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Q9H1P3

- OSBL2_HUMAN

UniProt

Q9H1P3 - OSBL2_HUMAN

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Protein
Oxysterol-binding protein-related protein 2
Gene
OSBPL2, KIAA0772, ORP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate.

GO - Molecular functioni

  1. cholesterol binding Source: BHF-UCL

GO - Biological processi

  1. lipid transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 2
Short name:
ORP-2
Short name:
OSBP-related protein 2
Gene namesi
Name:OSBPL2
Synonyms:KIAA0772, ORP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15761. OSBPL2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32827.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Oxysterol-binding protein-related protein 2
PRO_0000100369Add
BLAST

Proteomic databases

MaxQBiQ9H1P3.
PaxDbiQ9H1P3.
PRIDEiQ9H1P3.

PTM databases

PhosphoSiteiQ9H1P3.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

ArrayExpressiQ9H1P3.
BgeeiQ9H1P3.
CleanExiHS_OSBPL2.
GenevestigatoriQ9H1P3.

Organism-specific databases

HPAiHPA041127.
HPA042659.

Interactioni

Protein-protein interaction databases

BioGridi115216. 3 interactions.
IntActiQ9H1P3. 1 interaction.
STRINGi9606.ENSP00000316649.

Structurei

3D structure databases

ProteinModelPortaliQ9H1P3.
SMRiQ9H1P3. Positions 67-444.

Family & Domainsi

Sequence similaritiesi

Belongs to the OSBP family.

Phylogenomic databases

eggNOGiNOG281324.
HOGENOMiHOG000231233.
HOVERGENiHBG053374.
InParanoidiQ9H1P3.
OMAiEWRTRWF.
OrthoDBiEOG7F24SJ.
PhylomeDBiQ9H1P3.

Family and domain databases

InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 1 hit.
PfamiPF01237. Oxysterol_BP. 1 hit.
[Graphical view]
PROSITEiPS01013. OSBP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H1P3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNGEEEFFDA VTGFDSDNSS GEFSEANQKV TGMIDLDTSK NNRIGKTGER    50
PSQENGIQKH RTSLPAPMFS RSDFSVWTIL KKCVGLELSK ITMPIAFNEP 100
LSFLQRITEY MEHVYLIHRA SCQPQPLERM QSVAAFAVSA VASQWERTGK 150
PFNPLLGETY ELIREDLGFR FISEQVSHHP PISAFHSEGL NHDFLFHGSI 200
YPKLKFWGKS VEAEPRGTIT LELLKHNEAY TWTNPTCCVH NVIIGKLWIE 250
QYGTVEILNH RTGHKCVLHF KPCGLFGKEL HKVEGHIQDK NKKKLFMIYG 300
KWTECLWGID PVSYESFKKQ ERRGDHLRKA KLDEDSGKAD SDVADDVPVA 350
QETVQVIPGS KLLWRINTRP PNSAQMYNFT SFTVSLNELE TGMEKTLPPT 400
DCRLRPDIRG MENGNMDLAS QEKERLEEKQ REARRERAKE EAEWQTRWFY 450
PGNNPYTGTP DWLYAGDYFE RNFSDCPDIY 480
Length:480
Mass (Da):55,201
Last modified:March 1, 2001 - v1
Checksum:iA93D1B389D0A2740
GO
Isoform 2 (identifier: Q9H1P3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-24: Missing.

Show »
Length:468
Mass (Da):53,971
Checksum:i9C51392E0EDF4DF8
GO

Sequence cautioni

The sequence BAA34492.2 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei13 – 2412Missing in isoform 2.
VSP_003781Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY028168 mRNA. Translation: AAK18044.1.
AF392447 mRNA. Translation: AAL40660.1.
AB018315 mRNA. Translation: BAA34492.2. Different initiation.
AK291851 mRNA. Translation: BAF84540.1.
CR456722 mRNA. Translation: CAG33003.1.
AL354836 Genomic DNA. Translation: CAC22306.1.
AL354836 Genomic DNA. Translation: CAC22307.1.
CH471077 Genomic DNA. Translation: EAW75377.1.
CH471077 Genomic DNA. Translation: EAW75379.1.
BC000296 mRNA. Translation: AAH00296.1.
BC004455 mRNA. Translation: AAH04455.1.
AF331963 mRNA. Translation: AAG53416.1.
CCDSiCCDS13494.1. [Q9H1P3-2]
CCDS13495.1. [Q9H1P3-1]
RefSeqiNP_055650.1. NM_014835.3. [Q9H1P3-2]
NP_653081.1. NM_144498.2. [Q9H1P3-1]
UniGeneiHs.473254.

Genome annotation databases

EnsembliENST00000313733; ENSP00000316649; ENSG00000130703. [Q9H1P3-1]
ENST00000358053; ENSP00000350755; ENSG00000130703. [Q9H1P3-2]
GeneIDi9885.
KEGGihsa:9885.
UCSCiuc002yck.1. human. [Q9H1P3-1]
uc002ycl.1. human. [Q9H1P3-2]

Polymorphism databases

DMDMi20139174.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY028168 mRNA. Translation: AAK18044.1 .
AF392447 mRNA. Translation: AAL40660.1 .
AB018315 mRNA. Translation: BAA34492.2 . Different initiation.
AK291851 mRNA. Translation: BAF84540.1 .
CR456722 mRNA. Translation: CAG33003.1 .
AL354836 Genomic DNA. Translation: CAC22306.1 .
AL354836 Genomic DNA. Translation: CAC22307.1 .
CH471077 Genomic DNA. Translation: EAW75377.1 .
CH471077 Genomic DNA. Translation: EAW75379.1 .
BC000296 mRNA. Translation: AAH00296.1 .
BC004455 mRNA. Translation: AAH04455.1 .
AF331963 mRNA. Translation: AAG53416.1 .
CCDSi CCDS13494.1. [Q9H1P3-2 ]
CCDS13495.1. [Q9H1P3-1 ]
RefSeqi NP_055650.1. NM_014835.3. [Q9H1P3-2 ]
NP_653081.1. NM_144498.2. [Q9H1P3-1 ]
UniGenei Hs.473254.

3D structure databases

ProteinModelPortali Q9H1P3.
SMRi Q9H1P3. Positions 67-444.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115216. 3 interactions.
IntActi Q9H1P3. 1 interaction.
STRINGi 9606.ENSP00000316649.

PTM databases

PhosphoSitei Q9H1P3.

Polymorphism databases

DMDMi 20139174.

Proteomic databases

MaxQBi Q9H1P3.
PaxDbi Q9H1P3.
PRIDEi Q9H1P3.

Protocols and materials databases

DNASUi 9885.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000313733 ; ENSP00000316649 ; ENSG00000130703 . [Q9H1P3-1 ]
ENST00000358053 ; ENSP00000350755 ; ENSG00000130703 . [Q9H1P3-2 ]
GeneIDi 9885.
KEGGi hsa:9885.
UCSCi uc002yck.1. human. [Q9H1P3-1 ]
uc002ycl.1. human. [Q9H1P3-2 ]

Organism-specific databases

CTDi 9885.
GeneCardsi GC20P060813.
HGNCi HGNC:15761. OSBPL2.
HPAi HPA041127.
HPA042659.
MIMi 606731. gene.
neXtProti NX_Q9H1P3.
PharmGKBi PA32827.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG281324.
HOGENOMi HOG000231233.
HOVERGENi HBG053374.
InParanoidi Q9H1P3.
OMAi EWRTRWF.
OrthoDBi EOG7F24SJ.
PhylomeDBi Q9H1P3.

Miscellaneous databases

GeneWikii OSBPL2.
GenomeRNAii 9885.
NextBioi 37262.
PROi Q9H1P3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9H1P3.
Bgeei Q9H1P3.
CleanExi HS_OSBPL2.
Genevestigatori Q9H1P3.

Family and domain databases

InterProi IPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
[Graphical view ]
PANTHERi PTHR10972. PTHR10972. 1 hit.
Pfami PF01237. Oxysterol_BP. 1 hit.
[Graphical view ]
PROSITEi PS01013. OSBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport."
    Xu Y., Liu Y., Ridgway N.D., McMaster C.R.
    J. Biol. Chem. 276:18407-18414(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "A family of 12 human genes containing oxysterol-binding domains."
    Jaworski C.J., Moreira E., Li A., Lee R., Rodriguez I.R.
    Genomics 78:185-196(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Rectum.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1 AND 2).
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  9. "The OSBP-related protein family in humans."
    Lehto M., Laitinen S., Chinetti G., Johansson M., Ehnholm C., Staels B., Ikonen E., Olkkonen V.M.
    J. Lipid Res. 42:1203-1213(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-116 (ISOFORM 1).
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiOSBL2_HUMAN
AccessioniPrimary (citable) accession number: Q9H1P3
Secondary accession number(s): A8K736
, Q6IBT0, Q9BZB1, Q9Y4B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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