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Q9H1R6

- Q9H1R6_HUMAN

UniProt

Q9H1R6 - Q9H1R6_HUMAN

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Protein
Submitted name:

Bcl-2-like protein 1

Gene

BCL2L1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. apoptotic process in bone marrow Source: Ensembl
  2. cell proliferation Source: Ensembl
  3. cellular process regulating host cell cycle in response to virus Source: Ensembl
  4. cellular response to alkaloid Source: Ensembl
  5. cellular response to amino acid stimulus Source: Ensembl
  6. cellular response to gamma radiation Source: Ensembl
  7. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  8. fertilization Source: Ensembl
  9. germ cell development Source: Ensembl
  10. growth Source: Ensembl
  11. hepatocyte apoptotic process Source: Ensembl
  12. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  13. in utero embryonic development Source: Ensembl
  14. male gonad development Source: Ensembl
  15. mitochondrion morphogenesis Source: Ensembl
  16. negative regulation of neuron apoptotic process Source: Ensembl
  17. neuron apoptotic process Source: Ensembl
  18. ovarian follicle development Source: Ensembl
  19. positive regulation of apoptotic process Source: Ensembl
  20. positive regulation of cell proliferation Source: Ensembl
  21. release of cytochrome c from mitochondria Source: Ensembl
  22. response to cycloheximide Source: Ensembl
  23. spermatogenesis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Bcl-2-like protein 1Imported
Gene namesi
Name:BCL2L1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:992. BCL2L1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. mitochondrial membrane Source: Ensembl
  3. mitochondrion Source: HPA
  4. nucleolus Source: HPA
  5. nucleus Source: HPA
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ9H1R6. baseline and differential.

Interactioni

Protein-protein interaction databases

MINTiMINT-1448631.

Structurei

3D structure databases

ProteinModelPortaliQ9H1R6.
SMRiQ9H1R6. Positions 1-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000062935.
HOGENOMiHOG000056452.
HOVERGENiHBG004472.

Family and domain databases

InterProiIPR013279. Apop_reg_BclX.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR003093. Bcl2_BH4.
IPR020731. Bcl2_BH4_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF12. PTHR11256:SF12. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
PF02180. BH4. 1 hit.
[Graphical view]
PRINTSiPR01864. APOPREGBCLX.
PR01862. BCL2FAMILY.
SMARTiSM00265. BH4. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01259. BH3. 1 hit.
PS01260. BH4_1. 1 hit.
PS50063. BH4_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9H1R6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA
60 70 80 90 100
INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR
110 120 130 140 150
YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL
160 170 180
CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP WIQENGGW
Length:188
Mass (Da):21,029
Last modified:March 1, 2001 - v1
Checksum:i7074B6095145C324
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei188 – 1881Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117381 Genomic DNA. No translation available.
AL160175 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000420488; ENSP00000390760; ENSG00000171552.
ENST00000422920; ENSP00000411252; ENSG00000171552.
ENST00000456404; ENSP00000395545; ENSG00000171552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117381 Genomic DNA. No translation available.
AL160175 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali Q9H1R6.
SMRi Q9H1R6. Positions 1-188.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1448631.

Chemistry

BindingDBi Q9H1R6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000420488 ; ENSP00000390760 ; ENSG00000171552 .
ENST00000422920 ; ENSP00000411252 ; ENSG00000171552 .
ENST00000456404 ; ENSP00000395545 ; ENSG00000171552 .

Organism-specific databases

HGNCi HGNC:992. BCL2L1.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00530000062935.
HOGENOMi HOG000056452.
HOVERGENi HBG004472.

Miscellaneous databases

ChiTaRSi BCL2L1. human.

Gene expression databases

ExpressionAtlasi Q9H1R6. baseline and differential.

Family and domain databases

InterProi IPR013279. Apop_reg_BclX.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR003093. Bcl2_BH4.
IPR020731. Bcl2_BH4_motif_CS.
IPR026298. Blc2_fam.
[Graphical view ]
PANTHERi PTHR11256. PTHR11256. 1 hit.
PTHR11256:SF12. PTHR11256:SF12. 1 hit.
Pfami PF00452. Bcl-2. 1 hit.
PF02180. BH4. 1 hit.
[Graphical view ]
PRINTSi PR01864. APOPREGBCLX.
PR01862. BCL2FAMILY.
SMARTi SM00265. BH4. 1 hit.
[Graphical view ]
PROSITEi PS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01259. BH3. 1 hit.
PS01260. BH4_1. 1 hit.
PS50063. BH4_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ9H1R6_HUMAN
AccessioniPrimary (citable) accession number: Q9H1R6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3