##gff-version 3 Q9H1I8 UniProtKB Chain 1 757 . . . ID=PRO_0000064689;Note=Activating signal cointegrator 1 complex subunit 2 Q9H1I8 UniProtKB Domain 467 510 . . . Note=CUE;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00468 Q9H1I8 UniProtKB Region 617 687 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H1I8 UniProtKB Region 699 757 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H1I8 UniProtKB Compositional bias 657 671 . . . Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H1I8 UniProtKB Compositional bias 672 687 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H1I8 UniProtKB Compositional bias 720 742 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9H1I8 UniProtKB Modified residue 233 233 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q9H1I8 UniProtKB Modified residue 447 447 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q9H1I8 UniProtKB Modified residue 632 632 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q9H1I8 UniProtKB Modified residue 713 713 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:17924679,ECO:0007744|PubMed:20068231;Dbxref=PMID:17924679,PMID:20068231 Q9H1I8 UniProtKB Alternative sequence 1 114 . . . ID=VSP_011009;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q9H1I8 UniProtKB Alternative sequence 28 80 . . . ID=VSP_045878;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q9H1I8 UniProtKB Alternative sequence 137 159 . . . ID=VSP_045879;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q9H1I8 UniProtKB Alternative sequence 483 484 . . . ID=VSP_011010;Note=In isoform 2. GE->EK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q9H1I8 UniProtKB Alternative sequence 485 757 . . . ID=VSP_011011;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q9H1I8 UniProtKB Natural variant 96 96 . . . ID=VAR_050675;Note=R->C;Dbxref=dbSNP:rs1894473 Q9H1I8 UniProtKB Natural variant 123 123 . . . ID=VAR_050676;Note=V->I;Dbxref=dbSNP:rs11549795 Q9H1I8 UniProtKB Natural variant 407 407 . . . ID=VAR_025512;Note=D->H;Dbxref=dbSNP:rs28265 Q9H1I8 UniProtKB Natural variant 423 423 . . . ID=VAR_025513;Note=P->S;Dbxref=dbSNP:rs36571 Q9H1I8 UniProtKB Natural variant 509 509 . . . ID=VAR_019464;Note=R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12077347;Dbxref=dbSNP:rs4823054,PMID:12077347 Q9H1I8 UniProtKB Natural variant 546 546 . . . ID=VAR_050677;Note=D->G;Dbxref=dbSNP:rs34833047 Q9H1I8 UniProtKB Natural variant 588 588 . . . ID=VAR_050678;Note=E->K;Dbxref=dbSNP:rs34062345 Q9H1I8 UniProtKB Natural variant 639 639 . . . ID=VAR_025514;Note=R->L;Dbxref=dbSNP:rs6006259 Q9H1I8 UniProtKB Mutagenesis 478 479 . . . Note=Loss of ubiquitin binding. LL->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29144457;Dbxref=PMID:29144457 Q9H1I8 UniProtKB Mutagenesis 479 491 . . . Note=Decreases ubiquitin binding. LPDLGEGFILACL->AADLGEGFALACA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32099016;Dbxref=PMID:32099016 Q9H1I8 UniProtKB Mutagenesis 506 506 . . . Note=Loss of ubiquitin binding. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29144457;Dbxref=PMID:29144457 Q9H1I8 UniProtKB Sequence conflict 344 344 . . . Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H1I8 UniProtKB Sequence conflict 526 526 . . . Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H1I8 UniProtKB Sequence conflict 586 586 . . . Note=R->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H1I8 UniProtKB Sequence conflict 639 639 . . . Note=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H1I8 UniProtKB Sequence conflict 645 645 . . . Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H1I8 UniProtKB Sequence conflict 653 653 . . . Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H1I8 UniProtKB Sequence conflict 661 661 . . . Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H1I8 UniProtKB Sequence conflict 744 744 . . . Note=T->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9H1I8 UniProtKB Helix 6 8 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Beta strand 10 14 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Beta strand 21 27 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 29 31 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 49 71 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 74 83 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 85 97 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 110 131 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Beta strand 133 140 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 143 152 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 158 168 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Turn 169 171 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 173 186 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 189 211 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Turn 234 236 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 239 262 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 264 266 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 267 271 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Turn 272 274 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 275 296 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 297 299 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 302 330 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 332 336 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 344 355 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Turn 356 359 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 361 370 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 373 383 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 390 404 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6YXQ Q9H1I8 UniProtKB Helix 466 478 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2DI0 Q9H1I8 UniProtKB Helix 484 493 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2DI0 Q9H1I8 UniProtKB Turn 494 496 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2DI0 Q9H1I8 UniProtKB Helix 498 506 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2DI0 Q9H1I8 UniProtKB Turn 512 516 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2DI0