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Protein

Mesoderm development candidate 1

Gene

MESDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Mesoderm development candidate 1
Gene namesi
Name:MESDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140406.3.
HGNCiHGNC:13519. MESDC1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi59274.
OpenTargetsiENSG00000140406.
PharmGKBiPA30760.

Polymorphism and mutation databases

BioMutaiMESDC1.
DMDMi24418561.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000964412 – 362Mesoderm development candidate 1Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9H1K6.
MaxQBiQ9H1K6.
PaxDbiQ9H1K6.
PeptideAtlasiQ9H1K6.
PRIDEiQ9H1K6.

PTM databases

iPTMnetiQ9H1K6.
PhosphoSitePlusiQ9H1K6.

Expressioni

Gene expression databases

BgeeiENSG00000140406.
CleanExiHS_MESDC1.
GenevisibleiQ9H1K6. HS.

Organism-specific databases

HPAiHPA062713.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121865. 4 interactors.
IntActiQ9H1K6. 2 interactors.
STRINGi9606.ENSP00000267984.

Structurei

3D structure databases

ProteinModelPortaliQ9H1K6.
SMRiQ9H1K6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4261. Eukaryota.
ENOG410XQ0V. LUCA.
GeneTreeiENSGT00550000074542.
HOGENOMiHOG000294219.
HOVERGENiHBG052459.
InParanoidiQ9H1K6.
OMAiCRDTVIA.
OrthoDBiEOG091G0AM2.
PhylomeDBiQ9H1K6.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H1K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGSAGKPT GEAASPAPAS AIGGASSQPR KRLVSVCDHC KGKMQLVADL
60 70 80 90 100
LLLSSEARPV LFEGPASSGA GAESFEQCRD TIIARTKGLS ILTHDVQSQL
110 120 130 140 150
NMGRFGEAGD SLVELGDLVV SLTECSAHAA YLAAVATPGA QPAQPGLVDR
160 170 180 190 200
YRVTRCRHEV EQGCAVLRAT PLADMTPQLL LEVSQGLSRN LKFLTDACAL
210 220 230 240 250
ASDKSRDRFS REQFKLGVKC MSTSASALLA CVREVKVAPS ELARSRCALF
260 270 280 290 300
SGPLVQAVSA LVGFATEPQF LGRAAAVSAE GKAVQTAILG GAMSVVSACV
310 320 330 340 350
LLTQCLRDLA QHPDGGAKMS DHRERLRNSA CAVSEGCTLL SQALRERSSP
360
RTLPPVNSNS VN
Length:362
Mass (Da):37,758
Last modified:March 1, 2001 - v1
Checksum:i37BF391D663E1D6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007810 mRNA. Translation: AAG41058.1.
BC084554 mRNA. Translation: AAH84554.1.
CCDSiCCDS10316.1.
RefSeqiNP_072088.1. NM_022566.2.
UniGeneiHs.513071.

Genome annotation databases

EnsembliENST00000267984; ENSP00000267984; ENSG00000140406.
GeneIDi59274.
KEGGihsa:59274.
UCSCiuc002bfz.4. human.

Similar proteinsi

Entry informationi

Entry nameiMESD1_HUMAN
AccessioniPrimary (citable) accession number: Q9H1K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: March 1, 2001
Last modified: September 27, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot