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Q9H1J5

- WNT8A_HUMAN

UniProt

Q9H1J5 - WNT8A_HUMAN

Protein

Protein Wnt-8a

Gene

WNT8A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (09 Feb 2010)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.

    GO - Molecular functioni

    1. frizzled binding Source: BHF-UCL
    2. receptor agonist activity Source: BHF-UCL

    GO - Biological processi

    1. canonical Wnt signaling pathway Source: BHF-UCL
    2. canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment Source: BHF-UCL
    3. canonical Wnt signaling pathway involved in neural crest cell differentiation Source: BHF-UCL
    4. endoderm development Source: Ensembl
    5. establishment of organ orientation Source: Ensembl
    6. neural crest cell fate commitment Source: BHF-UCL
    7. neuron differentiation Source: RefGenome
    8. palate development Source: BHF-UCL
    9. polarity specification of anterior/posterior axis Source: Ensembl
    10. polarity specification of proximal/distal axis Source: Ensembl
    11. regulation of protein localization Source: Ensembl
    12. regulation of transcription involved in anterior/posterior axis specification Source: BHF-UCL
    13. response to retinoic acid Source: BHF-UCL

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
    REACT_18372. Class B/2 (Secretin family receptors).
    REACT_200610. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_200777. TCF dependent signaling in response to WNT.
    SignaLinkiQ9H1J5.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-8a
    Alternative name(s):
    Protein Wnt-8d
    Gene namesi
    Name:WNT8A
    Synonyms:WNT8D
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:12788. WNT8A.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: RefGenome
    3. proteinaceous extracellular matrix Source: BHF-UCL

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37389.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 351327Protein Wnt-8aPRO_0000041448Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 65By similarity
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi104 ↔ 112By similarity
    Disulfide bondi114 ↔ 132By similarity
    Disulfide bondi180 ↔ 194By similarity
    Disulfide bondi182 ↔ 189By similarity
    Disulfide bondi259 ↔ 297By similarity
    Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi275 ↔ 290By similarity
    Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi294 ↔ 336By similarity
    Disulfide bondi312 ↔ 327By similarity
    Disulfide bondi314 ↔ 324By similarity
    Disulfide bondi319 ↔ 320By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9H1J5.
    PRIDEiQ9H1J5.

    2D gel databases

    REPRODUCTION-2DPAGEQ9H1J5.

    PTM databases

    PhosphoSiteiQ9H1J5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H1J5.
    BgeeiQ9H1J5.
    CleanExiHS_WNT8A.
    GenevestigatoriQ9H1J5.

    Organism-specific databases

    HPAiHPA038539.

    Interactioni

    Protein-protein interaction databases

    BioGridi113315. 1 interaction.
    STRINGi9606.ENSP00000381739.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H1J5.
    SMRiQ9H1J5. Positions 31-337.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG277037.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    InParanoidiQ9H1J5.
    KOiK00714.
    OrthoDBiEOG7C8GJ8.
    PhylomeDBiQ9H1J5.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR013301. Wnt8.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF92. PTHR12027:SF92. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01892. WNT8PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H1J5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGNLFMLWAA LGICCAAFSA SAWSVNNFLI TGPKAYLTYT TSVALGAQSG    50
    IEECKFQFAW ERWNCPENAL QLSTHNRLRS ATRETSFIHA ISSAGVMYII 100
    TKNCSMGDFE NCGCDGSNNG KTGGHGWIWG GCSDNVEFGE RISKLFVDSL 150
    EKGKDARALM NLHNNRAGRL AVRATMKRTC KCHGISGSCS IQTCWLQLAE 200
    FREMGDYLKA KYDQALKIEM DKRQLRAGNS AEGHWVPAEA FLPSAEAELI 250
    FLEESPDYCT CNSSLGIYGT EGRECLQNSH NTSRWERRSC GRLCTECGLQ 300
    VEERKTEVIS SCNCKFQWCC TVKCDQCRHV VSKYYCARSP GSAQSLGKGS 350
    A 351
    Length:351
    Mass (Da):38,849
    Last modified:February 9, 2010 - v2
    Checksum:iB3432171301C17E5
    GO
    Isoform 2 (identifier: Q9H1J5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         348-351: KGSA → RVWFGVYI

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:355
    Mass (Da):39,527
    Checksum:i605B1D5DD755FBD6
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei348 – 3514KGSA → RVWFGVYI in isoform 2. 1 PublicationVSP_038706

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB057725 mRNA. Translation: BAB60960.1.
    AY009402 mRNA. Translation: AAG38662.1.
    CCDSiCCDS43368.1. [Q9H1J5-1]
    RefSeqiNP_490645.1. NM_058244.2. [Q9H1J5-1]
    XP_005272134.1. XM_005272077.1. [Q9H1J5-2]
    UniGeneiHs.591274.

    Genome annotation databases

    EnsembliENST00000361560; ENSP00000354726; ENSG00000061492. [Q9H1J5-2]
    ENST00000398754; ENSP00000381739; ENSG00000061492. [Q9H1J5-1]
    GeneIDi7478.
    KEGGihsa:7478.
    UCSCiuc003lcd.1. human. [Q9H1J5-1]

    Polymorphism databases

    DMDMi288558833.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB057725 mRNA. Translation: BAB60960.1 .
    AY009402 mRNA. Translation: AAG38662.1 .
    CCDSi CCDS43368.1. [Q9H1J5-1 ]
    RefSeqi NP_490645.1. NM_058244.2. [Q9H1J5-1 ]
    XP_005272134.1. XM_005272077.1. [Q9H1J5-2 ]
    UniGenei Hs.591274.

    3D structure databases

    ProteinModelPortali Q9H1J5.
    SMRi Q9H1J5. Positions 31-337.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113315. 1 interaction.
    STRINGi 9606.ENSP00000381739.

    PTM databases

    PhosphoSitei Q9H1J5.

    Polymorphism databases

    DMDMi 288558833.

    2D gel databases

    REPRODUCTION-2DPAGE Q9H1J5.

    Proteomic databases

    PaxDbi Q9H1J5.
    PRIDEi Q9H1J5.

    Protocols and materials databases

    DNASUi 7478.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361560 ; ENSP00000354726 ; ENSG00000061492 . [Q9H1J5-2 ]
    ENST00000398754 ; ENSP00000381739 ; ENSG00000061492 . [Q9H1J5-1 ]
    GeneIDi 7478.
    KEGGi hsa:7478.
    UCSCi uc003lcd.1. human. [Q9H1J5-1 ]

    Organism-specific databases

    CTDi 7478.
    GeneCardsi GC05P137447.
    HGNCi HGNC:12788. WNT8A.
    HPAi HPA038539.
    MIMi 606360. gene.
    neXtProti NX_Q9H1J5.
    PharmGKBi PA37389.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG277037.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    InParanoidi Q9H1J5.
    KOi K00714.
    OrthoDBi EOG7C8GJ8.
    PhylomeDBi Q9H1J5.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
    REACT_18372. Class B/2 (Secretin family receptors).
    REACT_200610. disassembly of the destruction complex and recruitment of AXIN to the membrane.
    REACT_200777. TCF dependent signaling in response to WNT.
    SignaLinki Q9H1J5.

    Miscellaneous databases

    GenomeRNAii 7478.
    NextBioi 29292.
    PROi Q9H1J5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H1J5.
    Bgeei Q9H1J5.
    CleanExi HS_WNT8A.
    Genevestigatori Q9H1J5.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR013301. Wnt8.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF92. PTHR12027:SF92. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01892. WNT8PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of human WNT8A."
      Saitoh T., Katoh M.
      Int. J. Oncol. 19:123-127(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Molecular cloning and characterization of six novel human WNT genes."
      Testa T.T., Mossakowska D.E., Carter P.S., Hu E., Zhu Y., Kelsell D.P., Murdock P.R., Herrity N.C., Lewis C.J., Cross D.A., Culbert A.A., Reith A.D., Barnes M.R.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).

    Entry informationi

    Entry nameiWNT8A_HUMAN
    AccessioniPrimary (citable) accession number: Q9H1J5
    Secondary accession number(s): Q96S51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3