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Protein

Sodium-dependent neutral amino acid transporter SLC6A17

Gene

SLC6A17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity).By similarity

GO - Molecular functioni

  1. neurotransmitter:sodium symporter activity Source: InterPro

GO - Biological processi

  1. alanine transport Source: UniProtKB
  2. glycine transport Source: UniProtKB
  3. leucine transport Source: UniProtKB
  4. neutral amino acid transport Source: UniProtKB
  5. proline transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Protein family/group databases

TCDBi2.A.22.6.6. the neurotransmitter:sodium symporter (nss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent neutral amino acid transporter SLC6A17
Alternative name(s):
Sodium-dependent neurotransmitter transporter NTT4
Solute carrier family 6 member 17
Gene namesi
Name:SLC6A17
Synonyms:NTT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:31399. SLC6A17.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6969CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei70 – 9021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini91 – 955ExtracellularSequence Analysis
Transmembranei96 – 11621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini117 – 14731CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei148 – 16821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini169 – 22254ExtracellularSequence AnalysisAdd
BLAST
Transmembranei223 – 24321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini244 – 25310CytoplasmicSequence Analysis
Transmembranei254 – 27421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini275 – 30026ExtracellularSequence AnalysisAdd
BLAST
Transmembranei301 – 32121Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini322 – 33413CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei335 – 35521Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini356 – 460105ExtracellularSequence AnalysisAdd
BLAST
Transmembranei461 – 48121Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini482 – 4909CytoplasmicSequence Analysis
Transmembranei491 – 51121Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini512 – 52716ExtracellularSequence AnalysisAdd
BLAST
Transmembranei528 – 54821Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini549 – 57325CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei574 – 59421Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini595 – 61723ExtracellularSequence AnalysisAdd
BLAST
Transmembranei618 – 63821Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini639 – 72789CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of plasma membrane Source: InterPro
  3. synaptic vesicle Source: UniProtKB
  4. synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134941636.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 727727Sodium-dependent neutral amino acid transporter SLC6A17PRO_0000214803Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
Modified residuei377 – 3771PhosphotyrosineBy similarity
Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9H1V8.
PRIDEiQ9H1V8.

PTM databases

PhosphoSiteiQ9H1V8.

Expressioni

Gene expression databases

BgeeiQ9H1V8.
CleanExiHS_SLC6A17.
GenevestigatoriQ9H1V8.

Organism-specific databases

HPAiHPA007663.
HPA008044.

Interactioni

Protein-protein interaction databases

BioGridi132799. 1 interaction.
STRINGi9606.ENSP00000330199.

Structurei

3D structure databases

ProteinModelPortaliQ9H1V8.
SMRiQ9H1V8. Positions 58-645.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ9H1V8.
KOiK05048.
OMAiMEMYNVI.
OrthoDBiEOG793B71.
PhylomeDBiQ9H1V8.
TreeFamiTF352709.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H1V8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKNSKVTQR EHSSEHVTES VADLLALEEP VDYKQSVLNV AGEAGGKQKA
60 70 80 90 100
VEEELDAEDR PAWNSKLQYI LAQIGFSVGL GNIWRFPYLC QKNGGGAYLV
110 120 130 140 150
PYLVLLIIIG IPLFFLELAV GQRIRRGSIG VWHYICPRLG GIGFSSCIVC
160 170 180 190 200
LFVGLYYNVI IGWSIFYFFK SFQYPLPWSE CPVVRNGSVA VVEAECEKSS
210 220 230 240 250
ATTYFWYREA LDISDSISES GGLNWKMTLC LLVAWSIVGM AVVKGIQSSG
260 270 280 290 300
KVMYFSSLFP YVVLACFLVR GLLLRGAVDG ILHMFTPKLD KMLDPQVWRE
310 320 330 340 350
AATQVFFALG LGFGGVIAFS SYNKQDNNCH FDAALVSFIN FFTSVLATLV
360 370 380 390 400
VFAVLGFKAN IMNEKCVVEN AEKILGYLNT NVLSRDLIPP HVNFSHLTTK
410 420 430 440 450
DYMEMYNVIM TVKEDQFSAL GLDPCLLEDE LDKSVQGTGL AFIAFTEAMT
460 470 480 490 500
HFPASPFWSV MFFLMLINLG LGSMIGTMAG ITTPIIDTFK VPKEMFTVGC
510 520 530 540 550
CVFAFLVGLL FVQRSGNYFV TMFDDYSATL PLTLIVILEN IAVAWIYGTK
560 570 580 590 600
KFMQELTEML GFRPYRFYFY MWKFVSPLCM AVLTTASIIQ LGVTPPGYSA
610 620 630 640 650
WIKEEAAERY LYFPNWAMAL LITLIVVATL PIPVVFVLRH FHLLSDGSNT
660 670 680 690 700
LSVSYKKGRM MKDISNLEEN DETRFILSKV PSEAPSPMPT HRSYLGPGST
710 720
SPLETSGNPN GRYGSGYLLA STPESEL
Length:727
Mass (Da):81,001
Last modified:February 1, 2005 - v3
Checksum:i454FAE5ACF53D9EB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571A → T.1 Publication
Corresponds to variant rs12737742 [ dbSNP | Ensembl ].
VAR_061814

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289982 mRNA. Translation: BAF82671.1.
AL355990, AL137790 Genomic DNA. Translation: CAI18927.1.
AL137790, AL355990 Genomic DNA. Translation: CAI18832.1.
BC140908 mRNA. Translation: AAI40909.1.
CCDSiCCDS30799.1.
RefSeqiNP_001010898.1. NM_001010898.2.
XP_006710706.1. XM_006710643.1.
UniGeneiHs.128382.

Genome annotation databases

EnsembliENST00000331565; ENSP00000330199; ENSG00000197106.
GeneIDi388662.
KEGGihsa:388662.
UCSCiuc009wfq.3. human.

Polymorphism databases

DMDMi59800227.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289982 mRNA. Translation: BAF82671.1.
AL355990, AL137790 Genomic DNA. Translation: CAI18927.1.
AL137790, AL355990 Genomic DNA. Translation: CAI18832.1.
BC140908 mRNA. Translation: AAI40909.1.
CCDSiCCDS30799.1.
RefSeqiNP_001010898.1. NM_001010898.2.
XP_006710706.1. XM_006710643.1.
UniGeneiHs.128382.

3D structure databases

ProteinModelPortaliQ9H1V8.
SMRiQ9H1V8. Positions 58-645.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132799. 1 interaction.
STRINGi9606.ENSP00000330199.

Protein family/group databases

TCDBi2.A.22.6.6. the neurotransmitter:sodium symporter (nss) family.

PTM databases

PhosphoSiteiQ9H1V8.

Polymorphism databases

DMDMi59800227.

Proteomic databases

PaxDbiQ9H1V8.
PRIDEiQ9H1V8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331565; ENSP00000330199; ENSG00000197106.
GeneIDi388662.
KEGGihsa:388662.
UCSCiuc009wfq.3. human.

Organism-specific databases

CTDi388662.
GeneCardsiGC01P110693.
HGNCiHGNC:31399. SLC6A17.
HPAiHPA007663.
HPA008044.
MIMi610299. gene.
neXtProtiNX_Q9H1V8.
PharmGKBiPA134941636.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ9H1V8.
KOiK05048.
OMAiMEMYNVI.
OrthoDBiEOG793B71.
PhylomeDBiQ9H1V8.
TreeFamiTF352709.

Miscellaneous databases

GenomeRNAii388662.
NextBioi102265.
PROiQ9H1V8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H1V8.
CleanExiHS_SLC6A17.
GenevestigatoriQ9H1V8.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-57.
    Tissue: Brain.
  4. "The repertoire of solute carriers of family 6: identification of new human and rodent genes."
    Hoglund P.J., Adzic D., Scicluna S.J., Lindblom J., Fredriksson R.
    Biochem. Biophys. Res. Commun. 336:175-189(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiS6A17_HUMAN
AccessioniPrimary (citable) accession number: Q9H1V8
Secondary accession number(s): A6NEA8
, A8K1R7, B9EIR5, Q5T5Q9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: February 1, 2005
Last modified: January 7, 2015
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.