Q9H1V8 (S6A17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium-dependent neutral amino acid transporter SLC6A17

Alternative name(s):
Sodium-dependent neurotransmitter transporter NTT4
Solute carrier family 6 member 17

Gene names

Name:	SLC6A17
Synonyms:	NTT4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	727 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent By similarity.
Subcellular location	Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A17 subfamily. [View classification]

Ontologies

Keywords
Biological process	Neurotransmitter transport Symport Transport
Cellular component	Cell junction Cytoplasmic vesicle Membrane Synapse
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	alanine transport Inferred from sequence or structural similarity. Source: UniProtKB glycine transport Inferred from sequence or structural similarity. Source: UniProtKB leucine transport Inferred from sequence or structural similarity. Source: UniProtKB proline transport Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membrane Inferred from electronic annotation. Source: InterPro synaptic vesicle Inferred from sequence or structural similarity. Source: UniProtKB synaptic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	neurotransmitter:sodium symporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 727	727	Sodium-dependent neutral amino acid transporter SLC6A17		PRO_0000214803
Regions
	Topological domain	1 – 69	69	Cytoplasmic Potential
	Transmembrane	70 – 90	21	Helical; Name=1; Potential
	Topological domain	91 – 95	5	Extracellular Potential
	Transmembrane	96 – 116	21	Helical; Name=2; Potential
	Topological domain	117 – 147	31	Cytoplasmic Potential
	Transmembrane	148 – 168	21	Helical; Name=3; Potential
	Topological domain	169 – 222	54	Extracellular Potential
	Transmembrane	223 – 243	21	Helical; Name=4; Potential
	Topological domain	244 – 253	10	Cytoplasmic Potential
	Transmembrane	254 – 274	21	Helical; Name=5; Potential
	Topological domain	275 – 300	26	Extracellular Potential
	Transmembrane	301 – 321	21	Helical; Name=6; Potential
	Topological domain	322 – 334	13	Cytoplasmic Potential
	Transmembrane	335 – 355	21	Helical; Name=7; Potential
	Topological domain	356 – 460	105	Extracellular Potential
	Transmembrane	461 – 481	21	Helical; Name=8; Potential
	Topological domain	482 – 490	9	Cytoplasmic Potential
	Transmembrane	491 – 511	21	Helical; Name=9; Potential
	Topological domain	512 – 527	16	Extracellular Potential
	Transmembrane	528 – 548	21	Helical; Name=10; Potential
	Topological domain	549 – 573	25	Cytoplasmic Potential
	Transmembrane	574 – 594	21	Helical; Name=11; Potential
	Topological domain	595 – 617	23	Extracellular Potential
	Transmembrane	618 – 638	21	Helical; Name=12; Potential
	Topological domain	639 – 727	89	Cytoplasmic Potential
Amino acid modifications
	Modified residue	377	1	Phosphotyrosine By similarity
	Modified residue	665	1	Phosphoserine By similarity
	Modified residue	700	1	Phosphothreonine By similarity
	Modified residue	722	1	Phosphothreonine By similarity
	Glycosylation	186	1	N-linked (GlcNAc...) Potential
	Glycosylation	393	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	57	1	A → T. Ref.3 Corresponds to variant rs12737742 [ dbSNP | Ensembl ].		VAR_061814

Sequences

	Sequence		Length	Mass (Da)
	Q9H1V8 [UniParc]. Last modified February 1, 2005. Version 3. Checksum: 454FAE5ACF53D9EB	FASTA	727	81,001
	10 20 30 40 50 60 MPKNSKVTQR EHSSEHVTES VADLLALEEP VDYKQSVLNV AGEAGGKQKA VEEELDAEDR 70 80 90 100 110 120 PAWNSKLQYI LAQIGFSVGL GNIWRFPYLC QKNGGGAYLV PYLVLLIIIG IPLFFLELAV 130 140 150 160 170 180 GQRIRRGSIG VWHYICPRLG GIGFSSCIVC LFVGLYYNVI IGWSIFYFFK SFQYPLPWSE 190 200 210 220 230 240 CPVVRNGSVA VVEAECEKSS ATTYFWYREA LDISDSISES GGLNWKMTLC LLVAWSIVGM 250 260 270 280 290 300 AVVKGIQSSG KVMYFSSLFP YVVLACFLVR GLLLRGAVDG ILHMFTPKLD KMLDPQVWRE 310 320 330 340 350 360 AATQVFFALG LGFGGVIAFS SYNKQDNNCH FDAALVSFIN FFTSVLATLV VFAVLGFKAN 370 380 390 400 410 420 IMNEKCVVEN AEKILGYLNT NVLSRDLIPP HVNFSHLTTK DYMEMYNVIM TVKEDQFSAL 430 440 450 460 470 480 GLDPCLLEDE LDKSVQGTGL AFIAFTEAMT HFPASPFWSV MFFLMLINLG LGSMIGTMAG 490 500 510 520 530 540 ITTPIIDTFK VPKEMFTVGC CVFAFLVGLL FVQRSGNYFV TMFDDYSATL PLTLIVILEN 550 560 570 580 590 600 IAVAWIYGTK KFMQELTEML GFRPYRFYFY MWKFVSPLCM AVLTTASIIQ LGVTPPGYSA 610 620 630 640 650 660 WIKEEAAERY LYFPNWAMAL LITLIVVATL PIPVVFVLRH FHLLSDGSNT LSVSYKKGRM 670 680 690 700 710 720 MKDISNLEEN DETRFILSKV PSEAPSPMPT HRSYLGPGST SPLETSGNPN GRYGSGYLLA STPESEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hippocampus.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-57. Tissue: Brain.
[4]	"The repertoire of solute carriers of family 6: identification of new human and rodent genes." Hoglund P.J., Adzic D., Scicluna S.J., Lindblom J., Fredriksson R. Biochem. Biophys. Res. Commun. 336:175-189(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK289982 mRNA. Translation: BAF82671.1. AL355990, AL137790 Genomic DNA. Translation: CAI18927.1. AL137790, AL355990 Genomic DNA. Translation: CAI18832.1. BC140908 mRNA. Translation: AAI40909.1.
IPI	IPI00335355.
RefSeq	NP_001010898.1. NM_001010898.2.
UniGene	Hs.128382.
3D structure databases
ProteinModelPortal	Q9H1V8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000330199.
PTM databases
PhosphoSite	Q9H1V8.
Polymorphism databases
DMDM	59800227.
Proteomic databases
PaxDb	Q9H1V8.
PRIDE	Q9H1V8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000331565; ENSP00000330199; ENSG00000197106. ENST00000450985; ENSP00000405461; ENSG00000197106.
GeneID	388662.
KEGG	hsa:388662.
UCSC	uc009wfq.3. human.
Organism-specific databases
CTD	388662.
GeneCards	GC01P110693.
HGNC	HGNC:31399. SLC6A17.
HPA	HPA007663. HPA008044.
MIM	610299. gene.
neXtProt	NX_Q9H1V8.
PharmGKB	PA134941636.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0733.
HOGENOM	HOG000116406.
HOVERGEN	HBG071421.
InParanoid	Q9H1V8.
KO	K05048.
OMA	MEMYNVI.
OrthoDB	EOG4GMTWF.
Gene expression databases
Bgee	Q9H1V8.
CleanEx	HS_SLC6A17.
Genevestigator	Q9H1V8.
GermOnline	ENSG00000197106. Homo sapiens.
Family and domain databases
InterPro	IPR000175. Na/ntran_symport. IPR002438. Na/ntran_symport_orphan. [Graphical view]
PANTHER	PTHR11616. PTHR11616. 1 hit.
Pfam	PF00209. SNF. 1 hit. [Graphical view]
PRINTS	PR00176. NANEUSMPORT. PR01206. ORPHTRNSPORT.
PROSITE	PS00610. NA_NEUROTRAN_SYMP_1. 1 hit. PS00754. NA_NEUROTRAN_SYMP_2. 1 hit. PS50267. NA_NEUROTRAN_SYMP_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	388662.
NextBio	102265.
SOURCE	Search...

Entry information

Entry name

S6A17_HUMAN

Accession

Primary (citable) accession number: Q9H1V8
Secondary accession number(s): A6NEA8 , A8K1R7, B9EIR5, Q5T5Q9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	February 1, 2005
Last modified:	April 3, 2013
This is version 90 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.