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Q9H1J5

- WNT8A_HUMAN

UniProt

Q9H1J5 - WNT8A_HUMAN

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Protein

Protein Wnt-8a

Gene

WNT8A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.

GO - Molecular functioni

  1. frizzled binding Source: BHF-UCL
  2. receptor agonist activity Source: BHF-UCL

GO - Biological processi

  1. canonical Wnt signaling pathway Source: BHF-UCL
  2. canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment Source: BHF-UCL
  3. canonical Wnt signaling pathway involved in neural crest cell differentiation Source: BHF-UCL
  4. endoderm development Source: Ensembl
  5. establishment of organ orientation Source: Ensembl
  6. neural crest cell fate commitment Source: BHF-UCL
  7. neuron differentiation Source: RefGenome
  8. palate development Source: BHF-UCL
  9. polarity specification of anterior/posterior axis Source: Ensembl
  10. polarity specification of proximal/distal axis Source: Ensembl
  11. regulation of protein localization Source: Ensembl
  12. regulation of transcription involved in anterior/posterior axis specification Source: BHF-UCL
  13. response to retinoic acid Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).
REACT_200610. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_200777. TCF dependent signaling in response to WNT.
SignaLinkiQ9H1J5.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-8a
Alternative name(s):
Protein Wnt-8d
Gene namesi
Name:WNT8A
Synonyms:WNT8D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:12788. WNT8A.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: RefGenome
  3. proteinaceous extracellular matrix Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37389.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 351327Protein Wnt-8aPRO_0000041448Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 65By similarity
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi104 ↔ 112By similarity
Disulfide bondi114 ↔ 132By similarity
Disulfide bondi180 ↔ 194By similarity
Disulfide bondi182 ↔ 189By similarity
Disulfide bondi259 ↔ 297By similarity
Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi275 ↔ 290By similarity
Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi294 ↔ 336By similarity
Disulfide bondi312 ↔ 327By similarity
Disulfide bondi314 ↔ 324By similarity
Disulfide bondi319 ↔ 320By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H1J5.
PRIDEiQ9H1J5.

2D gel databases

REPRODUCTION-2DPAGEQ9H1J5.

PTM databases

PhosphoSiteiQ9H1J5.

Expressioni

Gene expression databases

BgeeiQ9H1J5.
CleanExiHS_WNT8A.
ExpressionAtlasiQ9H1J5. baseline.
GenevestigatoriQ9H1J5.

Organism-specific databases

HPAiHPA038539.

Interactioni

Protein-protein interaction databases

BioGridi113315. 1 interaction.
STRINGi9606.ENSP00000381739.

Structurei

3D structure databases

ProteinModelPortaliQ9H1J5.
SMRiQ9H1J5. Positions 31-337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG277037.
GeneTreeiENSGT00690000101857.
HOGENOMiHOG000039529.
HOVERGENiHBG001595.
InParanoidiQ9H1J5.
KOiK00714.
OrthoDBiEOG7C8GJ8.
PhylomeDBiQ9H1J5.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR013301. Wnt8.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF92. PTHR12027:SF92. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01892. WNT8PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H1J5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNLFMLWAA LGICCAAFSA SAWSVNNFLI TGPKAYLTYT TSVALGAQSG
60 70 80 90 100
IEECKFQFAW ERWNCPENAL QLSTHNRLRS ATRETSFIHA ISSAGVMYII
110 120 130 140 150
TKNCSMGDFE NCGCDGSNNG KTGGHGWIWG GCSDNVEFGE RISKLFVDSL
160 170 180 190 200
EKGKDARALM NLHNNRAGRL AVRATMKRTC KCHGISGSCS IQTCWLQLAE
210 220 230 240 250
FREMGDYLKA KYDQALKIEM DKRQLRAGNS AEGHWVPAEA FLPSAEAELI
260 270 280 290 300
FLEESPDYCT CNSSLGIYGT EGRECLQNSH NTSRWERRSC GRLCTECGLQ
310 320 330 340 350
VEERKTEVIS SCNCKFQWCC TVKCDQCRHV VSKYYCARSP GSAQSLGKGS

A
Length:351
Mass (Da):38,849
Last modified:February 9, 2010 - v2
Checksum:iB3432171301C17E5
GO
Isoform 2 (identifier: Q9H1J5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-351: KGSA → RVWFGVYI

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:355
Mass (Da):39,527
Checksum:i605B1D5DD755FBD6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei348 – 3514KGSA → RVWFGVYI in isoform 2. 1 PublicationVSP_038706

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB057725 mRNA. Translation: BAB60960.1.
AY009402 mRNA. Translation: AAG38662.1.
CCDSiCCDS43368.1. [Q9H1J5-1]
RefSeqiNP_490645.1. NM_058244.3. [Q9H1J5-1]
XP_005272134.1. XM_005272077.1. [Q9H1J5-2]
UniGeneiHs.591274.

Genome annotation databases

EnsembliENST00000361560; ENSP00000354726; ENSG00000061492. [Q9H1J5-2]
ENST00000398754; ENSP00000381739; ENSG00000061492. [Q9H1J5-1]
GeneIDi7478.
KEGGihsa:7478.
UCSCiuc003lcd.1. human. [Q9H1J5-1]

Polymorphism databases

DMDMi288558833.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB057725 mRNA. Translation: BAB60960.1 .
AY009402 mRNA. Translation: AAG38662.1 .
CCDSi CCDS43368.1. [Q9H1J5-1 ]
RefSeqi NP_490645.1. NM_058244.3. [Q9H1J5-1 ]
XP_005272134.1. XM_005272077.1. [Q9H1J5-2 ]
UniGenei Hs.591274.

3D structure databases

ProteinModelPortali Q9H1J5.
SMRi Q9H1J5. Positions 31-337.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113315. 1 interaction.
STRINGi 9606.ENSP00000381739.

PTM databases

PhosphoSitei Q9H1J5.

Polymorphism databases

DMDMi 288558833.

2D gel databases

REPRODUCTION-2DPAGE Q9H1J5.

Proteomic databases

PaxDbi Q9H1J5.
PRIDEi Q9H1J5.

Protocols and materials databases

DNASUi 7478.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361560 ; ENSP00000354726 ; ENSG00000061492 . [Q9H1J5-2 ]
ENST00000398754 ; ENSP00000381739 ; ENSG00000061492 . [Q9H1J5-1 ]
GeneIDi 7478.
KEGGi hsa:7478.
UCSCi uc003lcd.1. human. [Q9H1J5-1 ]

Organism-specific databases

CTDi 7478.
GeneCardsi GC05P137447.
HGNCi HGNC:12788. WNT8A.
HPAi HPA038539.
MIMi 606360. gene.
neXtProti NX_Q9H1J5.
PharmGKBi PA37389.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG277037.
GeneTreei ENSGT00690000101857.
HOGENOMi HOG000039529.
HOVERGENi HBG001595.
InParanoidi Q9H1J5.
KOi K00714.
OrthoDBi EOG7C8GJ8.
PhylomeDBi Q9H1J5.
TreeFami TF105310.

Enzyme and pathway databases

Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).
REACT_200610. disassembly of the destruction complex and recruitment of AXIN to the membrane.
REACT_200777. TCF dependent signaling in response to WNT.
SignaLinki Q9H1J5.

Miscellaneous databases

GenomeRNAii 7478.
NextBioi 29292.
PROi Q9H1J5.
SOURCEi Search...

Gene expression databases

Bgeei Q9H1J5.
CleanExi HS_WNT8A.
ExpressionAtlasi Q9H1J5. baseline.
Genevestigatori Q9H1J5.

Family and domain databases

InterProi IPR005817. Wnt.
IPR013301. Wnt8.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
PTHR12027:SF92. PTHR12027:SF92. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01892. WNT8PROTEIN.
PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of human WNT8A."
    Saitoh T., Katoh M.
    Int. J. Oncol. 19:123-127(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Molecular cloning and characterization of six novel human WNT genes."
    Testa T.T., Mossakowska D.E., Carter P.S., Hu E., Zhu Y., Kelsell D.P., Murdock P.R., Herrity N.C., Lewis C.J., Cross D.A., Culbert A.A., Reith A.D., Barnes M.R.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).

Entry informationi

Entry nameiWNT8A_HUMAN
AccessioniPrimary (citable) accession number: Q9H1J5
Secondary accession number(s): Q96S51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: February 9, 2010
Last modified: October 29, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3