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Q9H1H9

- KI13A_HUMAN

UniProt

Q9H1H9 - KI13A_HUMAN

Protein

Kinesin-like protein KIF13A

Gene

KIF13A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi102 – 1098ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. microtubule motor activity Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. cargo loading into vesicle Source: UniProtKB
    2. cytokinesis Source: UniProtKB
    3. endosome to lysosome transport Source: UniProtKB
    4. Golgi to plasma membrane protein transport Source: UniProtKB
    5. intracellular protein transport Source: UniProtKB
    6. melanosome organization Source: UniProtKB
    7. metabolic process Source: GOC
    8. plus-end-directed vesicle transport along microtubule Source: UniProtKB

    Keywords - Molecular functioni

    Motor protein

    Keywords - Biological processi

    Cell cycle, Cell division, Protein transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_16907. Association of TriC/CCT with target proteins during biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIF13A
    Alternative name(s):
    Kinesin-like protein RBKIN
    Gene namesi
    Name:KIF13A
    Synonyms:RBKIN
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:14566. KIF13A.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Midbody. Endosome membrane. Golgi apparatus membrane By similarity
    Note: Recruited to the midbody during cytokinesis.

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. endosome membrane Source: UniProtKB
    3. Golgi membrane Source: UniProtKB-SubCell
    4. kinesin complex Source: InterPro
    5. microtubule Source: UniProtKB-KW
    6. midbody Source: UniProtKB
    7. trans-Golgi network membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Endosome, Golgi apparatus, Membrane, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30098.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18051805Kinesin-like protein KIF13APRO_0000125446Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1287 – 12871Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9H1H9.
    PaxDbiQ9H1H9.
    PRIDEiQ9H1H9.

    PTM databases

    PhosphoSiteiQ9H1H9.

    Expressioni

    Tissue specificityi

    Widely expressed, with highest levels in heart, brain and skeletal muscle.2 Publications

    Developmental stagei

    Expressed at very low level in most fetal tissues, but at higher levels in skeletal muscle and lung.1 Publication

    Gene expression databases

    ArrayExpressiQ9H1H9.
    BgeeiQ9H1H9.
    CleanExiHS_KIF13A.
    GenevestigatoriQ9H1H9.

    Organism-specific databases

    HPAiHPA029253.
    HPA029254.

    Interactioni

    Subunit structurei

    Interacts with AP2B1 By similarity. Interacts with ZFYVE26. Interacts with AP1G1 and AP1G2.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi122019. 7 interactions.
    DIPiDIP-52276N.
    IntActiQ9H1H9. 4 interactions.
    MINTiMINT-1185433.
    STRINGi9606.ENSP00000259711.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H1H9.
    SMRiQ9H1H9. Positions 2-380, 391-550.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 352348Kinesin motorPROSITE-ProRule annotationAdd
    BLAST
    Domaini469 – 51951FHAAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili359 – 43678Sequence AnalysisAdd
    BLAST
    Coiled coili602 – 775174Sequence AnalysisAdd
    BLAST
    Coiled coili1100 – 113839Sequence AnalysisAdd
    BLAST
    Coiled coili1518 – 154730Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
    Contains 1 FHA domain.Curated
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5059.
    HOVERGENiHBG052244.
    InParanoidiQ9H1H9.
    KOiK17914.
    OMAiQLAVTNF.
    OrthoDBiEOG72G16D.
    PhylomeDBiQ9H1H9.
    TreeFamiTF105221.

    Family and domain databases

    Gene3Di2.60.200.20. 1 hit.
    3.40.850.10. 1 hit.
    InterProiIPR000253. FHA_dom.
    IPR022140. KIF1B.
    IPR022164. Kinesin-like.
    IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    IPR008984. SMAD_FHA_domain.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PfamiPF12473. DUF3694. 2 hits.
    PF00498. FHA. 1 hit.
    PF12423. KIF1B. 1 hit.
    PF00225. Kinesin. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00240. FHA. 1 hit.
    SM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49879. SSF49879. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H1H9-1) [UniParc]FASTAAdd to Basket

    Also known as: RBKIN1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDTKVKVAV RVRPMNRREL ELNTKCVVEM EGNQTVLHPP PSNTKQGERK     50
    PPKVFAFDYC FWSMDESNTT KYAGQEVVFK CLGEGILEKA FQGYNACIFA 100
    YGQTGSGKSF SMMGHAEQLG LIPRLCCALF KRISLEQNES QTFKVEVSYM 150
    EIYNEKVRDL LDPKGSRQSL KVREHKVLGP YVDGLSQLAV TSFEDIESLM 200
    SEGNKSRTVA ATNMNEESSR SHAVFNIIIT QTLYDLQSGN SGEKVSKVSL 250
    VDLAGSERVS KTGAAGERLK EGSNINKSLT TLGLVISSLA DQAAGKGKSK 300
    FVPYRDSVLT WLLKDNLGGN SQTSMIATIS PAADNYEETL STLRYADRAK 350
    RIVNHAVVNE DPNAKVIREL REEVEKLREQ LSQAEAMKAP ELKEKLEESE 400
    KLIKELTVTW EEKLRKTEEI AQERQRQLES MGISLEMSGI KVGDDKCYLV 450
    NLNADPALNE LLVYYLKDHT RVGADTSQDI QLFGIGIQPQ HCEIDIASDG 500
    DVTLTPKENA RSCVNGTLVC STTQLWHGDR ILWGNNHFFR INLPKRKRRD 550
    WLKDFEKETG PPEHDLDAAS EASSEPDYNY EFAQMEVIMK TLNSNDPVQN 600
    VVQVLEKQYL EEKRSALEEQ RLMYERELEQ LRQQLSPDRQ PQSSGPDRLA 650
    YSSQTAQQKV TQWAEERDEL FRQSLAKLRE QLVKANTLVR EANFLAEEMS 700
    KLTDYQVTLQ IPAANLSANR KRGAIVSEPA IQVRRKGKST QVWTIEKLEN 750
    KLIDMRDLYQ EWKEKVPEAK RLYGKRGDPF YEAQENHNLI GVANVFLECL 800
    FCDVKLQYAV PIISQQGEVA GRLHVEVMRV TGAVPERVVE DDSSENSSES 850
    GSLEVVDSSG EIIHRVKKLT CRVKIKEATG LPLNLSNFVF CQYTFWDQCE 900
    STVAAPVVDP EVPSPQSKDA QYTVTFSHCK DYVVNVTEEF LEFISDGALA 950
    IEVWGHRCAG NGSSIWEVDS LHAKTRTLHD RWNEVTRRIE MWISILELNE 1000
    LGEYAAVELH QAKDVNTGGI FQLRQGHSRR VQVTVKPVQH SGTLPLMVEA 1050
    ILSVSIGCVT ARSTKLQRGL DSYQRDDEDG DDMDSYQEED LNCVRERWSD 1100
    ALIKRREYLD EQIKKVSNKT EKTEDDVERE AQLVEQWVGL TEERNAVLVP 1150
    APGSGIPGAP ADWIPPPGME THIPVLFLDL NADDLSANEQ LVGPHASGVN 1200
    SILPKEHGSQ FFYLPIIKHS DDEVSATASW DSSVHDSVHL NRVTPQNERI 1250
    YLIVKTTVQL SHPAAMELVL RKRIAANIYN KQSFTQSLKR RISLKNIFYS 1300
    CGVTYEIVSN IPKATEEIED RETLALLAAR SENEGTSDGE TYIEKYTRGV 1350
    LQVENILSLE RLRQAVTVKE ALSTKARHIR RSLSTPNVHN VSSSRPDLSG 1400
    FDEDDKGWPE NQLDMSDYSS SYQDVACYGT LPRDSPRRNK EGCTSETPHA 1450
    LTVSPFKAFS PQPPKFFKPL MPVKEEHKKR IALEARPLLS QESMPPPQAH 1500
    NPGCIVPSGS NGSSMPVEHN SKREKKIDSE EEENELEAIN RKLISSQPYV 1550
    PVEFADFSVY NASLENREWF SSKVDLSNSR VLEKEVSRSP TTSSITSGYF 1600
    SHSASNATLS DMVVPSSDSS DQLAIQTKDA DSTEHSTPSL VHDFRPSSNK 1650
    ELTEVEKGLV KDKIIVVPLK ENSALAKGSP SSQSIPEKNS KSLCRTGSCS 1700
    ELDACPSKIS QPARGFCPRE VTVEHTTNIL EDHSFTEFMG VSEGKDFDGL 1750
    TDSSAGELSS RRSLPNKTGG KTVSDGLHHP SQLHSKLEND QVIIPEAAFW 1800
    VLCCQ 1805
    Length:1,805
    Mass (Da):202,308
    Last modified:November 28, 2006 - v2
    Checksum:i5E5A6C6941DC67CC
    GO
    Isoform 2 (identifier: Q9H1H9-2) [UniParc]FASTAAdd to Basket

    Also known as: RBKIN2

    The sequence of this isoform differs from the canonical sequence as follows:
         1493-1527: Missing.

    Show »
    Length:1,770
    Mass (Da):198,627
    Checksum:i8117B6828ABF7193
    GO
    Isoform 3 (identifier: Q9H1H9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1071-1083: Missing.
         1493-1527: Missing.
         1792-1797: VIIPEA → GGTTSR
         1798-1805: Missing.

    Show »
    Length:1,749
    Mass (Da):196,070
    Checksum:iF4C1C2E8435D578D
    GO
    Isoform 4 (identifier: Q9H1H9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1071-1083: Missing.
         1493-1527: Missing.

    Show »
    Length:1,757
    Mass (Da):197,085
    Checksum:i92277256F8DDEF0F
    GO
    Isoform 5 (identifier: Q9H1H9-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         50-70: KPPKVFAFDYCFWSMDESNTT → LVTVAHISNSSTLGGQGKRIT
         71-1805: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:70
    Mass (Da):7,726
    Checksum:iA5457B8ACF8B75EE
    GO

    Sequence cautioni

    The sequence CAI21670.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI21671.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI40947.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI40948.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti674 – 6741S → G in AAG38890. (PubMed:11861365)Curated
    Sequence conflicti674 – 6741S → G in AAG38891. (PubMed:11861365)Curated
    Sequence conflicti925 – 9251T → A in AAG38890. (PubMed:11861365)Curated
    Sequence conflicti925 – 9251T → A in AAG38891. (PubMed:11861365)Curated
    Sequence conflicti1185 – 11851L → P in AAG38890. (PubMed:11861365)Curated
    Sequence conflicti1185 – 11851L → P in AAG38891. (PubMed:11861365)Curated
    Sequence conflicti1521 – 15211S → N in AAG38890. (PubMed:11861365)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1415 – 14151M → V.
    Corresponds to variant rs17689215 [ dbSNP | Ensembl ].
    VAR_029389
    Natural varianti1600 – 16001F → S.
    Corresponds to variant rs12211658 [ dbSNP | Ensembl ].
    VAR_049699

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei50 – 7021KPPKV…ESNTT → LVTVAHISNSSTLGGQGKRI T in isoform 5. 1 PublicationVSP_045584Add
    BLAST
    Alternative sequencei71 – 18051735Missing in isoform 5. 1 PublicationVSP_045585Add
    BLAST
    Alternative sequencei1071 – 108313Missing in isoform 3 and isoform 4. 2 PublicationsVSP_021724Add
    BLAST
    Alternative sequencei1493 – 152735Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_002870Add
    BLAST
    Alternative sequencei1792 – 17976VIIPEA → GGTTSR in isoform 3. 1 PublicationVSP_021725
    Alternative sequencei1798 – 18058Missing in isoform 3. 1 PublicationVSP_021726

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ291578 mRNA. Translation: CAC20442.1.
    AJ291579 mRNA. Translation: CAC20443.1.
    AY014403 mRNA. Translation: AAG38890.1.
    AY014404 mRNA. Translation: AAG38891.1.
    AL023807, AL138724 Genomic DNA. Translation: CAI21670.1. Sequence problems.
    AL023807, AL138724 Genomic DNA. Translation: CAI21671.1. Sequence problems.
    AL138724, AL023807 Genomic DNA. Translation: CAI40947.1. Sequence problems.
    AL138724, AL023807 Genomic DNA. Translation: CAI40948.1. Sequence problems.
    BC062673 mRNA. No translation available.
    BC127115 mRNA. Translation: AAI27116.1.
    BC127116 mRNA. Translation: AAI27117.1.
    CCDSiCCDS47380.1. [Q9H1H9-3]
    CCDS47381.1. [Q9H1H9-1]
    CCDS54967.1. [Q9H1H9-4]
    CCDS54968.1. [Q9H1H9-2]
    CCDS58998.1. [Q9H1H9-5]
    RefSeqiNP_001099036.1. NM_001105566.2. [Q9H1H9-2]
    NP_001099037.1. NM_001105567.2. [Q9H1H9-4]
    NP_001099038.1. NM_001105568.2. [Q9H1H9-3]
    NP_001230352.1. NM_001243423.1. [Q9H1H9-5]
    NP_071396.4. NM_022113.5. [Q9H1H9-1]
    UniGeneiHs.94499.

    Genome annotation databases

    EnsembliENST00000259711; ENSP00000259711; ENSG00000137177. [Q9H1H9-1]
    ENST00000378814; ENSP00000368091; ENSG00000137177. [Q9H1H9-3]
    ENST00000378826; ENSP00000368103; ENSG00000137177. [Q9H1H9-2]
    ENST00000378843; ENSP00000368120; ENSG00000137177. [Q9H1H9-4]
    ENST00000502704; ENSP00000425453; ENSG00000137177. [Q9H1H9-5]
    GeneIDi63971.
    KEGGihsa:63971.
    UCSCiuc003ncf.3. human. [Q9H1H9-3]
    uc003ncg.4. human. [Q9H1H9-1]
    uc003nch.4. human. [Q9H1H9-2]
    uc003nci.4. human. [Q9H1H9-4]

    Polymorphism databases

    DMDMi118572662.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ291578 mRNA. Translation: CAC20442.1 .
    AJ291579 mRNA. Translation: CAC20443.1 .
    AY014403 mRNA. Translation: AAG38890.1 .
    AY014404 mRNA. Translation: AAG38891.1 .
    AL023807 , AL138724 Genomic DNA. Translation: CAI21670.1 . Sequence problems.
    AL023807 , AL138724 Genomic DNA. Translation: CAI21671.1 . Sequence problems.
    AL138724 , AL023807 Genomic DNA. Translation: CAI40947.1 . Sequence problems.
    AL138724 , AL023807 Genomic DNA. Translation: CAI40948.1 . Sequence problems.
    BC062673 mRNA. No translation available.
    BC127115 mRNA. Translation: AAI27116.1 .
    BC127116 mRNA. Translation: AAI27117.1 .
    CCDSi CCDS47380.1. [Q9H1H9-3 ]
    CCDS47381.1. [Q9H1H9-1 ]
    CCDS54967.1. [Q9H1H9-4 ]
    CCDS54968.1. [Q9H1H9-2 ]
    CCDS58998.1. [Q9H1H9-5 ]
    RefSeqi NP_001099036.1. NM_001105566.2. [Q9H1H9-2 ]
    NP_001099037.1. NM_001105567.2. [Q9H1H9-4 ]
    NP_001099038.1. NM_001105568.2. [Q9H1H9-3 ]
    NP_001230352.1. NM_001243423.1. [Q9H1H9-5 ]
    NP_071396.4. NM_022113.5. [Q9H1H9-1 ]
    UniGenei Hs.94499.

    3D structure databases

    ProteinModelPortali Q9H1H9.
    SMRi Q9H1H9. Positions 2-380, 391-550.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122019. 7 interactions.
    DIPi DIP-52276N.
    IntActi Q9H1H9. 4 interactions.
    MINTi MINT-1185433.
    STRINGi 9606.ENSP00000259711.

    PTM databases

    PhosphoSitei Q9H1H9.

    Polymorphism databases

    DMDMi 118572662.

    Proteomic databases

    MaxQBi Q9H1H9.
    PaxDbi Q9H1H9.
    PRIDEi Q9H1H9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259711 ; ENSP00000259711 ; ENSG00000137177 . [Q9H1H9-1 ]
    ENST00000378814 ; ENSP00000368091 ; ENSG00000137177 . [Q9H1H9-3 ]
    ENST00000378826 ; ENSP00000368103 ; ENSG00000137177 . [Q9H1H9-2 ]
    ENST00000378843 ; ENSP00000368120 ; ENSG00000137177 . [Q9H1H9-4 ]
    ENST00000502704 ; ENSP00000425453 ; ENSG00000137177 . [Q9H1H9-5 ]
    GeneIDi 63971.
    KEGGi hsa:63971.
    UCSCi uc003ncf.3. human. [Q9H1H9-3 ]
    uc003ncg.4. human. [Q9H1H9-1 ]
    uc003nch.4. human. [Q9H1H9-2 ]
    uc003nci.4. human. [Q9H1H9-4 ]

    Organism-specific databases

    CTDi 63971.
    GeneCardsi GC06M017759.
    HGNCi HGNC:14566. KIF13A.
    HPAi HPA029253.
    HPA029254.
    MIMi 605433. gene.
    neXtProti NX_Q9H1H9.
    PharmGKBi PA30098.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5059.
    HOVERGENi HBG052244.
    InParanoidi Q9H1H9.
    KOi K17914.
    OMAi QLAVTNF.
    OrthoDBi EOG72G16D.
    PhylomeDBi Q9H1H9.
    TreeFami TF105221.

    Enzyme and pathway databases

    Reactomei REACT_16907. Association of TriC/CCT with target proteins during biosynthesis.

    Miscellaneous databases

    ChiTaRSi KIF13A. human.
    GeneWikii KIF13A.
    GenomeRNAii 63971.
    NextBioi 65762.
    PROi Q9H1H9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H1H9.
    Bgeei Q9H1H9.
    CleanExi HS_KIF13A.
    Genevestigatori Q9H1H9.

    Family and domain databases

    Gene3Di 2.60.200.20. 1 hit.
    3.40.850.10. 1 hit.
    InterProi IPR000253. FHA_dom.
    IPR022140. KIF1B.
    IPR022164. Kinesin-like.
    IPR027640. Kinesin-like_fam.
    IPR019821. Kinesin_motor_CS.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    IPR008984. SMAD_FHA_domain.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    Pfami PF12473. DUF3694. 2 hits.
    PF00498. FHA. 1 hit.
    PF12423. KIF1B. 1 hit.
    PF00225. Kinesin. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00240. FHA. 1 hit.
    SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49879. SSF49879. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
    PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the human KIF13A gene homologous to Drosophila kinesin-73 and candidate for schizophrenia."
      Jamain S., Quach H., Fellous M., Bourgeron T.
      Genomics 74:36-44(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), TISSUE SPECIFICITY.
      Tissue: Fetal brain.
    2. "Genomic amplification in retinoblastoma narrowed to 0.6 megabase on chromosome 6p containing a kinesin-like gene, RBKIN."
      Chen D., Pajovic S., Duckett A., Brown V.D., Squire J.A., Gallie B.L.
      Cancer Res. 62:967-971(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Tissue: Retina.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 4 AND 5).
      Tissue: Glioblastoma.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis."
      Delevoye C., Hurbain I., Tenza D., Sibarita J.B., Uzan-Gafsou S., Ohno H., Geerts W.J., Verkleij A.J., Salamero J., Marks M.S., Raposo G.
      J. Cell Biol. 187:247-264(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH AP1G1 AND AP1G2, SUBCELLULAR LOCATION.
    8. "PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody."
      Sagona A.P., Nezis I.P., Pedersen N.M., Liestol K., Poulton J., Rusten T.E., Skotheim R.I., Raiborg C., Stenmark H.
      Nat. Cell Biol. 12:362-371(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ZFYVE26.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1287, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKI13A_HUMAN
    AccessioniPrimary (citable) accession number: Q9H1H9
    Secondary accession number(s): A0JP21
    , A0JP22, F2Z382, Q5THQ2, Q5THQ3, Q9H193, Q9H194, Q9H1H8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3