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Q9H1J5 (WNT8A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-8a
Alternative name(s):
Protein Wnt-8d
Gene names
Name:WNT8A
Synonyms:WNT8D
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcanonical Wnt signaling pathway

Inferred from sequence or structural similarity. Source: BHF-UCL

canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment

Inferred from expression pattern PubMed 20559569. Source: BHF-UCL

canonical Wnt signaling pathway involved in neural crest cell differentiation

Inferred from sequence or structural similarity. Source: BHF-UCL

endoderm development

Inferred from electronic annotation. Source: Ensembl

establishment of organ orientation

Inferred from electronic annotation. Source: Ensembl

neural crest cell fate commitment

Inferred from sequence or structural similarity. Source: BHF-UCL

neuron differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

palate development

Inferred from mutant phenotype PubMed 18413325. Source: BHF-UCL

polarity specification of anterior/posterior axis

Inferred from electronic annotation. Source: Ensembl

polarity specification of proximal/distal axis

Inferred from electronic annotation. Source: Ensembl

regulation of protein localization

Inferred from electronic annotation. Source: Ensembl

regulation of transcription involved in anterior/posterior axis specification

Inferred from sequence or structural similarity. Source: BHF-UCL

response to retinoic acid

Non-traceable author statement PubMed 11956596. Source: BHF-UCL

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

proteinaceous extracellular matrix

Inferred from sequence or structural similarity. Source: BHF-UCL

   Molecular_functionfrizzled binding

Non-traceable author statement Ref.1. Source: BHF-UCL

receptor agonist activity

Non-traceable author statement Ref.1. Source: BHF-UCL

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H1J5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H1J5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     348-351: KGSA → RVWFGVYI
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 351327Protein Wnt-8a
PRO_0000041448

Amino acid modifications

Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation2621N-linked (GlcNAc...) Potential
Glycosylation2811N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence348 – 3514KGSA → RVWFGVYI in isoform 2.
VSP_038706

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 9, 2010. Version 2.
Checksum: B3432171301C17E5

FASTA35138,849
        10         20         30         40         50         60 
MGNLFMLWAA LGICCAAFSA SAWSVNNFLI TGPKAYLTYT TSVALGAQSG IEECKFQFAW 

        70         80         90        100        110        120 
ERWNCPENAL QLSTHNRLRS ATRETSFIHA ISSAGVMYII TKNCSMGDFE NCGCDGSNNG 

       130        140        150        160        170        180 
KTGGHGWIWG GCSDNVEFGE RISKLFVDSL EKGKDARALM NLHNNRAGRL AVRATMKRTC 

       190        200        210        220        230        240 
KCHGISGSCS IQTCWLQLAE FREMGDYLKA KYDQALKIEM DKRQLRAGNS AEGHWVPAEA 

       250        260        270        280        290        300 
FLPSAEAELI FLEESPDYCT CNSSLGIYGT EGRECLQNSH NTSRWERRSC GRLCTECGLQ 

       310        320        330        340        350 
VEERKTEVIS SCNCKFQWCC TVKCDQCRHV VSKYYCARSP GSAQSLGKGS A 

« Hide

Isoform 2 [UniParc].

Checksum: 605B1D5DD755FBD6
Show »

FASTA35539,527

References

[1]"Molecular cloning and characterization of human WNT8A."
Saitoh T., Katoh M.
Int. J. Oncol. 19:123-127(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Molecular cloning and characterization of six novel human WNT genes."
Testa T.T., Mossakowska D.E., Carter P.S., Hu E., Zhu Y., Kelsell D.P., Murdock P.R., Herrity N.C., Lewis C.J., Cross D.A., Culbert A.A., Reith A.D., Barnes M.R.
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB057725 mRNA. Translation: BAB60960.1.
AY009402 mRNA. Translation: AAG38662.1.
RefSeqNP_490645.1. NM_058244.2.
XP_005272134.1. XM_005272077.1.
UniGeneHs.591274.

3D structure databases

ProteinModelPortalQ9H1J5.
SMRQ9H1J5. Positions 31-337.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113315. 1 interaction.
STRING9606.ENSP00000381739.

PTM databases

PhosphoSiteQ9H1J5.

Polymorphism databases

DMDM288558833.

2D gel databases

REPRODUCTION-2DPAGEQ9H1J5.

Proteomic databases

PaxDbQ9H1J5.
PRIDEQ9H1J5.

Protocols and materials databases

DNASU7478.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361560; ENSP00000354726; ENSG00000061492. [Q9H1J5-2]
ENST00000398754; ENSP00000381739; ENSG00000061492. [Q9H1J5-1]
GeneID7478.
KEGGhsa:7478.
UCSCuc003lcd.1. human. [Q9H1J5-1]

Organism-specific databases

CTD7478.
GeneCardsGC05P137447.
HGNCHGNC:12788. WNT8A.
HPAHPA038539.
MIM606360. gene.
neXtProtNX_Q9H1J5.
PharmGKBPA37389.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG277037.
HOGENOMHOG000039529.
HOVERGENHBG001595.
InParanoidQ9H1J5.
KOK00714.
OrthoDBEOG7C8GJ8.
PhylomeDBQ9H1J5.
TreeFamTF105310.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
SignaLinkQ9H1J5.

Gene expression databases

ArrayExpressQ9H1J5.
BgeeQ9H1J5.
CleanExHS_WNT8A.
GenevestigatorQ9H1J5.

Family and domain databases

InterProIPR005817. Wnt.
IPR013301. Wnt8.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF6. PTHR12027:SF6. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01892. WNT8PROTEIN.
PR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi7478.
NextBio29292.
PROQ9H1J5.
SOURCESearch...

Entry information

Entry nameWNT8A_HUMAN
AccessionPrimary (citable) accession number: Q9H1J5
Secondary accession number(s): Q96S51
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: February 9, 2010
Last modified: April 16, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM