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Protein

Mitochondrial glutamate carrier 2

Gene

SLC25A18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H+.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Protein family/group databases

TCDBi2.A.29.14.5. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glutamate carrier 2
Short name:
GC-2
Alternative name(s):
Glutamate/H(+) symporter 2
Solute carrier family 25 member 18
Gene namesi
Name:SLC25A18
Synonyms:GC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:10988. SLC25A18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei61 – 8121Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei106 – 12621Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei185 – 20521Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei225 – 24521Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei288 – 30821Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35864.

Polymorphism and mutation databases

BioMutaiSLC25A18.
DMDMi20140247.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Mitochondrial glutamate carrier 2PRO_0000090621Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei145 – 1451PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H1K4.
MaxQBiQ9H1K4.
PaxDbiQ9H1K4.
PRIDEiQ9H1K4.

PTM databases

iPTMnetiQ9H1K4.
PhosphoSiteiQ9H1K4.
SwissPalmiQ9H1K4.

Expressioni

Gene expression databases

BgeeiQ9H1K4.
CleanExiHS_SLC25A18.
ExpressionAtlasiQ9H1K4. baseline and differential.
GenevisibleiQ9H1K4. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GOPCQ9HD263EBI-6269587,EBI-349832

Protein-protein interaction databases

BioGridi123744. 3 interactions.
IntActiQ9H1K4. 3 interactions.
MINTiMINT-8052484.
STRINGi9606.ENSP00000329033.

Structurei

3D structure databases

ProteinModelPortaliQ9H1K4.
SMRiQ9H1K4. Positions 4-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 9287Solcar 1Add
BLAST
Repeati100 – 210111Solcar 2Add
BLAST
Repeati219 – 30890Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0750. Eukaryota.
ENOG410Y240. LUCA.
GeneTreeiENSGT00530000062944.
HOGENOMiHOG000168308.
HOVERGENiHBG039469.
InParanoidiQ9H1K4.
KOiK15107.
OMAiHQGSASA.
OrthoDBiEOG7KM5TK.
PhylomeDBiQ9H1K4.
TreeFamiTF313209.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H1K4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHQDLSITA KLINGGVAGL VGVTCVFPID LAKTRLQNQH GKAMYKGMID
60 70 80 90 100
CLMKTARAEG FFGMYRGAAV NLTLVTPEKA IKLAANDFFR RLLMEDGMQR
110 120 130 140 150
NLKMEMLAGC GAGMCQVVVT CPMEMLKIQL QDAGRLAVHH QGSASAPSTS
160 170 180 190 200
RSYTTGSAST HRRPSATLIA WELLRTQGLA GLYRGLGATL LRDIPFSIIY
210 220 230 240 250
FPLFANLNNL GFNELAGKAS FAHSFVSGCV AGSIAAVAVT PLDVLKTRIQ
260 270 280 290 300
TLKKGLGEDM YSGITDCARK LWIQEGPSAF MKGAGCRALV IAPLFGIAQG
310
VYFIGIGERI LKCFD
Length:315
Mass (Da):33,849
Last modified:March 1, 2001 - v1
Checksum:iB23A9E5036671634
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ428203 mRNA. Translation: CAD21008.1.
AY008285 mRNA. Translation: AAG22855.1.
CR456578 mRNA. Translation: CAG30464.1.
BC031644 mRNA. Translation: AAH31644.1.
CCDSiCCDS13744.1.
RefSeqiNP_001290413.1. NM_001303484.1.
NP_113669.1. NM_031481.2.
XP_011544453.1. XM_011546151.1.
XP_011544454.1. XM_011546152.1.
XP_011544455.1. XM_011546153.1.
XP_011544456.1. XM_011546154.1.
UniGeneiHs.282982.

Genome annotation databases

EnsembliENST00000327451; ENSP00000329033; ENSG00000182902.
ENST00000399813; ENSP00000382710; ENSG00000182902.
GeneIDi83733.
KEGGihsa:83733.
UCSCiuc002zmp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ428203 mRNA. Translation: CAD21008.1.
AY008285 mRNA. Translation: AAG22855.1.
CR456578 mRNA. Translation: CAG30464.1.
BC031644 mRNA. Translation: AAH31644.1.
CCDSiCCDS13744.1.
RefSeqiNP_001290413.1. NM_001303484.1.
NP_113669.1. NM_031481.2.
XP_011544453.1. XM_011546151.1.
XP_011544454.1. XM_011546152.1.
XP_011544455.1. XM_011546153.1.
XP_011544456.1. XM_011546154.1.
UniGeneiHs.282982.

3D structure databases

ProteinModelPortaliQ9H1K4.
SMRiQ9H1K4. Positions 4-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123744. 3 interactions.
IntActiQ9H1K4. 3 interactions.
MINTiMINT-8052484.
STRINGi9606.ENSP00000329033.

Protein family/group databases

TCDBi2.A.29.14.5. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiQ9H1K4.
PhosphoSiteiQ9H1K4.
SwissPalmiQ9H1K4.

Polymorphism and mutation databases

BioMutaiSLC25A18.
DMDMi20140247.

Proteomic databases

EPDiQ9H1K4.
MaxQBiQ9H1K4.
PaxDbiQ9H1K4.
PRIDEiQ9H1K4.

Protocols and materials databases

DNASUi83733.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327451; ENSP00000329033; ENSG00000182902.
ENST00000399813; ENSP00000382710; ENSG00000182902.
GeneIDi83733.
KEGGihsa:83733.
UCSCiuc002zmp.2. human.

Organism-specific databases

CTDi83733.
GeneCardsiSLC25A18.
HGNCiHGNC:10988. SLC25A18.
MIMi609303. gene.
neXtProtiNX_Q9H1K4.
PharmGKBiPA35864.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0750. Eukaryota.
ENOG410Y240. LUCA.
GeneTreeiENSGT00530000062944.
HOGENOMiHOG000168308.
HOVERGENiHBG039469.
InParanoidiQ9H1K4.
KOiK15107.
OMAiHQGSASA.
OrthoDBiEOG7KM5TK.
PhylomeDBiQ9H1K4.
TreeFamiTF313209.

Miscellaneous databases

GenomeRNAii83733.
PROiQ9H1K4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H1K4.
CleanExiHS_SLC25A18.
ExpressionAtlasiQ9H1K4. baseline and differential.
GenevisibleiQ9H1K4. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms."
    Fiermonte G., Palmieri L., Todisco S., Agrimi G., Palmieri F., Walker J.E.
    J. Biol. Chem. 277:19289-19294(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Tissue: Brain.
  2. "Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere."
    Footz T.K., Brinkman-Mills P., Banting G.S., Maier S.A., Riazi M.A., Bridgland L.J., Hu S., Birren B., Minoshima S., Shimizu N., Pan H., Nguyen T., Fang F., Fu Y., Ray L., Wu H., Shaull S., Phan S.
    , Yao Z., Chen F., Huan A., Hu P., Wang Q., Loh P., Qi S., Roe B.A., McDermid H.E.
    Genome Res. 11:1053-1070(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-145, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiGHC2_HUMAN
AccessioniPrimary (citable) accession number: Q9H1K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.