSiCCDS43862.1. [Q9H1X3-1]
RefSeqiNP_001015882.2. NM_001015882.2. [Q9H1X3-1]
NP_004116.2. NM_004125.3. [Q9H1X3-3]
UniGeneiHs.534196.

Genome annotation databases

EnsembliENST00000313525; ENSP00000320650; ENSG00000059769. [Q9H1X3-1]
GeneIDi548645.
552891.
KEGGihsa:548645.
hsa:552891.
UCSCiuc004bfl.3. human. [Q9H1X3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF447177 mRNA. Translation: AAQ04643.1.
AK095452 mRNA. Translation: BAG53057.1.
BT007068 mRNA. Translation: AAP35731.1.
AL135787 Genomic DNA. Translation: CAC22154.1.
AL135787 Genomic DNA. Translation: CAI12405.1.
CH471105 Genomic DNA. Translation: EAW59082.1.
CH471105 Genomic DNA. Translation: EAW59085.1.
BC015391 mRNA. Translation: AAH15391.1.
BC048318 mRNA. Translation: AAH48318.1.
CCDSiCCDS43862.1. [Q9H1X3-1]
RefSeqiNP_001015882.2. NM_001015882.2. [Q9H1X3-1]
NP_004116.2. NM_004125.3. [Q9H1X3-3]
UniGeneiHs.534196.

3D structure databases

ProteinModelPortaliQ9H1X3.
SMRiQ9H1X3. Positions 43-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi139240. 1 interaction.
IntActiQ9H1X3. 1 interaction.
STRINGi9606.ENSP00000320650.

Polymorphism and mutation databases

BioMutaiDNAJC25.
DMDMi74752592.

Proteomic databases

EPDiQ9H1X3.
MaxQBiQ9H1X3.
PaxDbiQ9H1X3.
PRIDEiQ9H1X3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313525; ENSP00000320650; ENSG00000059769. [Q9H1X3-1]
GeneIDi548645.
552891.
KEGGihsa:548645.
hsa:552891.
UCSCiuc004bfl.3. human. [Q9H1X3-1]

Organism-specific databases

CTDi548645.
552891.
GeneCardsiDNAJC25.
HGNCiHGNC:34187. DNAJC25.
HPAiHPA019122.
neXtProtiNX_Q9H1X3.
PharmGKBiPA165585764.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0722. Eukaryota.
COG0484. LUCA.
GeneTreeiENSGT00390000013355.
HOGENOMiHOG000007844.
HOVERGENiHBG054790.
InParanoidiQ9H1X3.
KOiK19371.
OMAiQPYGREQ.
OrthoDBiEOG7FNC7Z.
PhylomeDBiQ9H1X3.
TreeFamiTF313563.

Miscellaneous databases

NextBioi112316.
PROiQ9H1X3.

Gene expression databases

BgeeiQ9H1X3.
ExpressionAtlasiQ9H1X3. baseline and differential.
GenevisibleiQ9H1X3. HS.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Zan Q., Guo J.H., Yu L.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Prostate.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Kidney.
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiDJC25_HUMAN
AccessioniPrimary (citable) accession number: Q9H1X3
Secondary accession number(s): Q5QTD8, Q96BN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2001
Last modified: April 13, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.