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Q9H1V8

- S6A17_HUMAN

UniProt

Q9H1V8 - S6A17_HUMAN

Protein

Sodium-dependent neutral amino acid transporter SLC6A17

Gene

SLC6A17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 3 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent By similarity.By similarity

    GO - Molecular functioni

    1. neurotransmitter:sodium symporter activity Source: InterPro

    GO - Biological processi

    1. alanine transport Source: UniProtKB
    2. glycine transport Source: UniProtKB
    3. leucine transport Source: UniProtKB
    4. neutral amino acid transport Source: UniProtKB
    5. proline transport Source: UniProtKB

    Keywords - Biological processi

    Neurotransmitter transport, Symport, Transport

    Protein family/group databases

    TCDBi2.A.22.6.6. the neurotransmitter:sodium symporter (nss) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-dependent neutral amino acid transporter SLC6A17
    Alternative name(s):
    Sodium-dependent neurotransmitter transporter NTT4
    Solute carrier family 6 member 17
    Gene namesi
    Name:SLC6A17
    Synonyms:NTT4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:31399. SLC6A17.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. integral component of plasma membrane Source: InterPro
    3. synaptic vesicle Source: UniProtKB
    4. synaptic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134941636.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 727727Sodium-dependent neutral amino acid transporter SLC6A17PRO_0000214803Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
    Modified residuei377 – 3771PhosphotyrosineBy similarity
    Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ9H1V8.
    PRIDEiQ9H1V8.

    PTM databases

    PhosphoSiteiQ9H1V8.

    Expressioni

    Gene expression databases

    BgeeiQ9H1V8.
    CleanExiHS_SLC6A17.
    GenevestigatoriQ9H1V8.

    Organism-specific databases

    HPAiHPA007663.
    HPA008044.

    Interactioni

    Protein-protein interaction databases

    BioGridi132799. 1 interaction.
    STRINGi9606.ENSP00000330199.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H1V8.
    SMRiQ9H1V8. Positions 58-645.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6969CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini91 – 955ExtracellularSequence Analysis
    Topological domaini117 – 14731CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini169 – 22254ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini244 – 25310CytoplasmicSequence Analysis
    Topological domaini275 – 30026ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini322 – 33413CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini356 – 460105ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini482 – 4909CytoplasmicSequence Analysis
    Topological domaini512 – 52716ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini549 – 57325CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini595 – 61723ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini639 – 72789CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei70 – 9021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei96 – 11621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei148 – 16821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei223 – 24321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei254 – 27421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei301 – 32121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei335 – 35521Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei461 – 48121Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei491 – 51121Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei528 – 54821Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei574 – 59421Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei618 – 63821Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0733.
    HOGENOMiHOG000116406.
    HOVERGENiHBG071421.
    InParanoidiQ9H1V8.
    KOiK05048.
    OMAiMEMYNVI.
    OrthoDBiEOG793B71.
    PhylomeDBiQ9H1V8.
    TreeFamiTF352709.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    IPR002438. Na/ntran_symport_orphan.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR00176. NANEUSMPORT.
    PR01206. ORPHTRNSPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H1V8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKNSKVTQR EHSSEHVTES VADLLALEEP VDYKQSVLNV AGEAGGKQKA    50
    VEEELDAEDR PAWNSKLQYI LAQIGFSVGL GNIWRFPYLC QKNGGGAYLV 100
    PYLVLLIIIG IPLFFLELAV GQRIRRGSIG VWHYICPRLG GIGFSSCIVC 150
    LFVGLYYNVI IGWSIFYFFK SFQYPLPWSE CPVVRNGSVA VVEAECEKSS 200
    ATTYFWYREA LDISDSISES GGLNWKMTLC LLVAWSIVGM AVVKGIQSSG 250
    KVMYFSSLFP YVVLACFLVR GLLLRGAVDG ILHMFTPKLD KMLDPQVWRE 300
    AATQVFFALG LGFGGVIAFS SYNKQDNNCH FDAALVSFIN FFTSVLATLV 350
    VFAVLGFKAN IMNEKCVVEN AEKILGYLNT NVLSRDLIPP HVNFSHLTTK 400
    DYMEMYNVIM TVKEDQFSAL GLDPCLLEDE LDKSVQGTGL AFIAFTEAMT 450
    HFPASPFWSV MFFLMLINLG LGSMIGTMAG ITTPIIDTFK VPKEMFTVGC 500
    CVFAFLVGLL FVQRSGNYFV TMFDDYSATL PLTLIVILEN IAVAWIYGTK 550
    KFMQELTEML GFRPYRFYFY MWKFVSPLCM AVLTTASIIQ LGVTPPGYSA 600
    WIKEEAAERY LYFPNWAMAL LITLIVVATL PIPVVFVLRH FHLLSDGSNT 650
    LSVSYKKGRM MKDISNLEEN DETRFILSKV PSEAPSPMPT HRSYLGPGST 700
    SPLETSGNPN GRYGSGYLLA STPESEL 727
    Length:727
    Mass (Da):81,001
    Last modified:February 1, 2005 - v3
    Checksum:i454FAE5ACF53D9EB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti57 – 571A → T.1 Publication
    Corresponds to variant rs12737742 [ dbSNP | Ensembl ].
    VAR_061814

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK289982 mRNA. Translation: BAF82671.1.
    AL355990, AL137790 Genomic DNA. Translation: CAI18927.1.
    AL137790, AL355990 Genomic DNA. Translation: CAI18832.1.
    BC140908 mRNA. Translation: AAI40909.1.
    CCDSiCCDS30799.1.
    RefSeqiNP_001010898.1. NM_001010898.2.
    XP_006710706.1. XM_006710643.1.
    UniGeneiHs.128382.

    Genome annotation databases

    EnsembliENST00000331565; ENSP00000330199; ENSG00000197106.
    GeneIDi388662.
    KEGGihsa:388662.
    UCSCiuc009wfq.3. human.

    Polymorphism databases

    DMDMi59800227.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK289982 mRNA. Translation: BAF82671.1 .
    AL355990 , AL137790 Genomic DNA. Translation: CAI18927.1 .
    AL137790 , AL355990 Genomic DNA. Translation: CAI18832.1 .
    BC140908 mRNA. Translation: AAI40909.1 .
    CCDSi CCDS30799.1.
    RefSeqi NP_001010898.1. NM_001010898.2.
    XP_006710706.1. XM_006710643.1.
    UniGenei Hs.128382.

    3D structure databases

    ProteinModelPortali Q9H1V8.
    SMRi Q9H1V8. Positions 58-645.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 132799. 1 interaction.
    STRINGi 9606.ENSP00000330199.

    Protein family/group databases

    TCDBi 2.A.22.6.6. the neurotransmitter:sodium symporter (nss) family.

    PTM databases

    PhosphoSitei Q9H1V8.

    Polymorphism databases

    DMDMi 59800227.

    Proteomic databases

    PaxDbi Q9H1V8.
    PRIDEi Q9H1V8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000331565 ; ENSP00000330199 ; ENSG00000197106 .
    GeneIDi 388662.
    KEGGi hsa:388662.
    UCSCi uc009wfq.3. human.

    Organism-specific databases

    CTDi 388662.
    GeneCardsi GC01P110693.
    HGNCi HGNC:31399. SLC6A17.
    HPAi HPA007663.
    HPA008044.
    MIMi 610299. gene.
    neXtProti NX_Q9H1V8.
    PharmGKBi PA134941636.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0733.
    HOGENOMi HOG000116406.
    HOVERGENi HBG071421.
    InParanoidi Q9H1V8.
    KOi K05048.
    OMAi MEMYNVI.
    OrthoDBi EOG793B71.
    PhylomeDBi Q9H1V8.
    TreeFami TF352709.

    Miscellaneous databases

    GenomeRNAii 388662.
    NextBioi 102265.
    PROi Q9H1V8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H1V8.
    CleanExi HS_SLC6A17.
    Genevestigatori Q9H1V8.

    Family and domain databases

    InterProi IPR000175. Na/ntran_symport.
    IPR002438. Na/ntran_symport_orphan.
    [Graphical view ]
    PANTHERi PTHR11616. PTHR11616. 1 hit.
    Pfami PF00209. SNF. 1 hit.
    [Graphical view ]
    PRINTSi PR00176. NANEUSMPORT.
    PR01206. ORPHTRNSPORT.
    PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hippocampus.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-57.
      Tissue: Brain.
    4. "The repertoire of solute carriers of family 6: identification of new human and rodent genes."
      Hoglund P.J., Adzic D., Scicluna S.J., Lindblom J., Fredriksson R.
      Biochem. Biophys. Res. Commun. 336:175-189(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiS6A17_HUMAN
    AccessioniPrimary (citable) accession number: Q9H1V8
    Secondary accession number(s): A6NEA8
    , A8K1R7, B9EIR5, Q5T5Q9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3