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Protein

Solute carrier family 25 member 51

Gene

SLC25A51

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.29.2.14. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 51
Alternative name(s):
Mitochondrial carrier triple repeat protein 1
Gene namesi
Name:SLC25A51
Synonyms:MCART1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000122696.12.
HGNCiHGNC:23323. SLC25A51.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei85 – 105Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei116 – 135Helical; Name=3Sequence analysisAdd BLAST20
Transmembranei179 – 199Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei215 – 235Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei268 – 289Helical; Name=6Sequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000122696.
PharmGKBiPA134888553.

Polymorphism and mutation databases

BioMutaiSLC25A51.
DMDMi38605048.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000907111 – 297Solute carrier family 25 member 51Add BLAST297

Proteomic databases

MaxQBiQ9H1U9.
PaxDbiQ9H1U9.
PeptideAtlasiQ9H1U9.
PRIDEiQ9H1U9.

PTM databases

iPTMnetiQ9H1U9.
PhosphoSitePlusiQ9H1U9.

Expressioni

Gene expression databases

BgeeiENSG00000122696.
CleanExiHS_MCART1.
GenevisibleiQ9H1U9. HS.

Organism-specific databases

HPAiHPA046388.
HPA058261.

Interactioni

Protein-protein interaction databases

BioGridi124902. 15 interactors.
IntActiQ9H1U9. 1 interactor.
STRINGi9606.ENSP00000242275.

Structurei

3D structure databases

ProteinModelPortaliQ9H1U9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati28 – 108Solcar 1Add BLAST81
Repeati116 – 200Solcar 2Add BLAST85
Repeati213 – 296Solcar 3Add BLAST84

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1519. Eukaryota.
ENOG410XNWT. LUCA.
GeneTreeiENSGT00730000110930.
HOGENOMiHOG000233158.
HOVERGENiHBG052423.
InParanoidiQ9H1U9.
OMAiGFLYRGM.
OrthoDBiEOG091G0L68.
PhylomeDBiQ9H1U9.
TreeFamiTF314192.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9H1U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDSEAHEKR PPILTSSKQD ISPHITNVGE MKHYLCGCCA AFNNVAITFP
60 70 80 90 100
IQKVLFRQQL YGIKTRDAIL QLRRDGFRNL YRGILPPLMQ KTTTLALMFG
110 120 130 140 150
LYEDLSCLLH KHVSAPEFAT SGVAAVLAGT TEAIFTPLER VQTLLQDHKH
160 170 180 190 200
HDKFTNTYQA FKALKCHGIG EYYRGLVPIL FRNGLSNVLF FGLRGPIKEH
210 220 230 240 250
LPTATTHSAH LVNDFICGGL LGAMLGFLFF PINVVKTRIQ SQIGGEFQSF
260 270 280 290
PKVFQKIWLE RDRKLINLFR GAHLNYHRSL ISWGIINATY EFLLKVI
Length:297
Mass (Da):33,672
Last modified:March 1, 2001 - v1
Checksum:i2AE13422BEDC5F1E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036333205T → M in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs780199922Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138752 Genomic DNA. No translation available.
BC008500 mRNA. Translation: AAH08500.1.
CCDSiCCDS6614.1.
RefSeqiNP_219480.1. NM_033412.3.
UniGeneiHs.634120.

Genome annotation databases

EnsembliENST00000242275; ENSP00000242275; ENSG00000122696.
ENST00000377716; ENSP00000366945; ENSG00000122696.
GeneIDi92014.
KEGGihsa:92014.
UCSCiuc004aav.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS2551_HUMAN
AccessioniPrimary (citable) accession number: Q9H1U9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2001
Last modified: September 27, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families