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Q9H1P3

- OSBL2_HUMAN

UniProt

Q9H1P3 - OSBL2_HUMAN

Protein

Oxysterol-binding protein-related protein 2

Gene

OSBPL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate.

    GO - Molecular functioni

    1. cholesterol binding Source: BHF-UCL

    GO - Biological processi

    1. lipid transport Source: UniProtKB-KW

    Keywords - Biological processi

    Lipid transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxysterol-binding protein-related protein 2
    Short name:
    ORP-2
    Short name:
    OSBP-related protein 2
    Gene namesi
    Name:OSBPL2
    Synonyms:KIAA0772, ORP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15761. OSBPL2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32827.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 480480Oxysterol-binding protein-related protein 2PRO_0000100369Add
    BLAST

    Proteomic databases

    MaxQBiQ9H1P3.
    PaxDbiQ9H1P3.
    PRIDEiQ9H1P3.

    PTM databases

    PhosphoSiteiQ9H1P3.

    Expressioni

    Tissue specificityi

    Widely expressed.

    Gene expression databases

    ArrayExpressiQ9H1P3.
    BgeeiQ9H1P3.
    CleanExiHS_OSBPL2.
    GenevestigatoriQ9H1P3.

    Organism-specific databases

    HPAiHPA041127.
    HPA042659.

    Interactioni

    Protein-protein interaction databases

    BioGridi115216. 3 interactions.
    IntActiQ9H1P3. 1 interaction.
    STRINGi9606.ENSP00000316649.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H1P3.
    SMRiQ9H1P3. Positions 67-444.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the OSBP family.Curated

    Phylogenomic databases

    eggNOGiNOG281324.
    HOGENOMiHOG000231233.
    HOVERGENiHBG053374.
    InParanoidiQ9H1P3.
    OMAiEWRTRWF.
    OrthoDBiEOG7F24SJ.
    PhylomeDBiQ9H1P3.

    Family and domain databases

    InterProiIPR000648. Oxysterol-bd.
    IPR018494. Oxysterol-bd_CS.
    [Graphical view]
    PANTHERiPTHR10972. PTHR10972. 1 hit.
    PfamiPF01237. Oxysterol_BP. 1 hit.
    [Graphical view]
    PROSITEiPS01013. OSBP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H1P3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNGEEEFFDA VTGFDSDNSS GEFSEANQKV TGMIDLDTSK NNRIGKTGER    50
    PSQENGIQKH RTSLPAPMFS RSDFSVWTIL KKCVGLELSK ITMPIAFNEP 100
    LSFLQRITEY MEHVYLIHRA SCQPQPLERM QSVAAFAVSA VASQWERTGK 150
    PFNPLLGETY ELIREDLGFR FISEQVSHHP PISAFHSEGL NHDFLFHGSI 200
    YPKLKFWGKS VEAEPRGTIT LELLKHNEAY TWTNPTCCVH NVIIGKLWIE 250
    QYGTVEILNH RTGHKCVLHF KPCGLFGKEL HKVEGHIQDK NKKKLFMIYG 300
    KWTECLWGID PVSYESFKKQ ERRGDHLRKA KLDEDSGKAD SDVADDVPVA 350
    QETVQVIPGS KLLWRINTRP PNSAQMYNFT SFTVSLNELE TGMEKTLPPT 400
    DCRLRPDIRG MENGNMDLAS QEKERLEEKQ REARRERAKE EAEWQTRWFY 450
    PGNNPYTGTP DWLYAGDYFE RNFSDCPDIY 480
    Length:480
    Mass (Da):55,201
    Last modified:March 1, 2001 - v1
    Checksum:iA93D1B389D0A2740
    GO
    Isoform 2 (identifier: Q9H1P3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         13-24: Missing.

    Show »
    Length:468
    Mass (Da):53,971
    Checksum:i9C51392E0EDF4DF8
    GO

    Sequence cautioni

    The sequence BAA34492.2 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei13 – 2412Missing in isoform 2. 4 PublicationsVSP_003781Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY028168 mRNA. Translation: AAK18044.1.
    AF392447 mRNA. Translation: AAL40660.1.
    AB018315 mRNA. Translation: BAA34492.2. Different initiation.
    AK291851 mRNA. Translation: BAF84540.1.
    CR456722 mRNA. Translation: CAG33003.1.
    AL354836 Genomic DNA. Translation: CAC22306.1.
    AL354836 Genomic DNA. Translation: CAC22307.1.
    CH471077 Genomic DNA. Translation: EAW75377.1.
    CH471077 Genomic DNA. Translation: EAW75379.1.
    BC000296 mRNA. Translation: AAH00296.1.
    BC004455 mRNA. Translation: AAH04455.1.
    AF331963 mRNA. Translation: AAG53416.1.
    CCDSiCCDS13494.1. [Q9H1P3-2]
    CCDS13495.1. [Q9H1P3-1]
    RefSeqiNP_055650.1. NM_014835.3. [Q9H1P3-2]
    NP_653081.1. NM_144498.2. [Q9H1P3-1]
    UniGeneiHs.473254.

    Genome annotation databases

    EnsembliENST00000313733; ENSP00000316649; ENSG00000130703. [Q9H1P3-1]
    ENST00000358053; ENSP00000350755; ENSG00000130703. [Q9H1P3-2]
    GeneIDi9885.
    KEGGihsa:9885.
    UCSCiuc002yck.1. human. [Q9H1P3-1]
    uc002ycl.1. human. [Q9H1P3-2]

    Polymorphism databases

    DMDMi20139174.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY028168 mRNA. Translation: AAK18044.1 .
    AF392447 mRNA. Translation: AAL40660.1 .
    AB018315 mRNA. Translation: BAA34492.2 . Different initiation.
    AK291851 mRNA. Translation: BAF84540.1 .
    CR456722 mRNA. Translation: CAG33003.1 .
    AL354836 Genomic DNA. Translation: CAC22306.1 .
    AL354836 Genomic DNA. Translation: CAC22307.1 .
    CH471077 Genomic DNA. Translation: EAW75377.1 .
    CH471077 Genomic DNA. Translation: EAW75379.1 .
    BC000296 mRNA. Translation: AAH00296.1 .
    BC004455 mRNA. Translation: AAH04455.1 .
    AF331963 mRNA. Translation: AAG53416.1 .
    CCDSi CCDS13494.1. [Q9H1P3-2 ]
    CCDS13495.1. [Q9H1P3-1 ]
    RefSeqi NP_055650.1. NM_014835.3. [Q9H1P3-2 ]
    NP_653081.1. NM_144498.2. [Q9H1P3-1 ]
    UniGenei Hs.473254.

    3D structure databases

    ProteinModelPortali Q9H1P3.
    SMRi Q9H1P3. Positions 67-444.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115216. 3 interactions.
    IntActi Q9H1P3. 1 interaction.
    STRINGi 9606.ENSP00000316649.

    PTM databases

    PhosphoSitei Q9H1P3.

    Polymorphism databases

    DMDMi 20139174.

    Proteomic databases

    MaxQBi Q9H1P3.
    PaxDbi Q9H1P3.
    PRIDEi Q9H1P3.

    Protocols and materials databases

    DNASUi 9885.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313733 ; ENSP00000316649 ; ENSG00000130703 . [Q9H1P3-1 ]
    ENST00000358053 ; ENSP00000350755 ; ENSG00000130703 . [Q9H1P3-2 ]
    GeneIDi 9885.
    KEGGi hsa:9885.
    UCSCi uc002yck.1. human. [Q9H1P3-1 ]
    uc002ycl.1. human. [Q9H1P3-2 ]

    Organism-specific databases

    CTDi 9885.
    GeneCardsi GC20P060813.
    HGNCi HGNC:15761. OSBPL2.
    HPAi HPA041127.
    HPA042659.
    MIMi 606731. gene.
    neXtProti NX_Q9H1P3.
    PharmGKBi PA32827.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG281324.
    HOGENOMi HOG000231233.
    HOVERGENi HBG053374.
    InParanoidi Q9H1P3.
    OMAi EWRTRWF.
    OrthoDBi EOG7F24SJ.
    PhylomeDBi Q9H1P3.

    Miscellaneous databases

    GeneWikii OSBPL2.
    GenomeRNAii 9885.
    NextBioi 37262.
    PROi Q9H1P3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H1P3.
    Bgeei Q9H1P3.
    CleanExi HS_OSBPL2.
    Genevestigatori Q9H1P3.

    Family and domain databases

    InterProi IPR000648. Oxysterol-bd.
    IPR018494. Oxysterol-bd_CS.
    [Graphical view ]
    PANTHERi PTHR10972. PTHR10972. 1 hit.
    Pfami PF01237. Oxysterol_BP. 1 hit.
    [Graphical view ]
    PROSITEi PS01013. OSBP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport."
      Xu Y., Liu Y., Ridgway N.D., McMaster C.R.
      J. Biol. Chem. 276:18407-18414(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "A family of 12 human genes containing oxysterol-binding domains."
      Jaworski C.J., Moreira E., Li A., Lee R., Rodriguez I.R.
      Genomics 78:185-196(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Rectum.
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1 AND 2).
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    9. "The OSBP-related protein family in humans."
      Lehto M., Laitinen S., Chinetti G., Johansson M., Ehnholm C., Staels B., Ikonen E., Olkkonen V.M.
      J. Lipid Res. 42:1203-1213(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-116 (ISOFORM 1).
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiOSBL2_HUMAN
    AccessioniPrimary (citable) accession number: Q9H1P3
    Secondary accession number(s): A8K736
    , Q6IBT0, Q9BZB1, Q9Y4B8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3