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Protein

PC-esterase domain-containing protein 1A

Gene

PCED1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
PC-esterase domain-containing protein 1A
Alternative name(s):
Protein FAM113A
Sarcoma antigen NY-SAR-23
Gene namesi
Name:PCED1A
Synonyms:C20orf81, FAM113A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16212. PCED1A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25790.

Polymorphism and mutation databases

DMDMi25008325.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454PC-esterase domain-containing protein 1APRO_0000079446Add
BLAST

Proteomic databases

PaxDbiQ9H1Q7.
PeptideAtlasiQ9H1Q7.
PRIDEiQ9H1Q7.

PTM databases

iPTMnetiQ9H1Q7.
PhosphoSiteiQ9H1Q7.

Expressioni

Gene expression databases

BgeeiENSG00000132635.
CleanExiHS_FAM113A.
ExpressionAtlasiQ9H1Q7. baseline and differential.
GenevisibleiQ9H1Q7. HS.

Organism-specific databases

HPAiHPA050816.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-748452,EBI-10172290
KRTAP10-8P604103EBI-748452,EBI-10171774
NOTCH2NLQ7Z3S93EBI-748452,EBI-945833

Protein-protein interaction databases

BioGridi122284. 7 interactions.
IntActiQ9H1Q7. 6 interactions.
MINTiMINT-1475245.
STRINGi9606.ENSP00000353868.

Structurei

3D structure databases

ProteinModelPortaliQ9H1Q7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi232 – 26433His-richAdd
BLAST
Compositional biasi312 – 3154Poly-Pro

Sequence similaritiesi

Belongs to the PC-esterase family.Curated

Phylogenomic databases

eggNOGiENOG410IGGE. Eukaryota.
ENOG410ZZG9. LUCA.
GeneTreeiENSGT00390000002231.
HOVERGENiHBG055737.
InParanoidiQ9H1Q7.
OMAiVELPKRD.
OrthoDBiEOG091G0QAX.
PhylomeDBiQ9H1Q7.
TreeFamiTF328972.

Family and domain databases

InterProiIPR026057. PC-Esterase.
IPR013830. SGNH_hydro.
[Graphical view]
PfamiPF13839. PC-Esterase. 1 hit.
[Graphical view]
SUPFAMiSSF52266. SSF52266. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H1Q7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVFCLSSEEP RRPLRSDMVH FQASEVQQLL HNKFVVILGD SIQRAVYKDL
60 70 80 90 100
VLLLQKDSLL TAAQLKAKGE LSFEQDQLVA GGQLGELHNG TQYREVRQFC
110 120 130 140 150
SGSGHHLVRF YFLTRVYSEY LEDVLEELTY GPAPDLVIIN SCLWDLSRYG
160 170 180 190 200
RCSMESYREN LERVFVRMDQ VLPDSCLLVW NMAMPLGERI TGGFLLPELQ
210 220 230 240 250
PLAGSLRRDV VEGNFYSATL AGDHCFDVLD LHFHFRHAVQ HRHRDGVHWD
260 270 280 290 300
QHAHRHLSHL LLTHVADAWG VELPKRGYPP DPWIEDWAEM NHPFQGSHRQ
310 320 330 340 350
TPDFGEHLAL LPPPPSSLPP PMPFPYPLPQ PSPPPLFPPL PQDTPFFPGQ
360 370 380 390 400
PFPPHEFFNY NPVEDFSMPP HLGCGPGVNF VPGPLPPPIP GPNPHGQHWG
410 420 430 440 450
PVVHRGMPRY VPNSPYHVRR MGGPCRQRLR HSERLIHTYK LDRRPPAHSG

TWPG
Length:454
Mass (Da):51,782
Last modified:March 1, 2001 - v1
Checksum:i6D783D66E3FD779A
GO
Isoform 2 (identifier: Q9H1Q7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-119: Missing.

Show »
Length:403
Mass (Da):45,953
Checksum:iF6A70D7EA699A6D3
GO
Isoform 3 (identifier: Q9H1Q7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-119: Missing.
     264-354: Missing.

Show »
Length:312
Mass (Da):35,786
Checksum:i6940F47267FECC04
GO
Isoform 4 (identifier: Q9H1Q7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-152: APDLVIINSCLWDLSRYGRC → SHPMNSSTIIQWRTSRCHPT
     153-454: Missing.

Note: No experimental confirmation available.
Show »
Length:152
Mass (Da):17,441
Checksum:i5834AE237F7085E2
GO

Sequence cautioni

The sequence AAO65166 differs from that shown.Contaminating sequence. Sequence of unknown origin in the C-terminal part.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti253 – 2531A → V in AAH14247 (PubMed:15489334).Curated
Sequence conflicti430 – 4301R → K in BAB15328 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 221Q → H.
Corresponds to variant rs2274670 [ dbSNP | Ensembl ].
VAR_021945

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei69 – 11951Missing in isoform 2 and isoform 3. 2 PublicationsVSP_003818Add
BLAST
Alternative sequencei133 – 15220APDLV…RYGRC → SHPMNSSTIIQWRTSRCHPT in isoform 4. 1 PublicationVSP_013917Add
BLAST
Alternative sequencei153 – 454302Missing in isoform 4. 1 PublicationVSP_013918Add
BLAST
Alternative sequencei264 – 35491Missing in isoform 3. 1 PublicationVSP_003819Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056353 mRNA. Translation: BAB71160.1.
AK026029 mRNA. Translation: BAB15328.1.
AL161656 Genomic DNA. Translation: CAC21463.1.
AL161656 Genomic DNA. Translation: CAC21464.1.
AL161656 Genomic DNA. Translation: CAI12118.1.
AL161656 Genomic DNA. Translation: CAI12119.1.
BC008864 mRNA. Translation: AAH08864.1.
BC014247 mRNA. Translation: AAH14247.1.
BC037240 mRNA. Translation: AAH37240.2.
BC051816 mRNA. Translation: AAH51816.1.
AY211913 mRNA. Translation: AAO65166.1. Sequence problems.
CCDSiCCDS13035.1. [Q9H1Q7-1]
CCDS59442.1. [Q9H1Q7-2]
RefSeqiNP_001258097.1. NM_001271168.1. [Q9H1Q7-2]
NP_073597.2. NM_022760.4. [Q9H1Q7-1]
XP_005260861.1. XM_005260804.2. [Q9H1Q7-1]
XP_005260862.1. XM_005260805.2. [Q9H1Q7-2]
UniGeneiHs.29341.
Hs.743644.

Genome annotation databases

EnsembliENST00000356872; ENSP00000349334; ENSG00000132635. [Q9H1Q7-2]
ENST00000360652; ENSP00000353868; ENSG00000132635. [Q9H1Q7-1]
GeneIDi64773.
KEGGihsa:64773.
UCSCiuc002wgz.3. human. [Q9H1Q7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056353 mRNA. Translation: BAB71160.1.
AK026029 mRNA. Translation: BAB15328.1.
AL161656 Genomic DNA. Translation: CAC21463.1.
AL161656 Genomic DNA. Translation: CAC21464.1.
AL161656 Genomic DNA. Translation: CAI12118.1.
AL161656 Genomic DNA. Translation: CAI12119.1.
BC008864 mRNA. Translation: AAH08864.1.
BC014247 mRNA. Translation: AAH14247.1.
BC037240 mRNA. Translation: AAH37240.2.
BC051816 mRNA. Translation: AAH51816.1.
AY211913 mRNA. Translation: AAO65166.1. Sequence problems.
CCDSiCCDS13035.1. [Q9H1Q7-1]
CCDS59442.1. [Q9H1Q7-2]
RefSeqiNP_001258097.1. NM_001271168.1. [Q9H1Q7-2]
NP_073597.2. NM_022760.4. [Q9H1Q7-1]
XP_005260861.1. XM_005260804.2. [Q9H1Q7-1]
XP_005260862.1. XM_005260805.2. [Q9H1Q7-2]
UniGeneiHs.29341.
Hs.743644.

3D structure databases

ProteinModelPortaliQ9H1Q7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122284. 7 interactions.
IntActiQ9H1Q7. 6 interactions.
MINTiMINT-1475245.
STRINGi9606.ENSP00000353868.

PTM databases

iPTMnetiQ9H1Q7.
PhosphoSiteiQ9H1Q7.

Polymorphism and mutation databases

DMDMi25008325.

Proteomic databases

PaxDbiQ9H1Q7.
PeptideAtlasiQ9H1Q7.
PRIDEiQ9H1Q7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356872; ENSP00000349334; ENSG00000132635. [Q9H1Q7-2]
ENST00000360652; ENSP00000353868; ENSG00000132635. [Q9H1Q7-1]
GeneIDi64773.
KEGGihsa:64773.
UCSCiuc002wgz.3. human. [Q9H1Q7-1]

Organism-specific databases

CTDi64773.
GeneCardsiPCED1A.
H-InvDBHIX0015583.
HGNCiHGNC:16212. PCED1A.
HPAiHPA050816.
neXtProtiNX_Q9H1Q7.
PharmGKBiPA25790.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGGE. Eukaryota.
ENOG410ZZG9. LUCA.
GeneTreeiENSGT00390000002231.
HOVERGENiHBG055737.
InParanoidiQ9H1Q7.
OMAiVELPKRD.
OrthoDBiEOG091G0QAX.
PhylomeDBiQ9H1Q7.
TreeFamiTF328972.

Miscellaneous databases

GenomeRNAii64773.
PROiQ9H1Q7.

Gene expression databases

BgeeiENSG00000132635.
CleanExiHS_FAM113A.
ExpressionAtlasiQ9H1Q7. baseline and differential.
GenevisibleiQ9H1Q7. HS.

Family and domain databases

InterProiIPR026057. PC-Esterase.
IPR013830. SGNH_hydro.
[Graphical view]
PfamiPF13839. PC-Esterase. 1 hit.
[Graphical view]
SUPFAMiSSF52266. SSF52266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPED1A_HUMAN
AccessioniPrimary (citable) accession number: Q9H1Q7
Secondary accession number(s): Q5JUA5
, Q5JUA6, Q6PK19, Q86WF5, Q96CG7, Q9H1Q6, Q9H6D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.