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Q9H1R6

- Q9H1R6_HUMAN

UniProt

Q9H1R6 - Q9H1R6_HUMAN

Protein
Submitted name:

Bcl-2-like protein 1

Gene

BCL2L1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. apoptotic process in bone marrow Source: Ensembl
    2. cell proliferation Source: Ensembl
    3. cellular process regulating host cell cycle in response to virus Source: Ensembl
    4. cellular response to alkaloid Source: Ensembl
    5. cellular response to amino acid stimulus Source: Ensembl
    6. cellular response to gamma radiation Source: Ensembl
    7. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    8. fertilization Source: Ensembl
    9. germ cell development Source: Ensembl
    10. growth Source: Ensembl
    11. hepatocyte apoptotic process Source: Ensembl
    12. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
    13. in utero embryonic development Source: Ensembl
    14. male gonad development Source: Ensembl
    15. negative regulation of neuron apoptotic process Source: Ensembl
    16. neuron apoptotic process Source: Ensembl
    17. ovarian follicle development Source: Ensembl
    18. positive regulation of apoptotic process Source: Ensembl
    19. positive regulation of cell proliferation Source: Ensembl
    20. release of cytochrome c from mitochondria Source: Ensembl
    21. response to cycloheximide Source: Ensembl
    22. spermatogenesis Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Bcl-2-like protein 1Imported
    Gene namesi
    Name:BCL2L1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:992. BCL2L1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. mitochondrial membrane Source: Ensembl
    3. mitochondrion Source: HPA
    4. nucleolus Source: HPA
    5. nucleus Source: HPA

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1448631.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H1R6.
    SMRiQ9H1R6. Positions 1-188.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000056452.
    HOVERGENiHBG004472.

    Family and domain databases

    InterProiIPR013279. Apop_reg_BclX.
    IPR002475. Bcl2-like.
    IPR020717. Bcl2_BH1_motif_CS.
    IPR020728. Bcl2_BH3_motif_CS.
    IPR003093. Bcl2_BH4.
    IPR020731. Bcl2_BH4_motif_CS.
    IPR026298. Blc2_fam.
    [Graphical view]
    PANTHERiPTHR11256. PTHR11256. 1 hit.
    PTHR11256:SF12. PTHR11256:SF12. 1 hit.
    PfamiPF00452. Bcl-2. 1 hit.
    PF02180. BH4. 1 hit.
    [Graphical view]
    PRINTSiPR01864. APOPREGBCLX.
    PR01862. BCL2FAMILY.
    SMARTiSM00265. BH4. 1 hit.
    [Graphical view]
    PROSITEiPS50062. BCL2_FAMILY. 1 hit.
    PS01080. BH1. 1 hit.
    PS01259. BH3. 1 hit.
    PS01260. BH4_1. 1 hit.
    PS50063. BH4_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9H1R6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA    50
    INGNPSWHLA DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR 100
    YRRAFSDLTS QLHITPGTAY QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL 150
    CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP WIQENGGW 188
    Length:188
    Mass (Da):21,029
    Last modified:March 1, 2001 - v1
    Checksum:i7074B6095145C324
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei188 – 1881Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL117381 Genomic DNA. No translation available.
    AL160175 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000420488; ENSP00000390760; ENSG00000171552.
    ENST00000422920; ENSP00000411252; ENSG00000171552.
    ENST00000456404; ENSP00000395545; ENSG00000171552.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL117381 Genomic DNA. No translation available.
    AL160175 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali Q9H1R6.
    SMRi Q9H1R6. Positions 1-188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1448631.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000420488 ; ENSP00000390760 ; ENSG00000171552 .
    ENST00000422920 ; ENSP00000411252 ; ENSG00000171552 .
    ENST00000456404 ; ENSP00000395545 ; ENSG00000171552 .

    Organism-specific databases

    HGNCi HGNC:992. BCL2L1.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000056452.
    HOVERGENi HBG004472.

    Miscellaneous databases

    ChiTaRSi BCL2L1. human.

    Family and domain databases

    InterProi IPR013279. Apop_reg_BclX.
    IPR002475. Bcl2-like.
    IPR020717. Bcl2_BH1_motif_CS.
    IPR020728. Bcl2_BH3_motif_CS.
    IPR003093. Bcl2_BH4.
    IPR020731. Bcl2_BH4_motif_CS.
    IPR026298. Blc2_fam.
    [Graphical view ]
    PANTHERi PTHR11256. PTHR11256. 1 hit.
    PTHR11256:SF12. PTHR11256:SF12. 1 hit.
    Pfami PF00452. Bcl-2. 1 hit.
    PF02180. BH4. 1 hit.
    [Graphical view ]
    PRINTSi PR01864. APOPREGBCLX.
    PR01862. BCL2FAMILY.
    SMARTi SM00265. BH4. 1 hit.
    [Graphical view ]
    PROSITEi PS50062. BCL2_FAMILY. 1 hit.
    PS01080. BH1. 1 hit.
    PS01259. BH3. 1 hit.
    PS01260. BH4_1. 1 hit.
    PS50063. BH4_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiQ9H1R6_HUMAN
    AccessioniPrimary (citable) accession number: Q9H1R6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3