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Protein

Multiple epidermal growth factor-like domains protein 9

Gene

MEGF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106780-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple epidermal growth factor-like domains protein 9
Short name:
Multiple EGF-like domains protein 9
Alternative name(s):
Epidermal growth factor-like protein 5
Short name:
EGF-like protein 5
Gene namesi
Name:MEGF9
Synonyms:EGFL5, KIAA0818
ORF Names:UNQ671/PRO1305
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:3234. MEGF9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 514ExtracellularSequence analysisAdd BLAST484
Transmembranei515 – 535HelicalSequence analysisAdd BLAST21
Topological domaini536 – 602CytoplasmicSequence analysisAdd BLAST67

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1955.
OpenTargetsiENSG00000106780.

Polymorphism and mutation databases

BioMutaiMEGF9.
DMDMi116242627.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000000752631 – 602Multiple epidermal growth factor-like domains protein 9Add BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...)Sequence analysis1
Glycosylationi182N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi204 ↔ 217PROSITE-ProRule annotation
Glycosylationi205N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi206 ↔ 224PROSITE-ProRule annotation
Glycosylationi218N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi226 ↔ 235PROSITE-ProRule annotation
Disulfide bondi238 ↔ 251PROSITE-ProRule annotation
Glycosylationi245N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi254 ↔ 266PROSITE-ProRule annotation
Disulfide bondi256 ↔ 272PROSITE-ProRule annotation
Glycosylationi267N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi274 ↔ 283PROSITE-ProRule annotation
Disulfide bondi286 ↔ 298PROSITE-ProRule annotation
Disulfide bondi301 ↔ 310PROSITE-ProRule annotation
Disulfide bondi303 ↔ 317PROSITE-ProRule annotation
Glycosylationi305N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi320 ↔ 329PROSITE-ProRule annotation
Disulfide bondi332 ↔ 346PROSITE-ProRule annotation
Disulfide bondi349 ↔ 360PROSITE-ProRule annotation
Disulfide bondi351 ↔ 371PROSITE-ProRule annotation
Disulfide bondi374 ↔ 383PROSITE-ProRule annotation
Disulfide bondi386 ↔ 397PROSITE-ProRule annotation
Disulfide bondi400 ↔ 415PROSITE-ProRule annotation
Disulfide bondi402 ↔ 422PROSITE-ProRule annotation
Disulfide bondi425 ↔ 434PROSITE-ProRule annotation
Glycosylationi428N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi437 ↔ 449PROSITE-ProRule annotation
Glycosylationi468N-linked (GlcNAc...)Sequence analysis1
Glycosylationi481N-linked (GlcNAc...)Sequence analysis1
Glycosylationi500N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9H1U4.
PaxDbiQ9H1U4.
PeptideAtlasiQ9H1U4.
PRIDEiQ9H1U4.

PTM databases

iPTMnetiQ9H1U4.
PhosphoSitePlusiQ9H1U4.

Expressioni

Gene expression databases

BgeeiENSG00000106780.
CleanExiHS_MEGF9.
GenevisibleiQ9H1U4. HS.

Organism-specific databases

HPAiHPA014319.
HPA050238.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363040.

Structurei

3D structure databases

ProteinModelPortaliQ9H1U4.
SMRiQ9H1U4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini204 – 253Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST50
Domaini254 – 300Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST47
Domaini301 – 348Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST48
Domaini349 – 399Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST51
Domaini400 – 451Laminin EGF-like 5PROSITE-ProRule annotationAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 38Ala-richAdd BLAST15
Compositional biasi55 – 200Pro-richAdd BLAST146

Sequence similaritiesi

Contains 5 laminin EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0994. Eukaryota.
ENOG410XPEG. LUCA.
GeneTreeiENSGT00840000129717.
HOGENOMiHOG000234343.
HOVERGENiHBG080442.
InParanoidiQ9H1U4.
OMAiNGCLPCQ.
OrthoDBiEOG091G045O.
PhylomeDBiQ9H1U4.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002049. Laminin_EGF.
[Graphical view]
PfamiPF00053. Laminin_EGF. 5 hits.
[Graphical view]
SMARTiSM00181. EGF. 5 hits.
SM00180. EGF_Lam. 5 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS01248. EGF_LAM_1. 5 hits.
PS50027. EGF_LAM_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H1U4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGGAERAMR SLPSLGGLAL LCCAAAAAAA AVASAASAGN VTGGGGAAGQ
60 70 80 90 100
VDASPGPGLR GEPSHPFPRA TAPTAQAPRT GPPRATVHRP LAATSPAQSP
110 120 130 140 150
ETTPLWATAG PSSTTFQAPL GPSPTTPPAA ERTSTTSQAP TRPAPTTLST
160 170 180 190 200
TTGPAPTTPV ATTVPAPTTP RTPTPDLPSS SNSSVLPTPP ATEAPSSPPP
210 220 230 240 250
EYVCNCSVVG SLNVNRCNQT TGQCECRPGY QGLHCETCKE GFYLNYTSGL
260 270 280 290 300
CQPCDCSPHG ALSIPCNSSG KCQCKVGVIG SICDRCQDGY YGFSKNGCLP
310 320 330 340 350
CQCNNRSASC DALTGACLNC QENSKGNHCE ECKEGFYQSP DATKECLRCP
360 370 380 390 400
CSAVTSTGSC SIKSSELEPE CDQCKDGYIG PNCNKCENGY YNFDSICRKC
410 420 430 440 450
QCHGHVDPVK TPKICKPESG ECINCLHNTT GFWCENCLEG YVHDLEGNCI
460 470 480 490 500
KKEVILPTPE GSTILVSNAS LTTSVPTPVI NSTFTPTTLQ TIFSVSTSEN
510 520 530 540 550
STSALADVSW TQFNIIILTV IIIVVVLLMG FVGAVYMYRE YQNRKLNAPF
560 570 580 590 600
WTIELKEDNI SFSSYHDSIP NADVSGLLED DGNEVAPNGQ LTLTTPIHNY

KA
Length:602
Mass (Da):62,984
Last modified:October 17, 2006 - v3
Checksum:iC2EF73E588C8E375
GO

Sequence cautioni

The sequence AAQ88736 differs from that shown. Intron retention.Curated

Polymorphismi

The poly-Ala stretch (positions 24 to 31) may be polymorphic and varies from 6 to 8 Ala residues.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295380 mRNA. Translation: BAH12051.1.
AL138836 Genomic DNA. Translation: CAC22313.2.
CH471090 Genomic DNA. Translation: EAW87465.1.
AY358370 mRNA. Translation: AAQ88736.1. Sequence problems.
AB011542 mRNA. Translation: BAA32470.1.
CCDSiCCDS48010.2.
RefSeqiNP_001073966.2. NM_001080497.2.
UniGeneiHs.744903.

Genome annotation databases

EnsembliENST00000373930; ENSP00000363040; ENSG00000106780.
GeneIDi1955.
KEGGihsa:1955.
UCSCiuc022bms.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295380 mRNA. Translation: BAH12051.1.
AL138836 Genomic DNA. Translation: CAC22313.2.
CH471090 Genomic DNA. Translation: EAW87465.1.
AY358370 mRNA. Translation: AAQ88736.1. Sequence problems.
AB011542 mRNA. Translation: BAA32470.1.
CCDSiCCDS48010.2.
RefSeqiNP_001073966.2. NM_001080497.2.
UniGeneiHs.744903.

3D structure databases

ProteinModelPortaliQ9H1U4.
SMRiQ9H1U4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000363040.

PTM databases

iPTMnetiQ9H1U4.
PhosphoSitePlusiQ9H1U4.

Polymorphism and mutation databases

BioMutaiMEGF9.
DMDMi116242627.

Proteomic databases

MaxQBiQ9H1U4.
PaxDbiQ9H1U4.
PeptideAtlasiQ9H1U4.
PRIDEiQ9H1U4.

Protocols and materials databases

DNASUi1955.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373930; ENSP00000363040; ENSG00000106780.
GeneIDi1955.
KEGGihsa:1955.
UCSCiuc022bms.2. human.

Organism-specific databases

CTDi1955.
DisGeNETi1955.
GeneCardsiMEGF9.
HGNCiHGNC:3234. MEGF9.
HPAiHPA014319.
HPA050238.
MIMi604268. gene.
neXtProtiNX_Q9H1U4.
OpenTargetsiENSG00000106780.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0994. Eukaryota.
ENOG410XPEG. LUCA.
GeneTreeiENSGT00840000129717.
HOGENOMiHOG000234343.
HOVERGENiHBG080442.
InParanoidiQ9H1U4.
OMAiNGCLPCQ.
OrthoDBiEOG091G045O.
PhylomeDBiQ9H1U4.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106780-MONOMER.

Miscellaneous databases

ChiTaRSiMEGF9. human.
GenomeRNAii1955.
PROiQ9H1U4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106780.
CleanExiHS_MEGF9.
GenevisibleiQ9H1U4. HS.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002049. Laminin_EGF.
[Graphical view]
PfamiPF00053. Laminin_EGF. 5 hits.
[Graphical view]
SMARTiSM00181. EGF. 5 hits.
SM00180. EGF_Lam. 5 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS01248. EGF_LAM_1. 5 hits.
PS50027. EGF_LAM_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMEGF9_HUMAN
AccessioniPrimary (citable) accession number: Q9H1U4
Secondary accession number(s): B7Z315, O75098
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.