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Protein

WAP four-disulfide core domain protein 10A

Gene

WFDC10A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
WAP four-disulfide core domain protein 10A
Alternative name(s):
Putative protease inhibitor WAP10A
Gene namesi
Name:WFDC10A
Synonyms:C20orf146, WAP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16139. WFDC10A.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25688.

Polymorphism and mutation databases

BioMutaiWFDC10A.
DMDMi24212617.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000004138722 – 79WAP four-disulfide core domain protein 10AAdd BLAST58

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 67PROSITE-ProRule annotation
Disulfide bondi50 ↔ 71PROSITE-ProRule annotation
Disulfide bondi54 ↔ 66PROSITE-ProRule annotation
Disulfide bondi60 ↔ 75PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9H1F0.
PRIDEiQ9H1F0.
TopDownProteomicsiQ9H1F0.

Expressioni

Gene expression databases

BgeeiENSG00000180305.
CleanExiHS_WFDC10A.
GenevisibleiQ9H1F0. HS.

Interactioni

Protein-protein interaction databases

BioGridi126725. 2 interactors.
STRINGi9606.ENSP00000361726.

Structurei

3D structure databases

ProteinModelPortaliQ9H1F0.
SMRiQ9H1F0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 79WAPPROSITE-ProRule annotationAdd BLAST46

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JI59. Eukaryota.
ENOG41113ND. LUCA.
GeneTreeiENSGT00860000133922.
HOGENOMiHOG000236258.
HOVERGENiHBG058739.
InParanoidiQ9H1F0.
OMAiNICCSTF.
OrthoDBiEOG091G12D8.
PhylomeDBiQ9H1F0.
TreeFamiTF338513.

Family and domain databases

Gene3Di4.10.75.10. 1 hit.
InterProiView protein in InterPro
IPR008197. WAP_dom.
PfamiView protein in Pfam
PF00095. WAP. 1 hit.
SUPFAMiSSF57256. SSF57256. 1 hit.
PROSITEiView protein in PROSITE
PS51390. WAP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H1F0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPQTLLPVL VLCVLLLQAQ GGYRDKKRMQ KTQLSPEIKV CQQQPKLYLC
60 70
KHLCESHRDC QANNICCSTY CGNVCMSIL
Length:79
Mass (Da):8,943
Last modified:October 19, 2002 - v2
Checksum:i2C25A0B258ADFD7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY038182 mRNA. Translation: AAK72469.1.
AL031671 Genomic DNA. Translation: CAI22433.1.
CH471077 Genomic DNA. Translation: EAW75827.1.
BC131579 mRNA. Translation: AAI31580.1.
CCDSiCCDS13363.1.
RefSeqiNP_542791.1. NM_080753.2.
UniGeneiHs.199380.

Genome annotation databases

EnsembliENST00000372643; ENSP00000361726; ENSG00000180305.
GeneIDi140832.
KEGGihsa:140832.
UCSCiuc002xoz.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY038182 mRNA. Translation: AAK72469.1.
AL031671 Genomic DNA. Translation: CAI22433.1.
CH471077 Genomic DNA. Translation: EAW75827.1.
BC131579 mRNA. Translation: AAI31580.1.
CCDSiCCDS13363.1.
RefSeqiNP_542791.1. NM_080753.2.
UniGeneiHs.199380.

3D structure databases

ProteinModelPortaliQ9H1F0.
SMRiQ9H1F0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126725. 2 interactors.
STRINGi9606.ENSP00000361726.

Polymorphism and mutation databases

BioMutaiWFDC10A.
DMDMi24212617.

Proteomic databases

PaxDbiQ9H1F0.
PRIDEiQ9H1F0.
TopDownProteomicsiQ9H1F0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372643; ENSP00000361726; ENSG00000180305.
GeneIDi140832.
KEGGihsa:140832.
UCSCiuc002xoz.4. human.

Organism-specific databases

CTDi140832.
GeneCardsiWFDC10A.
HGNCiHGNC:16139. WFDC10A.
neXtProtiNX_Q9H1F0.
PharmGKBiPA25688.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JI59. Eukaryota.
ENOG41113ND. LUCA.
GeneTreeiENSGT00860000133922.
HOGENOMiHOG000236258.
HOVERGENiHBG058739.
InParanoidiQ9H1F0.
OMAiNICCSTF.
OrthoDBiEOG091G12D8.
PhylomeDBiQ9H1F0.
TreeFamiTF338513.

Miscellaneous databases

GenomeRNAii140832.
PROiQ9H1F0.

Gene expression databases

BgeeiENSG00000180305.
CleanExiHS_WFDC10A.
GenevisibleiQ9H1F0. HS.

Family and domain databases

Gene3Di4.10.75.10. 1 hit.
InterProiView protein in InterPro
IPR008197. WAP_dom.
PfamiView protein in Pfam
PF00095. WAP. 1 hit.
SUPFAMiSSF57256. SSF57256. 1 hit.
PROSITEiView protein in PROSITE
PS51390. WAP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiWF10A_HUMAN
AccessioniPrimary (citable) accession number: Q9H1F0
Secondary accession number(s): A2RRE9, Q5TGZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: March 15, 2017
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.