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Q9H1J7

- WNT5B_HUMAN

UniProt

Q9H1J7 - WNT5B_HUMAN

Protein

Protein Wnt-5b

Gene

WNT5B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (10 May 2002)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.By similarity

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome
    2. receptor binding Source: UniProtKB

    GO - Biological processi

    1. cell fate commitment Source: RefGenome
    2. cellular response to retinoic acid Source: UniProtKB
    3. chondrocyte differentiation Source: UniProtKB
    4. fat cell differentiation Source: UniProtKB
    5. lens fiber cell development Source: BHF-UCL
    6. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    7. neuron differentiation Source: UniProtKB
    8. positive regulation of cell migration Source: UniProtKB
    9. positive regulation of fat cell differentiation Source: Ensembl
    10. Wnt signaling pathway Source: UniProtKB
    11. wound healing Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
    REACT_172581. PCP/CE pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-5b
    Gene namesi
    Name:WNT5B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:16265. WNT5B.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. endoplasmic reticulum lumen Source: Reactome
    3. extracellular region Source: Reactome
    4. extracellular space Source: UniProtKB
    5. extracellular vesicular exosome Source: UniProt
    6. Golgi lumen Source: Reactome
    7. plasma membrane Source: Reactome
    8. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38104.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 359342Protein Wnt-5bPRO_0000041434Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi83 ↔ 94By similarity
    Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi133 ↔ 141By similarity
    Disulfide bondi143 ↔ 161By similarity
    Disulfide bondi217 ↔ 231By similarity
    Disulfide bondi219 ↔ 226By similarity
    Lipidationi223 – 2231O-palmitoyl serine; by PORCNBy similarity
    Glycosylationi291 – 2911N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi304 ↔ 319By similarity
    Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi334 ↔ 349By similarity
    Disulfide bondi336 ↔ 346By similarity
    Disulfide bondi341 ↔ 342By similarity

    Post-translational modificationi

    Palmitoylation at Ser-223 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiQ9H1J7.
    PaxDbiQ9H1J7.
    PRIDEiQ9H1J7.

    PTM databases

    PhosphoSiteiQ9H1J7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H1J7.
    BgeeiQ9H1J7.
    CleanExiHS_WNT5B.
    GenevestigatoriQ9H1J7.

    Interactioni

    Subunit structurei

    Interacts with PORCN.By similarity

    Protein-protein interaction databases

    BioGridi123348. 2 interactions.
    IntActiQ9H1J7. 1 interaction.
    MINTiMINT-1485183.
    STRINGi9606.ENSP00000308887.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H1J7.
    SMRiQ9H1J7. Positions 73-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG284879.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    InParanoidiQ9H1J7.
    KOiK00444.
    OMAiLTDANSW.
    PhylomeDBiQ9H1J7.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR026537. Wnt5b.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF87. PTHR12027:SF87. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9H1J7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSLLLLFTA ALLSSWAQLL TDANSWWSLA LNPVQRPEMF IIGAQPVCSQ    50
    LPGLSPGQRK LCQLYQEHMA YIGEGAKTGI KECQHQFRQR RWNCSTADNA 100
    SVFGRVMQIG SRETAFTHAV SAAGVVNAIS RACREGELST CGCSRTARPK 150
    DLPRDWLWGG CGDNVEYGYR FAKEFVDARE REKNFAKGSE EQGRVLMNLQ 200
    NNEAGRRAVY KMADVACKCH GVSGSCSLKT CWLQLAEFRK VGDRLKEKYD 250
    SAAAMRVTRK GRLELVNSRF TQPTPEDLVY VDPSPDYCLR NESTGSLGTQ 300
    GRLCNKTSEG MDGCELMCCG RGYNQFKSVQ VERCHCKFHW CCFVRCKKCT 350
    EIVDQYICK 359
    Length:359
    Mass (Da):40,323
    Last modified:May 10, 2002 - v2
    Checksum:i6E35EE2B0AF1FD29
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti73 – 731G → R in AAG38659. 1 PublicationCurated
    Sequence conflicti88 – 881R → P in AAG38659. 1 PublicationCurated
    Sequence conflicti93 – 931N → K in AAG38659. 1 PublicationCurated
    Sequence conflicti134 – 1341R → S in AAG38659. 1 PublicationCurated
    Sequence conflicti224 – 2241G → R in AAG38659. 1 PublicationCurated
    Sequence conflicti227 – 2271S → R in AAG38659. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY009399 mRNA. Translation: AAG38659.1.
    AB060966 mRNA. Translation: BAB62039.1.
    AK290430 mRNA. Translation: BAF83119.1.
    CH471116 Genomic DNA. Translation: EAW88925.1.
    CH471116 Genomic DNA. Translation: EAW88927.1.
    BC001749 mRNA. Translation: AAH01749.1.
    CCDSiCCDS8510.1.
    RefSeqiNP_110402.2. NM_030775.2.
    NP_116031.1. NM_032642.2.
    UniGeneiHs.306051.

    Genome annotation databases

    EnsembliENST00000310594; ENSP00000308887; ENSG00000111186.
    ENST00000397196; ENSP00000380379; ENSG00000111186.
    ENST00000537031; ENSP00000439312; ENSG00000111186.
    GeneIDi81029.
    KEGGihsa:81029.
    UCSCiuc001qjj.3. human.

    Polymorphism databases

    DMDMi20532427.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY009399 mRNA. Translation: AAG38659.1 .
    AB060966 mRNA. Translation: BAB62039.1 .
    AK290430 mRNA. Translation: BAF83119.1 .
    CH471116 Genomic DNA. Translation: EAW88925.1 .
    CH471116 Genomic DNA. Translation: EAW88927.1 .
    BC001749 mRNA. Translation: AAH01749.1 .
    CCDSi CCDS8510.1.
    RefSeqi NP_110402.2. NM_030775.2.
    NP_116031.1. NM_032642.2.
    UniGenei Hs.306051.

    3D structure databases

    ProteinModelPortali Q9H1J7.
    SMRi Q9H1J7. Positions 73-288.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123348. 2 interactions.
    IntActi Q9H1J7. 1 interaction.
    MINTi MINT-1485183.
    STRINGi 9606.ENSP00000308887.

    PTM databases

    PhosphoSitei Q9H1J7.

    Polymorphism databases

    DMDMi 20532427.

    Proteomic databases

    MaxQBi Q9H1J7.
    PaxDbi Q9H1J7.
    PRIDEi Q9H1J7.

    Protocols and materials databases

    DNASUi 81029.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310594 ; ENSP00000308887 ; ENSG00000111186 .
    ENST00000397196 ; ENSP00000380379 ; ENSG00000111186 .
    ENST00000537031 ; ENSP00000439312 ; ENSG00000111186 .
    GeneIDi 81029.
    KEGGi hsa:81029.
    UCSCi uc001qjj.3. human.

    Organism-specific databases

    CTDi 81029.
    GeneCardsi GC12P001639.
    HGNCi HGNC:16265. WNT5B.
    MIMi 606361. gene.
    neXtProti NX_Q9H1J7.
    PharmGKBi PA38104.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284879.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    InParanoidi Q9H1J7.
    KOi K00444.
    OMAi LTDANSW.
    PhylomeDBi Q9H1J7.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
    REACT_172581. PCP/CE pathway.

    Miscellaneous databases

    ChiTaRSi WNT5B. human.
    GeneWikii WNT5B.
    GenomeRNAii 81029.
    NextBioi 71352.
    PROi Q9H1J7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H1J7.
    Bgeei Q9H1J7.
    CleanExi HS_WNT5B.
    Genevestigatori Q9H1J7.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR026537. Wnt5b.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF87. PTHR12027:SF87. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of six novel human WNT genes."
      Testa T.T., Mossakowska D.E., Carter P.S., Hu E., Zhu Y., Kelsell D.P., Murdock P.R., Herrity N.C., Lewis C.J., Cross D.A., Culbert A.A., Reith A.D., Barnes M.R.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning and characterization of human WNT5B on chromosome 12p13.3 region."
      Saitoh T., Katoh M.
      Int. J. Oncol. 19:347-351(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.

    Entry informationi

    Entry nameiWNT5B_HUMAN
    AccessioniPrimary (citable) accession number: Q9H1J7
    Secondary accession number(s): A8K315
    , D3DUP9, Q96S49, Q9BV04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: May 10, 2002
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3