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Q9H1F0

- WF10A_HUMAN

UniProt

Q9H1F0 - WF10A_HUMAN

Protein

WAP four-disulfide core domain protein 10A

Gene

WFDC10A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WAP four-disulfide core domain protein 10A
    Alternative name(s):
    Putative protease inhibitor WAP10A
    Gene namesi
    Name:WFDC10A
    Synonyms:C20orf146, WAP10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16139. WFDC10A.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25688.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 7958WAP four-disulfide core domain protein 10APRO_0000041387Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 67PROSITE-ProRule annotation
    Disulfide bondi50 ↔ 71PROSITE-ProRule annotation
    Disulfide bondi54 ↔ 66PROSITE-ProRule annotation
    Disulfide bondi60 ↔ 75PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ9H1F0.
    PRIDEiQ9H1F0.

    Expressioni

    Gene expression databases

    BgeeiQ9H1F0.
    CleanExiHS_WFDC10A.
    GenevestigatoriQ9H1F0.

    Organism-specific databases

    HPAiHPA055187.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000361726.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H1F0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 7946WAPPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 WAP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40341.
    HOGENOMiHOG000236258.
    HOVERGENiHBG058739.
    InParanoidiQ9H1F0.
    OMAiNICCSTF.
    OrthoDBiEOG72RN25.
    PhylomeDBiQ9H1F0.
    TreeFamiTF338513.

    Family and domain databases

    Gene3Di4.10.75.10. 1 hit.
    InterProiIPR008197. WAP.
    [Graphical view]
    PfamiPF00095. WAP. 1 hit.
    [Graphical view]
    SUPFAMiSSF57256. SSF57256. 1 hit.
    PROSITEiPS51390. WAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9H1F0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPQTLLPVL VLCVLLLQAQ GGYRDKKRMQ KTQLSPEIKV CQQQPKLYLC   50
    KHLCESHRDC QANNICCSTY CGNVCMSIL 79
    Length:79
    Mass (Da):8,943
    Last modified:October 19, 2002 - v2
    Checksum:i2C25A0B258ADFD7F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY038182 mRNA. Translation: AAK72469.1.
    AL031671 Genomic DNA. Translation: CAI22433.1.
    CH471077 Genomic DNA. Translation: EAW75827.1.
    BC131579 mRNA. Translation: AAI31580.1.
    CCDSiCCDS13363.1.
    RefSeqiNP_542791.1. NM_080753.2.
    UniGeneiHs.199380.

    Genome annotation databases

    EnsembliENST00000372643; ENSP00000361726; ENSG00000180305.
    GeneIDi140832.
    KEGGihsa:140832.
    UCSCiuc002xoz.3. human.

    Polymorphism databases

    DMDMi24212617.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY038182 mRNA. Translation: AAK72469.1 .
    AL031671 Genomic DNA. Translation: CAI22433.1 .
    CH471077 Genomic DNA. Translation: EAW75827.1 .
    BC131579 mRNA. Translation: AAI31580.1 .
    CCDSi CCDS13363.1.
    RefSeqi NP_542791.1. NM_080753.2.
    UniGenei Hs.199380.

    3D structure databases

    ProteinModelPortali Q9H1F0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000361726.

    Polymorphism databases

    DMDMi 24212617.

    Proteomic databases

    PaxDbi Q9H1F0.
    PRIDEi Q9H1F0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372643 ; ENSP00000361726 ; ENSG00000180305 .
    GeneIDi 140832.
    KEGGi hsa:140832.
    UCSCi uc002xoz.3. human.

    Organism-specific databases

    CTDi 140832.
    GeneCardsi GC20P044258.
    HGNCi HGNC:16139. WFDC10A.
    HPAi HPA055187.
    neXtProti NX_Q9H1F0.
    PharmGKBi PA25688.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40341.
    HOGENOMi HOG000236258.
    HOVERGENi HBG058739.
    InParanoidi Q9H1F0.
    OMAi NICCSTF.
    OrthoDBi EOG72RN25.
    PhylomeDBi Q9H1F0.
    TreeFami TF338513.

    Miscellaneous databases

    GenomeRNAii 140832.
    NextBioi 84444.
    PROi Q9H1F0.

    Gene expression databases

    Bgeei Q9H1F0.
    CleanExi HS_WFDC10A.
    Genevestigatori Q9H1F0.

    Family and domain databases

    Gene3Di 4.10.75.10. 1 hit.
    InterProi IPR008197. WAP.
    [Graphical view ]
    Pfami PF00095. WAP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57256. SSF57256. 1 hit.
    PROSITEi PS51390. WAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein."
      Clauss A., Lilja H., Lundwall A.
      Biochem. J. 368:233-242(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiWF10A_HUMAN
    AccessioniPrimary (citable) accession number: Q9H1F0
    Secondary accession number(s): A2RRE9, Q5TGZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: October 19, 2002
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3