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Q9H1V8 (S6A17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium-dependent neutral amino acid transporter SLC6A17
Alternative name(s):
Sodium-dependent neurotransmitter transporter NTT4
Solute carrier family 6 member 17
Gene names
Name:SLC6A17
Synonyms:NTT4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length727 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent By similarity.

Subcellular location

Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A17 subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 727727Sodium-dependent neutral amino acid transporter SLC6A17
PRO_0000214803

Regions

Topological domain1 – 6969Cytoplasmic Potential
Transmembrane70 – 9021Helical; Name=1; Potential
Topological domain91 – 955Extracellular Potential
Transmembrane96 – 11621Helical; Name=2; Potential
Topological domain117 – 14731Cytoplasmic Potential
Transmembrane148 – 16821Helical; Name=3; Potential
Topological domain169 – 22254Extracellular Potential
Transmembrane223 – 24321Helical; Name=4; Potential
Topological domain244 – 25310Cytoplasmic Potential
Transmembrane254 – 27421Helical; Name=5; Potential
Topological domain275 – 30026Extracellular Potential
Transmembrane301 – 32121Helical; Name=6; Potential
Topological domain322 – 33413Cytoplasmic Potential
Transmembrane335 – 35521Helical; Name=7; Potential
Topological domain356 – 460105Extracellular Potential
Transmembrane461 – 48121Helical; Name=8; Potential
Topological domain482 – 4909Cytoplasmic Potential
Transmembrane491 – 51121Helical; Name=9; Potential
Topological domain512 – 52716Extracellular Potential
Transmembrane528 – 54821Helical; Name=10; Potential
Topological domain549 – 57325Cytoplasmic Potential
Transmembrane574 – 59421Helical; Name=11; Potential
Topological domain595 – 61723Extracellular Potential
Transmembrane618 – 63821Helical; Name=12; Potential
Topological domain639 – 72789Cytoplasmic Potential

Amino acid modifications

Modified residue3771Phosphotyrosine By similarity
Glycosylation1861N-linked (GlcNAc...) Potential
Glycosylation3931N-linked (GlcNAc...) Potential

Natural variations

Natural variant571A → T. Ref.3
Corresponds to variant rs12737742 [ dbSNP | Ensembl ].
VAR_061814

Sequences

Sequence LengthMass (Da)Tools
Q9H1V8 [UniParc].

Last modified February 1, 2005. Version 3.
Checksum: 454FAE5ACF53D9EB

FASTA72781,001
        10         20         30         40         50         60 
MPKNSKVTQR EHSSEHVTES VADLLALEEP VDYKQSVLNV AGEAGGKQKA VEEELDAEDR 

        70         80         90        100        110        120 
PAWNSKLQYI LAQIGFSVGL GNIWRFPYLC QKNGGGAYLV PYLVLLIIIG IPLFFLELAV 

       130        140        150        160        170        180 
GQRIRRGSIG VWHYICPRLG GIGFSSCIVC LFVGLYYNVI IGWSIFYFFK SFQYPLPWSE 

       190        200        210        220        230        240 
CPVVRNGSVA VVEAECEKSS ATTYFWYREA LDISDSISES GGLNWKMTLC LLVAWSIVGM 

       250        260        270        280        290        300 
AVVKGIQSSG KVMYFSSLFP YVVLACFLVR GLLLRGAVDG ILHMFTPKLD KMLDPQVWRE 

       310        320        330        340        350        360 
AATQVFFALG LGFGGVIAFS SYNKQDNNCH FDAALVSFIN FFTSVLATLV VFAVLGFKAN 

       370        380        390        400        410        420 
IMNEKCVVEN AEKILGYLNT NVLSRDLIPP HVNFSHLTTK DYMEMYNVIM TVKEDQFSAL 

       430        440        450        460        470        480 
GLDPCLLEDE LDKSVQGTGL AFIAFTEAMT HFPASPFWSV MFFLMLINLG LGSMIGTMAG 

       490        500        510        520        530        540 
ITTPIIDTFK VPKEMFTVGC CVFAFLVGLL FVQRSGNYFV TMFDDYSATL PLTLIVILEN 

       550        560        570        580        590        600 
IAVAWIYGTK KFMQELTEML GFRPYRFYFY MWKFVSPLCM AVLTTASIIQ LGVTPPGYSA 

       610        620        630        640        650        660 
WIKEEAAERY LYFPNWAMAL LITLIVVATL PIPVVFVLRH FHLLSDGSNT LSVSYKKGRM 

       670        680        690        700        710        720 
MKDISNLEEN DETRFILSKV PSEAPSPMPT HRSYLGPGST SPLETSGNPN GRYGSGYLLA 


STPESEL 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hippocampus.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-57.
Tissue: Brain.
[4]"The repertoire of solute carriers of family 6: identification of new human and rodent genes."
Hoglund P.J., Adzic D., Scicluna S.J., Lindblom J., Fredriksson R.
Biochem. Biophys. Res. Commun. 336:175-189(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK289982 mRNA. Translation: BAF82671.1.
AL355990, AL137790 Genomic DNA. Translation: CAI18927.1.
AL137790, AL355990 Genomic DNA. Translation: CAI18832.1.
BC140908 mRNA. Translation: AAI40909.1.
RefSeqNP_001010898.1. NM_001010898.2.
UniGeneHs.128382.

3D structure databases

ProteinModelPortalQ9H1V8.
SMRQ9H1V8. Positions 58-642.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid132799. 1 interaction.
STRING9606.ENSP00000330199.

Protein family/group databases

TCDB2.A.22.6.6. the neurotransmitter:sodium symporter (nss) family.

PTM databases

PhosphoSiteQ9H1V8.

Polymorphism databases

DMDM59800227.

Proteomic databases

PaxDbQ9H1V8.
PRIDEQ9H1V8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000331565; ENSP00000330199; ENSG00000197106.
GeneID388662.
KEGGhsa:388662.
UCSCuc009wfq.3. human.

Organism-specific databases

CTD388662.
GeneCardsGC01P110693.
HGNCHGNC:31399. SLC6A17.
HPAHPA007663.
HPA008044.
MIM610299. gene.
neXtProtNX_Q9H1V8.
PharmGKBPA134941636.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0733.
HOGENOMHOG000116406.
HOVERGENHBG071421.
InParanoidQ9H1V8.
KOK05048.
OMAMEMYNVI.
OrthoDBEOG793B71.
PhylomeDBQ9H1V8.
TreeFamTF352709.

Gene expression databases

BgeeQ9H1V8.
CleanExHS_SLC6A17.
GenevestigatorQ9H1V8.

Family and domain databases

InterProIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERPTHR11616. PTHR11616. 1 hit.
PfamPF00209. SNF. 1 hit.
[Graphical view]
PRINTSPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi388662.
NextBio102265.
PROQ9H1V8.
SOURCESearch...

Entry information

Entry nameS6A17_HUMAN
AccessionPrimary (citable) accession number: Q9H1V8
Secondary accession number(s): A6NEA8 expand/collapse secondary AC list , A8K1R7, B9EIR5, Q5T5Q9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: February 1, 2005
Last modified: April 16, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM