ID   DB127_HUMAN             Reviewed;          99 AA.
AC   Q9H1M4; Q14DW7;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   07-JUL-2009, entry version 67.
DE   RecName: Full=Beta-defensin 127;
DE   AltName: Full=Defensin, beta 127;
DE   AltName: Full=Beta-defensin 27;
DE   AltName: Full=DEFB-27;
DE   Flags: Precursor;
GN   Name=DEFB127; Synonyms=C20orf73, DEFB27; ORFNames=UNQ1956/PRO6071;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=12620395; DOI=10.1016/S0888-7543(02)00034-4;
RA   Rodriguez-Jimenez F.-J., Krause A., Schulz S., Forssmann W.-G.,
RA   Conejo-Garcia J.-R., Schreeb R., Motzkus D.;
RT   "Distribution of new human beta-defensin genes clustered on chromosome
RT   20 in functionally different segments of epididymis.";
RL   Genomics 81:175-183(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA   Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA   Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA   Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA   Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA   Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA   Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale
RT   effort to identify novel human secreted and transmembrane proteins: a
RT   bioinformatics assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=21638749; PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 19-77, IDENTIFICATION, AND VARIANT
RP   ARG-31.
RC   TISSUE=B-cell, Fetal lung, and Testis;
RX   MEDLINE=21843921; PubMed=11854508; DOI=10.1073/pnas.042692699;
RA   Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P.,
RA   Welsh M.J., Casavant T.L., McCray P.B. Jr.;
RT   "Discovery of five conserved beta-defensin gene clusters using a
RT   computational search strategy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002).
RN   [6]
RP   PROTEIN SEQUENCE OF 21-35.
RX   PubMed=15340161; DOI=10.1110/ps.04682504;
RA   Zhang Z., Henzel W.J.;
RT   "Signal peptide prediction based on analysis of experimentally
RT   verified cleavage sites.";
RL   Protein Sci. 13:2819-2824(2004).
CC   -!- FUNCTION: Has antibacterial activity (Potential).
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- SIMILARITY: Belongs to the beta-defensin family.
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DR   EMBL; AF525929; AAP47222.1; -; mRNA.
DR   EMBL; AY358796; AAQ89156.1; -; mRNA.
DR   EMBL; AL360078; CAC17685.1; -; Genomic_DNA.
DR   EMBL; BC069486; AAH69486.1; -; mRNA.
DR   EMBL; BC109395; AAI09396.1; -; mRNA.
DR   EMBL; AY122479; AAM93920.1; -; mRNA.
DR   IPI; IPI00030785; -.
DR   RefSeq; NP_620713.1; -.
DR   UniGene; Hs.99362; -.
DR   Ensembl; ENSG00000088782; Homo sapiens.
DR   GeneID; 140850; -.
DR   KEGG; hsa:140850; -.
DR   UCSC; uc002wcy.1; human.
DR   GeneCards; GC20P000086; -.
DR   H-InvDB; HIX0040533; -.
DR   HGNC; HGNC:16206; DEFB127.
DR   PharmGKB; PA27247; -.
DR   HOGENOM; Q9H1M4; -.
DR   HOVERGEN; Q9H1M4; -.
DR   OMA; Q9H1M4; CENGRYC.
DR   NextBio; 84472; -.
DR   ArrayExpress; Q9H1M4; -.
DR   Bgee; Q9H1M4; -.
DR   CleanEx; HS_DEFB127; -.
DR   GermOnline; ENSG00000088782; Homo sapiens.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; TAS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; TAS:UniProtKB.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW   Complete proteome; Defensin; Direct protein sequencing;
KW   Disulfide bond; Polymorphism; Secreted; Signal.
FT   SIGNAL        1     20
FT   PEPTIDE      21     63       Beta-defensin 127.
FT                                /FTId=PRO_0000007002.
FT   PROPEP       66     99       Potential.
FT                                /FTId=PRO_0000007003.
FT   DISULFID     24     53       By similarity.
FT   DISULFID     33     47       By similarity.
FT   DISULFID     37     54       By similarity.
FT   VARIANT      31     31       G -> R (in dbSNP:rs12624954).
FT                                /FTId=VAR_048864.
FT   VARIANT      71     71       R -> S (in dbSNP:rs16995685).
FT                                /FTId=VAR_048865.
FT   CONFLICT     71     77       RPKPATL -> SPKQHLH (in Ref. 5).
SQ   SEQUENCE   99 AA;  11343 MW;  C9CBDB27D17AF380 CRC64;
     MGLFMIIAIL LFQKPTVTEQ LKKCWNNYVQ GHCRKICRVN EVPEALCENG RYCCLNIKEL
     EACKKITKPP RPKPATLALT LQDYVTIIEN FPSLKTQST
//