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Q9H1F0 (WF10A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WAP four-disulfide core domain protein 10A
Alternative name(s):
Putative protease inhibitor WAP10A
Gene names
Name:WFDC10A
Synonyms:C20orf146, WAP10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length79 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Sequence similarities

Contains 1 WAP domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionProtease inhibitor
Serine protease inhibitor
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 7958WAP four-disulfide core domain protein 10A
PRO_0000041387

Regions

Domain34 – 7946WAP

Amino acid modifications

Disulfide bond41 ↔ 67 By similarity
Disulfide bond50 ↔ 71 By similarity
Disulfide bond54 ↔ 66 By similarity
Disulfide bond60 ↔ 75 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9H1F0 [UniParc].

Last modified October 19, 2002. Version 2.
Checksum: 2C25A0B258ADFD7F

FASTA798,943
        10         20         30         40         50         60 
MAPQTLLPVL VLCVLLLQAQ GGYRDKKRMQ KTQLSPEIKV CQQQPKLYLC KHLCESHRDC 

        70 
QANNICCSTY CGNVCMSIL 

« Hide

References

« Hide 'large scale' references
[1]"A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein."
Clauss A., Lilja H., Lundwall A.
Biochem. J. 368:233-242(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY038182 mRNA. Translation: AAK72469.1.
AL031671 Genomic DNA. Translation: CAI22433.1.
CH471077 Genomic DNA. Translation: EAW75827.1.
BC131579 mRNA. Translation: AAI31580.1.
RefSeqNP_542791.1. NM_080753.2.
UniGeneHs.199380.

3D structure databases

ProteinModelPortalQ9H1F0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000361726.

Polymorphism databases

DMDM24212617.

Proteomic databases

PaxDbQ9H1F0.
PRIDEQ9H1F0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000372643; ENSP00000361726; ENSG00000180305.
GeneID140832.
KEGGhsa:140832.
UCSCuc002xoz.3. human.

Organism-specific databases

CTD140832.
GeneCardsGC20P044258.
HGNCHGNC:16139. WFDC10A.
HPAHPA055187.
neXtProtNX_Q9H1F0.
PharmGKBPA25688.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40341.
HOGENOMHOG000236258.
HOVERGENHBG058739.
InParanoidQ9H1F0.
OMANICCSTF.
OrthoDBEOG72RN25.
PhylomeDBQ9H1F0.
TreeFamTF338513.

Gene expression databases

BgeeQ9H1F0.
CleanExHS_WFDC10A.
GenevestigatorQ9H1F0.

Family and domain databases

Gene3D4.10.75.10. 1 hit.
InterProIPR008197. WAP-type_4-diS_core.
[Graphical view]
PfamPF00095. WAP. 1 hit.
[Graphical view]
SUPFAMSSF57256. SSF57256. 1 hit.
PROSITEPS51390. WAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi140832.
NextBio84444.
PROQ9H1F0.

Entry information

Entry nameWF10A_HUMAN
AccessionPrimary (citable) accession number: Q9H1F0
Secondary accession number(s): A2RRE9, Q5TGZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: April 16, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM