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Protein

Activating signal cointegrator 1 complex subunit 2

Gene

ASCC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enhances NF-kappa-B, SRF and AP1 transactivation.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-112126. ALKBH3 mediated reversal of alkylation damage.

Names & Taxonomyi

Protein namesi
Recommended name:
Activating signal cointegrator 1 complex subunit 2
Alternative name(s):
ASC-1 complex subunit p100
Trip4 complex subunit p100
Gene namesi
Name:ASCC2
Synonyms:ASC1P100
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:24103. ASCC2.

Subcellular locationi

GO - Cellular componenti

  • activating signal cointegrator 1 complex Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84164.
OpenTargetsiENSG00000100325.
PharmGKBiPA134916940.

Polymorphism and mutation databases

BioMutaiASCC2.
DMDMi92090990.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000646891 – 757Activating signal cointegrator 1 complex subunit 2Add BLAST757

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei233PhosphothreonineCombined sources1
Modified residuei447PhosphoserineCombined sources1
Modified residuei632PhosphoserineCombined sources1
Modified residuei713PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H1I8.
MaxQBiQ9H1I8.
PaxDbiQ9H1I8.
PeptideAtlasiQ9H1I8.
PRIDEiQ9H1I8.

PTM databases

iPTMnetiQ9H1I8.
PhosphoSitePlusiQ9H1I8.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000100325.
CleanExiHS_ASCC2.
ExpressionAtlasiQ9H1I8. baseline and differential.
GenevisibleiQ9H1I8. HS.

Organism-specific databases

HPAiHPA001439.

Interactioni

Subunit structurei

Part of the ASC-1 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3. The ASC-1 complex interacts with ALKBH3. Interacts with CSRP1.3 Publications

Protein-protein interaction databases

BioGridi123921. 54 interactors.
IntActiQ9H1I8. 50 interactors.
MINTiMINT-1182192.
STRINGi9606.ENSP00000305502.

Structurei

Secondary structure

1757
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi466 – 478Combined sources13
Helixi484 – 493Combined sources10
Turni494 – 496Combined sources3
Helixi498 – 506Combined sources9
Turni512 – 516Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DI0NMR-A463-526[»]
ProteinModelPortaliQ9H1I8.
SMRiQ9H1I8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H1I8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini467 – 510CUEPROSITE-ProRule annotationAdd BLAST44

Sequence similaritiesi

Belongs to the ASCC2 family.Curated
Contains 1 CUE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4501. Eukaryota.
ENOG410XSUE. LUCA.
GeneTreeiENSGT00390000018806.
HOGENOMiHOG000234347.
HOVERGENiHBG050589.
InParanoidiQ9H1I8.
KOiK18667.
OMAiQANSLRW.
OrthoDBiEOG091G06RW.
PhylomeDBiQ9H1I8.
TreeFamiTF323459.

Family and domain databases

InterProiIPR003892. CUE.
IPR009060. UBA-like.
[Graphical view]
PfamiPF02845. CUE. 1 hit.
[Graphical view]
SMARTiSM00546. CUE. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS51140. CUE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H1I8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPALPLDQLQ ITHKDPKTGK LRTSPALHPE QKADRYFVLY KPPPKDNIPA
60 70 80 90 100
LVEEYLERAT FVANDLDWLL ALPHDKFWCQ VIFDETLQKC LDSYLRYVPR
110 120 130 140 150
KFDEGVASAP EVVDMQKRLH RSVFLTFLRM STHKESKDHF ISPSAFGEIL
160 170 180 190 200
YNNFLFDIPK ILDLCVLFGK GNSPLLQKMI GNIFTQQPSY YSDLDETLPT
210 220 230 240 250
ILQVFSNILQ HCGLQGDGAN TTPQKLEERG RLTPSDMPLL ELKDIVLYLC
260 270 280 290 300
DTCTTLWAFL DIFPLACQTF QKHDFCYRLA SFYEAAIPEM ESAIKKRRLE
310 320 330 340 350
DSKLLGDLWQ RLSHSRKKLM EIFHIILNQI CLLPILESSC DNIQGFIEEF
360 370 380 390 400
LQIFSSLLQE KRFLRDYDAL FPVAEDISLL QQASSVLDET RTAYILQAVE
410 420 430 440 450
SAWEGVDRRK ATDAKDPSVI EEPNGEPNGV TVTAEAVSQA SSHPENSEEE
460 470 480 490 500
ECMGAAAAVG PAMCGVELDS LISQVKDLLP DLGEGFILAC LEYYHYDPEQ
510 520 530 540 550
VINNILEERL APTLSQLDRN LDREMKPDPT PLLTSRHNVF QNDEFDVFSR
560 570 580 590 600
DSVDLSRVHK GKSTRKEENT RSLLNDKRAV AAQRQRYEQY SVVVEEVPLQ
610 620 630 640 650
PGESLPYHSV YYEDEYDDTY DGNQVGANDA DSDDELISRR PFTIPQVLRT
660 670 680 690 700
KVPREGQEED DDDEEDDADE EAPKPDHFVQ DPAVLREKAE ARRMAFLAKK
710 720 730 740 750
GYRHDSSTAV AGSPRGHGQS RETTQERRKK EANKATRANH NRRTMADRKR

SKGMIPS
Length:757
Mass (Da):86,360
Last modified:March 7, 2006 - v3
Checksum:iBB1DCE21E3068E64
GO
Isoform 2 (identifier: Q9H1I8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.
     483-484: GE → EK
     485-757: Missing.

Note: No experimental confirmation available.
Show »
Length:370
Mass (Da):41,794
Checksum:iA89920B986C9E9B7
GO
Isoform 3 (identifier: Q9H1I8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-80: Missing.
     137-159: Missing.

Note: No experimental confirmation available.
Show »
Length:681
Mass (Da):77,369
Checksum:iB2D69EB5D82C311E
GO

Sequence cautioni

The sequence BAB15089 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti344Q → H in BAB15089 (PubMed:14702039).Curated1
Sequence conflicti526K → N in BAB15089 (PubMed:14702039).Curated1
Sequence conflicti586R → C in BAB15089 (PubMed:14702039).Curated1
Sequence conflicti639R → G in BAH13926 (PubMed:14702039).Curated1
Sequence conflicti645P → L in AAG45475 (PubMed:12077347).Curated1
Sequence conflicti653P → L in AAG45475 (PubMed:12077347).Curated1
Sequence conflicti661D → G in BAH13926 (PubMed:14702039).Curated1
Sequence conflicti744T → I in BAH13926 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05067596R → C.Corresponds to variant rs1894473dbSNPEnsembl.1
Natural variantiVAR_050676123V → I.Corresponds to variant rs11549795dbSNPEnsembl.1
Natural variantiVAR_025512407D → H.Corresponds to variant rs28265dbSNPEnsembl.1
Natural variantiVAR_025513423P → S.Corresponds to variant rs36571dbSNPEnsembl.1
Natural variantiVAR_019464509R → Q.1 PublicationCorresponds to variant rs4823054dbSNPEnsembl.1
Natural variantiVAR_050677546D → G.Corresponds to variant rs34833047dbSNPEnsembl.1
Natural variantiVAR_050678588E → K.Corresponds to variant rs34062345dbSNPEnsembl.1
Natural variantiVAR_025514639R → L.Corresponds to variant rs6006259dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0110091 – 114Missing in isoform 2. 1 PublicationAdd BLAST114
Alternative sequenceiVSP_04587828 – 80Missing in isoform 3. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_045879137 – 159Missing in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_011010483 – 484GE → EK in isoform 2. 1 Publication2
Alternative sequenceiVSP_011011485 – 757Missing in isoform 2. 1 PublicationAdd BLAST273

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY013289 mRNA. Translation: AAG45475.1.
AK022886 mRNA. Translation: BAB14293.1.
AK025241 mRNA. Translation: BAB15089.1. Different initiation.
AK303257 mRNA. Translation: BAH13926.1.
Z82171, AC004882 Genomic DNA. Translation: CAI95602.1.
BC025368 mRNA. Translation: AAH25368.1.
CCDSiCCDS13869.1. [Q9H1I8-1]
CCDS56226.1. [Q9H1I8-3]
RefSeqiNP_001229835.1. NM_001242906.1. [Q9H1I8-3]
NP_115580.2. NM_032204.4. [Q9H1I8-1]
XP_005261832.1. XM_005261775.2. [Q9H1I8-1]
XP_016884487.1. XM_017028998.1. [Q9H1I8-1]
XP_016884488.1. XM_017028999.1. [Q9H1I8-1]
XP_016884489.1. XM_017029000.1. [Q9H1I8-1]
UniGeneiHs.731754.

Genome annotation databases

EnsembliENST00000307790; ENSP00000305502; ENSG00000100325. [Q9H1I8-1]
ENST00000397771; ENSP00000380877; ENSG00000100325. [Q9H1I8-1]
ENST00000542393; ENSP00000437570; ENSG00000100325. [Q9H1I8-3]
GeneIDi84164.
KEGGihsa:84164.
UCSCiuc003agr.4. human. [Q9H1I8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY013289 mRNA. Translation: AAG45475.1.
AK022886 mRNA. Translation: BAB14293.1.
AK025241 mRNA. Translation: BAB15089.1. Different initiation.
AK303257 mRNA. Translation: BAH13926.1.
Z82171, AC004882 Genomic DNA. Translation: CAI95602.1.
BC025368 mRNA. Translation: AAH25368.1.
CCDSiCCDS13869.1. [Q9H1I8-1]
CCDS56226.1. [Q9H1I8-3]
RefSeqiNP_001229835.1. NM_001242906.1. [Q9H1I8-3]
NP_115580.2. NM_032204.4. [Q9H1I8-1]
XP_005261832.1. XM_005261775.2. [Q9H1I8-1]
XP_016884487.1. XM_017028998.1. [Q9H1I8-1]
XP_016884488.1. XM_017028999.1. [Q9H1I8-1]
XP_016884489.1. XM_017029000.1. [Q9H1I8-1]
UniGeneiHs.731754.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DI0NMR-A463-526[»]
ProteinModelPortaliQ9H1I8.
SMRiQ9H1I8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123921. 54 interactors.
IntActiQ9H1I8. 50 interactors.
MINTiMINT-1182192.
STRINGi9606.ENSP00000305502.

PTM databases

iPTMnetiQ9H1I8.
PhosphoSitePlusiQ9H1I8.

Polymorphism and mutation databases

BioMutaiASCC2.
DMDMi92090990.

Proteomic databases

EPDiQ9H1I8.
MaxQBiQ9H1I8.
PaxDbiQ9H1I8.
PeptideAtlasiQ9H1I8.
PRIDEiQ9H1I8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307790; ENSP00000305502; ENSG00000100325. [Q9H1I8-1]
ENST00000397771; ENSP00000380877; ENSG00000100325. [Q9H1I8-1]
ENST00000542393; ENSP00000437570; ENSG00000100325. [Q9H1I8-3]
GeneIDi84164.
KEGGihsa:84164.
UCSCiuc003agr.4. human. [Q9H1I8-1]

Organism-specific databases

CTDi84164.
DisGeNETi84164.
GeneCardsiASCC2.
HGNCiHGNC:24103. ASCC2.
HPAiHPA001439.
MIMi614216. gene.
neXtProtiNX_Q9H1I8.
OpenTargetsiENSG00000100325.
PharmGKBiPA134916940.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4501. Eukaryota.
ENOG410XSUE. LUCA.
GeneTreeiENSGT00390000018806.
HOGENOMiHOG000234347.
HOVERGENiHBG050589.
InParanoidiQ9H1I8.
KOiK18667.
OMAiQANSLRW.
OrthoDBiEOG091G06RW.
PhylomeDBiQ9H1I8.
TreeFamiTF323459.

Enzyme and pathway databases

ReactomeiR-HSA-112126. ALKBH3 mediated reversal of alkylation damage.

Miscellaneous databases

ChiTaRSiASCC2. human.
EvolutionaryTraceiQ9H1I8.
GeneWikiiASCC2.
GenomeRNAii84164.
PROiQ9H1I8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100325.
CleanExiHS_ASCC2.
ExpressionAtlasiQ9H1I8. baseline and differential.
GenevisibleiQ9H1I8. HS.

Family and domain databases

InterProiIPR003892. CUE.
IPR009060. UBA-like.
[Graphical view]
PfamiPF02845. CUE. 1 hit.
[Graphical view]
SMARTiSM00546. CUE. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS51140. CUE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASCC2_HUMAN
AccessioniPrimary (citable) accession number: Q9H1I8
Secondary accession number(s): B7Z8E0
, F5H6J9, Q4TT54, Q8TAZ0, Q9H711, Q9H9D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 7, 2006
Last modified: November 2, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.