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Protein

Solute carrier family 25 member 51

Gene

SLC25A51

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.2.14. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 51
Alternative name(s):
Mitochondrial carrier triple repeat protein 1
Gene namesi
Name:SLC25A51
Synonyms:MCART1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23323. SLC25A51.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei85 – 10521Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei116 – 13520Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei179 – 19921Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei215 – 23521Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei268 – 28922Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134888553.

Polymorphism and mutation databases

BioMutaiSLC25A51.
DMDMi38605048.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Solute carrier family 25 member 51PRO_0000090711Add
BLAST

Proteomic databases

MaxQBiQ9H1U9.
PaxDbiQ9H1U9.
PeptideAtlasiQ9H1U9.
PRIDEiQ9H1U9.

PTM databases

iPTMnetiQ9H1U9.
PhosphoSiteiQ9H1U9.

Expressioni

Gene expression databases

BgeeiENSG00000122696.
CleanExiHS_MCART1.
GenevisibleiQ9H1U9. HS.

Organism-specific databases

HPAiHPA058261.
HPA058273.

Interactioni

Protein-protein interaction databases

BioGridi124902. 11 interactions.
IntActiQ9H1U9. 1 interaction.
STRINGi9606.ENSP00000242275.

Structurei

3D structure databases

ProteinModelPortaliQ9H1U9.
SMRiQ9H1U9. Positions 47-249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati28 – 10881Solcar 1Add
BLAST
Repeati116 – 20085Solcar 2Add
BLAST
Repeati213 – 29684Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1519. Eukaryota.
ENOG410XNWT. LUCA.
GeneTreeiENSGT00730000110930.
HOGENOMiHOG000233158.
HOVERGENiHBG052423.
InParanoidiQ9H1U9.
OMAiLSWGIIN.
OrthoDBiEOG091G0L68.
PhylomeDBiQ9H1U9.
TreeFamiTF314192.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H1U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDSEAHEKR PPILTSSKQD ISPHITNVGE MKHYLCGCCA AFNNVAITFP
60 70 80 90 100
IQKVLFRQQL YGIKTRDAIL QLRRDGFRNL YRGILPPLMQ KTTTLALMFG
110 120 130 140 150
LYEDLSCLLH KHVSAPEFAT SGVAAVLAGT TEAIFTPLER VQTLLQDHKH
160 170 180 190 200
HDKFTNTYQA FKALKCHGIG EYYRGLVPIL FRNGLSNVLF FGLRGPIKEH
210 220 230 240 250
LPTATTHSAH LVNDFICGGL LGAMLGFLFF PINVVKTRIQ SQIGGEFQSF
260 270 280 290
PKVFQKIWLE RDRKLINLFR GAHLNYHRSL ISWGIINATY EFLLKVI
Length:297
Mass (Da):33,672
Last modified:March 1, 2001 - v1
Checksum:i2AE13422BEDC5F1E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti205 – 2051T → M in a breast cancer sample; somatic mutation. 1 Publication
Corresponds to variant rs780199922 [ dbSNP | Ensembl ].
VAR_036333

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138752 Genomic DNA. Translation: CAC22316.1.
BC008500 mRNA. Translation: AAH08500.1.
CCDSiCCDS6614.1.
RefSeqiNP_219480.1. NM_033412.3.
UniGeneiHs.634120.

Genome annotation databases

EnsembliENST00000242275; ENSP00000242275; ENSG00000122696.
ENST00000377716; ENSP00000366945; ENSG00000122696.
ENST00000380590; ENSP00000369964; ENSG00000122696.
GeneIDi92014.
KEGGihsa:92014.
UCSCiuc004aav.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138752 Genomic DNA. Translation: CAC22316.1.
BC008500 mRNA. Translation: AAH08500.1.
CCDSiCCDS6614.1.
RefSeqiNP_219480.1. NM_033412.3.
UniGeneiHs.634120.

3D structure databases

ProteinModelPortaliQ9H1U9.
SMRiQ9H1U9. Positions 47-249.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124902. 11 interactions.
IntActiQ9H1U9. 1 interaction.
STRINGi9606.ENSP00000242275.

Protein family/group databases

TCDBi2.A.29.2.14. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiQ9H1U9.
PhosphoSiteiQ9H1U9.

Polymorphism and mutation databases

BioMutaiSLC25A51.
DMDMi38605048.

Proteomic databases

MaxQBiQ9H1U9.
PaxDbiQ9H1U9.
PeptideAtlasiQ9H1U9.
PRIDEiQ9H1U9.

Protocols and materials databases

DNASUi92014.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242275; ENSP00000242275; ENSG00000122696.
ENST00000377716; ENSP00000366945; ENSG00000122696.
ENST00000380590; ENSP00000369964; ENSG00000122696.
GeneIDi92014.
KEGGihsa:92014.
UCSCiuc004aav.3. human.

Organism-specific databases

CTDi92014.
GeneCardsiSLC25A51.
H-InvDBHIX0026170.
HIX0033169.
HGNCiHGNC:23323. SLC25A51.
HPAiHPA058261.
HPA058273.
neXtProtiNX_Q9H1U9.
PharmGKBiPA134888553.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1519. Eukaryota.
ENOG410XNWT. LUCA.
GeneTreeiENSGT00730000110930.
HOGENOMiHOG000233158.
HOVERGENiHBG052423.
InParanoidiQ9H1U9.
OMAiLSWGIIN.
OrthoDBiEOG091G0L68.
PhylomeDBiQ9H1U9.
TreeFamiTF314192.

Miscellaneous databases

ChiTaRSiSLC25A51. human.
GenomeRNAii92014.
PROiQ9H1U9.

Gene expression databases

BgeeiENSG00000122696.
CleanExiHS_MCART1.
GenevisibleiQ9H1U9. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS2551_HUMAN
AccessioniPrimary (citable) accession number: Q9H1U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.