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Protein

Talin rod domain-containing protein 1

Gene

TLNRD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells.1 Publication

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Talin rod domain-containing protein 1Curated
Alternative name(s):
Mesoderm development candidate 1Imported
Gene namesi
Name:TLNRD1Imported
Synonyms:MESDC1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140406.3
HGNCiHGNC:13519 TLNRD1
MIMi615466 gene
neXtProtiNX_Q9H1K6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi59274
OpenTargetsiENSG00000140406
PharmGKBiPA30760

Polymorphism and mutation databases

BioMutaiMESDC1
DMDMi24418561

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000964412 – 362Talin rod domain-containing protein 1Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9H1K6
PaxDbiQ9H1K6
PeptideAtlasiQ9H1K6
PRIDEiQ9H1K6
ProteomicsDBi80425

PTM databases

iPTMnetiQ9H1K6
PhosphoSitePlusiQ9H1K6

Expressioni

Inductioni

Down-regulated by microRNA MIR574-3p.1 Publication

Gene expression databases

BgeeiENSG00000140406
CleanExiHS_MESDC1
GenevisibleiQ9H1K6 HS

Organism-specific databases

HPAiHPA071716

Interactioni

Subunit structurei

May homodimerize. Interacts with F-actin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121865, 4 interactors
IntActiQ9H1K6, 2 interactors
STRINGi9606.ENSP00000267984

Structurei

3D structure databases

ProteinModelPortaliQ9H1K6
SMRiQ9H1K6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4261 Eukaryota
ENOG410XQ0V LUCA
GeneTreeiENSGT00910000144335
HOGENOMiHOG000294219
HOVERGENiHBG052459
InParanoidiQ9H1K6
OMAiCRDTVIA
OrthoDBiEOG091G0AM2
PhylomeDBiQ9H1K6

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H1K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGSAGKPT GEAASPAPAS AIGGASSQPR KRLVSVCDHC KGKMQLVADL
60 70 80 90 100
LLLSSEARPV LFEGPASSGA GAESFEQCRD TIIARTKGLS ILTHDVQSQL
110 120 130 140 150
NMGRFGEAGD SLVELGDLVV SLTECSAHAA YLAAVATPGA QPAQPGLVDR
160 170 180 190 200
YRVTRCRHEV EQGCAVLRAT PLADMTPQLL LEVSQGLSRN LKFLTDACAL
210 220 230 240 250
ASDKSRDRFS REQFKLGVKC MSTSASALLA CVREVKVAPS ELARSRCALF
260 270 280 290 300
SGPLVQAVSA LVGFATEPQF LGRAAAVSAE GKAVQTAILG GAMSVVSACV
310 320 330 340 350
LLTQCLRDLA QHPDGGAKMS DHRERLRNSA CAVSEGCTLL SQALRERSSP
360
RTLPPVNSNS VN
Length:362
Mass (Da):37,758
Last modified:March 1, 2001 - v1
Checksum:i37BF391D663E1D6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007810 mRNA Translation: AAG41058.1
BC084554 mRNA Translation: AAH84554.1
CCDSiCCDS10316.1
RefSeqiNP_072088.1, NM_022566.2
UniGeneiHs.513071

Genome annotation databases

EnsembliENST00000267984; ENSP00000267984; ENSG00000140406
GeneIDi59274
KEGGihsa:59274
UCSCiuc002bfz.4 human

Similar proteinsi

Entry informationi

Entry nameiTLRN1_HUMAN
AccessioniPrimary (citable) accession number: Q9H1K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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