Q9H1H9 (KI13A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kinesin-like protein KIF13A

Alternative name(s):
Kinesin-like protein RBKIN

Gene names

Name:	KIF13A
Synonyms:	RBKIN

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1805 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis. Ref.6 Ref.7
Subunit structure	Interacts with AP2B1 By similarity. Interacts with ZFYVE26. Interacts with AP1G1 and AP1G2. Ref.6 Ref.7
Subcellular location	Cytoplasm › cytoskeleton › centrosome. Midbody. Endosome membrane. Golgi apparatus membrane By similarity. Note: Recruited to the midbody during cytokinesis. Ref.6 Ref.7
Tissue specificity	Widely expressed, with highest levels in heart, brain and skeletal muscle. Ref.1 Ref.2
Developmental stage	Expressed at very low level in most fetal tissues, but at higher levels in skeletal muscle and lung. Ref.2
Sequence similarities	Belongs to the kinesin-like protein family. Contains 1 FHA domain. Contains 1 kinesin-motor domain.
Sequence caution	The sequence CAI21670.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI21671.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI40947.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI40948.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Cell cycle Cell division Protein transport Transport
Cellular component	Cytoplasm Cytoskeleton Endosome Golgi apparatus Membrane Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Golgi to plasma membrane protein transport Inferred from sequence or structural similarity. Source: UniProtKB cargo loading into vesicle Inferred from mutant phenotype Ref.6. Source: UniProtKB cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cytokinesis Inferred from mutant phenotype Ref.7. Source: UniProtKB endosome to lysosome transport Inferred from mutant phenotype Ref.6. Source: UniProtKB melanosome organization Inferred from mutant phenotype Ref.6. Source: UniProtKB plus-end-directed vesicle transport along microtubule Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell centrosome Inferred from direct assay Ref.7. Source: UniProtKB endosome membrane Inferred from direct assay Ref.6. Source: UniProtKB microtubule Inferred from electronic annotation. Source: UniProtKB-KW microtubule associated complex Inferred from electronic annotation. Source: InterPro midbody Inferred from direct assay Ref.7. Source: UniProtKB trans-Golgi network membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H1H9-1)

Also known as: RBKIN1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H1H9-2)

Also known as: RBKIN2;

The sequence of this isoform differs from the canonical sequence as follows:
     1493-1527: Missing.

Isoform 3 (identifier: Q9H1H9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1071-1083: Missing.
     1493-1527: Missing.
     1792-1797: VIIPEA → GGTTSR
     1798-1805: Missing.

Isoform 4 (identifier: Q9H1H9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1071-1083: Missing.
     1493-1527: Missing.

Isoform 5 (identifier: Q9H1H9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     50-70: KPPKVFAFDYCFWSMDESNTT → LVTVAHISNSSTLGGQGKRIT
     71-1805: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1805	1805	Kinesin-like protein KIF13A		PRO_0000125446
Regions
	Domain	1 – 277	277	Kinesin-motor
	Domain	469 – 519	51	FHA
	Nucleotide binding	102 – 109	8	ATP By similarity
	Coiled coil	359 – 436	78	Potential
	Coiled coil	602 – 775	174	Potential
	Coiled coil	1100 – 1138	39	Potential
	Coiled coil	1518 – 1547	30	Potential
Amino acid modifications
	Modified residue	1287	1	Phosphoserine Ref.8
	Modified residue	1529	1	Phosphoserine By similarity
	Modified residue	1648	1	Phosphoserine By similarity
	Modified residue	1698	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	50 – 70	21	KPPKV…ESNTT → LVTVAHISNSSTLGGQGKRI T in isoform 5.		VSP_045584
	Alternative sequence	71 – 1805	1735	Missing in isoform 5.		VSP_045585
	Alternative sequence	1071 – 1083	13	Missing in isoform 3 and isoform 4.		VSP_021724
	Alternative sequence	1493 – 1527	35	Missing in isoform 2, isoform 3 and isoform 4.		VSP_002870
	Alternative sequence	1792 – 1797	6	VIIPEA → GGTTSR in isoform 3.		VSP_021725
	Alternative sequence	1798 – 1805	8	Missing in isoform 3.		VSP_021726
	Natural variant	1415	1	M → V. Corresponds to variant rs17689215 [ dbSNP | Ensembl ].		VAR_029389
	Natural variant	1600	1	F → S. Corresponds to variant rs12211658 [ dbSNP | Ensembl ].		VAR_049699
Experimental info
	Sequence conflict	674	1	S → G in AAG38890. Ref.2
	Sequence conflict	674	1	S → G in AAG38891. Ref.2
	Sequence conflict	925	1	T → A in AAG38890. Ref.2
	Sequence conflict	925	1	T → A in AAG38891. Ref.2
	Sequence conflict	1185	1	L → P in AAG38890. Ref.2
	Sequence conflict	1185	1	L → P in AAG38891. Ref.2
	Sequence conflict	1521	1	S → N in AAG38890. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (RBKIN1) [UniParc]. Last modified November 28, 2006. Version 2. Checksum: 5E5A6C6941DC67CC	FASTA	1,805	202,308
	10 20 30 40 50 60 MSDTKVKVAV RVRPMNRREL ELNTKCVVEM EGNQTVLHPP PSNTKQGERK PPKVFAFDYC 70 80 90 100 110 120 FWSMDESNTT KYAGQEVVFK CLGEGILEKA FQGYNACIFA YGQTGSGKSF SMMGHAEQLG 130 140 150 160 170 180 LIPRLCCALF KRISLEQNES QTFKVEVSYM EIYNEKVRDL LDPKGSRQSL KVREHKVLGP 190 200 210 220 230 240 YVDGLSQLAV TSFEDIESLM SEGNKSRTVA ATNMNEESSR SHAVFNIIIT QTLYDLQSGN 250 260 270 280 290 300 SGEKVSKVSL VDLAGSERVS KTGAAGERLK EGSNINKSLT TLGLVISSLA DQAAGKGKSK 310 320 330 340 350 360 FVPYRDSVLT WLLKDNLGGN SQTSMIATIS PAADNYEETL STLRYADRAK RIVNHAVVNE 370 380 390 400 410 420 DPNAKVIREL REEVEKLREQ LSQAEAMKAP ELKEKLEESE KLIKELTVTW EEKLRKTEEI 430 440 450 460 470 480 AQERQRQLES MGISLEMSGI KVGDDKCYLV NLNADPALNE LLVYYLKDHT RVGADTSQDI 490 500 510 520 530 540 QLFGIGIQPQ HCEIDIASDG DVTLTPKENA RSCVNGTLVC STTQLWHGDR ILWGNNHFFR 550 560 570 580 590 600 INLPKRKRRD WLKDFEKETG PPEHDLDAAS EASSEPDYNY EFAQMEVIMK TLNSNDPVQN 610 620 630 640 650 660 VVQVLEKQYL EEKRSALEEQ RLMYERELEQ LRQQLSPDRQ PQSSGPDRLA YSSQTAQQKV 670 680 690 700 710 720 TQWAEERDEL FRQSLAKLRE QLVKANTLVR EANFLAEEMS KLTDYQVTLQ IPAANLSANR 730 740 750 760 770 780 KRGAIVSEPA IQVRRKGKST QVWTIEKLEN KLIDMRDLYQ EWKEKVPEAK RLYGKRGDPF 790 800 810 820 830 840 YEAQENHNLI GVANVFLECL FCDVKLQYAV PIISQQGEVA GRLHVEVMRV TGAVPERVVE 850 860 870 880 890 900 DDSSENSSES GSLEVVDSSG EIIHRVKKLT CRVKIKEATG LPLNLSNFVF CQYTFWDQCE 910 920 930 940 950 960 STVAAPVVDP EVPSPQSKDA QYTVTFSHCK DYVVNVTEEF LEFISDGALA IEVWGHRCAG 970 980 990 1000 1010 1020 NGSSIWEVDS LHAKTRTLHD RWNEVTRRIE MWISILELNE LGEYAAVELH QAKDVNTGGI 1030 1040 1050 1060 1070 1080 FQLRQGHSRR VQVTVKPVQH SGTLPLMVEA ILSVSIGCVT ARSTKLQRGL DSYQRDDEDG 1090 1100 1110 1120 1130 1140 DDMDSYQEED LNCVRERWSD ALIKRREYLD EQIKKVSNKT EKTEDDVERE AQLVEQWVGL 1150 1160 1170 1180 1190 1200 TEERNAVLVP APGSGIPGAP ADWIPPPGME THIPVLFLDL NADDLSANEQ LVGPHASGVN 1210 1220 1230 1240 1250 1260 SILPKEHGSQ FFYLPIIKHS DDEVSATASW DSSVHDSVHL NRVTPQNERI YLIVKTTVQL 1270 1280 1290 1300 1310 1320 SHPAAMELVL RKRIAANIYN KQSFTQSLKR RISLKNIFYS CGVTYEIVSN IPKATEEIED 1330 1340 1350 1360 1370 1380 RETLALLAAR SENEGTSDGE TYIEKYTRGV LQVENILSLE RLRQAVTVKE ALSTKARHIR 1390 1400 1410 1420 1430 1440 RSLSTPNVHN VSSSRPDLSG FDEDDKGWPE NQLDMSDYSS SYQDVACYGT LPRDSPRRNK 1450 1460 1470 1480 1490 1500 EGCTSETPHA LTVSPFKAFS PQPPKFFKPL MPVKEEHKKR IALEARPLLS QESMPPPQAH 1510 1520 1530 1540 1550 1560 NPGCIVPSGS NGSSMPVEHN SKREKKIDSE EEENELEAIN RKLISSQPYV PVEFADFSVY 1570 1580 1590 1600 1610 1620 NASLENREWF SSKVDLSNSR VLEKEVSRSP TTSSITSGYF SHSASNATLS DMVVPSSDSS 1630 1640 1650 1660 1670 1680 DQLAIQTKDA DSTEHSTPSL VHDFRPSSNK ELTEVEKGLV KDKIIVVPLK ENSALAKGSP 1690 1700 1710 1720 1730 1740 SSQSIPEKNS KSLCRTGSCS ELDACPSKIS QPARGFCPRE VTVEHTTNIL EDHSFTEFMG 1750 1760 1770 1780 1790 1800 VSEGKDFDGL TDSSAGELSS RRSLPNKTGG KTVSDGLHHP SQLHSKLEND QVIIPEAAFW VLCCQ
	Isoform 2 (RBKIN2) [UniParc]. Checksum: 8117B6828ABF7193	FASTA	1,770	198,627
	10 20 30 40 50 60 MSDTKVKVAV RVRPMNRREL ELNTKCVVEM EGNQTVLHPP PSNTKQGERK PPKVFAFDYC 70 80 90 100 110 120 FWSMDESNTT KYAGQEVVFK CLGEGILEKA FQGYNACIFA YGQTGSGKSF SMMGHAEQLG 130 140 150 160 170 180 LIPRLCCALF KRISLEQNES QTFKVEVSYM EIYNEKVRDL LDPKGSRQSL KVREHKVLGP 190 200 210 220 230 240 YVDGLSQLAV TSFEDIESLM SEGNKSRTVA ATNMNEESSR SHAVFNIIIT QTLYDLQSGN 250 260 270 280 290 300 SGEKVSKVSL VDLAGSERVS KTGAAGERLK EGSNINKSLT TLGLVISSLA DQAAGKGKSK 310 320 330 340 350 360 FVPYRDSVLT WLLKDNLGGN SQTSMIATIS PAADNYEETL STLRYADRAK RIVNHAVVNE 370 380 390 400 410 420 DPNAKVIREL REEVEKLREQ LSQAEAMKAP ELKEKLEESE KLIKELTVTW EEKLRKTEEI 430 440 450 460 470 480 AQERQRQLES MGISLEMSGI KVGDDKCYLV NLNADPALNE LLVYYLKDHT RVGADTSQDI 490 500 510 520 530 540 QLFGIGIQPQ HCEIDIASDG DVTLTPKENA RSCVNGTLVC STTQLWHGDR ILWGNNHFFR 550 560 570 580 590 600 INLPKRKRRD WLKDFEKETG PPEHDLDAAS EASSEPDYNY EFAQMEVIMK TLNSNDPVQN 610 620 630 640 650 660 VVQVLEKQYL EEKRSALEEQ RLMYERELEQ LRQQLSPDRQ PQSSGPDRLA YSSQTAQQKV 670 680 690 700 710 720 TQWAEERDEL FRQSLAKLRE QLVKANTLVR EANFLAEEMS KLTDYQVTLQ IPAANLSANR 730 740 750 760 770 780 KRGAIVSEPA IQVRRKGKST QVWTIEKLEN KLIDMRDLYQ EWKEKVPEAK RLYGKRGDPF 790 800 810 820 830 840 YEAQENHNLI GVANVFLECL FCDVKLQYAV PIISQQGEVA GRLHVEVMRV TGAVPERVVE 850 860 870 880 890 900 DDSSENSSES GSLEVVDSSG EIIHRVKKLT CRVKIKEATG LPLNLSNFVF CQYTFWDQCE 910 920 930 940 950 960 STVAAPVVDP EVPSPQSKDA QYTVTFSHCK DYVVNVTEEF LEFISDGALA IEVWGHRCAG 970 980 990 1000 1010 1020 NGSSIWEVDS LHAKTRTLHD RWNEVTRRIE MWISILELNE LGEYAAVELH QAKDVNTGGI 1030 1040 1050 1060 1070 1080 FQLRQGHSRR VQVTVKPVQH SGTLPLMVEA ILSVSIGCVT ARSTKLQRGL DSYQRDDEDG 1090 1100 1110 1120 1130 1140 DDMDSYQEED LNCVRERWSD ALIKRREYLD EQIKKVSNKT EKTEDDVERE AQLVEQWVGL 1150 1160 1170 1180 1190 1200 TEERNAVLVP APGSGIPGAP ADWIPPPGME THIPVLFLDL NADDLSANEQ LVGPHASGVN 1210 1220 1230 1240 1250 1260 SILPKEHGSQ FFYLPIIKHS DDEVSATASW DSSVHDSVHL NRVTPQNERI YLIVKTTVQL 1270 1280 1290 1300 1310 1320 SHPAAMELVL RKRIAANIYN KQSFTQSLKR RISLKNIFYS CGVTYEIVSN IPKATEEIED 1330 1340 1350 1360 1370 1380 RETLALLAAR SENEGTSDGE TYIEKYTRGV LQVENILSLE RLRQAVTVKE ALSTKARHIR 1390 1400 1410 1420 1430 1440 RSLSTPNVHN VSSSRPDLSG FDEDDKGWPE NQLDMSDYSS SYQDVACYGT LPRDSPRRNK 1450 1460 1470 1480 1490 1500 EGCTSETPHA LTVSPFKAFS PQPPKFFKPL MPVKEEHKKR IALEARPLLS QEDSEEEENE 1510 1520 1530 1540 1550 1560 LEAINRKLIS SQPYVPVEFA DFSVYNASLE NREWFSSKVD LSNSRVLEKE VSRSPTTSSI 1570 1580 1590 1600 1610 1620 TSGYFSHSAS NATLSDMVVP SSDSSDQLAI QTKDADSTEH STPSLVHDFR PSSNKELTEV 1630 1640 1650 1660 1670 1680 EKGLVKDKII VVPLKENSAL AKGSPSSQSI PEKNSKSLCR TGSCSELDAC PSKISQPARG 1690 1700 1710 1720 1730 1740 FCPREVTVEH TTNILEDHSF TEFMGVSEGK DFDGLTDSSA GELSSRRSLP NKTGGKTVSD 1750 1760 1770 GLHHPSQLHS KLENDQVIIP EAAFWVLCCQ
	Isoform 3 [UniParc]. Checksum: F4C1C2E8435D578D	FASTA	1,749	196,070
	10 20 30 40 50 60 MSDTKVKVAV RVRPMNRREL ELNTKCVVEM EGNQTVLHPP PSNTKQGERK PPKVFAFDYC 70 80 90 100 110 120 FWSMDESNTT KYAGQEVVFK CLGEGILEKA FQGYNACIFA YGQTGSGKSF SMMGHAEQLG 130 140 150 160 170 180 LIPRLCCALF KRISLEQNES QTFKVEVSYM EIYNEKVRDL LDPKGSRQSL KVREHKVLGP 190 200 210 220 230 240 YVDGLSQLAV TSFEDIESLM SEGNKSRTVA ATNMNEESSR SHAVFNIIIT QTLYDLQSGN 250 260 270 280 290 300 SGEKVSKVSL VDLAGSERVS KTGAAGERLK EGSNINKSLT TLGLVISSLA DQAAGKGKSK 310 320 330 340 350 360 FVPYRDSVLT WLLKDNLGGN SQTSMIATIS PAADNYEETL STLRYADRAK RIVNHAVVNE 370 380 390 400 410 420 DPNAKVIREL REEVEKLREQ LSQAEAMKAP ELKEKLEESE KLIKELTVTW EEKLRKTEEI 430 440 450 460 470 480 AQERQRQLES MGISLEMSGI KVGDDKCYLV NLNADPALNE LLVYYLKDHT RVGADTSQDI 490 500 510 520 530 540 QLFGIGIQPQ HCEIDIASDG DVTLTPKENA RSCVNGTLVC STTQLWHGDR ILWGNNHFFR 550 560 570 580 590 600 INLPKRKRRD WLKDFEKETG PPEHDLDAAS EASSEPDYNY EFAQMEVIMK TLNSNDPVQN 610 620 630 640 650 660 VVQVLEKQYL EEKRSALEEQ RLMYERELEQ LRQQLSPDRQ PQSSGPDRLA YSSQTAQQKV 670 680 690 700 710 720 TQWAEERDEL FRQSLAKLRE QLVKANTLVR EANFLAEEMS KLTDYQVTLQ IPAANLSANR 730 740 750 760 770 780 KRGAIVSEPA IQVRRKGKST QVWTIEKLEN KLIDMRDLYQ EWKEKVPEAK RLYGKRGDPF 790 800 810 820 830 840 YEAQENHNLI GVANVFLECL FCDVKLQYAV PIISQQGEVA GRLHVEVMRV TGAVPERVVE 850 860 870 880 890 900 DDSSENSSES GSLEVVDSSG EIIHRVKKLT CRVKIKEATG LPLNLSNFVF CQYTFWDQCE 910 920 930 940 950 960 STVAAPVVDP EVPSPQSKDA QYTVTFSHCK DYVVNVTEEF LEFISDGALA IEVWGHRCAG 970 980 990 1000 1010 1020 NGSSIWEVDS LHAKTRTLHD RWNEVTRRIE MWISILELNE LGEYAAVELH QAKDVNTGGI 1030 1040 1050 1060 1070 1080 FQLRQGHSRR VQVTVKPVQH SGTLPLMVEA ILSVSIGCVT ARSTKLQRGL DSYQEEDLNC 1090 1100 1110 1120 1130 1140 VRERWSDALI KRREYLDEQI KKVSNKTEKT EDDVEREAQL VEQWVGLTEE RNAVLVPAPG 1150 1160 1170 1180 1190 1200 SGIPGAPADW IPPPGMETHI PVLFLDLNAD DLSANEQLVG PHASGVNSIL PKEHGSQFFY 1210 1220 1230 1240 1250 1260 LPIIKHSDDE VSATASWDSS VHDSVHLNRV TPQNERIYLI VKTTVQLSHP AAMELVLRKR 1270 1280 1290 1300 1310 1320 IAANIYNKQS FTQSLKRRIS LKNIFYSCGV TYEIVSNIPK ATEEIEDRET LALLAARSEN 1330 1340 1350 1360 1370 1380 EGTSDGETYI EKYTRGVLQV ENILSLERLR QAVTVKEALS TKARHIRRSL STPNVHNVSS 1390 1400 1410 1420 1430 1440 SRPDLSGFDE DDKGWPENQL DMSDYSSSYQ DVACYGTLPR DSPRRNKEGC TSETPHALTV 1450 1460 1470 1480 1490 1500 SPFKAFSPQP PKFFKPLMPV KEEHKKRIAL EARPLLSQED SEEEENELEA INRKLISSQP 1510 1520 1530 1540 1550 1560 YVPVEFADFS VYNASLENRE WFSSKVDLSN SRVLEKEVSR SPTTSSITSG YFSHSASNAT 1570 1580 1590 1600 1610 1620 LSDMVVPSSD SSDQLAIQTK DADSTEHSTP SLVHDFRPSS NKELTEVEKG LVKDKIIVVP 1630 1640 1650 1660 1670 1680 LKENSALAKG SPSSQSIPEK NSKSLCRTGS CSELDACPSK ISQPARGFCP REVTVEHTTN 1690 1700 1710 1720 1730 1740 ILEDHSFTEF MGVSEGKDFD GLTDSSAGEL SSRRSLPNKT GGKTVSDGLH HPSQLHSKLE NDQGGTTSR
	Isoform 4 [UniParc]. Checksum: 92277256F8DDEF0F	FASTA	1,757	197,085
	10 20 30 40 50 60 MSDTKVKVAV RVRPMNRREL ELNTKCVVEM EGNQTVLHPP PSNTKQGERK PPKVFAFDYC 70 80 90 100 110 120 FWSMDESNTT KYAGQEVVFK CLGEGILEKA FQGYNACIFA YGQTGSGKSF SMMGHAEQLG 130 140 150 160 170 180 LIPRLCCALF KRISLEQNES QTFKVEVSYM EIYNEKVRDL LDPKGSRQSL KVREHKVLGP 190 200 210 220 230 240 YVDGLSQLAV TSFEDIESLM SEGNKSRTVA ATNMNEESSR SHAVFNIIIT QTLYDLQSGN 250 260 270 280 290 300 SGEKVSKVSL VDLAGSERVS KTGAAGERLK EGSNINKSLT TLGLVISSLA DQAAGKGKSK 310 320 330 340 350 360 FVPYRDSVLT WLLKDNLGGN SQTSMIATIS PAADNYEETL STLRYADRAK RIVNHAVVNE 370 380 390 400 410 420 DPNAKVIREL REEVEKLREQ LSQAEAMKAP ELKEKLEESE KLIKELTVTW EEKLRKTEEI 430 440 450 460 470 480 AQERQRQLES MGISLEMSGI KVGDDKCYLV NLNADPALNE LLVYYLKDHT RVGADTSQDI 490 500 510 520 530 540 QLFGIGIQPQ HCEIDIASDG DVTLTPKENA RSCVNGTLVC STTQLWHGDR ILWGNNHFFR 550 560 570 580 590 600 INLPKRKRRD WLKDFEKETG PPEHDLDAAS EASSEPDYNY EFAQMEVIMK TLNSNDPVQN 610 620 630 640 650 660 VVQVLEKQYL EEKRSALEEQ RLMYERELEQ LRQQLSPDRQ PQSSGPDRLA YSSQTAQQKV 670 680 690 700 710 720 TQWAEERDEL FRQSLAKLRE QLVKANTLVR EANFLAEEMS KLTDYQVTLQ IPAANLSANR 730 740 750 760 770 780 KRGAIVSEPA IQVRRKGKST QVWTIEKLEN KLIDMRDLYQ EWKEKVPEAK RLYGKRGDPF 790 800 810 820 830 840 YEAQENHNLI GVANVFLECL FCDVKLQYAV PIISQQGEVA GRLHVEVMRV TGAVPERVVE 850 860 870 880 890 900 DDSSENSSES GSLEVVDSSG EIIHRVKKLT CRVKIKEATG LPLNLSNFVF CQYTFWDQCE 910 920 930 940 950 960 STVAAPVVDP EVPSPQSKDA QYTVTFSHCK DYVVNVTEEF LEFISDGALA IEVWGHRCAG 970 980 990 1000 1010 1020 NGSSIWEVDS LHAKTRTLHD RWNEVTRRIE MWISILELNE LGEYAAVELH QAKDVNTGGI 1030 1040 1050 1060 1070 1080 FQLRQGHSRR VQVTVKPVQH SGTLPLMVEA ILSVSIGCVT ARSTKLQRGL DSYQEEDLNC 1090 1100 1110 1120 1130 1140 VRERWSDALI KRREYLDEQI KKVSNKTEKT EDDVEREAQL VEQWVGLTEE RNAVLVPAPG 1150 1160 1170 1180 1190 1200 SGIPGAPADW IPPPGMETHI PVLFLDLNAD DLSANEQLVG PHASGVNSIL PKEHGSQFFY 1210 1220 1230 1240 1250 1260 LPIIKHSDDE VSATASWDSS VHDSVHLNRV TPQNERIYLI VKTTVQLSHP AAMELVLRKR 1270 1280 1290 1300 1310 1320 IAANIYNKQS FTQSLKRRIS LKNIFYSCGV TYEIVSNIPK ATEEIEDRET LALLAARSEN 1330 1340 1350 1360 1370 1380 EGTSDGETYI EKYTRGVLQV ENILSLERLR QAVTVKEALS TKARHIRRSL STPNVHNVSS 1390 1400 1410 1420 1430 1440 SRPDLSGFDE DDKGWPENQL DMSDYSSSYQ DVACYGTLPR DSPRRNKEGC TSETPHALTV 1450 1460 1470 1480 1490 1500 SPFKAFSPQP PKFFKPLMPV KEEHKKRIAL EARPLLSQED SEEEENELEA INRKLISSQP 1510 1520 1530 1540 1550 1560 YVPVEFADFS VYNASLENRE WFSSKVDLSN SRVLEKEVSR SPTTSSITSG YFSHSASNAT 1570 1580 1590 1600 1610 1620 LSDMVVPSSD SSDQLAIQTK DADSTEHSTP SLVHDFRPSS NKELTEVEKG LVKDKIIVVP 1630 1640 1650 1660 1670 1680 LKENSALAKG SPSSQSIPEK NSKSLCRTGS CSELDACPSK ISQPARGFCP REVTVEHTTN 1690 1700 1710 1720 1730 1740 ILEDHSFTEF MGVSEGKDFD GLTDSSAGEL SSRRSLPNKT GGKTVSDGLH HPSQLHSKLE 1750 NDQVIIPEAA FWVLCCQ
	Isoform 5 [UniParc]. Checksum: A5457B8ACF8B75EE	FASTA	70	7,726
	10 20 30 40 50 60 MSDTKVKVAV RVRPMNRREL ELNTKCVVEM EGNQTVLHPP PSNTKQGERL VTVAHISNSS 70 TLGGQGKRIT

References

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[1]	"Identification of the human KIF13A gene homologous to Drosophila kinesin-73 and candidate for schizophrenia." Jamain S., Quach H., Fellous M., Bourgeron T. Genomics 74:36-44(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), TISSUE SPECIFICITY. Tissue: Fetal brain.
[2]	"Genomic amplification in retinoblastoma narrowed to 0.6 megabase on chromosome 6p containing a kinesin-like gene, RBKIN." Chen D., Pajovic S., Duckett A., Brown V.D., Squire J.A., Gallie B.L. Cancer Res. 62:967-971(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Retina.
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 4 AND 5). Tissue: Glioblastoma.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[6]	"AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis." Delevoye C., Hurbain I., Tenza D., Sibarita J.B., Uzan-Gafsou S., Ohno H., Geerts W.J., Verkleij A.J., Salamero J., Marks M.S., Raposo G. J. Cell Biol. 187:247-264(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH AP1G1 AND AP1G2, SUBCELLULAR LOCATION.
[7]	"PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody." Sagona A.P., Nezis I.P., Pedersen N.M., Liestol K., Poulton J., Rusten T.E., Skotheim R.I., Raiborg C., Stenmark H. Nat. Cell Biol. 12:362-371(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ZFYVE26.
[8]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1287, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ291578 mRNA. Translation: CAC20442.1. AJ291579 mRNA. Translation: CAC20443.1. AY014403 mRNA. Translation: AAG38890.1. AY014404 mRNA. Translation: AAG38891.1. AL023807, AL138724 Genomic DNA. Translation: CAI21670.1. Sequence problems. AL023807, AL138724 Genomic DNA. Translation: CAI21671.1. Sequence problems. AL138724, AL023807 Genomic DNA. Translation: CAI40947.1. Sequence problems. AL138724, AL023807 Genomic DNA. Translation: CAI40948.1. Sequence problems. BC062673 mRNA. No translation available. BC127115 mRNA. Translation: AAI27116.1. BC127116 mRNA. Translation: AAI27117.1.
IPI	IPI00164861. IPI00218490. IPI00295487. IPI00807394. IPI00967988.
RefSeq	NP_001099036.1. NM_001105566.2. NP_001099037.1. NM_001105567.2. NP_001099038.1. NM_001105568.2. NP_001230352.1. NM_001243423.1. NP_071396.4. NM_022113.5.
UniGene	Hs.94499.
3D structure databases
ProteinModelPortal	Q9H1H9.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-52276N.
IntAct	Q9H1H9. 3 interactions.
MINT	MINT-1185433.
STRING	9606.ENSP00000259711.
PTM databases
PhosphoSite	Q9H1H9.
Polymorphism databases
DMDM	118572662.
Proteomic databases
PaxDb	Q9H1H9.
PRIDE	Q9H1H9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000259711; ENSP00000259711; ENSG00000137177. ENST00000378814; ENSP00000368091; ENSG00000137177. ENST00000378826; ENSP00000368103; ENSG00000137177. ENST00000378843; ENSP00000368120; ENSG00000137177. ENST00000502704; ENSP00000425453; ENSG00000137177.
GeneID	63971.
KEGG	hsa:63971.
UCSC	uc003ncf.3. human. uc003ncg.4. human. uc003nch.4. human. uc003nci.4. human.
Organism-specific databases
CTD	63971.
GeneCards	GC06M017759.
HGNC	HGNC:14566. KIF13A.
HPA	HPA029253. HPA029254.
MIM	605433. gene.
neXtProt	NX_Q9H1H9.
PharmGKB	PA30098.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5059.
HOVERGEN	HBG052244.
InParanoid	Q9H1H9.
KO	K10392.
OMA	SKNGQPA.
Enzyme and pathway databases
Reactome	REACT_17015. Metabolism of proteins.
Gene expression databases
ArrayExpress	Q9H1H9.
Bgee	Q9H1H9.
CleanEx	HS_KIF13A.
Genevestigator	Q9H1H9.
GermOnline	ENSG00000137177. Homo sapiens.
Family and domain databases
Gene3D	2.60.200.20. 1 hit. 3.40.850.10. 1 hit.
InterPro	IPR000253. FHA_dom. IPR022140. KIF1B. IPR022164. Kinesin-like. IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. IPR008984. SMAD_FHA_domain. [Graphical view]
Pfam	PF12473. DUF3694. 2 hits. PF00498. FHA. 1 hit. PF12423. KIF1B. 1 hit. PF00225. Kinesin. 1 hit. [Graphical view]
PRINTS	PR00380. KINESINHEAVY.
SMART	SM00240. FHA. 1 hit. SM00129. KISc. 1 hit. [Graphical view]
SUPFAM	SSF49879. SMAD_FHA. 1 hit.
PROSITE	PS50006. FHA_DOMAIN. False negative. PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit. PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	KIF13A. human.
GenomeRNAi	63971.
NextBio	65762.
SOURCE	Search...

Entry information

Entry name

KI13A_HUMAN

Accession

Primary (citable) accession number: Q9H1H9
Secondary accession number(s): A0JP21 , A0JP22, F2Z382, Q5THQ2, Q5THQ3, Q9H193, Q9H194, Q9H1H8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	November 28, 2006
Last modified:	May 1, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.