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Q9H1I8 (ASCC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Activating signal cointegrator 1 complex subunit 2
Alternative name(s):
ASC-1 complex subunit p100
Trip4 complex subunit p100
Gene names
Name:ASCC2
Synonyms:ASC1P100
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length757 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Enhances NF-kappa-B, SRF and AP1 transactivation.

Subunit structure

Part of TRIP4 complex, that contains ASCC1, ASCC2 and ASCC3. The TRIP4 complex interacts with ALKHB3. Ref.1 Ref.8

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the ASCC2 family.

Contains 1 CUE domain.

Sequence caution

The sequence BAB15089.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H1I8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H1I8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.
     483-484: GE → EK
     485-757: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9H1I8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     28-80: Missing.
     137-159: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 757757Activating signal cointegrator 1 complex subunit 2
PRO_0000064689

Regions

Domain467 – 51044CUE

Amino acid modifications

Modified residue7131Phosphoserine Ref.5 Ref.6

Natural variations

Alternative sequence1 – 114114Missing in isoform 2.
VSP_011009
Alternative sequence28 – 8053Missing in isoform 3.
VSP_045878
Alternative sequence137 – 15923Missing in isoform 3.
VSP_045879
Alternative sequence483 – 4842GE → EK in isoform 2.
VSP_011010
Alternative sequence485 – 757273Missing in isoform 2.
VSP_011011
Natural variant961R → C.
Corresponds to variant rs1894473 [ dbSNP | Ensembl ].
VAR_050675
Natural variant1231V → I.
Corresponds to variant rs11549795 [ dbSNP | Ensembl ].
VAR_050676
Natural variant4071D → H.
Corresponds to variant rs28265 [ dbSNP | Ensembl ].
VAR_025512
Natural variant4231P → S.
Corresponds to variant rs36571 [ dbSNP | Ensembl ].
VAR_025513
Natural variant5091R → Q. Ref.1
Corresponds to variant rs4823054 [ dbSNP | Ensembl ].
VAR_019464
Natural variant5461D → G.
Corresponds to variant rs34833047 [ dbSNP | Ensembl ].
VAR_050677
Natural variant5881E → K.
Corresponds to variant rs34062345 [ dbSNP | Ensembl ].
VAR_050678
Natural variant6391R → L.
Corresponds to variant rs6006259 [ dbSNP | Ensembl ].
VAR_025514

Experimental info

Sequence conflict3441Q → H in BAB15089. Ref.2
Sequence conflict5261K → N in BAB15089. Ref.2
Sequence conflict5861R → C in BAB15089. Ref.2
Sequence conflict6391R → G in BAH13926. Ref.2
Sequence conflict6451P → L in AAG45475. Ref.1
Sequence conflict6531P → L in AAG45475. Ref.1
Sequence conflict6611D → G in BAH13926. Ref.2
Sequence conflict7441T → I in BAH13926. Ref.2

Secondary structure

.......... 757
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 7, 2006. Version 3.
Checksum: BB1DCE21E3068E64

FASTA75786,360
        10         20         30         40         50         60 
MPALPLDQLQ ITHKDPKTGK LRTSPALHPE QKADRYFVLY KPPPKDNIPA LVEEYLERAT 

        70         80         90        100        110        120 
FVANDLDWLL ALPHDKFWCQ VIFDETLQKC LDSYLRYVPR KFDEGVASAP EVVDMQKRLH 

       130        140        150        160        170        180 
RSVFLTFLRM STHKESKDHF ISPSAFGEIL YNNFLFDIPK ILDLCVLFGK GNSPLLQKMI 

       190        200        210        220        230        240 
GNIFTQQPSY YSDLDETLPT ILQVFSNILQ HCGLQGDGAN TTPQKLEERG RLTPSDMPLL 

       250        260        270        280        290        300 
ELKDIVLYLC DTCTTLWAFL DIFPLACQTF QKHDFCYRLA SFYEAAIPEM ESAIKKRRLE 

       310        320        330        340        350        360 
DSKLLGDLWQ RLSHSRKKLM EIFHIILNQI CLLPILESSC DNIQGFIEEF LQIFSSLLQE 

       370        380        390        400        410        420 
KRFLRDYDAL FPVAEDISLL QQASSVLDET RTAYILQAVE SAWEGVDRRK ATDAKDPSVI 

       430        440        450        460        470        480 
EEPNGEPNGV TVTAEAVSQA SSHPENSEEE ECMGAAAAVG PAMCGVELDS LISQVKDLLP 

       490        500        510        520        530        540 
DLGEGFILAC LEYYHYDPEQ VINNILEERL APTLSQLDRN LDREMKPDPT PLLTSRHNVF 

       550        560        570        580        590        600 
QNDEFDVFSR DSVDLSRVHK GKSTRKEENT RSLLNDKRAV AAQRQRYEQY SVVVEEVPLQ 

       610        620        630        640        650        660 
PGESLPYHSV YYEDEYDDTY DGNQVGANDA DSDDELISRR PFTIPQVLRT KVPREGQEED 

       670        680        690        700        710        720 
DDDEEDDADE EAPKPDHFVQ DPAVLREKAE ARRMAFLAKK GYRHDSSTAV AGSPRGHGQS 

       730        740        750 
RETTQERRKK EANKATRANH NRRTMADRKR SKGMIPS 

« Hide

Isoform 2 [UniParc].

Checksum: A89920B986C9E9B7
Show »

FASTA37041,794
Isoform 3 [UniParc].

Checksum: B2D69EB5D82C311E
Show »

FASTA68177,369

References

« Hide 'large scale' references
[1]"Novel transcription coactivator complex containing activating signal cointegrator 1."
Jung D.-J., Sung H.-S., Goo Y.-W., Lee H.M., Park O.K., Jung S.-Y., Lim J., Kim H.-J., Lee S.-K., Kim T.S., Lee J.W., Lee Y.C.
Mol. Cell. Biol. 22:5203-5211(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, VARIANT GLN-509, INTERACTION WITH ASCC1 AND ASCC3.
Tissue: Cervix carcinoma.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Colon, Teratocarcinoma and Thymus.
[3]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Skin.
[5]"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-713, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-713, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation."
Dango S., Mosammaparast N., Sowa M.E., Xiong L.J., Wu F., Park K., Rubin M., Gygi S., Harper J.W., Shi Y.
Mol. Cell 44:373-384(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ALKHB3.
[9]"Solution structure of the CUE domain in the human activating signal cointegrator 1 complex subunit 2 (ASCC2)."
RIKEN structural genomics initiative (RSGI)
Submitted (SEP-2006) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 463-525.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY013289 mRNA. Translation: AAG45475.1.
AK022886 mRNA. Translation: BAB14293.1.
AK025241 mRNA. Translation: BAB15089.1. Different initiation.
AK303257 mRNA. Translation: BAH13926.1.
Z82171, AC004882 Genomic DNA. Translation: CAI95602.1.
BC025368 mRNA. Translation: AAH25368.1.
RefSeqNP_001229835.1. NM_001242906.1.
NP_115580.2. NM_032204.4.
XP_005261832.1. XM_005261775.1.
XP_005261833.1. XM_005261776.1.
UniGeneHs.731754.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2DI0NMR-A463-525[»]
ProteinModelPortalQ9H1I8.
SMRQ9H1I8. Positions 463-525.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123921. 39 interactions.
IntActQ9H1I8. 34 interactions.
MINTMINT-1182192.
STRING9606.ENSP00000305502.

PTM databases

PhosphoSiteQ9H1I8.

Polymorphism databases

DMDM92090990.

Proteomic databases

PaxDbQ9H1I8.
PeptideAtlasQ9H1I8.
PRIDEQ9H1I8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000307790; ENSP00000305502; ENSG00000100325. [Q9H1I8-1]
ENST00000397771; ENSP00000380877; ENSG00000100325. [Q9H1I8-1]
ENST00000542393; ENSP00000437570; ENSG00000100325. [Q9H1I8-3]
GeneID84164.
KEGGhsa:84164.
UCSCuc003agr.3. human. [Q9H1I8-1]

Organism-specific databases

CTD84164.
GeneCardsGC22M030184.
HGNCHGNC:24103. ASCC2.
HPAHPA001439.
MIM614216. gene.
neXtProtNX_Q9H1I8.
PharmGKBPA134916940.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG245009.
HOGENOMHOG000234347.
HOVERGENHBG050589.
InParanoidQ9H1I8.
OMAMPTILQV.
OrthoDBEOG708VZP.
PhylomeDBQ9H1I8.
TreeFamTF323459.

Gene expression databases

ArrayExpressQ9H1I8.
BgeeQ9H1I8.
CleanExHS_ASCC2.
GenevestigatorQ9H1I8.

Family and domain databases

InterProIPR003892. CUE.
IPR009060. UBA-like.
[Graphical view]
PfamPF02845. CUE. 1 hit.
[Graphical view]
SMARTSM00546. CUE. 1 hit.
[Graphical view]
SUPFAMSSF46934. SSF46934. 1 hit.
PROSITEPS51140. CUE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSASCC2. human.
EvolutionaryTraceQ9H1I8.
GeneWikiASCC2.
GenomeRNAi84164.
NextBio73512.
PROQ9H1I8.
SOURCESearch...

Entry information

Entry nameASCC2_HUMAN
AccessionPrimary (citable) accession number: Q9H1I8
Secondary accession number(s): B7Z8E0 expand/collapse secondary AC list , F5H6J9, Q4TT54, Q8TAZ0, Q9H711, Q9H9D6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 7, 2006
Last modified: March 19, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM