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Protein

WAP four-disulfide core domain protein 10A

Gene

WFDC10A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
WAP four-disulfide core domain protein 10A
Alternative name(s):
Putative protease inhibitor WAP10A
Gene namesi
Name:WFDC10A
Synonyms:C20orf146, WAP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16139. WFDC10A.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25688.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 7958WAP four-disulfide core domain protein 10APRO_0000041387Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 67PROSITE-ProRule annotation
Disulfide bondi50 ↔ 71PROSITE-ProRule annotation
Disulfide bondi54 ↔ 66PROSITE-ProRule annotation
Disulfide bondi60 ↔ 75PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9H1F0.
PRIDEiQ9H1F0.

Expressioni

Gene expression databases

BgeeiQ9H1F0.
CleanExiHS_WFDC10A.
GenevestigatoriQ9H1F0.

Organism-specific databases

HPAiHPA055187.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361726.

Structurei

3D structure databases

ProteinModelPortaliQ9H1F0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 7946WAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 WAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40341.
GeneTreeiENSGT00730000111577.
HOGENOMiHOG000236258.
HOVERGENiHBG058739.
InParanoidiQ9H1F0.
OMAiNICCSTF.
OrthoDBiEOG72RN25.
PhylomeDBiQ9H1F0.
TreeFamiTF338513.

Family and domain databases

Gene3Di4.10.75.10. 1 hit.
InterProiIPR008197. WAP.
IPR029721. WFDC10A.
[Graphical view]
PANTHERiPTHR19441:SF21. PTHR19441:SF21. 1 hit.
PfamiPF00095. WAP. 1 hit.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 1 hit.
PROSITEiPS51390. WAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H1F0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPQTLLPVL VLCVLLLQAQ GGYRDKKRMQ KTQLSPEIKV CQQQPKLYLC
60 70
KHLCESHRDC QANNICCSTY CGNVCMSIL
Length:79
Mass (Da):8,943
Last modified:October 19, 2002 - v2
Checksum:i2C25A0B258ADFD7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY038182 mRNA. Translation: AAK72469.1.
AL031671 Genomic DNA. Translation: CAI22433.1.
CH471077 Genomic DNA. Translation: EAW75827.1.
BC131579 mRNA. Translation: AAI31580.1.
CCDSiCCDS13363.1.
RefSeqiNP_542791.1. NM_080753.2.
UniGeneiHs.199380.

Genome annotation databases

EnsembliENST00000372643; ENSP00000361726; ENSG00000180305.
GeneIDi140832.
KEGGihsa:140832.
UCSCiuc002xoz.3. human.

Polymorphism databases

DMDMi24212617.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY038182 mRNA. Translation: AAK72469.1.
AL031671 Genomic DNA. Translation: CAI22433.1.
CH471077 Genomic DNA. Translation: EAW75827.1.
BC131579 mRNA. Translation: AAI31580.1.
CCDSiCCDS13363.1.
RefSeqiNP_542791.1. NM_080753.2.
UniGeneiHs.199380.

3D structure databases

ProteinModelPortaliQ9H1F0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000361726.

Polymorphism databases

DMDMi24212617.

Proteomic databases

PaxDbiQ9H1F0.
PRIDEiQ9H1F0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372643; ENSP00000361726; ENSG00000180305.
GeneIDi140832.
KEGGihsa:140832.
UCSCiuc002xoz.3. human.

Organism-specific databases

CTDi140832.
GeneCardsiGC20P044258.
HGNCiHGNC:16139. WFDC10A.
HPAiHPA055187.
neXtProtiNX_Q9H1F0.
PharmGKBiPA25688.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40341.
GeneTreeiENSGT00730000111577.
HOGENOMiHOG000236258.
HOVERGENiHBG058739.
InParanoidiQ9H1F0.
OMAiNICCSTF.
OrthoDBiEOG72RN25.
PhylomeDBiQ9H1F0.
TreeFamiTF338513.

Miscellaneous databases

GenomeRNAii140832.
NextBioi84444.
PROiQ9H1F0.

Gene expression databases

BgeeiQ9H1F0.
CleanExiHS_WFDC10A.
GenevestigatoriQ9H1F0.

Family and domain databases

Gene3Di4.10.75.10. 1 hit.
InterProiIPR008197. WAP.
IPR029721. WFDC10A.
[Graphical view]
PANTHERiPTHR19441:SF21. PTHR19441:SF21. 1 hit.
PfamiPF00095. WAP. 1 hit.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 1 hit.
PROSITEiPS51390. WAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein."
    Clauss A., Lilja H., Lundwall A.
    Biochem. J. 368:233-242(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiWF10A_HUMAN
AccessioniPrimary (citable) accession number: Q9H1F0
Secondary accession number(s): A2RRE9, Q5TGZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: January 7, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.