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Protein

Protein Wnt-5b

Gene

WNT5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).By similarity

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

  • cell fate commitment Source: GO_Central
  • cellular response to retinoic acid Source: UniProtKB
  • chondrocyte differentiation Source: UniProtKB
  • fat cell differentiation Source: UniProtKB
  • lens fiber cell development Source: BHF-UCL
  • negative regulation of canonical Wnt signaling pathway Source: Ensembl
  • neuron differentiation Source: UniProtKB
  • positive regulation of cell migration Source: UniProtKB
  • positive regulation of fat cell differentiation Source: Ensembl
  • Wnt signaling pathway Source: UniProtKB
  • wound healing Source: Ensembl

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-3238698 WNT ligand biogenesis and trafficking
R-HSA-4086400 PCP/CE pathway
SIGNORiQ9H1J7

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-5b
Gene namesi
Name:WNT5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111186.12
HGNCiHGNC:16265 WNT5B
MIMi606361 gene
neXtProtiNX_Q9H1J7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi81029
OpenTargetsiENSG00000111186
PharmGKBiPA38104

Polymorphism and mutation databases

BioMutaiWNT5B
DMDMi20532427

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000004143418 – 359Protein Wnt-5bAdd BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 94By similarity
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi133 ↔ 141By similarity
Disulfide bondi143 ↔ 161By similarity
Disulfide bondi217 ↔ 231By similarity
Disulfide bondi219 ↔ 226By similarity
Lipidationi223O-palmitoleoyl serine; by PORCNBy similarity1
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi304 ↔ 319By similarity
Glycosylationi305N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi334 ↔ 349By similarity
Disulfide bondi336 ↔ 346By similarity
Disulfide bondi341 ↔ 342By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

MaxQBiQ9H1J7
PaxDbiQ9H1J7
PeptideAtlasiQ9H1J7
PRIDEiQ9H1J7

PTM databases

iPTMnetiQ9H1J7
PhosphoSitePlusiQ9H1J7

Expressioni

Gene expression databases

BgeeiENSG00000111186
CleanExiHS_WNT5B
ExpressionAtlasiQ9H1J7 baseline and differential
GenevisibleiQ9H1J7 HS

Organism-specific databases

HPAiHPA061991

Interactioni

Subunit structurei

Interacts with PORCN.By similarity

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • signaling receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123348, 3 interactors
IntActiQ9H1J7, 1 interactor
STRINGi9606.ENSP00000308887

Structurei

3D structure databases

ProteinModelPortaliQ9H1J7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiQ9H1J7
KOiK00444
OMAiFRRVGEF
OrthoDBiEOG091G0OFF
PhylomeDBiQ9H1J7
TreeFamiTF105310

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR026537 Wnt5b
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PTHR12027:SF87 PTHR12027:SF87, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H1J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLLLLFTA ALLSSWAQLL TDANSWWSLA LNPVQRPEMF IIGAQPVCSQ
60 70 80 90 100
LPGLSPGQRK LCQLYQEHMA YIGEGAKTGI KECQHQFRQR RWNCSTADNA
110 120 130 140 150
SVFGRVMQIG SRETAFTHAV SAAGVVNAIS RACREGELST CGCSRTARPK
160 170 180 190 200
DLPRDWLWGG CGDNVEYGYR FAKEFVDARE REKNFAKGSE EQGRVLMNLQ
210 220 230 240 250
NNEAGRRAVY KMADVACKCH GVSGSCSLKT CWLQLAEFRK VGDRLKEKYD
260 270 280 290 300
SAAAMRVTRK GRLELVNSRF TQPTPEDLVY VDPSPDYCLR NESTGSLGTQ
310 320 330 340 350
GRLCNKTSEG MDGCELMCCG RGYNQFKSVQ VERCHCKFHW CCFVRCKKCT

EIVDQYICK
Length:359
Mass (Da):40,323
Last modified:May 10, 2002 - v2
Checksum:i6E35EE2B0AF1FD29
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73G → R in AAG38659 (Ref. 1) Curated1
Sequence conflicti88R → P in AAG38659 (Ref. 1) Curated1
Sequence conflicti93N → K in AAG38659 (Ref. 1) Curated1
Sequence conflicti134R → S in AAG38659 (Ref. 1) Curated1
Sequence conflicti224G → R in AAG38659 (Ref. 1) Curated1
Sequence conflicti227S → R in AAG38659 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009399 mRNA Translation: AAG38659.1
AB060966 mRNA Translation: BAB62039.1
AK290430 mRNA Translation: BAF83119.1
CH471116 Genomic DNA Translation: EAW88925.1
CH471116 Genomic DNA Translation: EAW88927.1
BC001749 mRNA Translation: AAH01749.1
CCDSiCCDS8510.1
RefSeqiNP_110402.2, NM_030775.2
NP_116031.1, NM_032642.2
UniGeneiHs.306051

Genome annotation databases

EnsembliENST00000310594; ENSP00000308887; ENSG00000111186
ENST00000397196; ENSP00000380379; ENSG00000111186
ENST00000537031; ENSP00000439312; ENSG00000111186
GeneIDi81029
KEGGihsa:81029
UCSCiuc001qjj.4 human

Similar proteinsi

Entry informationi

Entry nameiWNT5B_HUMAN
AccessioniPrimary (citable) accession number: Q9H1J7
Secondary accession number(s): A8K315
, D3DUP9, Q96S49, Q9BV04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 10, 2002
Last modified: May 23, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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