Q9H1F0 (WF10A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WAP four-disulfide core domain protein 10A

Alternative name(s):
Putative protease inhibitor WAP10A

Gene names

Name:	WFDC10A
Synonyms:	C20orf146, WAP10

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	79 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted Potential.
Sequence similarities	Contains 1 WAP domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	serine-type endopeptidase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 79	58	WAP four-disulfide core domain protein 10A		PRO_0000041387
Regions
	Domain	34 – 79	46	WAP
Amino acid modifications
	Disulfide bond	41 ↔ 67		By similarity
	Disulfide bond	50 ↔ 71		By similarity
	Disulfide bond	54 ↔ 66		By similarity
	Disulfide bond	60 ↔ 75		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9H1F0 [UniParc]. Last modified October 19, 2002. Version 2. Checksum: 2C25A0B258ADFD7F	FASTA	79	8,943
	10 20 30 40 50 60 MAPQTLLPVL VLCVLLLQAQ GGYRDKKRMQ KTQLSPEIKV CQQQPKLYLC KHLCESHRDC 70 QANNICCSTY CGNVCMSIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein." Clauss A., Lilja H., Lundwall A. Biochem. J. 368:233-242(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY038182 mRNA. Translation: AAK72469.1. AL031671 Genomic DNA. Translation: CAI22433.1. CH471077 Genomic DNA. Translation: EAW75827.1. BC131579 mRNA. Translation: AAI31580.1.
IPI	IPI00167942.
RefSeq	NP_542791.1. NM_080753.2.
UniGene	Hs.199380.
3D structure databases
ProteinModelPortal	Q9H1F0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000361726.
Polymorphism databases
DMDM	24212617.
Proteomic databases
PaxDb	Q9H1F0.
PRIDE	Q9H1F0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372643; ENSP00000361726; ENSG00000180305.
GeneID	140832.
KEGG	hsa:140832.
UCSC	uc002xoz.3. human.
Organism-specific databases
CTD	140832.
GeneCards	GC20P044258.
HGNC	HGNC:16139. WFDC10A.
HPA	HPA055187.
neXtProt	NX_Q9H1F0.
PharmGKB	PA25688.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG40341.
HOGENOM	HOG000236258.
HOVERGEN	HBG058739.
InParanoid	Q9H1F0.
OMA	NICCSTF.
OrthoDB	EOG469QWG.
PhylomeDB	Q9H1F0.
Gene expression databases
Bgee	Q9H1F0.
CleanEx	HS_WFDC10A.
Genevestigator	Q9H1F0.
GermOnline	ENSG00000180305. Homo sapiens.
Family and domain databases
Gene3D	4.10.75.10. 1 hit.
InterPro	IPR008197. WAP-type_4-diS_core. [Graphical view]
Pfam	PF00095. WAP. 1 hit. [Graphical view]
PROSITE	PS51390. WAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	140832.
NextBio	84444.

Entry information

Entry name

WF10A_HUMAN

Accession

Primary (citable) accession number: Q9H1F0
Secondary accession number(s): A2RRE9, Q5TGZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	October 19, 2002
Last modified:	May 1, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.