Q9H1P3 (OSBL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Oxysterol-binding protein-related protein 2
Short name=ORP-2
Short name=OSBP-related protein 2

Gene names

Name:	OSBPL2
Synonyms:	KIAA0772, ORP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	480 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate.
Tissue specificity	Widely expressed.
Sequence similarities	Belongs to the OSBP family.
Sequence caution	The sequence BAA34492.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Lipid transport Transport
Coding sequence diversity	Alternative splicing
Ligand	Lipid-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	lipid transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cholesterol binding Inferred from direct assay PubMed 17428193. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H1P3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H1P3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     13-24: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 480	480	Oxysterol-binding protein-related protein 2		PRO_0000100369
Natural variations
	Alternative sequence	13 – 24	12	Missing in isoform 2.		VSP_003781

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: A93D1B389D0A2740	FASTA	480	55,201
	10 20 30 40 50 60 MNGEEEFFDA VTGFDSDNSS GEFSEANQKV TGMIDLDTSK NNRIGKTGER PSQENGIQKH 70 80 90 100 110 120 RTSLPAPMFS RSDFSVWTIL KKCVGLELSK ITMPIAFNEP LSFLQRITEY MEHVYLIHRA 130 140 150 160 170 180 SCQPQPLERM QSVAAFAVSA VASQWERTGK PFNPLLGETY ELIREDLGFR FISEQVSHHP 190 200 210 220 230 240 PISAFHSEGL NHDFLFHGSI YPKLKFWGKS VEAEPRGTIT LELLKHNEAY TWTNPTCCVH 250 260 270 280 290 300 NVIIGKLWIE QYGTVEILNH RTGHKCVLHF KPCGLFGKEL HKVEGHIQDK NKKKLFMIYG 310 320 330 340 350 360 KWTECLWGID PVSYESFKKQ ERRGDHLRKA KLDEDSGKAD SDVADDVPVA QETVQVIPGS 370 380 390 400 410 420 KLLWRINTRP PNSAQMYNFT SFTVSLNELE TGMEKTLPPT DCRLRPDIRG MENGNMDLAS 430 440 450 460 470 480 QEKERLEEKQ REARRERAKE EAEWQTRWFY PGNNPYTGTP DWLYAGDYFE RNFSDCPDIY
	Isoform 2 [UniParc]. Checksum: 9C51392E0EDF4DF8	FASTA	468	53,971
	10 20 30 40 50 60 MNGEEEFFDA VTEANQKVTG MIDLDTSKNN RIGKTGERPS QENGIQKHRT SLPAPMFSRS 70 80 90 100 110 120 DFSVWTILKK CVGLELSKIT MPIAFNEPLS FLQRITEYME HVYLIHRASC QPQPLERMQS 130 140 150 160 170 180 VAAFAVSAVA SQWERTGKPF NPLLGETYEL IREDLGFRFI SEQVSHHPPI SAFHSEGLNH 190 200 210 220 230 240 DFLFHGSIYP KLKFWGKSVE AEPRGTITLE LLKHNEAYTW TNPTCCVHNV IIGKLWIEQY 250 260 270 280 290 300 GTVEILNHRT GHKCVLHFKP CGLFGKELHK VEGHIQDKNK KKLFMIYGKW TECLWGIDPV 310 320 330 340 350 360 SYESFKKQER RGDHLRKAKL DEDSGKADSD VADDVPVAQE TVQVIPGSKL LWRINTRPPN 370 380 390 400 410 420 SAQMYNFTSF TVSLNELETG MEKTLPPTDC RLRPDIRGME NGNMDLASQE KERLEEKQRE 430 440 450 460 ARRERAKEEA EWQTRWFYPG NNPYTGTPDW LYAGDYFERN FSDCPDIY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport." Xu Y., Liu Y., Ridgway N.D., McMaster C.R. J. Biol. Chem. 276:18407-18414(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"A family of 12 human genes containing oxysterol-binding domains." Jaworski C.J., Moreira E., Li A., Lee R., Rodriguez I.R. Genomics 78:185-196(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Rectum.
[5]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1 AND 2).
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung.
[9]	"The OSBP-related protein family in humans." Lehto M., Laitinen S., Chinetti G., Johansson M., Ehnholm C., Staels B., Ikonen E., Olkkonen V.M. J. Lipid Res. 42:1203-1213(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-116 (ISOFORM 1).
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY028168 mRNA. Translation: AAK18044.1. AF392447 mRNA. Translation: AAL40660.1. AB018315 mRNA. Translation: BAA34492.2. Different initiation. AK291851 mRNA. Translation: BAF84540.1. CR456722 mRNA. Translation: CAG33003.1. AL354836 Genomic DNA. Translation: CAC22306.1. AL354836 Genomic DNA. Translation: CAC22307.1. CH471077 Genomic DNA. Translation: EAW75377.1. CH471077 Genomic DNA. Translation: EAW75379.1. BC000296 mRNA. Translation: AAH00296.1. BC004455 mRNA. Translation: AAH04455.1. AF331963 mRNA. Translation: AAG53416.1.
IPI	IPI00014137. IPI00220460.
RefSeq	NP_055650.1. NM_014835.2. NP_653081.1. NM_144498.1.
UniGene	Hs.473254.
3D structure databases
ProteinModelPortal	Q9H1P3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H1P3. 1 interaction.
STRING	9606.ENSP00000316649.
PTM databases
PhosphoSite	Q9H1P3.
Polymorphism databases
DMDM	20139174.
Proteomic databases
PaxDb	Q9H1P3.
PRIDE	Q9H1P3.
Protocols and materials databases
DNASU	9885.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000313733; ENSP00000316649; ENSG00000130703. ENST00000358053; ENSP00000350755; ENSG00000130703.
GeneID	9885.
KEGG	hsa:9885.
UCSC	uc002yck.1. human. uc002ycl.1. human.
Organism-specific databases
CTD	9885.
GeneCards	GC20P060813.
HGNC	HGNC:15761. OSBPL2.
HPA	HPA041127. HPA042659.
MIM	606731. gene.
neXtProt	NX_Q9H1P3.
PharmGKB	PA32827.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG281324.
HOGENOM	HOG000231233.
HOVERGEN	HBG053374.
InParanoid	Q9H1P3.
OMA	ILAPTDC.
PhylomeDB	Q9H1P3.
Gene expression databases
ArrayExpress	Q9H1P3.
Bgee	Q9H1P3.
CleanEx	HS_OSBPL2.
Genevestigator	Q9H1P3.
GermOnline	ENSG00000130703. Homo sapiens.
Family and domain databases
InterPro	IPR000648. Oxysterol-bd. IPR018494. Oxysterol-bd_CS. [Graphical view]
PANTHER	PTHR10972. PTHR10972. 1 hit.
Pfam	PF01237. Oxysterol_BP. 1 hit. [Graphical view]
PROSITE	PS01013. OSBP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9885.
NextBio	37262.
SOURCE	Search...

Entry information

Entry name

OSBL2_HUMAN

Accession

Primary (citable) accession number: Q9H1P3
Secondary accession number(s): A8K736 , Q6IBT0, Q9BZB1, Q9Y4B8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.