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Q9H1F0

- WF10A_HUMAN

UniProt

Q9H1F0 - WF10A_HUMAN

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Protein

WAP four-disulfide core domain protein 10A

Gene

WFDC10A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
WAP four-disulfide core domain protein 10A
Alternative name(s):
Putative protease inhibitor WAP10A
Gene namesi
Name:WFDC10A
Synonyms:C20orf146, WAP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16139. WFDC10A.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25688.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 7958WAP four-disulfide core domain protein 10APRO_0000041387Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 67PROSITE-ProRule annotation
Disulfide bondi50 ↔ 71PROSITE-ProRule annotation
Disulfide bondi54 ↔ 66PROSITE-ProRule annotation
Disulfide bondi60 ↔ 75PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9H1F0.
PRIDEiQ9H1F0.

Expressioni

Gene expression databases

BgeeiQ9H1F0.
CleanExiHS_WFDC10A.
GenevestigatoriQ9H1F0.

Organism-specific databases

HPAiHPA055187.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361726.

Structurei

3D structure databases

ProteinModelPortaliQ9H1F0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 7946WAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 WAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40341.
GeneTreeiENSGT00730000111577.
HOGENOMiHOG000236258.
HOVERGENiHBG058739.
InParanoidiQ9H1F0.
OMAiNICCSTF.
OrthoDBiEOG72RN25.
PhylomeDBiQ9H1F0.
TreeFamiTF338513.

Family and domain databases

Gene3Di4.10.75.10. 1 hit.
InterProiIPR008197. WAP.
IPR029721. WFDC10A.
[Graphical view]
PANTHERiPTHR19441:SF21. PTHR19441:SF21. 1 hit.
PfamiPF00095. WAP. 1 hit.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 1 hit.
PROSITEiPS51390. WAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H1F0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPQTLLPVL VLCVLLLQAQ GGYRDKKRMQ KTQLSPEIKV CQQQPKLYLC
60 70
KHLCESHRDC QANNICCSTY CGNVCMSIL
Length:79
Mass (Da):8,943
Last modified:October 19, 2002 - v2
Checksum:i2C25A0B258ADFD7F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY038182 mRNA. Translation: AAK72469.1.
AL031671 Genomic DNA. Translation: CAI22433.1.
CH471077 Genomic DNA. Translation: EAW75827.1.
BC131579 mRNA. Translation: AAI31580.1.
CCDSiCCDS13363.1.
RefSeqiNP_542791.1. NM_080753.2.
UniGeneiHs.199380.

Genome annotation databases

EnsembliENST00000372643; ENSP00000361726; ENSG00000180305.
GeneIDi140832.
KEGGihsa:140832.
UCSCiuc002xoz.3. human.

Polymorphism databases

DMDMi24212617.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY038182 mRNA. Translation: AAK72469.1 .
AL031671 Genomic DNA. Translation: CAI22433.1 .
CH471077 Genomic DNA. Translation: EAW75827.1 .
BC131579 mRNA. Translation: AAI31580.1 .
CCDSi CCDS13363.1.
RefSeqi NP_542791.1. NM_080753.2.
UniGenei Hs.199380.

3D structure databases

ProteinModelPortali Q9H1F0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000361726.

Polymorphism databases

DMDMi 24212617.

Proteomic databases

PaxDbi Q9H1F0.
PRIDEi Q9H1F0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372643 ; ENSP00000361726 ; ENSG00000180305 .
GeneIDi 140832.
KEGGi hsa:140832.
UCSCi uc002xoz.3. human.

Organism-specific databases

CTDi 140832.
GeneCardsi GC20P044258.
HGNCi HGNC:16139. WFDC10A.
HPAi HPA055187.
neXtProti NX_Q9H1F0.
PharmGKBi PA25688.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40341.
GeneTreei ENSGT00730000111577.
HOGENOMi HOG000236258.
HOVERGENi HBG058739.
InParanoidi Q9H1F0.
OMAi NICCSTF.
OrthoDBi EOG72RN25.
PhylomeDBi Q9H1F0.
TreeFami TF338513.

Miscellaneous databases

GenomeRNAii 140832.
NextBioi 84444.
PROi Q9H1F0.

Gene expression databases

Bgeei Q9H1F0.
CleanExi HS_WFDC10A.
Genevestigatori Q9H1F0.

Family and domain databases

Gene3Di 4.10.75.10. 1 hit.
InterProi IPR008197. WAP.
IPR029721. WFDC10A.
[Graphical view ]
PANTHERi PTHR19441:SF21. PTHR19441:SF21. 1 hit.
Pfami PF00095. WAP. 1 hit.
[Graphical view ]
SUPFAMi SSF57256. SSF57256. 1 hit.
PROSITEi PS51390. WAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein."
    Clauss A., Lilja H., Lundwall A.
    Biochem. J. 368:233-242(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiWF10A_HUMAN
AccessioniPrimary (citable) accession number: Q9H1F0
Secondary accession number(s): A2RRE9, Q5TGZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: October 29, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3